MY100694A - Cephalosporanic acid derivatives. - Google Patents

Cephalosporanic acid derivatives.

Info

Publication number
MY100694A
MY100694A MYPI87002270A MYPI19872270A MY100694A MY 100694 A MY100694 A MY 100694A MY PI87002270 A MYPI87002270 A MY PI87002270A MY PI19872270 A MYPI19872270 A MY PI19872270A MY 100694 A MY100694 A MY 100694A
Authority
MY
Malaysia
Prior art keywords
acid derivatives
hydrogen
cephalosporanic acid
intermediates
formula
Prior art date
Application number
MYPI87002270A
Inventor
Naito Takayuki
Aburaki Shimpei
Hoshi Hideaki
Okumura Jun
Abe Yoshio
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MY100694A publication Critical patent/MY100694A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

THIS INVENTION PROVIDES NOVEL CEPHALOSPORIN INTERMEDIATES. 7- AMINO- 3- (Z)-1-PROPEN-1- Y1] - 3- CEPHEM- 4- CARBOXYLIC ACID AND ESTERS THEREOF HAVING THE GENERAL FORMULA (FORMULA 1) WHEREIN THE CONFIRGURATION OF THE 3- PROPENYL GROUP IS Z SOMETIMES REFERRED TO AS CIS- AND R IS HYDROGEN OR A CONVENTIONAL CARBOXY- PROTECTING GROUP, AND ACID ADDITION SALTS THEREOF AND THE METAL SALTS OF THE FOREGOING SUBTANCE WHEREIN R IS HYDROGEN. THESE COMPOUNDS ARE USEFUL AS INTERMEDIATES FOR PREPARATION OF ORALLY ACTIVE CEPHALOSPORINS.
MYPI87002270A 1985-04-22 1987-09-29 Cephalosporanic acid derivatives. MY100694A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72587185A 1985-04-22 1985-04-22
GB08609661A GB2173798B (en) 1985-04-22 1986-04-21 Cephalosporanic acid derivatives

Publications (1)

Publication Number Publication Date
MY100694A true MY100694A (en) 1991-01-17

Family

ID=24916301

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI87002270A MY100694A (en) 1985-04-22 1987-09-29 Cephalosporanic acid derivatives.

Country Status (38)

Country Link
JP (1) JPS61249989A (en)
KR (1) KR860008189A (en)
CN (1) CN1015714B (en)
AR (1) AR242581A1 (en)
AT (1) AT392072B (en)
AU (1) AU589170B2 (en)
BE (1) BE904646A (en)
CA (1) CA1273629A (en)
CH (1) CH671399A5 (en)
CS (1) CS270435B2 (en)
CY (1) CY1571A (en)
DD (1) DD244557A5 (en)
DE (1) DE3613365A1 (en)
DK (1) DK163584C (en)
EG (1) EG18001A (en)
ES (1) ES8800236A1 (en)
FI (1) FI84268C (en)
FR (1) FR2580652B1 (en)
GB (1) GB2173798B (en)
GR (1) GR861065B (en)
HK (1) HK106290A (en)
HU (1) HU195223B (en)
IE (1) IE59014B1 (en)
IT (1) IT1228241B (en)
LU (1) LU86402A1 (en)
MY (1) MY100694A (en)
NL (1) NL192205C (en)
NO (1) NO164659C (en)
NZ (1) NZ215717A (en)
OA (1) OA08245A (en)
PT (1) PT82436B (en)
SE (1) SE500217C2 (en)
SG (1) SG90890G (en)
SU (1) SU1435155A3 (en)
YU (1) YU43697B (en)
ZA (1) ZA862985B (en)
ZM (1) ZM4286A1 (en)
ZW (1) ZW9086A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
DE3933934A1 (en) * 1989-10-03 1991-04-11 Bayer Ag METHOD FOR PRODUCING 7-AMINO-3 - ((Z) -1-PROPEN-1-YL) -3-CEPHEM-4-CARBONIC ACID
ES2157199T3 (en) * 1991-03-08 2001-08-16 Biochemie Gmbh NEW PROCEDURE FOR THE PRODUCTION OF CEPHALOSPORINS AND NEW INTERMEDIATE COMPOUNDS FOR THIS PROCEDURE.
KR950700311A (en) 1992-02-05 1995-01-16 게오르게스 그렐리니, 한스 루돌프하우스 Process for the purification of a 3-cephem-4-carboxylic acid derivatives
AT399876B (en) * 1992-02-05 1995-08-25 Biochemie Gmbh Purificn. of 7-amino-3-((z)-1-propen-1-yl)-3 -cephem-4-carboxylic acid - useful in prodn. of broadband antibiotics
JPH07173168A (en) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd Cephem compound, its production and utilization of the compound for production of cephem antibiotic substance
WO2004033464A1 (en) * 2002-10-08 2004-04-22 Ranbaxy Laboratories Limited Process for the preparation of (z)-isomer enriched 7-amino-3-propen-1-yl-3-cephem-4- carboxylic acid
EP1678186A4 (en) * 2003-10-30 2007-04-25 Cj Corp Processes for the preparation of cephem derivatives
JP4046708B2 (en) * 2004-06-04 2008-02-13 明治製菓株式会社 Method for producing 3-alkenylcephem compound
EP1809638B1 (en) 2004-11-01 2010-02-17 Hetero Drugs Limited A novel process for preparation of cefprozil intermediate
CN103183686B (en) * 2011-12-30 2016-06-29 浙江新和成股份有限公司 The preparation method of 7 beta-amino-7 α-methoxyl group-3-cephem compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110534A (en) * 1970-01-23 1978-08-29 Glaxo Laboratories Limited Process for the preparation of 3-vinyl and substituted vinyl cephalosporins
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
AU566944B2 (en) * 1983-10-07 1987-11-05 Gist-Brocades N.V. Preparation of 3-cephem derivatives

