AR054474A1 - Formulacion de anticuerpos estables - Google Patents
Formulacion de anticuerpos establesInfo
- Publication number
- AR054474A1 AR054474A1 ARP060102524A ARP060102524A AR054474A1 AR 054474 A1 AR054474 A1 AR 054474A1 AR P060102524 A ARP060102524 A AR P060102524A AR P060102524 A ARP060102524 A AR P060102524A AR 054474 A1 AR054474 A1 AR 054474A1
- Authority
- AR
- Argentina
- Prior art keywords
- formulation
- stable antibodies
- antibodies
- stable
- antibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Abstract
La presente proporciona una formulacion farmacéutica que comprende un anticuerpo o fragmento vinculante de antígeno del mismo que presenta alta estabilidad; junto con métodos de uso de la misma.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69081005P | 2005-06-15 | 2005-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR054474A1 true AR054474A1 (es) | 2007-06-27 |
Family
ID=37571071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060102524A AR054474A1 (es) | 2005-06-15 | 2006-06-14 | Formulacion de anticuerpos estables |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060286103A1 (es) |
EP (1) | EP1896505A2 (es) |
JP (2) | JP2008546699A (es) |
KR (1) | KR20080019249A (es) |
CN (1) | CN101287761A (es) |
AR (1) | AR054474A1 (es) |
AU (1) | AU2006259536A1 (es) |
BR (1) | BRPI0611800A2 (es) |
CA (1) | CA2611149A1 (es) |
MX (1) | MX2007016306A (es) |
NO (1) | NO20080246L (es) |
NZ (1) | NZ564098A (es) |
PE (2) | PE20100096A1 (es) |
TW (1) | TW200745161A (es) |
WO (1) | WO2006138315A2 (es) |
ZA (1) | ZA200710855B (es) |
Families Citing this family (55)
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ES2536709T3 (es) * | 2002-02-14 | 2015-05-27 | Chugai Seiyaku Kabushiki Kaisha | Utilización de ácido acético para eliminar los problemas inducidos por el ión Fe en las formulaciones de anticuerpos anti-HM1.24 o anti-IL6R |
NZ554740A (en) | 2002-05-24 | 2009-01-31 | Schering Corp | Neutralizing human anti-IGFR antibody |
AR046639A1 (es) * | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
ES2356830T3 (es) * | 2004-12-03 | 2011-04-13 | Schering Corporation | Biomarcadores para preselección de pacientes para terapia de anti-igf-1r. |
NZ561648A (en) * | 2005-04-15 | 2009-11-27 | Schering Corp | Methods and composition of IGF1R inhibitors for treating or preventing cancer |
ES2427924T3 (es) * | 2006-06-30 | 2013-11-04 | Merck Sharp & Dohme Corp. | Biomarcador IGFBP2 |
WO2009131553A2 (en) * | 2006-12-29 | 2009-10-29 | Osteogenex Inc. | Methods of altering bone growth by administration of sost or wise antagonist or agonist |
BRPI0809112A2 (pt) * | 2007-03-22 | 2014-08-26 | Imclone Llc | Formulações estáveis de anticorpos |
US20090181027A1 (en) * | 2007-09-28 | 2009-07-16 | Paul Dal Monte | Anti-IL-12/23p40 Antibodies, Epitopes, Formulations, Compositions, Methods and Uses |
WO2009142810A2 (en) * | 2008-03-25 | 2009-11-26 | Schering Corporation | Methods for treating or preventing colorectal cancer |
CN102202655B (zh) * | 2008-08-27 | 2013-06-19 | 默沙东公司 | 基因工程抗IL-23p19抗体的冻干制剂 |
WO2010056816A2 (en) * | 2008-11-12 | 2010-05-20 | Schering Corporation | βGI-IGG INTRON FOR ENHANCED ANTI-IGF1 R EXPRESSION |
WO2011017520A1 (en) * | 2009-08-05 | 2011-02-10 | Wake Forest University Health Sciences | Compositions and methods for inducing apoptosis in prostate cancer cells |
WO2011029823A1 (en) | 2009-09-09 | 2011-03-17 | Novartis Ag | Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells |
