SG58382G - Cephalosporin antibiotics - Google Patents

Cephalosporin antibiotics

Info

Publication number
SG58382G
SG58382G SG583/82A SG58382A SG58382G SG 58382 G SG58382 G SG 58382G SG 583/82 A SG583/82 A SG 583/82A SG 58382 A SG58382 A SG 58382A SG 58382 G SG58382 G SG 58382G
Authority
SG
Singapore
Prior art keywords
cephalosporin antibiotics
cephalosporin
antibiotics
Prior art date
Application number
SG583/82A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SG58382G publication Critical patent/SG58382G/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
SG583/82A 1978-05-26 1982-11-16 Cephalosporin antibiotics SG58382G (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2291378 1978-05-26
GB2291178 1978-05-26

Publications (1)

Publication Number Publication Date
SG58382G true SG58382G (en) 1983-09-02

Family

ID=26256190

Family Applications (1)

Application Number Title Priority Date Filing Date
SG583/82A SG58382G (en) 1978-05-26 1982-11-16 Cephalosporin antibiotics

Country Status (27)

Country Link
US (2) US4258041A (nl)
AR (2) AR228726A1 (nl)
AT (1) AT370420B (nl)
AU (1) AU524671B2 (nl)
CA (1) CA1127633A (nl)
CH (2) CH646178A5 (nl)
DE (1) DE2921316C2 (nl)
DK (1) DK157685C (nl)
ES (2) ES480914A1 (nl)
FI (2) FI67555C (nl)
FR (2) FR2426695A1 (nl)
HK (1) HK40183A (nl)
IE (2) IE49173B1 (nl)
IL (3) IL59793A (nl)
IT (1) IT1116198B (nl)
KE (1) KE3252A (nl)
LU (1) LU81319A1 (nl)
MY (1) MY8400017A (nl)
NL (2) NL176855C (nl)
NO (2) NO155347C (nl)
NZ (2) NZ190558A (nl)
PH (1) PH16961A (nl)
PT (2) PT69669A (nl)
SE (2) SE438507B (nl)
SG (1) SG58382G (nl)
SI (2) SI7911231A8 (nl)
YU (2) YU41635B (nl)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963542A (en) * 1976-09-08 1990-10-16 Takeda Chemical Industries, Ltd. Cephalosporin derivatives
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
NL8003003A (nl) * 1979-05-25 1980-11-27 Glaxo Group Ltd Tussenprodukten te gebruiken bij de bereiding van cefalosporine antibiotica.
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
NZ195116A (en) * 1979-10-02 1982-09-07 Glaxo Group Ltd The crystalline bishydrochloride of a certain cephalosporin medicinal preparations
IT1143007B (it) * 1979-10-02 1986-10-22 Glaxo Group Ltd Composti cefalosporinici composizioni che li contengono e procedimento per la loro produzione ed applicazione
US4338313A (en) * 1979-10-12 1982-07-06 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4332800A (en) * 1979-10-12 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
FR2476647A2 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn
US4252802A (en) * 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
GR75706B (nl) * 1980-06-30 1984-08-02 Sanofi Sa
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0046964B1 (en) * 1980-08-29 1986-08-20 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
US4427677A (en) 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS57144291A (en) * 1981-03-02 1982-09-06 Ajinomoto Co Inc Preparation of imidazoledicarboxylic acid derivative
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
JPS6011917B2 (ja) * 1981-04-09 1985-03-28 山之内製薬株式会社 新規なセファロスポリン化合物
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
GR75487B (nl) * 1981-06-22 1984-07-23 Fujisawa Pharmaceutical Co
US4382931A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company 3'-Substituted quinolinium cephalosporins
US4577014A (en) * 1981-09-08 1986-03-18 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
US4436912A (en) 1981-09-08 1984-03-13 Eli Lilly And Company 7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido cephalosporin antibiotics and intermediates therefor
US4382932A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company Isoquinolinium substituted cephalosporins
US4430499A (en) 1981-09-08 1984-02-07 Eli Lilly And Company 7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido]cephalosporin antibiotics
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
US4402955A (en) * 1981-10-02 1983-09-06 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4388316A (en) * 1981-10-02 1983-06-14 Eli Lilly And Company Amino-substituted oxazole, oxadiazole and isoxazole-substituted cephalosporins
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
US4450270A (en) * 1981-10-02 1984-05-22 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4406887A (en) * 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
