SI9111599A - Postopek za pridobivanje vodotopnih analogov kamptotecina in intermediatov za njihovo pripravo, kot tudi spojine, ki jih dobimo s tem postopkom - Google Patents
Postopek za pridobivanje vodotopnih analogov kamptotecina in intermediatov za njihovo pripravo, kot tudi spojine, ki jih dobimo s tem postopkom Download PDFInfo
- Publication number
- SI9111599A SI9111599A SI9111599A SI9111599A SI9111599A SI 9111599 A SI9111599 A SI 9111599A SI 9111599 A SI9111599 A SI 9111599A SI 9111599 A SI9111599 A SI 9111599A SI 9111599 A SI9111599 A SI 9111599A
- Authority
- SI
- Slovenia
- Prior art keywords
- compound
- camptothecin
- process according
- formula
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Auxiliary Devices For And Details Of Packaging Control (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58964390A | 1990-09-28 | 1990-09-28 | |
| YU159991A YU159991A (sh) | 1990-09-28 | 1991-09-30 | Postupak za dobijanje u vodi rastvornih analoga kamptotecina i intermedijera za njihovu proizvodnju kao i jedinjenja dobijena ovim postupkom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI9111599A true SI9111599A (sl) | 1998-02-28 |
Family
ID=24358879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9111599A SI9111599A (sl) | 1990-09-28 | 1991-09-30 | Postopek za pridobivanje vodotopnih analogov kamptotecina in intermediatov za njihovo pripravo, kot tudi spojine, ki jih dobimo s tem postopkom |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5734056A (OSRAM) |
| EP (1) | EP0547165B1 (OSRAM) |
| JP (1) | JP2848958B2 (OSRAM) |
| CN (1) | CN1033509C (OSRAM) |
| AT (1) | ATE186461T1 (OSRAM) |
| AU (1) | AU664830B2 (OSRAM) |
| CA (1) | CA2090967C (OSRAM) |
| CZ (1) | CZ51593A3 (OSRAM) |
| DE (1) | DE69131775T2 (OSRAM) |
| DK (1) | DK0547165T3 (OSRAM) |
| ES (1) | ES2137932T3 (OSRAM) |
| FI (1) | FI931384A0 (OSRAM) |
| GR (1) | GR3031823T3 (OSRAM) |
| HU (1) | HUT70024A (OSRAM) |
| IE (1) | IE913402A1 (OSRAM) |
| IL (1) | IL99571A (OSRAM) |
| NO (1) | NO931153D0 (OSRAM) |
| NZ (1) | NZ239947A (OSRAM) |
| PT (1) | PT99109B (OSRAM) |
| SI (1) | SI9111599A (OSRAM) |
| SK (1) | SK283693B6 (OSRAM) |
| WO (1) | WO1992005785A1 (OSRAM) |
| YU (1) | YU159991A (OSRAM) |
| ZA (1) | ZA917748B (OSRAM) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
| US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
| GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
| KR960029336A (ko) * | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| JPH08333370A (ja) * | 1995-06-08 | 1996-12-17 | Kyorin Pharmaceut Co Ltd | 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法 |
| AU7732996A (en) * | 1995-11-22 | 1997-06-11 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
| US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| GB9601779D0 (en) * | 1996-01-30 | 1996-04-03 | Pharmacia Spa | 9, 10 Disubstituted camptothecin derivatives |
| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6043367A (en) * | 1998-09-30 | 2000-03-28 | Roffler; Steve | Proactive antitumor compounds |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| WO2004055020A1 (en) * | 2002-12-16 | 2004-07-01 | Council Of Scientific And Industrial Research | Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones |
| AU2003223109A1 (en) * | 2003-03-31 | 2004-10-25 | Council Of Scientific And Industrial Research | Process for preparing topotecan from 10-hydroxy-4-(s) camptothecin |