JP2013528570A (ja) * | 2010-03-31 | 2013-07-11 | ユニベルシテ ドゥ ジュネーブ | 安定化された抗体調製物およびその使用 |
JP5864556B2 (ja) * | 2010-05-27 | 2016-02-17 | ヤンセン バイオテツク,インコーポレーテツド | インスリン様成長因子1受容体結合ペプチド |
SG186421A1 (en) * | 2010-07-02 | 2013-01-30 | Medimmune Llc | Antibody formulations |
JP2013543384A (ja) | 2010-10-05 | 2013-12-05 | ノバルティス アーゲー | 抗−il12rベータ1抗体ならびに自己免疫性および炎症性疾患の処置おけるその使用 |
MX371052B (es) | 2013-02-08 | 2020-01-14 | Novartis Ag | Anticuerpos anti-il-17a y su uso en el tratamiento de trastornos autoinmunes e inflamatorios. |
EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
US20170291939A1 (en) | 2014-06-25 | 2017-10-12 | Novartis Ag | Antibodies specific for il-17a fused to hyaluronan binding peptide tags |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
WO2016172583A1 (en) | 2015-04-23 | 2016-10-27 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
US11667691B2 (en) | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
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CN116731173A (zh) * | 2017-12-14 | 2023-09-12 | Abl生物公司 | 抗a-syn/igf1r的双特异性抗体及其用途 |
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-
2006
- 2006-06-13 KR KR1020077030486A patent/KR20080019249A/ko not_active Application Discontinuation
- 2006-06-13 CA CA002611149A patent/CA2611149A1/en not_active Abandoned
- 2006-06-13 CN CNA2006800285673A patent/CN101287761A/zh active Pending
- 2006-06-13 WO PCT/US2006/022995 patent/WO2006138315A2/en active Application Filing
- 2006-06-13 EP EP06773043A patent/EP1896505A2/en not_active Withdrawn
- 2006-06-13 NZ NZ564098A patent/NZ564098A/en not_active IP Right Cessation
- 2006-06-13 AU AU2006259536A patent/AU2006259536A1/en not_active Abandoned
- 2006-06-13 JP JP2008517021A patent/JP2008546699A/ja not_active Ceased
- 2006-06-13 US US11/452,167 patent/US20060286103A1/en not_active Abandoned
- 2006-06-13 MX MX2007016306A patent/MX2007016306A/es not_active Application Discontinuation
- 2006-06-13 BR BRPI0611800-3A patent/BRPI0611800A2/pt not_active IP Right Cessation
- 2006-06-14 PE PE2009001322A patent/PE20100096A1/es not_active Application Discontinuation
- 2006-06-14 AR ARP060102524A patent/AR054474A1/es not_active Application Discontinuation
- 2006-06-14 PE PE2006000669A patent/PE20070116A1/es not_active Application Discontinuation
- 2006-06-15 TW TW095121416A patent/TW200745161A/zh unknown
-
2007
- 2007-12-13 ZA ZA200710855A patent/ZA200710855B/xx unknown
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2008
- 2008-01-14 NO NO20080246A patent/NO20080246L/no not_active Application Discontinuation
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2011
- 2011-05-06 JP JP2011103850A patent/JP2011148841A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
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US20060286103A1 (en) | 2006-12-21 |
ZA200710855B (en) | 2008-12-31 |
JP2011148841A (ja) | 2011-08-04 |
NO20080246L (no) | 2008-03-17 |
WO2006138315A2 (en) | 2006-12-28 |
MX2007016306A (es) | 2008-03-07 |
CN101287761A (zh) | 2008-10-15 |
EP1896505A2 (en) | 2008-03-12 |
NZ564098A (en) | 2010-04-30 |
BRPI0611800A2 (pt) | 2008-12-09 |
KR20080019249A (ko) | 2008-03-03 |
JP2008546699A (ja) | 2008-12-25 |
AU2006259536A1 (en) | 2006-12-28 |
PE20100096A1 (es) | 2010-02-17 |
WO2006138315A3 (en) | 2007-06-07 |
PE20070116A1 (es) | 2007-02-09 |
CA2611149A1 (en) | 2006-12-28 |
TW200745161A (en) | 2007-12-16 |
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