KR890701595A - 결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체 - Google Patents

결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체

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Publication number
KR890701595A
KR890701595A KR1019890700324A KR890700324A KR890701595A KR 890701595 A KR890701595 A KR 890701595A KR 1019890700324 A KR1019890700324 A KR 1019890700324A KR 890700324 A KR890700324 A KR 890700324A KR 890701595 A KR890701595 A KR 890701595A
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KR
South Korea
Prior art keywords
methyl
isoindolinium
acetamido
dihydroxy
carboxylate
Prior art date
Application number
KR1019890700324A
Other languages
English (en)
Other versions
KR950010084B1 (ko
Inventor
스스무 나까가와
료스께 우시지마
푸미오 나까노
고지 야마다
에이이찌 마노
Original Assignee
도오야마 노리유끼
반유세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 도오야마 노리유끼, 반유세이야꾸 가부시끼가이샤 filed Critical 도오야마 노리유끼
Publication of KR890701595A publication Critical patent/KR890701595A/ko
Application granted granted Critical
Publication of KR950010084B1 publication Critical patent/KR950010084B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 결정성(6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1-카르복시-1-메틸에톡시이미노)아세트아미도]-3-(5,6-디히드록시-2-메틸-2-이소인돌리늄)메틸-3-세펨-4-카르복실레이트,황산염 또는 그의 수화물.
  2. 제1항에 있어서, (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1-카르복시-1-메틸에톡시이미노)아세트아미도]-3-(5,6-디히드록시-2-메틸-2-이소인돌리늄)메틸-3-세펨-4-카르복실레이트의 산부가염, 그의 수화물, 그의 용매 화물, 그의 무정형 분말 또는 그것들의 조제물을 물, 친수성 유기 용매 또는 그것들의 혼합용매에 가하고, 이어서 황산 및 필요에 따라 물을 가하고, (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1-카르복시-1-메틸에톡시이미노)아세트아미도]-3-(5,6-디히드록시-2-메틸-2-이소인돌리늄)메틸-3-세펨-4-카르복실레이트, 황산염 또는 그의 수화물의 결정을 석출시키는 것을 특징으로하는 화합물의 제조법.
  3. (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1-카르복시-1-메틸에톡시이미노)아세트아미도]-3-(5,6-디히드록시-2-메틸-2-이소인돌리늄)메틸-3-세펨-4-카르복실레이트,황산염 또는 그의 수화물.
  4. 제2항에 있어서, (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1-카르복시-1-메틸에톡시이미노)아세트아미도]-3-(5,6-디히드록시-2-메틸-2-이소인돌리늄)메틸-3-세펨-4-카르복실레이트,염산염 또는 그의 수화물을 물, 친수성 유기용매 또는 그것들의 혼합용매에 가하고 이어서 황산 및 필요에 따라 물을 가하여 (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-(1-카르복시-1-메틸에톡시이미노)아세트아미도]-3-(5,6-디히드록시-2-메틸-2-이소인돌리늄)메틸-3-세펨-4-카르복실레이트,황산염 또는 그의 수화물의 결정을 석출시키는 것을 특징으로 하느 화합물의 제조법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890700324A 1987-06-25 1987-06-25 결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체 KR950010084B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1987/000417 WO1988010263A1 (en) 1987-06-25 1987-06-25 Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation

Publications (2)

Publication Number Publication Date
KR890701595A true KR890701595A (ko) 1989-12-21
KR950010084B1 KR950010084B1 (ko) 1995-09-06

Family

ID=13902738

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890700324A KR950010084B1 (ko) 1987-06-25 1987-06-25 결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체

Country Status (5)

Country Link
EP (1) EP0321562B1 (ko)
KR (1) KR950010084B1 (ko)
AT (1) ATE97668T1 (ko)
DE (1) DE3788279T2 (ko)
WO (1) WO1988010263A1 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632540B2 (en) 2003-07-01 2009-12-15 Transitions Optical, Inc. Alignment facilities for optical dyes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
JPH0645630B2 (ja) * 1984-12-27 1994-06-15 萬有製薬株式会社 新規セファロスポリン誘導体
CA1267647A (en) * 1984-12-27 1990-04-10 Ryosuke Ushijima Cephalosporin derivatives
JPH064856B2 (ja) * 1985-03-20 1994-01-19 関西熱化学株式会社 装炭車より原料炭を装入する対象炭化室を確認する方法
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables
JPH0613793A (ja) * 1991-01-25 1994-01-21 Toko Inc 電子部品連とその製造方法

Also Published As

Publication number Publication date
ATE97668T1 (de) 1993-12-15
WO1988010263A1 (en) 1988-12-29
EP0321562B1 (en) 1993-11-24
DE3788279D1 (de) 1994-01-05
EP0321562A1 (en) 1989-06-28
DE3788279T2 (de) 1994-06-16
KR950010084B1 (ko) 1995-09-06
EP0321562A4 (en) 1990-06-05

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