DE69840962D1 - Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel - Google Patents
Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittelInfo
- Publication number
- DE69840962D1 DE69840962D1 DE69840962T DE69840962T DE69840962D1 DE 69840962 D1 DE69840962 D1 DE 69840962D1 DE 69840962 T DE69840962 T DE 69840962T DE 69840962 T DE69840962 T DE 69840962T DE 69840962 D1 DE69840962 D1 DE 69840962D1
- Authority
- DE
- Germany
- Prior art keywords
- adjuvant
- compositions
- polysorbate
- cyclodextrin
- aid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5725597P | 1997-08-29 | 1997-08-29 | |
PCT/US1998/017940 WO1999010008A1 (en) | 1997-08-29 | 1998-08-28 | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69840962D1 true DE69840962D1 (de) | 2009-08-20 |
Family
ID=22009474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69840962T Expired - Lifetime DE69840962D1 (de) | 1997-08-29 | 1998-08-28 | Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel |
Country Status (10)
Country | Link |
---|---|
US (2) | US6645495B1 (de) |
EP (2) | EP1009429B1 (de) |
JP (3) | JP5220248B2 (de) |
AT (1) | ATE435661T1 (de) |
AU (1) | AU734180B2 (de) |
CA (2) | CA2654522C (de) |
DE (1) | DE69840962D1 (de) |
ES (2) | ES2327693T3 (de) |
HK (1) | HK1129846A1 (de) |
WO (1) | WO1999010008A1 (de) |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999010008A1 (en) * | 1997-08-29 | 1999-03-04 | Aquila Biopharmaceuticals, Inc. | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20010034330A1 (en) * | 1998-08-10 | 2001-10-25 | Charlotte Kensil | Innate immunity-stimulating compositions of CpG and saponin and methods thereof |
EP1104306B1 (de) * | 1998-08-10 | 2006-01-11 | Antigenics Inc. | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
IL145982A0 (en) | 1999-04-19 | 2002-07-25 | Smithkline Beecham Biolog | Vaccines |
AU5793600A (en) * | 1999-09-22 | 2001-03-29 | Baker Hughes Incorporated | Hydraulic fracturing using non-ionic surfactant gelling agent |
US8017590B1 (en) | 1999-10-22 | 2011-09-13 | Sanofi Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
EP1282702B1 (de) | 2000-05-10 | 2006-11-29 | Sanofi Pasteur Limited | Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen |
PL211151B1 (pl) | 2000-10-18 | 2012-04-30 | Glaxosmithkline Biolog Sa | Kompozycja immunogenna oraz zastosowanie połączenia saponiny, oligonukleotydu immunostymulującego i lipopolisacharydu |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
AU2002218535A8 (en) * | 2000-12-12 | 2008-01-17 | Japan Tobacco Inc | Pharmaceutical composition containing an active with a hemolytic action and a surfactant |
US6982256B2 (en) | 2001-09-07 | 2006-01-03 | Boehringer Ingelheim Pharma Kg | Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration |
DE10144030A1 (de) * | 2001-09-07 | 2003-03-27 | Boehringer Ingelheim Pharma | Verbesserung der lokalen Verträglichkeit bei intravenöser Verabreichung von 4-(4-(2-Pyrrolylcarbonyl-1-piperazinyl)-3-trifluormethyl-benzoylguanidin |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
WO2004037189A2 (en) | 2002-10-23 | 2004-05-06 | Glaxosmithkline Biologicals S.A. | Methods for vaccinating against malaria |
TWI374893B (en) | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
EP1687022A4 (de) | 2003-11-12 | 2008-02-13 | Medical Res Council | Renta: hiv-immunogen und seine anwendungen |
ATE491467T1 (de) | 2004-05-28 | 2011-01-15 | Glaxosmithkline Biolog Sa | Impfstoffzusammensetzungen mit virosomen und einem saponin-adjuvans |
GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
WO2006055875A2 (en) * | 2004-11-18 | 2006-05-26 | University Of Rochester | Methods and compositions related to esculentoside a |
CA2590337C (en) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
GB0513421D0 (en) | 2005-06-30 | 2005-08-03 | Glaxosmithkline Biolog Sa | Vaccines |
US7622121B2 (en) * | 2005-09-21 | 2009-11-24 | New York University | Heat shock proteins from Mycobacterium leprae and uses thereof |
EP1965856A2 (de) | 2005-12-30 | 2008-09-10 | Tti Ellebeau, Inc. | Iontophoretische systeme, vorrichtungen und verfahren zur abgabe von wirkstoffen an eine biologische schnittstelle |
WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
WO2007143606A2 (en) | 2006-06-02 | 2007-12-13 | International Aids Vaccine Initiative | Hiv-1 clade a consensus sequences, antigens, and transgenes |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
AU2007354917B2 (en) | 2006-09-26 | 2013-06-06 | Access To Advanced Health Institute | Vaccine composition containing synthetic adjuvant |
LT2137210T (lt) | 2007-03-02 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Naujas būdas ir kompozicijos |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
KR101540920B1 (ko) * | 2007-07-26 | 2015-08-03 | 사노피 파스퇴르 리미티드 | 항원-애주번트 조성물 및 방법 |
KR20100068390A (ko) | 2007-08-13 | 2010-06-23 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
EP2062594A1 (de) | 2007-11-21 | 2009-05-27 | Wyeth Farma, S.A. | Impfstoff und immunogene Zusammensetzung gegen den Blauzungenvirus, Verfahren zu deren Verwendung und Verfahren zu deren Herstellung |
WO2009143524A2 (en) | 2008-05-23 | 2009-11-26 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
TW201010719A (en) * | 2008-08-19 | 2010-03-16 | Wyeth Corp | Immunological composition |
CN102223876A (zh) | 2008-09-26 | 2011-10-19 | 纳米生物公司 | 纳米乳剂治疗性组合物及其使用方法 |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
CA2764374C (en) | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
EP2442827B1 (de) | 2009-06-16 | 2016-01-06 | The Regents of the University of Michigan | Nanoemulsionsimpfstoffe |
US20110110980A1 (en) | 2009-09-02 | 2011-05-12 | Wyeth Llc | Heterlogous prime-boost immunization regimen |
MY157607A (en) * | 2009-09-10 | 2016-06-30 | Merial Inc | New vaccine formulations comprising saponin-containing adjuvants |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
US8658603B2 (en) | 2010-06-16 | 2014-02-25 | The Regents Of The University Of Michigan | Compositions and methods for inducing an immune response |
US9168292B2 (en) | 2010-09-27 | 2015-10-27 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
EP2701736A1 (de) | 2011-04-25 | 2014-03-05 | Advanced Bioscience Laboratories, Inc. | Trunkierte hiv-hüllproteine (env), verfahren und zugehörige zusammensetzungen |
AU2012267786B2 (en) | 2011-06-10 | 2017-08-03 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
AU2012216792A1 (en) | 2011-09-12 | 2013-03-28 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies |
PE20141547A1 (es) | 2011-09-16 | 2014-10-25 | Ucb Pharma Sa | Anticuerpos neutralizantes frente a las exotoxinas principales tcda y tcdb de clostridium difficile |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
JP6121436B2 (ja) | 2011-11-23 | 2017-04-26 | バイオベン・3・リミテッドBioven 3 Limited | 組換えタンパク質及びそれらの治療的用途 |