| AU2004238358B2 (en) | 2003-05-12 | 2010-05-13 | Scinopharm Taiwan, Ltd. | Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin |
| CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
| CZ298934B6 (cs) * | 2003-08-26 | 2008-03-12 | Pliva- Lachema A.S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| TWI333492B (en) * | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
| CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| US20050267141A1 (en) | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
| US20050272757A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
| EP1791846A1 (en) * | 2004-08-09 | 2007-06-06 | Shilpa Medicare Limited | An improved process for the preparation of irinotecan hydrochloride trihydrate |
| AU2005301500B2 (en) * | 2004-11-05 | 2011-02-03 | Samyang Biopharmaceuticals Corporation | Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents |
| US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
| EP1906948A4 (en) * | 2005-07-18 | 2010-03-17 | Bipar Sciences Inc | TREATMENT OF CANCER |
| KR20080068052A (ko) * | 2005-10-10 | 2008-07-22 | 씨아이피엘에이 엘티디. | 신규의 결정형 |
| US7547785B2 (en) | 2005-12-26 | 2009-06-16 | Dr. Reddy's Laboratories Limited | Process for preparing topotecan |
| US20070259031A1 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
| PE20080695A1 (es) | 2006-04-27 | 2008-06-28 | Banyu Pharma Co Ltd | Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel |
| EP2038654A4 (en) * | 2006-06-12 | 2010-08-11 | Bipar Sciences Inc | METHOD FOR THE TREATMENT OF DISEASES WITH PARP INHIBITORS |
| US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
| US20080039485A1 (en) * | 2006-08-08 | 2008-02-14 | Targetgen Biotechnology Co., Ltd. | Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers |
| JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
| CA2662517A1 (en) * | 2006-09-05 | 2008-03-13 | Jerome Moore | Treatment of cancer |
| EP2061479A4 (en) * | 2006-09-05 | 2010-08-04 | Bipar Sciences Inc | FETTIC ACID SYNTHESIS INHIBITED BY PARP HEMMER AND TREATMENT PROCEDURES THEREWITH |
| US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
| US7977483B2 (en) | 2007-04-11 | 2011-07-12 | Scinopharm Taiwan, Ltd. | Process for making topotecan |
| WO2009051815A1 (en) * | 2007-10-19 | 2009-04-23 | Bipar Sciences, Inc. | Methods and compositions for the treatment of cancer using benzopyrone-type parp inhibitors |
| JPWO2009054332A1 (ja) | 2007-10-23 | 2011-03-03 | 萬有製薬株式会社 | ピリドン置換ジヒドロピラゾロピリミジノン誘導体 |
| US7732491B2 (en) * | 2007-11-12 | 2010-06-08 | Bipar Sciences, Inc. | Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents |
| JP2011503071A (ja) * | 2007-11-12 | 2011-01-27 | バイパー サイエンシズ,インコーポレイティド | Parp阻害剤単独又は抗腫瘍剤との組み合わせによる子宮がん及び卵巣がんの治療 |
| ITMI20072268A1 (it) | 2007-12-04 | 2009-06-05 | Antibioticos Spa | Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione |
| CN101450949B (zh) * | 2007-12-07 | 2011-10-05 | 上海龙翔生物医药开发有限公司 | 一种10-羟基喜树碱的化学半合成工艺 |
| MX2010006154A (es) * | 2007-12-07 | 2010-09-24 | Bipar Sciences Inc | Tratamiento del cancer con combinaciones de inhibidores de la topoisomerasa e inhibidores de la poli-adp-ribosa-polimerasa. |
| JP5376532B2 (ja) | 2008-05-29 | 2013-12-25 | 日本マイクロバイオファーマ株式会社 | カンプトテシン誘導体の製造方法 |
| JP2012518598A (ja) | 2009-02-25 | 2012-08-16 | Msd株式会社 | ピリミドピリミドインダゾール誘導体 |
