FR2426695A1 - Nouvelles cephalosporines, leur procede de preparation et leur application therapeutique - Google Patents

Nouvelles cephalosporines, leur procede de preparation et leur application therapeutique

Info

Publication number
FR2426695A1
FR2426695A1 FR7913531A FR7913531A FR2426695A1 FR 2426695 A1 FR2426695 A1 FR 2426695A1 FR 7913531 A FR7913531 A FR 7913531A FR 7913531 A FR7913531 A FR 7913531A FR 2426695 A1 FR2426695 A1 FR 2426695A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic application
cephalosporins
new cephalosporins
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7913531A
Other languages
English (en)
Other versions
FR2426695B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2426695A1 publication Critical patent/FR2426695A1/fr
Application granted granted Critical
Publication of FR2426695B1 publication Critical patent/FR2426695B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

L'invention concerne des céphalosporines. L'invention a plus particulièrement pour objet des composés de la formule générale 1 dans laquelle R**a et R** b identiques ou différents représentent chacun un groupe alkyle en C1 à C4 ou forment un groupe cycloalkylidène en C3 -C7 avec l'atome de carbone auquel ils sont attachés et R**4 représente un atome d'hydrogène ou un groupe 4-carbamoyle. L'invention concerne aussi les sels et les esters métaboliquement labiles atoxiques des composés en question qui constituent des antibiotiques de valeur.
FR7913531A 1978-05-26 1979-05-28 Nouvelles cephalosporines, leur procede de preparation et leur application therapeutique Granted FR2426695A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2291378 1978-05-26
GB2291178 1978-05-26

Publications (2)

Publication Number Publication Date
FR2426695A1 true FR2426695A1 (fr) 1979-12-21
FR2426695B1 FR2426695B1 (fr) 1982-06-11

Family

ID=26256190

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7913531A Granted FR2426695A1 (fr) 1978-05-26 1979-05-28 Nouvelles cephalosporines, leur procede de preparation et leur application therapeutique
FR8007929A Granted FR2445835A1 (fr) 1978-05-26 1980-04-09 Nouvelles cephalosporines, leur procede de preparation et leur application therapeutique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8007929A Granted FR2445835A1 (fr) 1978-05-26 1980-04-09 Nouvelles cephalosporines, leur procede de preparation et leur application therapeutique

Country Status (27)

Country Link
US (2) US4258041A (fr)
AR (2) AR229883A1 (fr)
AT (1) AT370420B (fr)
AU (1) AU524671B2 (fr)
CA (1) CA1127633A (fr)
CH (2) CH646178A5 (fr)
DE (1) DE2921316C2 (fr)
DK (1) DK157685C (fr)
ES (2) ES480914A1 (fr)
FI (2) FI67555C (fr)
FR (2) FR2426695A1 (fr)
HK (1) HK40183A (fr)
IE (2) IE49172B1 (fr)
IL (3) IL57400A (fr)
IT (1) IT1116198B (fr)
KE (1) KE3252A (fr)
LU (1) LU81319A1 (fr)
MY (1) MY8400017A (fr)
NL (2) NL176855C (fr)
NO (2) NO155347C (fr)
NZ (2) NZ190558A (fr)
PH (1) PH16961A (fr)
PT (2) PT69670A (fr)
SE (2) SE438507B (fr)
SG (1) SG58382G (fr)
SI (2) SI7911231A8 (fr)
YU (2) YU41635B (fr)

Cited By (6)

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FR2465737A1 (fr) * 1979-04-12 1981-03-27 Squibb & Sons Inc 7-(2-(2-amino-4-thiazolyl)-2 - ((1-carboxy-1,1 - dialkyl)alcoxyimino)acetamido)cephem sulfoxydes a action antibacterienne
FR2476647A2 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn
EP0044238A1 (fr) * 1980-06-30 1982-01-20 Sanofi S.A. Dérivés de céphalosporines sulfoxydes, procédé de préparation et compositions pharmaceutiques en contenant
FR2560879A1 (fr) * 1984-03-09 1985-09-13 Glaxo Group Ltd Procede de recuperation de l'antibiotique ceftazidime
EP0192210A2 (fr) * 1985-02-18 1986-08-27 Fujisawa Pharmaceutical Co., Ltd. Composés céphem et procédés pour leur préparation
EP0278656A1 (fr) * 1987-02-02 1988-08-17 Eli Lilly And Company Procédé pour la préparation de pentahydrate de ceftazidime