WO2013082476A1 (en) | 2011-11-30 | 2013-06-06 | Emory University | Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
TR201908003T4 (tr) | 2012-02-07 | 2019-06-21 | Infectious Disease Res Inst | TLR4 agonistleri içeren gelişmiş adjuvan formülasyonları ve bunların kullanım metotları. |
US9347065B2 (en) | 2012-03-29 | 2016-05-24 | International Aids Vaccine Initiative | Methods to improve vector expression and genetic stability |
EP2679596B1 (de) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 Env-proteinvariante |
EP2892555B1 (de) | 2012-09-10 | 2020-03-25 | International Aids Vaccine Initiative | Immunogene aus breit neutralisierenden hiv-1-antikörpern, verfahren zur herstellung und verwendungen davon |
MY187936A (en) | 2013-03-15 | 2021-10-29 | In3Bio Ltd | Self-assembling synthetic proteins |
WO2015017280A1 (en) | 2013-07-28 | 2015-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations that induce a th2 immune response |
EP2848937A1 (de) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Verfahren zur Identifizierung neuartiger HIV-1-Immunogene |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
WO2015063611A2 (en) | 2013-11-01 | 2015-05-07 | University Of Oslo | Albumin variants and uses thereof |
DK3069138T3 (en) | 2013-11-15 | 2019-04-08 | Univ Oslo Hf | CTL PEPTID EPITOPES AND ANTIGEN-SPECIFIC T-CELLS, METHODS OF RECOGNITION THEREOF, AND APPLICATIONS THEREOF |
WO2015092710A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Biologicals, S.A. | Contralateral co-administration of vaccines |
BR112016015422A2 (pt) | 2013-12-31 | 2017-10-24 | Infectious Disease Res Inst | formulações de vacina de frasco único |
JP6458809B2 (ja) | 2014-04-25 | 2019-01-30 | 味の素株式会社 | 免疫賦活剤 |
WO2015171975A1 (en) | 2014-05-09 | 2015-11-12 | The Regents Of The University Of Michigan | Use of modified banana lectin in purification of glycoproteins |
MA47849A (fr) | 2014-05-28 | 2020-01-29 | Agenus Inc | Anticorps anti-gitr et leurs procédés d'utilisation |
US10093720B2 (en) | 2014-06-11 | 2018-10-09 | International Aids Vaccine Initiative | Broadly neutralizing antibody and uses thereof |
JP7158853B2 (ja) | 2014-10-10 | 2022-10-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 対象における食物アレルギーまたは呼吸器アレルギーを処置するための、かつ上記対象の鼻腔内に投与するための免疫原性組成物 |
WO2016141320A2 (en) | 2015-03-05 | 2016-09-09 | Northwestern University | Non-neuroinvasive viruses and uses thereof |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (de) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
AU2016260540B2 (en) | 2015-05-13 | 2021-01-07 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
BR112018003186A2 (pt) | 2015-09-01 | 2018-09-25 | Agenus Inc. | anticorpos anti-pd-1 e seus métodos de uso |
US9925258B2 (en) | 2015-10-02 | 2018-03-27 | International Aids Vaccine Initiative | Replication-competent VSV-HIV Env vaccines |
EP3368508A1 (de) | 2015-10-28 | 2018-09-05 | Ajinomoto Co., Inc. | Immunstimulierendes mittel |
US11447557B2 (en) | 2015-12-02 | 2022-09-20 | Agenus Inc. | Antibodies and methods of use thereof |
WO2017158421A1 (en) | 2016-03-14 | 2017-09-21 | University Of Oslo | Anti-viral engineered immunoglobulins |
TN2018000301A1 (en) | 2016-03-14 | 2020-01-16 | Univ Oslo | Engineered immunoglobulins with altered fcrn binding |
US11173207B2 (en) | 2016-05-19 | 2021-11-16 | The Regents Of The University Of Michigan | Adjuvant compositions |
CA3024508A1 (en) | 2016-05-27 | 2017-11-30 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