| WO2010101734A1 (en) | 2009-03-06 | 2010-09-10 | Merck Sharp & Dohme Corp. | Combination cancer therapy with an akt inhibitor and other anticancer agents |
| WO2012082337A2 (en) | 2010-12-17 | 2012-06-21 | Glaxo Wellcome Manufacturing Pte Ltd | Combination |
| US20130303560A1 (en) | 2011-02-01 | 2013-11-14 | Sunnybrook Research Institute | Combination |
| CN103145720B (zh) * | 2013-02-20 | 2015-09-30 | 上海北卡医药技术有限公司 | 一种10-羟基喜树碱的一水合物的制备方法 |
| EP2881396A1 (en) * | 2013-12-03 | 2015-06-10 | Synbias Pharma AG | Method for the synthesis of irinotecan |
| CN109475590A (zh) * | 2016-03-08 | 2019-03-15 | 成氏实验室有限公司 | 用以提升人体酸碱度从酸性变为碱性的中药配方制剂 |
| CN115551552A (zh) | 2020-02-25 | 2022-12-30 | 祐方有限公司 | 喜树碱衍生物及其缀合物 |
| US12521444B2 (en) | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
| JP2025516629A (ja) | 2022-05-11 | 2025-05-30 | セルジーン コーポレーション | T細胞療法に関連する方法および使用、ならびにその生成 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5842192B2 (ja) * | 1974-05-18 | 1983-09-17 | フセソユ−ズヌイ ナウチノ イスレドワ−チエレスキ− ヒミコ フアルマツエフチチエスキ− インスチツ−ト イメ−ニ エス オルジヨニキ−ゼ | 5− オキシ −6− アミノメチルベンゾフランノ ユウドウタイノ セイホウ |
| US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| JPS595188A (ja) * | 1982-06-30 | 1984-01-12 | Yakult Honsha Co Ltd | 10−ヒドロキシカンプトテシンの製造法 |
| JPS5946284A (ja) * | 1982-09-10 | 1984-03-15 | Yakult Honsha Co Ltd | 11−ニトロカンプトテシン誘導体およびその製造法 |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
| HU213136B (en) * | 1990-08-14 | 1997-02-28 | Kyorin Seiyaku Kk | Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them |
| US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
-
1991
- 1991-09-23 AU AU87399/91A patent/AU664830B2/en not_active Expired
- 1991-09-23 JP JP3516992A patent/JP2848958B2/ja not_active Expired - Lifetime
- 1991-09-23 FI FI931384A patent/FI931384A0/fi not_active Application Discontinuation
- 1991-09-23 AT AT91918278T patent/ATE186461T1/de not_active IP Right Cessation
- 1991-09-23 CA CA002090967A patent/CA2090967C/en not_active Expired - Lifetime
- 1991-09-23 HU HU9300878A patent/HUT70024A/hu unknown
- 1991-09-23 CZ CS93515A patent/CZ51593A3/cs unknown
- 1991-09-23 DE DE69131775T patent/DE69131775T2/de not_active Expired - Lifetime
- 1991-09-23 ES ES91918278T patent/ES2137932T3/es not_active Expired - Lifetime
- 1991-09-23 SK SK259-93A patent/SK283693B6/sk not_active IP Right Cessation
- 1991-09-23 DK DK91918278T patent/DK0547165T3/da active
- 1991-09-23 WO PCT/US1991/006888 patent/WO1992005785A1/en not_active Ceased
- 1991-09-23 EP EP91918278A patent/EP0547165B1/en not_active Expired - Lifetime
- 1991-09-26 NZ NZ23994791A patent/NZ239947A/en not_active IP Right Cessation
- 1991-09-26 IL IL9957191A patent/IL99571A/xx not_active IP Right Cessation
- 1991-09-27 IE IE340291A patent/IE913402A1/en not_active IP Right Cessation
- 1991-09-27 PT PT99109A patent/PT99109B/pt not_active IP Right Cessation
- 1991-09-27 ZA ZA917748A patent/ZA917748B/xx unknown
- 1991-09-28 CN CN91110656A patent/CN1033509C/zh not_active Expired - Lifetime
- 1991-09-30 YU YU159991A patent/YU159991A/sh unknown
- 1991-09-30 SI SI9111599A patent/SI9111599A/sl unknown
-
1993
- 1993-03-26 NO NO931153A patent/NO931153D0/no unknown
-
1995
- 1995-05-25 US US08/451,079 patent/US5734056A/en not_active Expired - Lifetime
-
1999
- 1999-11-11 GR GR990402820T patent/GR3031823T3/el unknown
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