BE904646A - 7-AMINO-3-PROPENYLCEPHALOSPORANIC ACID AND ITS ESTERS. - Google Patents

7-AMINO-3-PROPENYLCEPHALOSPORANIC ACID AND ITS ESTERS.

Info

Publication number
BE904646A
BE904646A BE0/216572A BE216572A BE904646A BE 904646 A BE904646 A BE 904646A BE 0/216572 A BE0/216572 A BE 0/216572A BE 216572 A BE216572 A BE 216572A BE 904646 A BE904646 A BE 904646A
Authority
BE
Belgium
Prior art keywords
esters
amino
acid
propenylcephalosporanic
hydrogen
Prior art date
Application number
BE0/216572A
Other languages
French (fr)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE904646A publication Critical patent/BE904646A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Intermédiaires nouveaux de la céphalosporine, l'acide 7 betha-amino-3-((Z) -1- propen-1-yl) -3- céphem -4- carboxylique et ses esters ayant la formule générale,dans laquelle: la configuration du groupe 3-propényle est Z, souvent considéré comme cis-; et R est de l'hydrogène ou un groupe classique protecteur de carboxy, et leurs sels d'addition d'acides et sels métalliques du composé précité dans lequel R est un atome d'hydrogène.Novel intermediates of cephalosporin, 7 betha-amino-3 - ((Z) -1- propen-1-yl) -3- cephem -4- carboxylic acid and its esters having the general formula, in which: the configuration of the 3-propenyl group is Z, often considered to be cis-; and R is hydrogen or a conventional carboxy protecting group, and their acid addition salts and metal salts of the above compound in which R is a hydrogen atom.

BE0/216572A 1985-04-22 1986-04-21 7-AMINO-3-PROPENYLCEPHALOSPORANIC ACID AND ITS ESTERS. BE904646A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72587185A 1985-04-22 1985-04-22

Publications (1)

Publication Number Publication Date
BE904646A true BE904646A (en) 1986-10-21

Family

ID=24916301

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216572A BE904646A (en) 1985-04-22 1986-04-21 7-AMINO-3-PROPENYLCEPHALOSPORANIC ACID AND ITS ESTERS.

Country Status (38)

Country Link
JP (1) JPS61249989A (en)
KR (1) KR860008189A (en)
CN (1) CN1015714B (en)
AR (1) AR242581A1 (en)
AT (1) AT392072B (en)
AU (1) AU589170B2 (en)
BE (1) BE904646A (en)
CA (1) CA1273629A (en)
CH (1) CH671399A5 (en)
CS (1) CS270435B2 (en)
CY (1) CY1571A (en)
DD (1) DD244557A5 (en)
DE (1) DE3613365A1 (en)
DK (1) DK163584C (en)
EG (1) EG18001A (en)
ES (1) ES8800236A1 (en)
FI (1) FI84268C (en)
FR (1) FR2580652B1 (en)
GB (1) GB2173798B (en)
GR (1) GR861065B (en)
HK (1) HK106290A (en)
HU (1) HU195223B (en)
IE (1) IE59014B1 (en)
IT (1) IT1228241B (en)
LU (1) LU86402A1 (en)
MY (1) MY100694A (en)
NL (1) NL192205C (en)
NO (1) NO164659C (en)
NZ (1) NZ215717A (en)
OA (1) OA08245A (en)
PT (1) PT82436B (en)
SE (1) SE500217C2 (en)
SG (1) SG90890G (en)
SU (1) SU1435155A3 (en)
YU (1) YU43697B (en)
ZA (1) ZA862985B (en)
ZM (1) ZM4286A1 (en)
ZW (1) ZW9086A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
DE3933934A1 (en) * 1989-10-03 1991-04-11 Bayer Ag METHOD FOR PRODUCING 7-AMINO-3 - ((Z) -1-PROPEN-1-YL) -3-CEPHEM-4-CARBONIC ACID
ATE201025T1 (en) * 1991-03-08 2001-05-15 Biochemie Gmbh METHOD FOR PRODUCING CEPHALOSPORINS AND INTERMEDIATE PRODUCTS IN THIS METHOD
AT399876B (en) * 1992-02-05 1995-08-25 Biochemie Gmbh Purificn. of 7-amino-3-((z)-1-propen-1-yl)-3 -cephem-4-carboxylic acid - useful in prodn. of broadband antibiotics
PT630380E (en) * 1992-02-05 2002-02-28 Biochemie Gmbh PROCESS FOR THE PURIFICATION OF A DERIVATIVE OF 3-CEFEM-4-CARBOXYLIC ACID
JPH07173168A (en) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd Cephem compound, its production and utilization of the compound for production of cephem antibiotic substance
WO2004033464A1 (en) * 2002-10-08 2004-04-22 Ranbaxy Laboratories Limited Process for the preparation of (z)-isomer enriched 7-amino-3-propen-1-yl-3-cephem-4- carboxylic acid
US7544797B2 (en) 2003-10-30 2009-06-09 Cj Cheiljedang Corporation Processes for the preparation of cephem derivatives
JP4046708B2 (en) * 2004-06-04 2008-02-13 明治製菓株式会社 Method for producing 3-alkenylcephem compound
WO2006048887A1 (en) * 2004-11-01 2006-05-11 Hetero Drugs Limited A novel process for preparation of cefprozil intermediate
CN103183686B (en) * 2011-12-30 2016-06-29 浙江新和成股份有限公司 The preparation method of 7 beta-amino-7 α-methoxyl group-3-cephem compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110534A (en) * 1970-01-23 1978-08-29 Glaxo Laboratories Limited Process for the preparation of 3-vinyl and substituted vinyl cephalosporins
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
AU566944B2 (en) * 1983-10-07 1987-11-05 Gist-Brocades N.V. Preparation of 3-cephem derivatives

