TR201903546T4 - Aşı stabilizatörü. - Google Patents

Aşı stabilizatörü. Download PDF

Info

Publication number
TR201903546T4
TR201903546T4 TR2019/03546T TR201903546T TR201903546T4 TR 201903546 T4 TR201903546 T4 TR 201903546T4 TR 2019/03546 T TR2019/03546 T TR 2019/03546T TR 201903546 T TR201903546 T TR 201903546T TR 201903546 T4 TR201903546 T4 TR 201903546T4
Authority
TR
Turkey
Prior art keywords
formulation
oxide
tertiary amine
vaccine
vaccine stabilizer
Prior art date
Application number
TR2019/03546T
Other languages
English (en)
Inventor
Sun Tianxiao
M Levesque Philip
T Brown Alicja
K Lee Cynthia
Original Assignee
Ge Healthcare Bio Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bio Sciences Corp filed Critical Ge Healthcare Bio Sciences Corp
Publication of TR201903546T4 publication Critical patent/TR201903546T4/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Burada, bir biyolojik ürünün termostabilitesini ve raf ömrünü geliştirebilen bir formülasyon açıklanmaktadır, bu formülasyon, şunları içermektedir, formül (I) ile temsil edilen bir tersiyer amin N-oksit veya bunun bir türevi, burada R1, R2 ve R3 aynı veya farklı olabilmektedir ve her biri, 1 ila 4 karbon atomuna sahip bir düz veya dallanmış düşük alkil grubudur; bu formülasyon, ayrıca, bir inorganik asit; glütamik asit veya bunun bir tuzu; bir poliol; fizyolojik olarak kabul edilebilir bir tampon ve farmasötik olarak kabul edilebilir bir taşıyıcı içermektedir. Tersiyer amin N-oksit, trimetilamin-N-oksit (CH3)3NO olabilmektedir. Formülasyon, aşı stabilizasyonu için kullanışlıdır.
TR2019/03546T 2009-07-28 2010-07-23 Aşı stabilizatörü. TR201903546T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22915309P 2009-07-28 2009-07-28

Publications (1)

Publication Number Publication Date
TR201903546T4 true TR201903546T4 (tr) 2019-04-22

Family

ID=43529651

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/03546T TR201903546T4 (tr) 2009-07-28 2010-07-23 Aşı stabilizatörü.

Country Status (5)

Country Link
US (2) US9248107B2 (tr)
EP (1) EP2461679B1 (tr)
CA (1) CA2769011C (tr)
TR (1) TR201903546T4 (tr)
WO (1) WO2011014418A1 (tr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014418A1 (en) * 2009-07-28 2011-02-03 Xcellerex, Inc. Vaccine stabilizer
CN112165951A (zh) * 2018-04-16 2021-01-01 默克专利股份有限公司 用于改善热稳定性的蛋白质制剂添加剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580856A (en) 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
US6051238A (en) 1996-12-20 2000-04-18 Merck & Co., Inc. Stabilizers for lyophilized mumps vaccines
KR20020059719A (ko) * 1999-11-12 2002-07-13 추후보정 재조합 젤라틴
ES2311094T3 (es) * 2002-02-27 2009-02-01 Immunex Corporation Composicion estabilizada de tnfr-fc que comprende arginina.
JP2006512102A (ja) * 2002-04-11 2006-04-13 メディミューン・ヴァクシンズ・インコーポレーテッド 噴霧乾燥による生物活性材料の防腐
CA2533796A1 (en) 2003-08-01 2005-02-10 Amgen Inc. Crystalline tumor necrosis factor receptor 2 polypeptides
RU2458125C2 (ru) 2004-11-05 2012-08-10 Веллстат Байолоджикс Корпорейшн Способ стабилизации вируса ньюкаслской болезни для хранения в водном растворе и способ сохранения его стабильности
EP1929042A4 (en) * 2005-08-23 2010-03-17 Illumigen Biosciences Inc DETECTION OF MUTATIONS IN A GENE ASSOCIATED WITH RESISTANCE TO A VIRUS INFECTION, OAS2 OR OAS3
EP3795173A1 (en) 2006-09-26 2021-03-24 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
WO2011014418A1 (en) * 2009-07-28 2011-02-03 Xcellerex, Inc. Vaccine stabilizer

Also Published As

Publication number Publication date
WO2011014418A1 (en) 2011-02-03
EP2461679A1 (en) 2012-06-13
US9821064B2 (en) 2017-11-21
CA2769011C (en) 2017-06-06
US9248107B2 (en) 2016-02-02
EP2461679A4 (en) 2014-05-07
US20120201849A1 (en) 2012-08-09
EP2461679B1 (en) 2019-02-13
US20160120982A1 (en) 2016-05-05
CA2769011A1 (en) 2011-02-03

Similar Documents

Publication Publication Date Title
MX2009002802A (es) Derivados de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparacion y su aplicacion en terapeutica.
CY1118973T1 (el) Παραγωγα αμιδιου βενζοϊμιδαζολο-καρβοξυλικου οξεος για τη θεραπεια μεταβολικων ή καρδιαγγειακων νοσηματων
NZ720174A (en) Ionizable cationic lipid for rna delivery
GEP201706728B (en) Noxious organism control agent
BR112014002191A2 (pt) amidas de ácido n-(tetrazol-5-il)- e n-(triazol-5-il)arilcarboxílico e seu uso como herbicidas
PE20120648A1 (es) Compuestos de 4-isopropilfenilglucitol como inhibidores de sglt1
MA33939B1 (fr) 5-alcynyl-pyrimidines
PH12014501719A1 (en) Pyridone derivatives
MY156938A (en) Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application
CY1117157T1 (el) Υποκατεστημενο παραγωγο ισοκινολινης
CY1114759T1 (el) Παραγωγα πυριδιν-4-υλι0υ ως s1p1/edg1 αγωνιστες
CY1112211T1 (el) Σταθερο στην αποθηκευση διαλυμα διυδροπτεριδινονων για εγχυση
MX2012015023A (es) Derivado novedoso de nicotinamida o sal del mismo.
MX2012006994A (es) Agente antiplaquetas novedoso.
MY168201A (en) Agricultural And Horticultural Fungicidal Composition
BR112013023911A2 (pt) amidas de ácido n-(1,3,4-oxadiazol-2-il)-arilcarboxílico e o uso das mesmas como herbicidas
CY1115643T1 (el) Διεγερτης νευρογενεσης ή θεραπευτικος παραγων νευροπαθειας που περιλαμβανει παραγωγα αλκυλ αιθερα ή αλας αυτου
EA201170098A1 (ru) Замещенные производные алкилпиримидин-4-она
TW201129558A (en) Piperazine compound having a pgds inhibitory effect
MA32192B1 (fr) Composés dérivés d'azétidines, leur préparation et leur application en thérapeutique
EA201400822A1 (ru) Производные гетероциклических амидов в качестве антагонистов p2xрецептора
BR112012016802A2 (pt) derivados de piridino-piridinonas arilsulfonamidas, seus preparos e suas aplicações em terapêutica
PH12014502663B1 (en) Aromatic heterocyclic derivative and pharmaceutical
CY1120101T1 (el) Παραγωγο πυριδονης και φαρμακο που το περιεχει
TR201903546T4 (tr) Aşı stabilizatörü.