SI2484375T1 - Sestavek za cepljenje, ki vsebuje sintetični adjuvant - Google Patents
Sestavek za cepljenje, ki vsebuje sintetični adjuvant Download PDFInfo
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- SI2484375T1 SI2484375T1 SI200732037T SI200732037T SI2484375T1 SI 2484375 T1 SI2484375 T1 SI 2484375T1 SI 200732037 T SI200732037 T SI 200732037T SI 200732037 T SI200732037 T SI 200732037T SI 2484375 T1 SI2484375 T1 SI 2484375T1
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- 239000000203 mixture Substances 0.000 title claims abstract 11
- 239000002671 adjuvant Substances 0.000 title claims abstract 5
- 229960005486 vaccine Drugs 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 5
- 230000028993 immune response Effects 0.000 claims abstract 3
- 238000004113 cell culture Methods 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 229940124856 vaccine component Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/008—Leishmania antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (9)
- Sestavek za cepljenje, ki vsebuje sintetični adjuvant PATENTNI ZAHTEVKI1. Sestavek celic in GLA za uporabo pri metodi za povečanje ali izzvanje imunskega odziva pri bolniku, kjer so celice izolirane iz celične kulture ex vivo, ki obsega celice pacienta, pri čemer ima GLA formulo:pri čemer: so R1, R3, R5 in R6 undecil in R2 in R4 sta tridecil.
- 2. Sestavek za uporabo po zahtevku 1, kjer je pacient obolel za rakom.
- 3. Sestavek za uporabo po zahtevku 1, kjer je pacient prizadet z nalezljivo boleznijo.
- 4. Sestavek za uporabo po zahtevku 1, kjer je pacient prizadet z avtoimunsko boleznijo.
- 5. Sestavek za uporabo po katerem koli od zahtevkov 1-4, kjer celična kultura obsega imunokompetentne celice.
- 6. Sestavek za uporabo po katerem koli od zahtevkov 1-4, kjer celična kultura obsega izolirane celice imunskega sistema.
- 7. Sestavek za uporabo po katerem koli od zahtevkov 1-4, kjer celična kultura obsega T celice, makrofage, monocite, B celice ali dendritične celice.
- 8. Metoda za povečanje ali izzivanje imunskega odziva v celični kulturi, metoda obsega kombiniranje sestavka, ki obsega GLA in ekscipient, s celično kulturo, ki obsega izolirane celice imunskega sistema, pri čemer ima GLA formulo: pri čemer: so R1, R3, R5 in R6 undecil in R2 in R4 sta tridecil.
- 9. Metoda po zahtevku 8, kjer celična kultura obsega T celice, makrofage, monocite, B celice ali dendritične celice.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84740406P | 2006-09-26 | 2006-09-26 | |
EP12153249.3A EP2484375B1 (en) | 2006-09-26 | 2007-09-26 | Vaccine composition containing synthetic adjuvant |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2484375T1 true SI2484375T1 (sl) | 2018-08-31 |
Family
ID=39776582
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200732032T SI2486938T1 (sl) | 2006-09-26 | 2007-09-26 | Sestavek cepiva, ki vsebuje sintetični adjuvans |
SI200730970T SI2068918T1 (sl) | 2006-09-26 | 2007-09-26 | Si - ep sestavek za cepljenje, ki vsebuje sintetiäśna pomagala |
SI200732037T SI2484375T1 (sl) | 2006-09-26 | 2007-09-26 | Sestavek za cepljenje, ki vsebuje sintetični adjuvant |
SI200732001T SI2468300T1 (sl) | 2006-09-26 | 2007-09-26 | Sestavek cepiva, ki vsebuje sintetični adjuvant |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200732032T SI2486938T1 (sl) | 2006-09-26 | 2007-09-26 | Sestavek cepiva, ki vsebuje sintetični adjuvans |
SI200730970T SI2068918T1 (sl) | 2006-09-26 | 2007-09-26 | Si - ep sestavek za cepljenje, ki vsebuje sintetiäśna pomagala |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200732001T SI2468300T1 (sl) | 2006-09-26 | 2007-09-26 | Sestavek cepiva, ki vsebuje sintetični adjuvant |
Country Status (20)
Country | Link |
---|---|
US (10) | US8273361B2 (sl) |
EP (6) | EP2484375B1 (sl) |
JP (6) | JP5443164B2 (sl) |
KR (1) | KR101378872B1 (sl) |
CN (2) | CN103705919B (sl) |
AT (1) | ATE555808T1 (sl) |
AU (1) | AU2007354917B2 (sl) |
BR (1) | BRPI0716959A2 (sl) |
CA (1) | CA2662921C (sl) |
CY (4) | CY1112943T1 (sl) |
DK (4) | DK2468300T3 (sl) |
ES (5) | ES2387327T3 (sl) |
HK (1) | HK1132934A1 (sl) |
HU (3) | HUE037808T2 (sl) |
LT (3) | LT2484375T (sl) |
PL (4) | PL2468300T3 (sl) |
PT (4) | PT2484375T (sl) |
SI (4) | SI2486938T1 (sl) |
TR (2) | TR201807756T4 (sl) |
WO (1) | WO2008153541A1 (sl) |
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US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
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JP5328975B2 (ja) | 2012-12-19 | 2013-10-30 | ルネサスエレクトロニクス株式会社 | Rfパワーモジュール |
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