ES2063058T3 - N,n'-carbonil-bis-(4-etil-2,3-dioxo)-piperazina, proceso para su preparacion y uso de la misma. - Google Patents

N,n'-carbonil-bis-(4-etil-2,3-dioxo)-piperazina, proceso para su preparacion y uso de la misma.

Info

Publication number
ES2063058T3
ES2063058T3 ES88500107T ES88500107T ES2063058T3 ES 2063058 T3 ES2063058 T3 ES 2063058T3 ES 88500107 T ES88500107 T ES 88500107T ES 88500107 T ES88500107 T ES 88500107T ES 2063058 T3 ES2063058 T3 ES 2063058T3
Authority
ES
Spain
Prior art keywords
dioxo
piperazine
preparation
bis
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88500107T
Other languages
English (en)
Inventor
Castellvi Juan Cabre
Meseguer Jose Diago
Bianchini Asunci N Esteve
Lenhardt Carlos E Padro
Pitarch Esteve Sans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Gema SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gema SA filed Critical Gema SA
Application granted granted Critical
Publication of ES2063058T3 publication Critical patent/ES2063058T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

UN NUEVO COMPUESTO LLAMADO N,N''- CARBOXIL - (4 - ETIL - 2,3 DIOXO) - PIPERAZINA DE FORMULA(I). UN PROCESO PARA LA PREPARACION DE ESTO BASADO EN LA REACCION DE 4 - ETIL - 2,3 - DIOXO PIPERAZINA O UN DERIVADO DE TRIMETILSILILO CON CLORURO DE CARBONILO O UN DERIVADO SUYO. EL USO DEL COMPUESTO DE FORMULA(I) COMO INTERMEDIARIO EN LA PREPARACION DE COMPUESTOS DE FORMULA(II), DONDE R ES UN RADICAL, SUSTITUIDO EN POSICION ALFA, UNA MOLECULA DE UN ACIDO SELECCIONADO DEL GRUPO FORMADO POR ACIDO FENILACETICO, ACIDO P - HIDROXIFENILACETICO, UN ACIDO SES (FENIL - ACETAMIDO) - PENILAMICO Y UN ACIDO 7 - ( FENILACETAMIDA) - CEFALOSPORANICO.
ES88500107T 1987-11-16 1988-11-07 N,n'-carbonil-bis-(4-etil-2,3-dioxo)-piperazina, proceso para su preparacion y uso de la misma. Expired - Lifetime ES2063058T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8703260A ES2005450A6 (es) 1987-11-16 1987-11-16 Procedimiento para la preparacion de derivados n(4-etil-2,3-dioxo)-piperacin-1-iln-carbonilo.

Publications (1)

Publication Number Publication Date
ES2063058T3 true ES2063058T3 (es) 1995-01-01

Family

ID=8253271

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8703260A Expired ES2005450A6 (es) 1987-11-16 1987-11-16 Procedimiento para la preparacion de derivados n(4-etil-2,3-dioxo)-piperacin-1-iln-carbonilo.
ES88500107T Expired - Lifetime ES2063058T3 (es) 1987-11-16 1988-11-07 N,n'-carbonil-bis-(4-etil-2,3-dioxo)-piperazina, proceso para su preparacion y uso de la misma.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES8703260A Expired ES2005450A6 (es) 1987-11-16 1987-11-16 Procedimiento para la preparacion de derivados n(4-etil-2,3-dioxo)-piperacin-1-iln-carbonilo.

Country Status (7)

Country Link
US (2) US4965358A (es)
EP (1) EP0317484B1 (es)
JP (1) JP2693189B2 (es)
AT (1) ATE102926T1 (es)
CA (1) CA1338624C (es)
DE (1) DE3888458T2 (es)
ES (2) ES2005450A6 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2010104A6 (es) * 1989-01-26 1989-10-16 Gema Sa Procedimiento de preparacion de ureas asimetricas y utilizacion de las mismas.
IT1282955B1 (it) * 1996-05-03 1998-04-02 Abres Associated Biotechnology Processo per la preparazione di derivati ureidici e intermedi di sintesi
IT1283530B1 (it) * 1996-07-26 1998-04-21 Ribbon Srl Procedimento per la preparazione di penicilline
AU2002952259A0 (en) * 2002-10-25 2002-11-07 Silverbrook Research Pty Ltd Methods and apparatus
EP2385039B1 (en) 2001-04-19 2014-03-12 Eisai R&D Management Co., Ltd. 2-Iminoisoindolinone derivatives as thrombin receptor antagonists
ES2321153B1 (es) * 2007-10-11 2010-02-26 Astur Pharma S.A. Intermedio para la sintesis de piperacilina.
CN101508679B (zh) * 2009-03-31 2010-05-12 山西新天源医药化工有限公司 D(-)-α-(4-乙基-2,3-双氧哌嗪-1-甲酰胺基)对羟基苯乙酸的合成方法
CN105524001B (zh) * 2015-03-13 2018-04-06 山东艾孚特科技有限公司 一种n,n＇‑碳酰基‑双‑（4‑乙基‑2,3‑双氧哌嗪）的制备方法
CN104910178B (zh) * 2015-05-22 2017-06-13 华北制药集团先泰药业有限公司 一种哌拉西林酸的制备方法
CN109438476A (zh) * 2018-12-24 2019-03-08 常州红太阳药业有限公司 哌拉西林酸的制备方法
CN112321605B (zh) * 2020-11-04 2022-01-28 山东安信制药有限公司 一种哌拉西林的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4217832B1 (es) * 1965-01-28 1967-09-18
FR2092556A5 (es) * 1970-04-02 1972-01-21 Snam Progetti
US4110327A (en) * 1974-05-09 1978-08-29 Toyama Chemical Co., Ltd. 2,3 Diketo-piperazinocarbonylamino alkanoic acids and derivatives
DE2648858A1 (de) * 1975-10-30 1977-05-18 Cooper Lab Antimikrobielle verbindungen auf der grundlage von bis-carbamylguanidinoazaalkanen
DE2600880C2 (de) * 1976-01-12 1984-09-13 Toyama Chemical Co. Ltd., Tokio / Tokyo Cephalosporinverbindungen
JPS6026800B2 (ja) * 1976-01-22 1985-06-25 富山化学工業株式会社 新規な７α−メトキシセフアロスポリン類およびその製造法
US4200744A (en) * 1976-01-22 1980-04-29 Toyama Chemical Company, Limited Substituted 7α-methoxy-7β[(2,3-dioxo-1-piperazinyl)carbonylaminophenylacetamido]cephalosporins
JPS52106883A (en) * 1976-02-13 1977-09-07 Toyama Chem Co Ltd Novel penicillins and cephalosporins
JPS5618969A (en) * 1979-07-24 1981-02-23 Toyama Chem Co Ltd Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation
EP0131174B1 (en) * 1983-07-07 1989-09-13 Beecham Group Plc Substituted phenylglycine derivatives of beta-lactam antibiotics

Also Published As

Publication number Publication date
US4965358A (en) 1990-10-23
EP0317484A3 (en) 1990-08-01
EP0317484A2 (en) 1989-05-24
EP0317484B1 (en) 1994-03-16
DE3888458T2 (de) 1994-09-01
ATE102926T1 (de) 1994-04-15
ES2005450A6 (es) 1989-03-01
CA1338624C (en) 1996-10-01
JPH01250367A (ja) 1989-10-05
JP2693189B2 (ja) 1997-12-24
US5015736A (en) 1991-05-14
DE3888458D1 (de) 1994-04-21

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