IE913402A1 - Process for the preparation of water soluble camptothecin¹analogs and intermediates thereof, compounds prepared by¹said process, and methods of use thereof - Google Patents

Process for the preparation of water soluble camptothecin¹analogs and intermediates thereof, compounds prepared by¹said process, and methods of use thereof

Info

Publication number
IE913402A1
IE913402A1 IE340291A IE340291A IE913402A1 IE 913402 A1 IE913402 A1 IE 913402A1 IE 340291 A IE340291 A IE 340291A IE 340291 A IE340291 A IE 340291A IE 913402 A1 IE913402 A1 IE 913402A1
Authority
IE
Ireland
Prior art keywords
compound
formula
camptothecin
liquid
hydrogen
Prior art date
Application number
IE340291A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of IE913402A1 publication Critical patent/IE913402A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
IE340291A 1990-09-28 1991-09-27 Process for the preparation of water soluble camptothecin¹analogs and intermediates thereof, compounds prepared by¹said process, and methods of use thereof IE913402A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28

Publications (1)

Publication Number Publication Date
IE913402A1 true IE913402A1 (en) 1992-04-08

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
IE340291A IE913402A1 (en) 1990-09-28 1991-09-27 Process for the preparation of water soluble camptothecin¹analogs and intermediates thereof, compounds prepared by¹said process, and methods of use thereof

Country Status (24)

Country Link
US (1) US5734056A (OSRAM)
EP (1) EP0547165B1 (OSRAM)
JP (1) JP2848958B2 (OSRAM)
CN (1) CN1033509C (OSRAM)
AT (1) ATE186461T1 (OSRAM)
AU (1) AU664830B2 (OSRAM)
CA (1) CA2090967C (OSRAM)
CZ (1) CZ51593A3 (OSRAM)
DE (1) DE69131775T2 (OSRAM)
DK (1) DK0547165T3 (OSRAM)
ES (1) ES2137932T3 (OSRAM)
FI (1) FI931384A0 (OSRAM)
GR (1) GR3031823T3 (OSRAM)
HU (1) HUT70024A (OSRAM)
IE (1) IE913402A1 (OSRAM)
IL (1) IL99571A (OSRAM)
NO (1) NO931153D0 (OSRAM)
NZ (1) NZ239947A (OSRAM)
PT (1) PT99109B (OSRAM)
SI (1) SI9111599A (OSRAM)
SK (1) SK283693B6 (OSRAM)
WO (1) WO1992005785A1 (OSRAM)
YU (1) YU159991A (OSRAM)
ZA (1) ZA917748B (OSRAM)

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US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
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US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
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JP4477510B2 (ja) * 2003-03-31 2010-06-09 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ １０−ヒドロキシ−４−（ｓ）カンプトテンシンからトポテカンを調製する方法
WO2004100897A2 (en) 2003-05-12 2004-11-25 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin
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CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
AR046579A1 (es) * 2003-11-12 2005-12-14 Smithkline Beecham Corp Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
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US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
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US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
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CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
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JP6013359B2 (ja) 2010-12-17 2016-10-25 ノバルティス アーゲー 組合せ
JP2014504638A (ja) 2011-02-01 2014-02-24 グラクソスミスクライン インテレクチュアル プロパティ リミテッド 組合せ
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (en) * 2013-12-03 2015-06-10 Synbias Pharma AG Method for the synthesis of irinotecan
US20190070239A1 (en) * 2016-03-08 2019-03-07 Cheng Lab & Company, Llc Herbal formulation to raise the human body's ph level from one that is acidic to one that is more alkaline
JP2023520605A (ja) 2020-02-25 2023-05-17 メディボストン リミテッド カンプトテシン誘導体およびそのコンジュゲート
US12521444B2 (en) 2021-02-25 2026-01-13 Fortvita Biologics Limited Anti-HER2 antibody-drug conjugates and uses thereof
KR20250008774A (ko) 2022-05-11 2025-01-15 셀진 코포레이션 T 세포 요법 및 그의 생산과 관련된 방법 및 용도

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JPS5842192B2 (ja) * 1974-05-18 1983-09-17 フセソユ−ズヌイ ナウチノ イスレドワ−チエレスキ− ヒミコ フアルマツエフチチエスキ− インスチツ−ト イメ−ニ エス オルジヨニキ−ゼ ５− オキシ −６− アミノメチルベンゾフランノ ユウドウタイノ セイホウ
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Also Published As

Publication number Publication date
ZA917748B (en) 1992-09-30
SK283693B6 (sk) 2003-12-02
US5734056A (en) 1998-03-31
ATE186461T1 (de) 1999-11-15
DK0547165T3 (da) 2000-03-27
JP2848958B2 (ja) 1999-01-20
NO931153L (no) 1993-03-26
CN1062731A (zh) 1992-07-15
WO1992005785A1 (en) 1992-04-16
GR3031823T3 (en) 2000-02-29
CA2090967C (en) 2007-02-06
CZ51593A3 (en) 1994-01-19
PT99109A (pt) 1992-08-31
AU664830B2 (en) 1995-12-07
HK1012283A1 (en) 1999-07-30
FI931384A7 (fi) 1993-03-26
HU9300878D0 (en) 1993-06-28
HUT70024A (en) 1995-09-28
CN1033509C (zh) 1996-12-11
NO931153D0 (no) 1993-03-26
CA2090967A1 (en) 1992-03-29
FI931384L (fi) 1993-03-26
IL99571A0 (en) 1992-08-18
IL99571A (en) 2000-08-31
PT99109B (pt) 1999-02-26
JPH06501476A (ja) 1994-02-17
DE69131775D1 (de) 1999-12-16
YU159991A (sh) 1994-06-10
FI931384A0 (fi) 1993-03-26
SK25993A3 (en) 1993-07-07
EP0547165A4 (OSRAM) 1994-03-30
SI9111599A (sl) 1998-02-28
DE69131775T2 (de) 2000-04-20
EP0547165A1 (en) 1993-06-23
ES2137932T3 (es) 2000-01-01
EP0547165B1 (en) 1999-11-10
NZ239947A (en) 1994-07-26
AU8739991A (en) 1992-04-28

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