WO2017221072A2 (en) | 2016-06-21 | 2017-12-28 | University Of Oslo | Hla binding vaccine moieties and uses thereof |
WO2018037045A1 (en) | 2016-08-23 | 2018-03-01 | Glaxosmithkline Biologicals Sa | Fusion peptides with antigens linked to short fragments of invariant chain (cd74) |
BE1024774B1 (fr) | 2016-09-29 | 2018-07-02 | Glaxosmithkline Biologicals Sa | Compositions et procedes de traitement |
MA46529A (fr) | 2016-10-11 | 2019-08-21 | Agenus Inc | Anticorps anti-lag-3 et leurs procédés d'utilisation |
WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
BR112019014510A2 (pt) | 2017-01-13 | 2020-02-18 | Agenus Inc. | Receptores de célula t que se ligam ao ny-eso-1 e métodos de uso dos mesmos |
KR102629972B1 (ko) | 2017-04-13 | 2024-01-29 | 아게누스 인코포레이티드 | 항-cd137 항체 및 이의 사용 방법 |
PL3618863T3 (pl) | 2017-05-01 | 2023-11-06 | Agenus Inc. | Przeciwciała anty- tigit i sposoby ich zastosowania |
IL300235A (en) | 2017-07-18 | 2023-03-01 | In3Bio Ltd | Synthetic proteins and their therapeutic uses |
SG11202001319QA (en) | 2017-09-04 | 2020-03-30 | Agenus Inc | T cell receptors that bind to mixed lineage leukemia (mll)-specific phosphopeptides and methods of use thereof |
EP3678699A1 (de) | 2017-09-07 | 2020-07-15 | University Of Oslo | Impfstoffmoleküle |
US20220118076A1 (en) | 2017-09-07 | 2022-04-21 | University Of Oslo | Vaccine molecules |
US20200276299A1 (en) | 2017-09-08 | 2020-09-03 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
GB201721069D0 (en) | 2017-12-15 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Hepatitis B Immunisation regimen and compositions |
GB201721068D0 (en) | 2017-12-15 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Hepatitis B immunisation regimen and compositions |
US11065317B2 (en) | 2018-04-26 | 2021-07-20 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
AU2019277361A1 (en) | 2018-05-30 | 2020-12-17 | Translate Bio, Inc. | Messenger RNA vaccines and uses thereof |
MX2020013553A (es) | 2018-06-12 | 2021-02-26 | Glaxosmithkline Biologicals Sa | Polinucleotidos y polipeptidos de adenovirus. |
EP3581201A1 (de) | 2018-06-15 | 2019-12-18 | GlaxoSmithKline Biologicals S.A. | Escherichia coli o157:h7 polypeptide und verwendungen davon |
MX2021001479A (es) | 2018-08-07 | 2021-04-28 | Glaxosmithkline Biologicals Sa | Novedosos procesos y vacunas. |
WO2020128012A1 (en) | 2018-12-21 | 2020-06-25 | Glaxosmithkline Biologicals Sa | Methods of inducing an immune response |
TW202102256A (zh) | 2019-03-05 | 2021-01-16 | 比利時商葛蘭素史密斯克藍生物品公司 | B型肝炎免疫法及組合物 |
WO2020243115A1 (en) | 2019-05-25 | 2020-12-03 | Infectious Disease Research Institute | Composition and method for spray drying an adjuvant vaccine emulsion |
KR20220058527A (ko) | 2019-06-25 | 2022-05-09 | 인3바이오 리미티드 | 안정화된 키메라 합성 단백질 및 그 치료 용도 |
CR20220076A (es) | 2019-08-30 | 2022-06-24 | Agenus Inc | Anticuerpos anti-cd96 y sus métodos de uso |
WO2021097347A1 (en) | 2019-11-15 | 2021-05-20 | Infectious Disease Research Institute | Rig-i agonist and adjuvant formulation for tumor treatment |
US20210338804A1 (en) | 2020-02-21 | 2021-11-04 | International Aids Vaccine Initiative Inc. | Vaccine Compositions For Preventing Coronavirus Disease |
WO2021177248A1 (ja) | 2020-03-02 | 2021-09-10 | 株式会社シクロケムバイオ | 腸管機能向上剤 |
MX2023006320A (es) | 2020-12-02 | 2023-06-14 | Glaxosmithkline Biologicals Sa | Cadena donante complementada fimh. |