US4510312A (en) * 1981-11-13 1985-04-09 Glaxo Group Limited Manufacture of antibiotics
JPS58109477A (ja) * 1981-11-13 1983-06-29 グラクソ・グル−プ・リミテツド 新規な化合物
US4394503A (en) * 1981-12-07 1983-07-19 Bristol-Myers Company Cephalosporin derivatives
US4474954A (en) * 1981-12-07 1984-10-02 Bristol-Myers Company Intermediates for cephalosporin derivatives
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
ATE31532T1 (de) * 1982-04-29 1988-01-15 Glaxo Group Ltd Thiazolderivat, verfahren zu seiner herstellung sowie seine verwendung bei der herstellung von beta-lactam-antibiotika.
DE3374410D1 (en) 1982-06-28 1987-12-17 Bristol Myers Co Cephalosporin derivatives, a process for the manufacture thereof and pharmaceutical compositions containing said derivatives
IE55406B1 (en) * 1982-08-07 1990-09-12 Tanabe Seiyaku Co Novel cephalosporin compounds and preparation thereof
ES8502863A1 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
DE3381408D1 (de) * 1982-12-27 1990-05-10 Lilly Co Eli Zwischenverbindungen fuer die herstellung von ceftazidin und verfahren zu ihrer herstellung.
EP0115770B2 (en) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazole Derivatives
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
DE3313816A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
US4540779A (en) * 1983-06-20 1985-09-10 Eli Lilly And Company Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound
US4497811A (en) * 1983-07-01 1985-02-05 Seiji Shibahara 1-Oxadethiacephalosporin compound and antibacterial agent containing the _same
JPS6061528A (ja) * 1983-09-09 1985-04-09 ブリストル―マイヤーズ スクイブ カンパニー 嫌気性菌を包含する耐性バクテリアの処理法
AU566944B2 (en) * 1983-10-07 1987-11-05 Gist-Brocades N.V. Preparation of 3-cephem derivatives
JPS60178891A (ja) * 1984-02-24 1985-09-12 Kureha Chem Ind Co Ltd セファロスポリン誘導体及び該誘導体を含有する医薬
GB8406218D0 (en) * 1984-03-09 1984-04-11 Glaxo Group Ltd Process
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
US4788185A (en) * 1984-04-23 1988-11-29 Takeda Chemical Industries, Ltd. Cephalosporin compounds
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
CA1236089A (en) * 1984-06-25 1988-05-03 Perry C. Heath Ceftazidime
US4616080A (en) * 1984-07-02 1986-10-07 Eli Lilly And Company Simplified process of forming crystalline ceftazidime pentahydrate
US4626534A (en) * 1984-07-23 1986-12-02 Eli Lilly And Company Pharmaceutical formulation
EP0175544A3 (en) * 1984-09-17 1987-06-03 Eli Lilly And Company An improved process for cephalosporin intermediates
US4659813A (en) * 1984-11-08 1987-04-21 Eli Lilly And Company Crystallization process for ceftazidime derivative
WO1988010263A1 (en) * 1987-06-25 1988-12-29 Banyu Pharmaceutical Co., Ltd. Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
GB8504072D0 (en) * 1985-02-18 1985-03-20 Fujisawa Pharmaceutical Co Cephem compounds
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4692518A (en) * 1985-11-06 1987-09-08 Eli Lilly And Company Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound
JPS62175489A (ja) * 1986-01-29 1987-08-01 Sanwa Kagaku Kenkyusho:Kk 新規なセフアロスポリン誘導体及びその塩、これらの製法並びに該化合物を有効成分とする感染症治療剤
US5359057A (en) * 1986-02-07 1994-10-25 Hoffmann-La Roche Inc. Acylation of amines
JPS63107989A (ja) * 1986-06-04 1988-05-12 Tanabe Seiyaku Co Ltd セファロスポリン化合物
AT387022B (de) * 1986-06-04 1988-11-25 Biochemie Gmbh Verfahren zur herstellung einer neuen kristallinen form eines cefalosporinderivats
IL82738A0 (en) * 1986-06-16 1987-12-20 Tanabe Seiyaku Co Cephalosporin compounds,their preparation and pharmaceutical compositions containing them
DE3778346D1 (de) * 1986-09-10 1992-05-21 Biochemie Gmbh Stabile, kristalline form eines cefalosporin-zwischenproduktes.
US4954624A (en) * 1986-10-07 1990-09-04 Sandoz Ltd. Process for the production of cephalosporin derivatives
US5021564A (en) * 1987-02-02 1991-06-04 Eli Lilly And Company Process for preparing ceftazidime pentahydrate
JP2533151B2 (ja) * 1987-02-02 1996-09-11 イーライ・リリー・アンド・カンパニー 抗生物質製造の改良法
GB8802622D0 (en) * 1988-02-05 1988-03-02 Glaxo Group Ltd Chemical compound
KR0159760B1 (ko) * 1988-12-27 1998-12-01 리로이 휘테커 아실화 방법
US5194604A (en) * 1990-06-29 1993-03-16 E. R. Squibb & Sons, Inc. Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains
KR940000112B1 (ko) * 1990-07-05 1994-01-05 주식회사 대웅제약 신규의 3-치환 세펨화합물 및 그의 제조방법
US5281589A (en) * 1991-06-15 1994-01-25 Cheil Foods & Chemicals, Inc. 3-fused pyridiniummethyl cephalosporins
