SI2468300T1 - Sestavek cepiva, ki vsebuje sintetični adjuvant - Google Patents

Sestavek cepiva, ki vsebuje sintetični adjuvant Download PDF

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Publication number
SI2468300T1
SI2468300T1 SI200732001T SI200732001T SI2468300T1 SI 2468300 T1 SI2468300 T1 SI 2468300T1 SI 200732001 T SI200732001 T SI 200732001T SI 200732001 T SI200732001 T SI 200732001T SI 2468300 T1 SI2468300 T1 SI 2468300T1
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SI
Slovenia
Prior art keywords
group
adjuvant
agonist
modifier
gla
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SI200732001T
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English (en)
Inventor
Steven G. Reed
Darrick Carter
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Infectios Disease Research Institute
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Application filed by Infectios Disease Research Institute filed Critical Infectios Disease Research Institute
Publication of SI2468300T1 publication Critical patent/SI2468300T1/sl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/008—Leishmania antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Claims (4)

  1. Sestavek cepiva, ki vsebuje sintetični adjuvant PATENTNI ZAHTEVKI
    1. Farmacevtski sestavek, ki obsega (i) adjuvant glikopiranozillipida (GLA), (ii) epitop, biomolekulo, celico ali tkivo, povezano z alergijo ali astmo, in (iii) farmacevtsko sprejemljiv nosilec ali ekscipient, za uporabo pri metodi za stimulacijo antigen-specifičnega imunskega odziva za zdravljenje alergije ali astme v gostitelju, pri čemer ima GLA formulo:
    kjer: R1, R3, R5 in R6 pomenijo undecil, R2 in R4 sta tridecil.
  2. 2. Sestavek za uporabo po zahtevku 1, ki nadalje obsega vsaj eno dodatno komponento, izbrano iz skupine, ki jo sestavljajo: (a) ko-adjuvant; (b) Tollu-podobni receptor (TLR) agaonist; (c) saponin ali saponinski mimetik; (d) olje; (e) imunostimulatomi kompleks, kot je ISCOMATRIX ™; (f) modifikator imidazokinolinskega imunskega odziva; in (g) imunski modifikator z dvojno izvorno zanko (dSLIM);
  3. 3. Sestavek za uporabo po zahtevku 1 ali 2, ki nadalje obsega vsaj eno dodatno komponento, izbrano iz skupine, ki jo sestavljajo (i) ko-adjuvant, izbran iz skupine, ki jo sestavljajo galun, rastlinski alkaloid in detergent, pri čemer je rastlinski alkaloid izbran izmed tomatina in detergent je izbran izmed saponina, polisorbata 80, spana 85 in Stearil tirozina; (ii) agonist TLR je izbran iz skupine, ki jo sestavljajo lipopolisaharid, peptidoglikan, polihC, CpG, 3M003, flagelin, Leishmania homolog evkariotske ribosomske elongacije in iniciacijski faktor 4a (LeIF) in vsaj en hepatitis C antigen; (iii) modifikator imidazokinolinskega imunskega odziva, izbranega iz skupine, ki jo sestavljajo resikvimod (R848), imikvimod in gardikvimod; (iv) ko-adjuvant, izbran iz skupine, ki jo sestavljajo citokin, detergent in blok kopolimer ali biološko razgradljiv polimer; in (v) nosilec, izbran iz skupine, ki jo sestavljajo kalcijev fosfat, emulzija olje-v-vodi, emulzija voda-v-olju, liposom in mikrodelec.
  4. 4. Sestavek za uporabo po zahtevku 3, kjer je TLR agonist TLR7 agonist.
SI200732001T 2006-09-26 2007-09-26 Sestavek cepiva, ki vsebuje sintetični adjuvant SI2468300T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84740406P 2006-09-26 2006-09-26
EP12153267.5A EP2468300B1 (en) 2006-09-26 2007-09-26 Vaccine composition containing synthetic adjuvant

Publications (1)

Publication Number Publication Date
SI2468300T1 true SI2468300T1 (sl) 2018-03-30

Family

ID=39776582

Family Applications (4)

Application Number Title Priority Date Filing Date
SI200730970T SI2068918T1 (sl) 2006-09-26 2007-09-26 Si - ep sestavek za cepljenje, ki vsebuje sintetiäśna pomagala
SI200732032T SI2486938T1 (sl) 2006-09-26 2007-09-26 Sestavek cepiva, ki vsebuje sintetični adjuvans
SI200732037T SI2484375T1 (sl) 2006-09-26 2007-09-26 Sestavek za cepljenje, ki vsebuje sintetični adjuvant
SI200732001T SI2468300T1 (sl) 2006-09-26 2007-09-26 Sestavek cepiva, ki vsebuje sintetični adjuvant

Family Applications Before (3)

Application Number Title Priority Date Filing Date
SI200730970T SI2068918T1 (sl) 2006-09-26 2007-09-26 Si - ep sestavek za cepljenje, ki vsebuje sintetiäśna pomagala
SI200732032T SI2486938T1 (sl) 2006-09-26 2007-09-26 Sestavek cepiva, ki vsebuje sintetični adjuvans
SI200732037T SI2484375T1 (sl) 2006-09-26 2007-09-26 Sestavek za cepljenje, ki vsebuje sintetični adjuvant

Country Status (20)

Country Link
US (10) US8273361B2 (sl)
EP (6) EP2468300B1 (sl)
JP (6) JP5443164B2 (sl)
KR (1) KR101378872B1 (sl)
CN (2) CN101516396B (sl)
AT (1) ATE555808T1 (sl)
AU (1) AU2007354917B2 (sl)
BR (1) BRPI0716959A2 (sl)
CA (1) CA2662921C (sl)
CY (4) CY1112943T1 (sl)
DK (4) DK2486938T3 (sl)
ES (5) ES2387327T3 (sl)
HK (1) HK1132934A1 (sl)
HU (3) HUE036180T2 (sl)
LT (3) LT2484375T (sl)
PL (4) PL2468300T3 (sl)
PT (4) PT2486938T (sl)
SI (4) SI2068918T1 (sl)
TR (2) TR201807756T4 (sl)
WO (1) WO2008153541A1 (sl)

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