BR112021024363A2 - Purificação de saponina - Google Patents
Purificação de saponinaInfo
- Publication number
- BR112021024363A2 BR112021024363A2 BR112021024363A BR112021024363A BR112021024363A2 BR 112021024363 A2 BR112021024363 A2 BR 112021024363A2 BR 112021024363 A BR112021024363 A BR 112021024363A BR 112021024363 A BR112021024363 A BR 112021024363A BR 112021024363 A2 BR112021024363 A2 BR 112021024363A2
- Authority
- BR
- Brazil
- Prior art keywords
- saponin
- purification
- saponin purification
- extracts
- absorbance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
purificação de saponina. extratos de saponina contendo pelo menos 88% de pico principal de qs-21 e >3% a 10% de componente 2018 por absorvância de uv em 214 nm, métodos para preparar os referidos extratos, seu uso como adjuvantes de vacina e aspectos relacionados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962857490P | 2019-06-05 | 2019-06-05 | |
US202062966170P | 2020-01-27 | 2020-01-27 | |
PCT/EP2020/065366 WO2020245207A1 (en) | 2019-06-05 | 2020-06-03 | Saponin purification |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021024363A2 true BR112021024363A2 (pt) | 2022-03-22 |
Family
ID=71083599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021024363A BR112021024363A2 (pt) | 2019-06-05 | 2020-06-03 | Purificação de saponina |
Country Status (7)
Country | Link |
---|---|
US (1) | US20220235095A1 (pt) |
EP (1) | EP3980044A1 (pt) |
JP (1) | JP2022535091A (pt) |
CN (1) | CN114080393A (pt) |
BR (1) | BR112021024363A2 (pt) |
CA (1) | CA3142300A1 (pt) |
WO (1) | WO2020245207A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023223255A1 (en) | 2022-05-20 | 2023-11-23 | Glaxosmithkline Biologicals Sa | Modified varicella zoster virus glycoprotein e proteins |
Family Cites Families (55)
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US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
US4769239A (en) | 1984-08-21 | 1988-09-06 | Merck & Co., Inc. | Vaccine against varicella-zoster virus |
US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
US5173294A (en) | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
DE69017769T2 (de) | 1989-06-27 | 1995-07-13 | Smithkline Beecham Biolog | Verbindungen. |
SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
DK0614465T3 (da) | 1991-11-16 | 1999-09-27 | Smithkline Beecham Biolog | Hybridprotein mellem CS fra Plasmodium og HBsAg |
US5928902A (en) | 1992-02-27 | 1999-07-27 | Smithkline Beecham Biologicals (S.A.) | Hybrid protein between CS from plasmodium and HBsAg |
US6169171B1 (en) | 1992-02-27 | 2001-01-02 | Smithkline Beecham Biologicals (S.A.) | Hybrid protein between CS from plasmodium and HBSAG |
GB9224584D0 (en) | 1992-11-23 | 1993-01-13 | Connaught Lab | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases |
HU221420B1 (en) * | 1993-01-22 | 2002-09-28 | Sloan Kettering Inst Cancer | Ganglioside-protein conjugate vaccines |
EP0699076B1 (en) | 1993-05-18 | 2002-10-30 | The Ohio State University Research Foundation | Otitis media vaccine |
US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
GB9513074D0 (en) | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
US6290970B1 (en) | 1995-10-11 | 2001-09-18 | Aventis Pasteur Limited | Transferrin receptor protein of Moraxella |
US6090576A (en) | 1996-03-08 | 2000-07-18 | Connaught Laboratories Limited | DNA encoding a transferrin receptor of Moraxella |
US7341727B1 (en) | 1996-05-03 | 2008-03-11 | Emergent Product Development Gaithersburg Inc. | M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same |
FR2748748B1 (fr) | 1996-05-17 | 1998-11-06 | Pasteur Institut | Identification et clonage d'un antigene mycobacterien correspondant a une hemagglutine de liaison a l'heparine |
GB9616351D0 (en) | 1996-08-02 | 1996-09-11 | Smithkline Beecham Biolog | Vaccine composition |
ES2297841T3 (es) * | 1996-12-02 | 2008-05-01 | Antigenics Inc. | Nuevas composiciones de saponina y usos de las mismas. |
US6231859B1 (en) * | 1996-12-02 | 2001-05-15 | Aquila Biopharmaceuticals, Inc. | Saponin adjuvant compositions |