Also Published As

Publication number Publication date
LU86402A1 (en) 1986-11-05
IT8620162A0 (en) 1986-04-21
SU1435155A3 (en) 1988-10-30
CS287286A2 (en) 1989-11-14
AR242581A1 (en) 1993-04-30
PT82436B (en) 1988-11-30
FI84268C (en) 1991-11-11
GB2173798B (en) 1988-11-30
FI861634A0 (en) 1986-04-17
SE500217C2 (en) 1994-05-09
DK182486D0 (en) 1986-04-21
ES554215A0 (en) 1987-10-16
ZM4286A1 (en) 1989-03-27
HU195223B (en) 1988-04-28
FR2580652A1 (en) 1986-10-24
CA1273629A (en) 1990-09-04
DE3613365C2 (en) 1989-06-15
DE3613365A1 (en) 1987-01-02
JPS61249989A (en) 1986-11-07
CY1571A (en) 1991-12-20
NO164659B (en) 1990-07-23
DK182486A (en) 1986-10-23
SG90890G (en) 1991-01-18
NO861430L (en) 1986-10-23
FI84268B (en) 1991-07-31
NL8601011A (en) 1986-11-17
OA08245A (en) 1987-10-30
IT1228241B (en) 1991-06-05
EG18001A (en) 1991-11-30
AT392072B (en) 1991-01-25
GR861065B (en) 1986-09-01
IE861048L (en) 1986-10-22
DD244557A5 (en) 1987-04-08
SE8601825L (en) 1986-10-23
GB8609661D0 (en) 1986-05-29
CS270435B2 (en) 1990-06-13
DK163584B (en) 1992-03-16
PT82436A (en) 1986-05-01
CN86102630A (en) 1987-02-04
ZA862985B (en) 1986-12-30
FR2580652B1 (en) 1989-01-06
GB2173798A (en) 1986-10-22
NL192205B (en) 1996-11-01
NZ215717A (en) 1989-06-28
JPH0327554B2 (en) 1991-04-16
YU65986A (en) 1987-12-31
YU43697B (en) 1989-10-31
IE59014B1 (en) 1993-12-15
NO164659C (en) 1990-10-31
BE904646A (en) 1986-10-21
HK106290A (en) 1990-12-28
AU5616886A (en) 1986-11-06
NL192205C (en) 1997-03-04
KR860008189A (en) 1986-11-12
HUT41033A (en) 1987-03-30
SE8601825D0 (en) 1986-04-21
ATA106786A (en) 1990-07-15
ZW9086A1 (en) 1986-12-03
FI861634A (en) 1986-10-23
DK163584C (en) 1992-08-10
AU589170B2 (en) 1989-10-05
CN1015714B (en) 1992-03-04
ES8800236A1 (en) 1987-10-16
CH671399A5 (en) 1989-08-31

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