KR100194994B1 (ko) * 1993-06-05 1999-06-15 손경식 새로운 세펨 화합물
US6472383B1 (en) 1994-04-25 2002-10-29 Smithkline Beecham P.L.C. Pharmaceutical formulations
JP3865770B2 (ja) * 1994-04-25 2007-01-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ベータ−ラクタム抗生物質と組み合わせてベータ−ラクタマーゼ阻害性ペネムを含有する医薬製剤および細菌感染の治療におけるそれらの使用
US5593985A (en) * 1994-05-23 1997-01-14 Korea Institute Of Science And Technology Cephalosporin compounds
US5831085A (en) * 1997-01-16 1998-11-03 Lupin Laboratories Limited Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof
IN189047B (nl) 1998-06-01 2002-12-14 Ranbaxy Lab Ltd
US6930983B2 (en) * 2000-03-15 2005-08-16 Texas Instruments Incorporated Integrated circuits, systems, apparatus, packets and processes utilizing path diversity for media over packet applications
KR100342600B1 (ko) 2000-03-06 2002-07-04 한미정밀화학주식회사 신규한 티아졸 화합물 및 그의 제조 방법
KR100392409B1 (ko) 2000-03-20 2003-07-22 한미정밀화학주식회사 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법
US6911441B2 (en) * 2002-12-16 2005-06-28 Akzo Nobel N.V. Prolonged release pharmaceutical composition
CN1312158C (zh) * 2005-05-20 2007-04-25 天津市医药集团技术发展有限公司 一种头孢克肟的制备方法
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
CN101293891B (zh) * 2008-06-12 2011-01-12 齐鲁安替制药有限公司 头孢他啶中间体的制备方法
CN103945842A (zh) 2011-09-09 2014-07-23 丘比斯特药物股份有限公司 治疗肺内感染的方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
ES2633964T3 (es) 2013-03-13 2017-09-26 Theravance Biopharma Antibiotics Ip, Llc Sales de clorhidrato de un compuesto antibiótico
MX2015012833A (es) 2013-03-15 2016-06-10 Merck Sharp & Dohme Composiciones antibioticas de ceftolozano.
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
AU2014233637A1 (en) 2013-09-09 2015-03-26 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN106336418B (zh) * 2016-08-19 2019-02-01 上海上药新亚药业有限公司 一种头孢他啶盐酸盐的固相合成法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4079178A (en) * 1971-05-14 1978-03-14 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position
US4024137A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
GB1399086A (en) 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US4033950A (en) * 1971-05-14 1977-07-05 Glaxo Laboratories Limited 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US4091209A (en) * 1971-05-14 1978-05-23 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]cephalosporins having a 2-haloalkylcarbamoyloxymethyl group at the 3-position
US4093803A (en) * 1971-05-14 1978-06-06 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
US4064346A (en) * 1971-05-14 1977-12-20 Glaxo Laboratories Limited 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
US4024133A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
US4017515A (en) * 1971-05-14 1977-04-12 Glaxo Laboratories Limited α-(Etherified oximino) carboxylic acids and acid chlorides
US4162360A (en) * 1973-12-21 1979-07-24 Glaxo Laboratories Limited 3-Carbamoyloxymethyl-7-substituted oximino acetamido cephalosporanic acid derivatives
US4060686A (en) * 1973-12-21 1977-11-29 Janice Bradshaw Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group
GB1496757A (en) 1973-12-21 1978-01-05 Glaxo Lab Ltd Cephalosporin derivatives
US4095021A (en) * 1973-12-21 1978-06-13 Glaxo Laboratories Limited 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
US4144392A (en) * 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
US4032950A (en) * 1974-12-06 1977-06-28 Hughes Aircraft Company Liquid phase epitaxial process for growing semi-insulating gaas layers
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
JPS52125188A (en) 1976-04-14 1977-10-20 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
ZA781502B (en) 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
FR2384782A1 (fr) 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-acetoxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2716677C2 (de) 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
HU184680B (en) 1977-04-02 1984-09-28 Hoechst Ag Process for producing ceph-3-eme-4-carboxylic acid derivatives containing amino-thiazolyl group in the side chain
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
GB1602725A (en) 1977-04-27 1981-11-18 Glaxo Operations Ltd 7-(a-oxyiminoacetamido)-ceph-3-em-4-carboxylic acid derivatives
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
US4394503A (en) * 1981-12-07 1983-07-19 Bristol-Myers Company Cephalosporin derivatives