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AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
GB2052490B (en) * 1979-05-25 1983-09-07 Glaxo Group Ltd Intermediates for use in the preparation of cephalosporin antibiotics
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
CH644609A5 (de) * 1979-10-02 1984-08-15 Glaxo Group Ltd Cephalosporinantibiotikum.
NL8005440A (nl) * 1979-10-02 1981-04-06 Glaxo Group Ltd Cefalosporinen met antibiotische werking.
US4332800A (en) * 1979-10-12 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4338313A (en) * 1979-10-12 1982-07-06 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4252802A (en) * 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
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DE3175156D1 (en) * 1980-08-29 1986-09-25 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
FR2494276A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
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US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
JPS6011917B2 (ja) * 1981-04-09 1985-03-28 山之内製薬株式会社 新規なセファロスポリン化合物
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
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US4577014A (en) * 1981-09-08 1986-03-18 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
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US4382932A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company Isoquinolinium substituted cephalosporins
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JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
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US4060686A (en) * 1973-12-21 1977-11-29 Janice Bradshaw Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group
US4032950A (en) * 1974-12-06 1977-06-28 Hughes Aircraft Company Liquid phase epitaxial process for growing semi-insulating gaas layers
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
JPS52125188A (en) 1976-04-14 1977-10-20 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
ZA781502B (en) 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
FR2384782A1 (fr) 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-acetoxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
HU184680B (en) 1977-04-02 1984-09-28 Hoechst Ag Process for producing ceph-3-eme-4-carboxylic acid derivatives containing amino-thiazolyl group in the side chain
DE2716677C2 (de) 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
GB1602725A (en) 1977-04-27 1981-11-18 Glaxo Operations Ltd 7-(a-oxyiminoacetamido)-ceph-3-em-4-carboxylic acid derivatives
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
US4237128A (en) * 1979-04-12 1980-12-02 E. R. Squibb & Sons, Inc. 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
US4394503A (en) * 1981-12-07 1983-07-19 Bristol-Myers Company Cephalosporin derivatives

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2465737A1 (fr) * 1979-04-12 1981-03-27 Squibb & Sons Inc 7-(2-(2-amino-4-thiazolyl)-2 - ((1-carboxy-1,1 - dialkyl)alcoxyimino)acetamido)cephem sulfoxydes a action antibacterienne
FR2476647A2 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn
EP0044238A1 (fr) * 1980-06-30 1982-01-20 Sanofi S.A. Dérivés de céphalosporines sulfoxydes, procédé de préparation et compositions pharmaceutiques en contenant
FR2560879A1 (fr) * 1984-03-09 1985-09-13 Glaxo Group Ltd Procede de recuperation de l'antibiotique ceftazidime
EP0192210A2 (fr) * 1985-02-18 1986-08-27 Fujisawa Pharmaceutical Co., Ltd. Composés céphem et procédés pour leur préparation
EP0192210A3 (en) * 1985-02-18 1988-03-30 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
US4861769A (en) * 1985-02-18 1989-08-29 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0278656A1 (fr) * 1987-02-02 1988-08-17 Eli Lilly And Company Procédé pour la préparation de pentahydrate de ceftazidime

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AR229883A1 (es) 1983-12-30
SE8402887L (sv) 1984-05-28
IL59793A (en) 1982-08-31
MY8400017A (en) 1984-12-31
YU41635B (en) 1987-12-31
DK157685B (da) 1990-02-05
IE791025L (en) 1979-11-26
HK40183A (en) 1983-10-21
AT370420B (de) 1983-03-25
ATA239281A (de) 1982-08-15
FI67705B (fi) 1985-01-31
YU123179A (en) 1983-01-21
NZ193326A (en) 1982-05-31
SE8402887D0 (sv) 1984-05-28
NL176855C (nl) 1985-06-17
AU524671B2 (en) 1982-09-30
PH16961A (en) 1984-04-27
NL176855B (nl) 1985-01-16
NL8001348A (nl) 1980-06-30
IL57400A0 (en) 1979-09-30
FR2445835B1 (fr) 1983-06-03
NO791731L (no) 1979-11-27
IE802453L (en) 1979-11-26
YU43097B (en) 1989-02-28
FI67555B (fi) 1984-12-31
IL57400A (en) 1982-08-31
NZ190558A (en) 1982-05-31
FI791678A (fi) 1979-11-27
CH649556A5 (de) 1985-05-31
SG58382G (en) 1983-09-02
SE438507B (sv) 1985-04-22
FI67705C (fi) 1985-05-10
NO155347C (no) 1987-03-18
NO850153L (no) 1979-11-27
LU81319A1 (fr) 1979-09-11
PT69669A (en) 1979-06-01
IE49172B1 (en) 1985-08-21
ES480914A1 (es) 1980-02-01
SI8212234A8 (en) 1997-06-30
US4600772A (en) 1986-07-15
FR2426695B1 (fr) 1982-06-11
KE3252A (en) 1983-01-28
CH646178A5 (de) 1984-11-15
NO155347B (no) 1966-12-08
FI67555C (fi) 1985-04-10
SI7911231A8 (en) 1997-06-30
DK216779A (da) 1979-11-27
PT69670A (en) 1979-06-01
DK157685C (da) 1990-07-09
AR228726A1 (es) 1983-04-15
DE2921316C2 (de) 1982-09-16
US4258041A (en) 1981-03-24
NL7904122A (nl) 1979-11-28
IE49173B1 (en) 1985-08-21
FR2445835A1 (fr) 1980-08-01
CA1127633A (fr) 1982-07-13
DE2921316A1 (de) 1979-12-06
YU223482A (en) 1983-04-30
ES480915A1 (es) 1980-02-01
AU4742279A (en) 1979-11-29
IT1116198B (it) 1986-02-10
FI801609A (fi) 1980-05-19
IL59793A0 (en) 1980-06-30

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