KR900006350A - 세팔로스포린유도체의 결정성 2염산염 및 그 제조법 - Google Patents

세팔로스포린유도체의 결정성 2염산염 및 그 제조법 Download PDF

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Publication number
KR900006350A
KR900006350A KR1019890014438A KR890014438A KR900006350A KR 900006350 A KR900006350 A KR 900006350A KR 1019890014438 A KR1019890014438 A KR 1019890014438A KR 890014438 A KR890014438 A KR 890014438A KR 900006350 A KR900006350 A KR 900006350A
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KR
South Korea
Prior art keywords
preparation
crystalline dihydrochloride
cephalosporin derivatives
carboxyethoxyimino
aminothiazol
Prior art date
Application number
KR1019890014438A
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English (en)
Other versions
KR0137211B1 (ko
Inventor
쓰네오 오코노기
야스시 무라이
마사히로 오노데라
니시즈카 토시오
야스히코 이라이
세이지 시바하라
시게하루 이노우에
Original Assignee
사사이 아키라
메이지제과 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 사사이 아키라, 메이지제과 주식회사 filed Critical 사사이 아키라
Publication of KR900006350A publication Critical patent/KR900006350A/ko
Application granted granted Critical
Publication of KR0137211B1 publication Critical patent/KR0137211B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음

Description

세팔로스포린유도체의 결정성 2염산염 및 그 제조법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. (6R,7R)-7[(Z)-2-(2-아미노티아졸-4-일)-2-((1S)-1-카르복시에톡시이미노)아세트아미드]-3-[(1-에틸피리디늄-4-일)티오메틸]세프-3-엠-4-카르복시레이트결정성 2염산염.
  2. 아미노기 및 카르복실기를 보호한 (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-((1S)-1-카르복시에톡시이미노)아세트아미드]-3-[(1-에틸피리디늄-4-일)티오메틸]세프-3-엠-4-카르본산을 탈보호하고, 그다음 이것을 염산수용액에서 결정화시킴을 특징으로 하는 (6R,7R)-7-[(Z)-2-(2-아미노티아졸-4-일)-2-((1S)-1-카르복시에톡시이미노)아세트아미드]-3-[(1-에틸피리디늄-4-일)티오메틸]세프-3-엠-4-카르복실레이트결정성 2염산염의 제조법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890014438A 1988-10-08 1989-10-07 세팔로스포린유도체의 결정성 2염산염 및 그 제조법 KR0137211B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63254340A JPH02101081A (ja) 1988-10-08 1988-10-08 セファロスポリン誘導体結晶性二塩酸塩及びその製造法
JP63-254340 1988-10-08

Publications (2)

Publication Number Publication Date
KR900006350A true KR900006350A (ko) 1990-05-08
KR0137211B1 KR0137211B1 (ko) 1998-04-25

Family

ID=17263641

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890014438A KR0137211B1 (ko) 1988-10-08 1989-10-07 세팔로스포린유도체의 결정성 2염산염 및 그 제조법

Country Status (5)

Country Link
US (1) US4970305A (ko)
EP (1) EP0363826A3 (ko)
JP (1) JPH02101081A (ko)
KR (1) KR0137211B1 (ko)
CA (1) CA1339419C (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
JP4656798B2 (ja) * 2002-02-05 2011-03-23 武田薬品工業株式会社 セフェム化合物
WO2004039816A1 (ja) * 2002-10-29 2004-05-13 Shionogi & Co., Ltd. セフェム化合物の無機酸塩の結晶
EP1606293B1 (en) 2003-03-27 2009-08-19 Basilea Pharmaceutica AG Cephalosporin in crystalline form

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS523091A (en) * 1975-06-23 1977-01-11 Takeda Chem Ind Ltd A prcess for preparing cephalosporins
JPS5657789A (en) * 1979-10-02 1981-05-20 Glaxo Group Ltd Novel cephalosporin antibiotic
GR78221B (ko) * 1980-02-01 1984-09-26 Ciba Geigy Ag
JPS5913088A (ja) * 1982-07-13 1984-01-23 Mitsubishi Steel Mfg Co Ltd 電解析出金属の陰極板からのはく離防止法
EP0175544A3 (en) * 1984-09-17 1987-06-03 Eli Lilly And Company An improved process for cephalosporin intermediates
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables
JPH064645B2 (ja) * 1985-11-27 1994-01-19 明治製菓株式会社 新規セフアロスポリン誘導体およびそれを含む抗菌剤
JPS63154622A (ja) * 1986-12-18 1988-06-27 Meiji Seika Kaisha Ltd セフアロスポリン誘導体を有効成分とする哺乳動物用抗菌剤

Also Published As

Publication number Publication date
EP0363826A2 (en) 1990-04-18
EP0363826A3 (en) 1991-11-27
KR0137211B1 (ko) 1998-04-25
CA1339419C (en) 1997-09-02
JPH02101081A (ja) 1990-04-12
US4970305A (en) 1990-11-13

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