KR830005235A - 결정성염의 제조방법 - Google Patents

결정성염의 제조방법 Download PDF

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Publication number
KR830005235A
KR830005235A KR1019810000311A KR810000311A KR830005235A KR 830005235 A KR830005235 A KR 830005235A KR 1019810000311 A KR1019810000311 A KR 1019810000311A KR 810000311 A KR810000311 A KR 810000311A KR 830005235 A KR830005235 A KR 830005235A
Authority
KR
South Korea
Prior art keywords
thiazolyl
amino
manufacturing
carboxylic acid
hydrobromide
Prior art date
Application number
KR1019810000311A
Other languages
English (en)
Other versions
KR840000502B1 (ko
Inventor
스카르타찌니 리카르도
Original Assignee
아놀드 자일러, 에른스트 알테르
시비-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아놀드 자일러, 에른스트 알테르, 시비-가이기 에이지 filed Critical 아놀드 자일러, 에른스트 알테르
Publication of KR830005235A publication Critical patent/KR830005235A/ko
Application granted granted Critical
Publication of KR840000502B1 publication Critical patent/KR840000502B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Sorption Type Refrigeration Machines (AREA)
  • Magnetic Heads (AREA)
  • Fats And Perfumes (AREA)
  • Liquid Crystal Substances (AREA)
  • Seasonings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

결정성염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 7β-[2-(2-아미노-4-티아졸릴)-2-메톡시이미노 아세트아미도]-3-세펨-4-카복실산 피발로일옥시메틸에스테르를 염화수소 또는 브롬화수소로 처리하여 하이드로클로라이드 또는 하이드로브로마이드로 전환시키고 생성된 염을 결정화하는 것을 특징으로 하여, 결정성 7β-[2-(2-아미노-4-티아졸릴)-2-메톡시이미노 아세트아미도]-3-세펨-4-카복실산 피발로일옥시메틸 에스테르 하이드로클로라이드 또는 하이드로브로마이드를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810000311A 1980-02-01 1981-01-31 세팔로스포란산 피발로일옥시메틸 에스테르의 결정성염을 제조하는 방법 KR840000502B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH83680 1980-02-01
CH836/80-3 1980-02-01
CH836/80-3? 1980-02-01

Publications (2)

Publication Number Publication Date
KR830005235A true KR830005235A (ko) 1983-08-03
KR840000502B1 KR840000502B1 (ko) 1984-04-16

Family

ID=4196332

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000311A KR840000502B1 (ko) 1980-02-01 1981-01-31 세팔로스포란산 피발로일옥시메틸 에스테르의 결정성염을 제조하는 방법

Country Status (26)

Country Link
US (1) US4411897A (ko)
EP (1) EP0033518B1 (ko)
JP (1) JPS56122382A (ko)
KR (1) KR840000502B1 (ko)
AT (1) ATE3550T1 (ko)
AU (1) AU6677981A (ko)
CA (1) CA1146540A (ko)
CS (1) CS219851B2 (ko)
DD (1) DD157462A5 (ko)
DE (1) DE3160328D1 (ko)
DK (1) DK32081A (ko)
ES (1) ES8204439A1 (ko)
FI (1) FI66874B (ko)
GR (1) GR78221B (ko)
IE (1) IE50888B1 (ko)
IL (1) IL62017A (ko)
MC (1) MC1367A1 (ko)
MT (1) MTP882B (ko)
NO (1) NO810338L (ko)
NZ (1) NZ196159A (ko)
OA (1) OA06732A (ko)
PL (1) PL125899B1 (ko)
PT (1) PT72421A (ko)
SU (1) SU1036250A1 (ko)
ZA (1) ZA81631B (ko)
ZW (1) ZW2281A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054512A3 (de) * 1980-12-12 1983-08-03 Ciba-Geigy Ag Cephalosporinester, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
US4400503A (en) * 1981-10-30 1983-08-23 Eli Lilly And Company Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid
US4594417A (en) * 1981-10-30 1986-06-10 Eli Lilly Company Crystalline antibiotic salt
JPS60190783A (ja) * 1983-12-21 1985-09-28 Sumitomo Seiyaku Kk セフエム系化合物
US4683227A (en) * 1985-07-09 1987-07-28 Eli Lilly And Company Antibiotic derivatives of 7β-[2-(thiazol-4-yl)acetamide]-3-chloro-3-cephem-4-carboxylic acids and compositions and method of use thereof
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
EP0638573A1 (en) * 1993-08-10 1995-02-15 Lucky Ltd. Crystalline hydrates of cephalosporin and process for preparation thereof
US20040067192A1 (en) * 2002-10-07 2004-04-08 The Procter & Gamble Company Conversion of sodium bromide to anhydrous hydrobromic acid and sodium bisulfate
AU2004224181B2 (en) * 2003-03-27 2011-06-02 Basilea Pharmaceutica Ag Cephalosporin in crystalline form

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17188A (en) 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
US4370326A (en) * 1977-09-13 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and composition
GB2025933B (en) 1978-06-13 1982-10-27 Fujisawa Pharmaceutical Co Cephem and cepham compounds
MA18686A1 (fr) * 1978-07-07 1980-10-01 Ciba Geigy Ag Composes aminothiazoliques
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal

Also Published As

Publication number Publication date
CS219851B2 (en) 1983-03-25
MC1367A1 (fr) 1981-10-23
KR840000502B1 (ko) 1984-04-16
US4411897A (en) 1983-10-25
PL125899B1 (en) 1983-06-30
OA06732A (fr) 1982-06-30
IE50888B1 (en) 1986-08-06
PL229457A1 (ko) 1981-10-02
MTP882B (en) 1984-06-05
AU6677981A (en) 1981-08-06
ATE3550T1 (de) 1983-06-15
ES498989A0 (es) 1982-05-01
NZ196159A (en) 1983-09-30
GR78221B (ko) 1984-09-26
DK32081A (da) 1981-08-02
DE3160328D1 (en) 1983-07-07
IE810176L (en) 1981-08-01
NO810338L (no) 1981-08-03
SU1036250A1 (ru) 1983-08-15
DD157462A5 (de) 1982-11-10
IL62017A0 (en) 1981-02-27
PT72421A (de) 1981-02-01
FI66874B (fi) 1984-08-31
JPS56122382A (en) 1981-09-25
EP0033518B1 (de) 1983-05-25
EP0033518A1 (de) 1981-08-12
CA1146540A (en) 1983-05-17
FI810270L (fi) 1981-08-02
ES8204439A1 (es) 1982-05-01
ZA81631B (en) 1982-02-24
ZW2281A1 (en) 1981-09-02
IL62017A (en) 1984-06-29

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