Also Published As

Publication number Publication date
YU65986A (en) 1987-12-31
CY1571A (en) 1991-12-20
SG90890G (en) 1991-01-18
DK182486A (en) 1986-10-23
FR2580652B1 (en) 1989-01-06
CA1273629A (en) 1990-09-04
NL8601011A (en) 1986-11-17
NO164659B (en) 1990-07-23
YU43697B (en) 1989-10-31
NL192205C (en) 1997-03-04
FI84268B (en) 1991-07-31
FI861634A (en) 1986-10-23
JPH0327554B2 (en) 1991-04-16
AT392072B (en) 1991-01-25
NZ215717A (en) 1989-06-28
IE861048L (en) 1986-10-22
DD244557A5 (en) 1987-04-08
ES554215A0 (en) 1987-10-16
AR242581A1 (en) 1993-04-30
OA08245A (en) 1987-10-30
ZM4286A1 (en) 1989-03-27
FI84268C (en) 1991-11-11
GR861065B (en) 1986-09-01
CH671399A5 (en) 1989-08-31
AU589170B2 (en) 1989-10-05
ES8800236A1 (en) 1987-10-16
NO861430L (en) 1986-10-23
FI861634A0 (en) 1986-04-17
SE8601825L (en) 1986-10-23
JPS61249989A (en) 1986-11-07
GB8609661D0 (en) 1986-05-29
DE3613365A1 (en) 1987-01-02
KR860008189A (en) 1986-11-12
DK182486D0 (en) 1986-04-21
DK163584C (en) 1992-08-10
CS287286A2 (en) 1989-11-14
HUT41033A (en) 1987-03-30
MY100694A (en) 1991-01-17
LU86402A1 (en) 1986-11-05
CN86102630A (en) 1987-02-04
IE59014B1 (en) 1993-12-15
HK106290A (en) 1990-12-28
ZW9086A1 (en) 1986-12-03
EG18001A (en) 1991-11-30
FR2580652A1 (en) 1986-10-24
ZA862985B (en) 1986-12-30
NL192205B (en) 1996-11-01
SE8601825D0 (en) 1986-04-21
NO164659C (en) 1990-10-31
PT82436A (en) 1986-05-01
CS270435B2 (en) 1990-06-13
IT8620162A0 (en) 1986-04-21
AU5616886A (en) 1986-11-06
CN1015714B (en) 1992-03-04
GB2173798A (en) 1986-10-22
SU1435155A3 (en) 1988-10-30
SE500217C2 (en) 1994-05-09
HU195223B (en) 1988-04-28
PT82436B (en) 1988-11-30
IT1228241B (en) 1991-06-05
DE3613365C2 (en) 1989-06-15
GB2173798B (en) 1988-11-30
DK163584B (en) 1992-03-16
ATA106786A (en) 1990-07-15

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *BRISTOL-MYERS CY

Effective date: 20060421