WO2022207793A1 (en) | 2021-03-31 | 2022-10-06 | Vib Vzw | Vaccine compositions for trypanosomatids |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1083815A (en) * | 1963-10-01 | 1967-09-20 | Wellcome Found | Vaccine adjuvants |
US4772466A (en) * | 1983-08-22 | 1988-09-20 | Syntex (U.S.A.) Inc. | Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants |
US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
DE3446515A1 (de) * | 1984-12-20 | 1986-06-26 | Behringwerke Ag, 3550 Marburg | Oeladjuvierte vaccine und verfahren zu ihrer herstellung |
US4806350A (en) * | 1986-04-18 | 1989-02-21 | Norden Laboratories, Inc. | Vaccine formulation |
ZA872532B (en) * | 1986-04-21 | 1987-11-25 | Akzo Nv | Combined vaccine |
US4717717A (en) * | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
US5583112A (en) * | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
GB8921470D0 (en) * | 1989-09-22 | 1989-11-08 | Peptide Technology Ltd | Vaccines |
NL9002314A (nl) * | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
ZA927037B (en) * | 1991-09-30 | 1993-03-29 | Akzo Nv | Respiratory disease vaccine for cats. |
US5650398A (en) * | 1992-07-02 | 1997-07-22 | Cambridge Biotech Corporation | Drug delivery enhancement via modified saponins |
JP2510943B2 (ja) * | 1993-06-07 | 1996-06-26 | 株式会社ドクターマインツ | 痩身用食品 |
EP0724433B1 (de) * | 1993-10-22 | 1998-12-30 | Genentech, Inc. | Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe |
GB9326253D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US5688772A (en) * | 1994-08-01 | 1997-11-18 | University Of Saskatchewan | Quinoa saponin compositions and methods of use |
AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
BE1008978A5 (fr) * | 1994-12-27 | 1996-10-01 | Solvay | Adjuvants pour vaccins. |
KR0184779B1 (ko) * | 1995-04-13 | 1999-04-01 | 성재갑 | 퀼라야 사포나리아 몰리나로부터 분리정제된 사포닌 변이체, 이의 분리정제 방법 및 이를 함유하는 백신 제형 |
GB9620795D0 (en) * | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
US6231859B1 (en) * | 1996-12-02 | 2001-05-15 | Aquila Biopharmaceuticals, Inc. | Saponin adjuvant compositions |
EP0996451B1 (de) * | 1997-05-20 | 2005-01-05 | Galenica Pharmaceuticals, Inc. | Triterpene-saponin analoga mit adjuvans und immunostimulierender wirkung |
WO1999010008A1 (en) * | 1997-08-29 | 1999-03-04 | Aquila Biopharmaceuticals, Inc. | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
-
1998
- 1998-08-28 WO PCT/US1998/017940 patent/WO1999010008A1/en active IP Right Grant
- 1998-08-28 CA CA2654522A patent/CA2654522C/en not_active Expired - Lifetime
- 1998-08-28 CA CA2302522A patent/CA2302522C/en not_active Expired - Lifetime
- 1998-08-28 EP EP98944600A patent/EP1009429B1/de not_active Expired - Lifetime
- 1998-08-28 ES ES98944600T patent/ES2327693T3/es not_active Expired - Lifetime
- 1998-08-28 AT AT98944600T patent/ATE435661T1/de not_active IP Right Cessation
- 1998-08-28 AU AU92107/98A patent/AU734180B2/en not_active Expired
- 1998-08-28 EP EP08020939.8A patent/EP2050465B1/de not_active Expired - Lifetime
- 1998-08-28 DE DE69840962T patent/DE69840962D1/de not_active Expired - Lifetime
- 1998-08-28 JP JP2000507397A patent/JP5220248B2/ja not_active Expired - Lifetime
- 1998-08-28 US US09/143,145 patent/US6645495B1/en not_active Expired - Lifetime
- 1998-08-28 ES ES08020939.8T patent/ES2500490T3/es not_active Expired - Lifetime
-
2003
- 2003-10-03 US US10/679,708 patent/US20050191310A1/en not_active Abandoned
-
2009
- 2009-04-21 JP JP2009103126A patent/JP2009197014A/ja active Pending
