IE861048L - 3-propenylcephalosporin derivatives - Google Patents

3-propenylcephalosporin derivatives

Info

Publication number
IE861048L
IE861048L IE861048A IE104886A IE861048L IE 861048 L IE861048 L IE 861048L IE 861048 A IE861048 A IE 861048A IE 104886 A IE104886 A IE 104886A IE 861048 L IE861048 L IE 861048L
Authority
IE
Ireland
Prior art keywords
hydrogen
image
intermediates
propenylcephalosporin
derivatives
Prior art date
Application number
IE861048A
Other versions
IE59014B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE861048L publication Critical patent/IE861048L/en
Publication of IE59014B1 publication Critical patent/IE59014B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

This invention provides novel cephalosporin intermediates, 7 beta -amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and esters thereof having the general formula <IMAGE> wherein the configuration of the 3-propenyl group is Z sometimes referred to as cis- and R is hydrogen or a conventional carboxy-protecting group, and acid addition salts thereof and the metal salts of the foregoing substance wherein R is hydrogen. These compounds are useful as intermediates for preparation of orally active cephalosporins. <IMAGE> [GB2173798A]
IE104886A 1985-04-22 1986-04-21 Cephalosporanic acid derivatives IE59014B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72587185A 1985-04-22 1985-04-22

Publications (2)

Publication Number Publication Date
IE861048L true IE861048L (en) 1986-10-22
IE59014B1 IE59014B1 (en) 1993-12-15

Family

ID=24916301

Family Applications (1)

Application Number Title Priority Date Filing Date
IE104886A IE59014B1 (en) 1985-04-22 1986-04-21 Cephalosporanic acid derivatives

Country Status (38)

Country Link
JP (1) JPS61249989A (en)
KR (1) KR860008189A (en)
CN (1) CN1015714B (en)
AR (1) AR242581A1 (en)
AT (1) AT392072B (en)
AU (1) AU589170B2 (en)
BE (1) BE904646A (en)
CA (1) CA1273629A (en)
CH (1) CH671399A5 (en)
CS (1) CS270435B2 (en)
CY (1) CY1571A (en)
DD (1) DD244557A5 (en)
DE (1) DE3613365A1 (en)
DK (1) DK163584C (en)
EG (1) EG18001A (en)
ES (1) ES8800236A1 (en)
FI (1) FI84268C (en)
FR (1) FR2580652B1 (en)
GB (1) GB2173798B (en)
GR (1) GR861065B (en)
HK (1) HK106290A (en)
HU (1) HU195223B (en)
IE (1) IE59014B1 (en)
IT (1) IT1228241B (en)
LU (1) LU86402A1 (en)
MY (1) MY100694A (en)
NL (1) NL192205C (en)
NO (1) NO164659C (en)
NZ (1) NZ215717A (en)
OA (1) OA08245A (en)
PT (1) PT82436B (en)
SE (1) SE500217C2 (en)
SG (1) SG90890G (en)
SU (1) SU1435155A3 (en)
YU (1) YU43697B (en)
ZA (1) ZA862985B (en)
ZM (1) ZM4286A1 (en)
ZW (1) ZW9086A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
DE3933934A1 (en) * 1989-10-03 1991-04-11 Bayer Ag METHOD FOR PRODUCING 7-AMINO-3 - ((Z) -1-PROPEN-1-YL) -3-CEPHEM-4-CARBONIC ACID
PT503453E (en) * 1991-03-08 2001-10-31 Biochemie Gmbh NEW PROCESS FOR THE PRODUCTION OF CEFALOSPORINAS AND NEW INTERMEDIARIES IN THIS PROCESS
ATE253583T1 (en) 1992-02-05 2003-11-15 Biochemie Gmbh METHOD FOR PRODUCING A 3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVE
AT399876B (en) * 1992-02-05 1995-08-25 Biochemie Gmbh Purificn. of 7-amino-3-((z)-1-propen-1-yl)-3 -cephem-4-carboxylic acid - useful in prodn. of broadband antibiotics
JPH07173168A (en) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd Cephem compound, its production and utilization of the compound for production of cephem antibiotic substance
AU2003267733A1 (en) * 2002-10-08 2004-05-04 Ranbaxy Laboratories Limited Process for the preparation of (z)-isomer enriched 7-amino-3-propen-1-yl-3-cephem-4- carboxylic acid
WO2005042543A1 (en) 2003-10-30 2005-05-12 Cj Corporation Processes for the preparation of cephem derivatives
JP4046708B2 (en) * 2004-06-04 2008-02-13 明治製菓株式会社 Method for producing 3-alkenylcephem compound
DE602004025631D1 (en) * 2004-11-01 2010-04-01 Hetero Drugs Ltd ISCHENPRODUKTS
CN103183686B (en) * 2011-12-30 2016-06-29 浙江新和成股份有限公司 The preparation method of 7 beta-amino-7 α-methoxyl group-3-cephem compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4110534A (en) * 1970-01-23 1978-08-29 Glaxo Laboratories Limited Process for the preparation of 3-vinyl and substituted vinyl cephalosporins
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
AU566944B2 (en) * 1983-10-07 1987-11-05 Gist-Brocades N.V. Preparation of 3-cephem derivatives