Also Published As

Publication number Publication date
YU41635B (en) 1987-12-31
SE8402887D0 (sv) 1984-05-28
ATA239281A (de) 1982-08-15
DK157685C (da) 1990-07-09
NZ190558A (en) 1982-05-31
AU4742279A (en) 1979-11-29
SE8402887L (sv) 1984-05-28
IT1116198B (it) 1986-02-10
AR229883A1 (es) 1983-12-30
US4600772A (en) 1986-07-15
NO155347B (no) 1966-12-08
YU223482A (en) 1983-04-30
YU123179A (en) 1983-01-21
NO850153L (no) 1979-11-27
NL176855C (nl) 1985-06-17
NL8001348A (nl) 1980-06-30
FI791678A (fi) 1979-11-27
MY8400017A (en) 1984-12-31
FR2426695A1 (fr) 1979-12-21
PT69669A (en) 1979-06-01
FR2426695B1 (nl) 1982-06-11
ES480914A1 (es) 1980-02-01
IL59793A (en) 1982-08-31
IL59793A0 (en) 1980-06-30
FI67705C (fi) 1985-05-10
SI8212234A8 (en) 1997-06-30
DE2921316C2 (de) 1982-09-16
CA1127633A (en) 1982-07-13
FR2445835A1 (fr) 1980-08-01
AR228726A1 (es) 1983-04-15
NO791731L (no) 1979-11-27
FI67705B (fi) 1985-01-31
FI801609A (fi) 1980-05-19
IE49172B1 (en) 1985-08-21
SE438507B (sv) 1985-04-22
PH16961A (en) 1984-04-27
DK157685B (da) 1990-02-05
NZ193326A (en) 1982-05-31
DE2921316A1 (de) 1979-12-06
NL7904122A (nl) 1979-11-28
SI7911231A8 (en) 1997-06-30
AU524671B2 (en) 1982-09-30
NO155347C (no) 1987-03-18
IL57400A0 (en) 1979-09-30
IE791025L (en) 1979-11-26
IE802453L (en) 1979-11-26
LU81319A1 (fr) 1979-09-11
US4258041A (en) 1981-03-24
PT69670A (en) 1979-06-01
KE3252A (en) 1983-01-28
AT370420B (de) 1983-03-25
CH646178A5 (de) 1984-11-15
HK40183A (en) 1983-10-21
CH649556A5 (de) 1985-05-31
YU43097B (en) 1989-02-28
DK216779A (da) 1979-11-27
FI67555C (fi) 1985-04-10
IE49173B1 (en) 1985-08-21
NL176855B (nl) 1985-01-16
ES480915A1 (es) 1980-02-01
FI67555B (fi) 1984-12-31
IL57400A (en) 1982-08-31
SE7904576L (sv) 1980-02-11
FR2445835B1 (nl) 1983-06-03

Similar Documents

Publication Publication Date Title
KE3252A (en) Cephalosporin antibiotics
GB2058791B (en) Cephalosporin antibiotics
PT69673A (en) Cephalosporin antibiotics
IL58717A0 (en) Cephalosporin antibiotics
ZA796195B (en) Cephalosporin antibiotics
PT70996A (en) Cephalosporin antibiotics
NZ192943A (en) Cephalosporin antibiotics
GB2040921B (en) Cephalosporin antibiotics
ZA792582B (en) Cephalosporin antibiotics
ZA796130B (en) Cephalosporin antibiotics
GB2036738B (en) Cephalosporin antibiotics
GB2027691B (en) Cephalosporin antibiotics
GB2046261B (en) Cephalosporin antibiotics
ZA801661B (en) Cephalosporin antibiotics
GB2027692B (en) Cephalosporin antibiotics
ZA801011B (en) Cephalosporin antibiotics
ZA792584B (en) Cephalosporin antibiotics
GB2024808B (en) Cephalosporin antibiotics
AU4742179A (en) Cephalosporin antibiotics
AU4742379A (en) Cephalosporin antibiotics
GB2062624B (en) Cephalosporin antibiotics