- 2009-10-19 HK HK09109616A patent/HK1129846A1/xx not_active IP Right Cessation
-
2011
- 2011-05-18 JP JP2011111575A patent/JP2011162559A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2011162559A (ja) | 2011-08-25 |
HK1129846A1 (en) | 2009-12-11 |
WO1999010008A1 (en) | 1999-03-04 |
JP2001513575A (ja) | 2001-09-04 |
CA2302522A1 (en) | 1999-03-04 |
ES2327693T3 (es) | 2009-11-02 |
ATE435661T1 (de) | 2009-07-15 |
CA2654522C (en) | 2014-01-28 |
CA2302522C (en) | 2010-08-17 |
ES2500490T3 (es) | 2014-09-30 |
EP1009429B1 (de) | 2009-07-08 |
JP5220248B2 (ja) | 2013-06-26 |
EP2050465A2 (de) | 2009-04-22 |
US20050191310A1 (en) | 2005-09-01 |
EP2050465A3 (de) | 2009-09-02 |
EP1009429A1 (de) | 2000-06-21 |
AU9210798A (en) | 1999-03-16 |
AU734180B2 (en) | 2001-06-07 |
EP2050465B1 (de) | 2014-06-11 |
CA2654522A1 (en) | 1999-03-04 |
US6645495B1 (en) | 2003-11-11 |
JP2009197014A (ja) | 2009-09-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE435661T1 (de) | Adjuvant qs-21 enthaltende zusammensetzungen mit polysorbate oder cyclodextrin als hilfsmittel | |
PT770397E (pt) | Vacina de combinacao contra o virus da doenca de newcastle | |
HK1046016B (zh) | 疫苗中的重組脫氧核糖核酸膠原 | |
BR9910973A (pt) | Vacina | |
BR9107206A (pt) | Processo para produzir uma variante de proteina que evoca uma resposta imunogenica diminuida em animais,produtos obtidos,composicao e uso | |
ATE146360T1 (de) | Gonadotropin enthaltende gefriergetrocknete troepfen | |
DK0910406T3 (da) | Rekombinante hunde-herpesvirus | |
GR3032543T3 (en) | Signal transmission and tag power consumption measurement circuit for an inductive reader. | |
ES2182914T3 (es) | Inmunopotenciacion inducida de quitosan. | |
DE69828801D1 (de) | Peptide abgeleitet vom bindungs (g) protein des respiratorisches synzytialvirus | |
DE69614390T2 (de) | Antiwachstumwirksame proteine aus oozyten von rana pipiens | |
ES2096727T3 (es) | Productos cosmeticos y farmaceuticos que contienen extensinas. | |
ES2119779T3 (es) | Solubilizacion de proteinas en formas activas. | |
ES2170144T3 (es) | Variantes que no se empalman de gp350/220. | |
DK0588177T3 (da) | Interferon-alpha/beta-bindende protein, fremstilling heraf samt farmaceutiske præparater indeholdende proteinet | |
NO942323L (no) | Soyaprotein eller hydrolysater i farmasöytiske preparater for beskyttelse av bioaktive peptider mot enzymatisk inaktivering | |
DE69637435D1 (de) | Saponin-zusammensetzungen und deren verwendung | |
ATE353226T1 (de) | Adjuvanszusammensetzung enthaltend fha oder ein fha-fragment in freier form | |
PT97584A (pt) | Processo para a preparacao de composicoes farmaceuticas que contem eritropolietina | |
TR200002611T2 (tr) | Beta-lipotropin ve kullanımları | |
FR2559157B1 (fr) | Nouvel hexapeptide, son procede d'obtention et les compositions pharmaceutiques qui le contiennent | |
DE69130953D1 (de) | Immunverstärkung von impfstoffen, besonders von impfstoffen gegen schweinepleuropneumonie | |
IT1153208B (it) | Procedimento per l'estrazione di sostanze azotate, in particolare proteine e/o amminoacidi da sostanze vegetali, in particolare da sottoprodotti della lavorazione della soia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: ANTIGENICS INC., LEXINGTON, MASS., US |
|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: JONES DAY RECHTSANWAELTE PATENTANWAELTE, 80538 MUE |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: DERZEIT KEIN VERTRETER BESTELLT |