DE69032733D1 - Lyophilisiertes Dihydrochloridsalz von 7-[alpha-(2-Aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamid]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylsäure - Google Patents

Lyophilisiertes Dihydrochloridsalz von 7-[alpha-(2-Aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamid]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylsäure

Info

Publication number
DE69032733D1
DE69032733D1 DE69032733T DE69032733T DE69032733D1 DE 69032733 D1 DE69032733 D1 DE 69032733D1 DE 69032733 T DE69032733 T DE 69032733T DE 69032733 T DE69032733 T DE 69032733T DE 69032733 D1 DE69032733 D1 DE 69032733D1
Authority
DE
Germany
Prior art keywords
alpha
methyl
lyophilized
aminothiazol
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69032733T
Other languages
English (en)
Other versions
DE69032733T2 (de
Inventor
Murray A Kaplan
Munir N Nassar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE69032733D1 publication Critical patent/DE69032733D1/de
Publication of DE69032733T2 publication Critical patent/DE69032733T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69032733T 1989-03-06 1990-03-05 Lyophilisiertes Dihydrochloridsalz von 7-[alpha-(2-Aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamid]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylsäure Expired - Lifetime DE69032733T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31898589A 1989-03-06 1989-03-06

Publications (2)

Publication Number Publication Date
DE69032733D1 true DE69032733D1 (de) 1998-12-10
DE69032733T2 DE69032733T2 (de) 1999-07-08

Family

ID=23240400

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69032733T Expired - Lifetime DE69032733T2 (de) 1989-03-06 1990-03-05 Lyophilisiertes Dihydrochloridsalz von 7-[alpha-(2-Aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamid]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylsäure

Country Status (8)

Country Link
US (1) US5095011A (de)
EP (1) EP0386668B1 (de)
JP (1) JP2958567B2 (de)
AT (1) ATE172977T1 (de)
CA (1) CA2011116C (de)
DE (1) DE69032733T2 (de)
DK (1) DK0386668T3 (de)
ES (1) ES2125218T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1606293T3 (da) * 2003-03-27 2009-10-05 Basilea Pharmaceutica Ag Cephalosporin i krystallinsk form
WO2006109324A2 (en) * 2005-04-13 2006-10-19 Lupin Limited Processes for preparation of amorphous cefepime acid addition salts
US20080108664A1 (en) * 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
CN104606199B (zh) 2006-03-29 2022-09-13 维斯塔实验室有限公司 3,7-二氨基-10h-吩噻嗪化合物盐及其用途
US20090275552A1 (en) * 2006-04-28 2009-11-05 Mahesh Vithalbhai Patel Therapy for Treating Resistant Bacterial Infections
PT2673266T (pt) 2011-02-11 2016-10-07 Wista Lab Ltd Sais de fenotiazina diamínio e sua utilização
CN103304580B (zh) * 2013-06-09 2014-07-09 四川省惠达药业有限公司 一种盐酸头孢吡肟化合物、其制备方法及其药物组合物
CN114042048B (zh) * 2021-10-29 2023-02-28 海南海灵化学制药有限公司 一种注射用盐酸头孢吡肟的制备工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
CA1284994C (en) * 1985-08-05 1991-06-18 Murray Arthur Kaplan Cephalosporin salts and injectable compositions
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination

Also Published As

Publication number Publication date
US5095011A (en) 1992-03-10
DE69032733T2 (de) 1999-07-08
JP2958567B2 (ja) 1999-10-06
ES2125218T3 (es) 1999-03-01
CA2011116A1 (en) 1990-09-06
EP0386668A2 (de) 1990-09-12
ATE172977T1 (de) 1998-11-15
JPH02273684A (ja) 1990-11-08
EP0386668A3 (de) 1992-01-08
DK0386668T3 (da) 1999-07-19
EP0386668B1 (de) 1998-11-04
CA2011116C (en) 1999-11-16

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