CY1112943T1 - Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο - Google Patents
Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικοInfo
- Publication number
- CY1112943T1 CY1112943T1 CY20121100668T CY121100668T CY1112943T1 CY 1112943 T1 CY1112943 T1 CY 1112943T1 CY 20121100668 T CY20121100668 T CY 20121100668T CY 121100668 T CY121100668 T CY 121100668T CY 1112943 T1 CY1112943 T1 CY 1112943T1
- Authority
- CY
- Cyprus
- Prior art keywords
- gla
- adjuvant
- composition
- synthetic
- carrier
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 230000036039 immunity Effects 0.000 title 1
- 239000002671 adjuvant Substances 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000568 immunological adjuvant Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940124856 vaccine component Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/008—Leishmania antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Συνθέσεις και μέθοδοι, που συμπεριλαμβάνουν εμβόλια και φαρμακευτικές συνθέσεις για διέγερση ή ενίσχυση ανοσοαπόκρισης αποκαλύπτονται επί τη βάσει της ανακάλυψης χρήσιμων ιδιοτήτων ανοσολογικού ανοσοενισχυτικού σε ένα συνθετικό, γλυκοπυρανοζύλ λιπιδίου ανοσοενισχυτικό (GLA) που παρέχεται σε ουσιαστικώς ομοιογενή μορφή. Χημικώς ορισμένο, συνθετικό GLΑ προσφέρει σαφές συστατικό εμβολίου από παρτίδα σε παρτίδα χωρίς τις διακυμάνσεις σε μολυντές ή δραστικότητα που διακυβεύουν φυσικού-προϊόντος ανοσοενισχυτικά. Παρέχονται επίσης εμβόλια και φαρμακευτικές συνθέσεις που περιλαμβάνουν GLA και ένα ή περισσότερα από αντιγόνο, Τοll-ομοιάζοντα υποδοχέα (ΤLR) αγωνιστή, ένα συν-ανοσοενισχυτικό κι ένα φορέα όπως φαρμακευτικό φορέα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84740406P | 2006-09-26 | 2006-09-26 | |
EP07875082A EP2068918B1 (en) | 2006-09-26 | 2007-09-26 | Vaccine composition containing synthetic adjuvant |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112943T1 true CY1112943T1 (el) | 2016-04-13 |
Family
ID=39776582
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100668T CY1112943T1 (el) | 2006-09-26 | 2012-07-26 | Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο |
CY20181100089T CY1119822T1 (el) | 2006-09-26 | 2018-01-24 | Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο |
CY20181100594T CY1120305T1 (el) | 2006-09-26 | 2018-06-06 | Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο |
CY20181100609T CY1120328T1 (el) | 2006-09-26 | 2018-06-12 | Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100089T CY1119822T1 (el) | 2006-09-26 | 2018-01-24 | Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο |
CY20181100594T CY1120305T1 (el) | 2006-09-26 | 2018-06-06 | Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο |
CY20181100609T CY1120328T1 (el) | 2006-09-26 | 2018-06-12 | Συνθεση εμβολιου περιεχουσα συνθετικο ανοσοενισχυτικο |
Country Status (20)
Country | Link |
---|---|
US (10) | US8273361B2 (el) |
EP (6) | EP2484375B1 (el) |
JP (6) | JP5443164B2 (el) |
KR (1) | KR101378872B1 (el) |
CN (2) | CN103705919B (el) |
AT (1) | ATE555808T1 (el) |
AU (1) | AU2007354917B2 (el) |
BR (1) | BRPI0716959A2 (el) |
CA (1) | CA2662921C (el) |
CY (4) | CY1112943T1 (el) |
DK (4) | DK2484375T3 (el) |
ES (5) | ES2822058T3 (el) |
HK (1) | HK1132934A1 (el) |
HU (3) | HUE037808T2 (el) |
LT (3) | LT2484375T (el) |
PL (4) | PL2484375T3 (el) |
PT (4) | PT2484375T (el) |
SI (4) | SI2484375T1 (el) |
TR (2) | TR201809043T4 (el) |
WO (1) | WO2008153541A1 (el) |
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PL2484375T3 (pl) | 2006-09-26 | 2018-09-28 | Infectious Disease Research Institute | Kompozycja szczepionki zawierająca syntetyczny adiuwant |
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