ATE380867T1 (de) | 1997-06-03 | 2007-12-15 | Sanofi Pasteur Ltd | Lactoferrinrezeptorgen von moraxella |
GB9812613D0 (en) | 1998-06-11 | 1998-08-12 | Smithkline Beecham Biolog | Vaccine |
FR2832410B1 (fr) | 2001-11-19 | 2004-04-02 | Pasteur Institut | Antigene mycobacterien recombinant de type hemagglutinine de liaison a l'heparine methylee, procedes de preparation et compositions immunogenes comprenant un tel antigene |
ATE529123T1 (de) * | 2002-04-15 | 2011-11-15 | Oncothyreon Inc | Synthetische glykolipopeptide als impfstoffe |
DE602004026218D1 (de) | 2003-12-23 | 2010-05-06 | Nationwide Childrens Hospital | Pili von haemophilus influenzae typ iv |
GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
MY150105A (en) | 2006-01-17 | 2013-11-29 | Forsgren Arne | A novel surface exposed haemophilus influenzae protein (protein e; pe) |
SI2486938T1 (sl) | 2006-09-26 | 2018-09-28 | Infectious Disease Research Institute | Sestavek cepiva, ki vsebuje sintetični adjuvans |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
AR065523A1 (es) | 2007-03-02 | 2009-06-10 | Glaxosmithkline Biolog Sa | Procedimiento para fomentar una respuesta inmunitaria frente a un patogeno y composiciones |
BRPI0821532A2 (pt) | 2007-12-24 | 2015-06-16 | Id Biomedical Corp Quebec | Antígenos de rsv recombinantes |
KR20110060891A (ko) | 2008-07-25 | 2011-06-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 신규한 조성물 및 방법 |
AU2009273132B2 (en) | 2008-07-25 | 2015-09-03 | Glaxo Group Limited | The tuberculosis Rv2386c protein, compositions and uses thereof |
ES2602430T3 (es) | 2008-07-25 | 2017-02-21 | Glaxosmithkline Biologicals S.A. | Polipéptidos, polinucleótidos y composiciones para uso en el tratamiento de tuberculosis latente |
US20130018178A1 (en) | 2009-06-22 | 2013-01-17 | Px Therapeutics | Method for the purification of hbha |
HUE028085T2 (en) | 2009-06-24 | 2016-11-28 | Glaxosmithkline Biologicals Sa | Recombinant RSV antigens |
HRP20220756T1 (hr) | 2009-07-15 | 2022-09-02 | Glaxosmithkline Biologicals S.A. | Proteinski pripravci rsv f i postupci za izradu istih |
JP6010463B2 (ja) | 2010-01-27 | 2016-10-19 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 改変された結核抗原 |
EA027920B1 (ru) | 2010-12-14 | 2017-09-29 | Глаксосмитклайн Байолоджикалс С.А. | Композиция микобактериальных антигенов |
TW201302779A (zh) | 2011-04-13 | 2013-01-16 | Glaxosmithkline Biolog Sa | 融合蛋白質及組合疫苗 |
SG194755A1 (en) | 2011-05-13 | 2013-12-30 | Novartis Ag | Pre-fusion rsv f antigens |
GB201213364D0 (en) | 2012-07-27 | 2012-09-12 | Glaxosmithkline Biolog Sa | Purification process |
US20140141037A1 (en) | 2012-11-20 | 2014-05-22 | Novartis Ag | Rsv f prefusion trimers |
EP2970398B1 (en) | 2013-03-13 | 2024-05-08 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Prefusion rsv f proteins and their use |
GB201316463D0 (en) | 2013-09-16 | 2013-10-30 | Giles Clark & Cook Ltd | Novel compositions |
TW201620927A (zh) | 2014-02-24 | 2016-06-16 | 葛蘭素史密斯克藍生物品公司 | Uspa2蛋白質構築體及其用途 |
GB201405921D0 (en) | 2014-04-02 | 2014-05-14 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
US10455225B2 (en) | 2017-05-12 | 2019-10-22 | Pure Depth Limited | Multi-layered display with interstitial layer air filter |
BR112020010635A2 (pt) * | 2017-12-01 | 2020-11-10 | Glaxosmithkline Biologicals S.A. | extração de saponina |
-
2020
- 2020-06-03 WO PCT/EP2020/065366 patent/WO2020245207A1/en unknown
- 2020-06-03 CN CN202080041410.4A patent/CN114080393A/zh active Pending
- 2020-06-03 EP EP20732141.5A patent/EP3980044A1/en active Pending
- 2020-06-03 US US17/615,254 patent/US20220235095A1/en active Pending
- 2020-06-03 BR BR112021024363A patent/BR112021024363A2/pt unknown
- 2020-06-03 JP JP2021571859A patent/JP2022535091A/ja active Pending
- 2020-06-03 CA CA3142300A patent/CA3142300A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022535091A (ja) | 2022-08-04 |
CN114080393A (zh) | 2022-02-22 |
CA3142300A1 (en) | 2020-12-10 |
EP3980044A1 (en) | 2022-04-13 |
US20220235095A1 (en) | 2022-07-28 |
WO2020245207A1 (en) | 2020-12-10 |
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