Also Published As

Publication number Publication date
FI861634A0 (en) 1986-04-17
FI84268C (en) 1991-11-11
CH671399A5 (en) 1989-08-31
HK106290A (en) 1990-12-28
JPH0327554B2 (en) 1991-04-16
SG90890G (en) 1991-01-18
AU589170B2 (en) 1989-10-05
DE3613365A1 (en) 1987-01-02
ZW9086A1 (en) 1986-12-03
GB2173798B (en) 1988-11-30
PT82436A (en) 1986-05-01
HU195223B (en) 1988-04-28
NZ215717A (en) 1989-06-28
FR2580652B1 (en) 1989-01-06
ES8800236A1 (en) 1987-10-16
SE500217C2 (en) 1994-05-09
SE8601825D0 (en) 1986-04-21
ES554215A0 (en) 1987-10-16
CS270435B2 (en) 1990-06-13
SE8601825L (en) 1986-10-23
ZM4286A1 (en) 1989-03-27
GB2173798A (en) 1986-10-22
FI84268B (en) 1991-07-31
CA1273629A (en) 1990-09-04
DK182486D0 (en) 1986-04-21
IE59014B1 (en) 1993-12-15
PT82436B (en) 1988-11-30
GR861065B (en) 1986-09-01
NO164659B (en) 1990-07-23
DK163584C (en) 1992-08-10
HUT41033A (en) 1987-03-30
FR2580652A1 (en) 1986-10-24
EG18001A (en) 1991-11-30
DK182486A (en) 1986-10-23
ATA106786A (en) 1990-07-15
LU86402A1 (en) 1986-11-05
NL8601011A (en) 1986-11-17
NO861430L (en) 1986-10-23
KR860008189A (en) 1986-11-12
JPS61249989A (en) 1986-11-07
NL192205C (en) 1997-03-04
FI861634A (en) 1986-10-23
SU1435155A3 (en) 1988-10-30
CN86102630A (en) 1987-02-04
AT392072B (en) 1991-01-25
DE3613365C2 (en) 1989-06-15
CY1571A (en) 1991-12-20
AU5616886A (en) 1986-11-06
BE904646A (en) 1986-10-21
DK163584B (en) 1992-03-16
MY100694A (en) 1991-01-17
NL192205B (en) 1996-11-01
GB8609661D0 (en) 1986-05-29
OA08245A (en) 1987-10-30
DD244557A5 (en) 1987-04-08
CN1015714B (en) 1992-03-04
CS287286A2 (en) 1989-11-14
YU43697B (en) 1989-10-31
YU65986A (en) 1987-12-31
AR242581A1 (en) 1993-04-30
IT1228241B (en) 1991-06-05
NO164659C (en) 1990-10-31
IT8620162A0 (en) 1986-04-21
ZA862985B (en) 1986-12-30

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Legal Events

Date Code Title Description
MM9A Patent lapsed through non-payment of renewal fee
NE4A Application for restoration sect. 37 patents act 1992
NF4A Order made for restoration sect. 37 patents act 1992

Free format text: 19961030

MK9A Patent expired