ATE97668T1 - Kristalline cephalosporinzusammensetzungen, verfahren und zwischenprodukte fuer ihre herstellung. - Google Patents

Kristalline cephalosporinzusammensetzungen, verfahren und zwischenprodukte fuer ihre herstellung.

Info

Publication number
ATE97668T1
ATE97668T1 AT87904113T AT87904113T ATE97668T1 AT E97668 T1 ATE97668 T1 AT E97668T1 AT 87904113 T AT87904113 T AT 87904113T AT 87904113 T AT87904113 T AT 87904113T AT E97668 T1 ATE97668 T1 AT E97668T1
Authority
AT
Austria
Prior art keywords
hydrochloride
methyl
water
manufacture
processes
Prior art date
Application number
AT87904113T
Other languages
English (en)
Inventor
Susumu Nakagawa
Ryosuke Ushijima
Fumio Nakano
Koji Yamada
Eiichi Mano
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of ATE97668T1 publication Critical patent/ATE97668T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT87904113T 1987-06-25 1987-06-25 Kristalline cephalosporinzusammensetzungen, verfahren und zwischenprodukte fuer ihre herstellung. ATE97668T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1987/000417 WO1988010263A1 (en) 1987-06-25 1987-06-25 Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation

Publications (1)

Publication Number Publication Date
ATE97668T1 true ATE97668T1 (de) 1993-12-15

Family

ID=13902738

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87904113T ATE97668T1 (de) 1987-06-25 1987-06-25 Kristalline cephalosporinzusammensetzungen, verfahren und zwischenprodukte fuer ihre herstellung.

Country Status (5)

Country Link
EP (1) EP0321562B1 (de)
KR (1) KR950010084B1 (de)
AT (1) ATE97668T1 (de)
DE (1) DE3788279T2 (de)
WO (1) WO1988010263A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632540B2 (en) 2003-07-01 2009-12-15 Transitions Optical, Inc. Alignment facilities for optical dyes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
JPH0645630B2 (ja) * 1984-12-27 1994-06-15 萬有製薬株式会社 新規セファロスポリン誘導体
EP0452987B1 (de) * 1984-12-27 1995-03-01 Banyu Pharmaceutical Co., Ltd. Isoindolinderivate
JPH064856B2 (ja) * 1985-03-20 1994-01-19 関西熱化学株式会社 装炭車より原料炭を装入する対象炭化室を確認する方法
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables
JPH0613793A (ja) * 1991-01-25 1994-01-21 Toko Inc 電子部品連とその製造方法

Also Published As

Publication number Publication date
EP0321562B1 (de) 1993-11-24
KR950010084B1 (ko) 1995-09-06
EP0321562A4 (de) 1990-06-05
EP0321562A1 (de) 1989-06-28
WO1988010263A1 (en) 1988-12-29
DE3788279T2 (de) 1994-06-16
DE3788279D1 (de) 1994-01-05
KR890701595A (ko) 1989-12-21

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties