MX351247B - Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos. - Google Patents

Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos.

Info

Publication number
MX351247B
MX351247B MX2012011371A MX2012011371A MX351247B MX 351247 B MX351247 B MX 351247B MX 2012011371 A MX2012011371 A MX 2012011371A MX 2012011371 A MX2012011371 A MX 2012011371A MX 351247 B MX351247 B MX 351247B
Authority
MX
Mexico
Prior art keywords
fusions
mycobacterium tuberculosis
immunogenic compositions
tuberculosis polypeptides
compositions
Prior art date
Application number
MX2012011371A
Other languages
English (en)
Inventor
Steven G Reed
Rhea N Coler
Gregory C Ireton
Sylvie Bertholet
Original Assignee
Infectious Disease Res Institute Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infectious Disease Res Institute Star filed Critical Infectious Disease Res Institute Star
Publication of MX351247B publication Critical patent/MX351247B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se refiere a una composición, caracterizada porque comprende un inmunoestimulante y una combinación de dos o más antígenos de Mycobacterium tuberculosis, en donde la combinación comprende un antígeno que tiene una secuencia que tiene por lo menos 90% de identidad (SEQ ID NO: 41) y un antígeno que tiene una secuencia que tiene por lo menos 905% de identidad a (SEQ ID NO: 46). Un polipéptido de fusión aislado, caracterizado porque comprende una combinación de dos o más antígenos de Mycobacterium tuberculosis covalentemente enlazados, en donde la combinación comprende un antígeno que tiene una secuencia que tiene por lo menos 90% de identidad y sus usos para estimular una respuesta inmune protectora.
MX2012011371A 2007-04-04 2008-04-04 Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos. MX351247B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91016907P 2007-04-04 2007-04-04
PCT/US2008/059500 WO2008124647A2 (en) 2007-04-04 2008-04-04 Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof

Publications (1)

Publication Number Publication Date
MX351247B true MX351247B (es) 2017-10-05

Family

ID=39620241

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012011371A MX351247B (es) 2007-04-04 2008-04-04 Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos.
MX2009010800A MX2009010800A (es) 2007-04-04 2008-04-04 Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2009010800A MX2009010800A (es) 2007-04-04 2008-04-04 Composiciones inmunogenicas que comprenden polipeptidos de mycobacterium tuberculosis y fusiones de los mismos.

Country Status (11)

Country Link
US (4) US8486414B2 (es)
EP (2) EP2136836B8 (es)
JP (3) JP5378350B2 (es)
CN (2) CN101687027B (es)
BR (1) BRPI0809926B8 (es)
DK (1) DK2136836T3 (es)
ES (1) ES2621211T3 (es)
MX (2) MX351247B (es)
PL (1) PL2136836T3 (es)
WO (1) WO2008124647A2 (es)
ZA (1) ZA200907316B (es)

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JP5378350B2 (ja) 2013-12-25
EP2136836A2 (en) 2009-12-30
MX2009010800A (es) 2010-01-29
US11091521B2 (en) 2021-08-17
JP2014058520A (ja) 2014-04-03
JP5922074B2 (ja) 2016-05-24
CN101687027A (zh) 2010-03-31
ES2621211T3 (es) 2017-07-03
BRPI0809926A2 (pt) 2014-10-07
WO2008124647A2 (en) 2008-10-16
EP3199176A1 (en) 2017-08-02
DK2136836T3 (en) 2017-04-10
US20100129391A1 (en) 2010-05-27
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EP2136836B8 (en) 2017-04-12
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US20180170975A1 (en) 2018-06-21
WO2008124647A3 (en) 2009-04-02
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CN104815324A (zh) 2015-08-05
BRPI0809926B8 (pt) 2021-05-25
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