SG188572A1 - Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases - Google Patents

Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases Download PDF

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Publication number
SG188572A1
SG188572A1 SG2013019575A SG2013019575A SG188572A1 SG 188572 A1 SG188572 A1 SG 188572A1 SG 2013019575 A SG2013019575 A SG 2013019575A SG 2013019575 A SG2013019575 A SG 2013019575A SG 188572 A1 SG188572 A1 SG 188572A1
Authority
SG
Singapore
Prior art keywords
methyl
ethyl
imidazol
benzyl ester
alkyl
Prior art date
Application number
SG2013019575A
Other languages
English (en)
Inventor
Mohammed I Dibas
Daniel W Gil
Ken Chow
Liming Wang
Michael E Garst
John E Donello
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44675870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG188572(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of SG188572A1 publication Critical patent/SG188572A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG2013019575A 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases SG188572A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38337010P 2010-09-16 2010-09-16
PCT/US2011/051926 WO2012037453A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases

Publications (1)

Publication Number Publication Date
SG188572A1 true SG188572A1 (en) 2013-04-30

Family

ID=44675870

Family Applications (4)

Application Number Title Priority Date Filing Date
SG2013019575A SG188572A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases
SG2013019567A SG188571A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for lowering intraocular pressure
SG2013019591A SG188573A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions
SG2013019559A SG188570A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol

Family Applications After (3)

Application Number Title Priority Date Filing Date
SG2013019567A SG188571A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for lowering intraocular pressure
SG2013019591A SG188573A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions
SG2013019559A SG188570A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol

Country Status (28)

Country Link
US (9) US8653123B2 (enExample)
EP (13) EP3078376B1 (enExample)
JP (4) JP2013537236A (enExample)
KR (7) KR101952457B1 (enExample)
CN (5) CN105412092B (enExample)
AR (4) AR083018A1 (enExample)
AU (4) AU2011301856C1 (enExample)
BR (4) BR112013006352A2 (enExample)
CA (8) CA2812195A1 (enExample)
CL (4) CL2013000735A1 (enExample)
CY (3) CY1121024T1 (enExample)
DK (9) DK2616069T3 (enExample)
ES (10) ES2613509T3 (enExample)
HU (5) HUE038698T2 (enExample)
IL (4) IL225282A0 (enExample)
MX (4) MX2013003009A (enExample)
MY (4) MY173846A (enExample)
NZ (1) NZ608751A (enExample)
PL (7) PL3050563T3 (enExample)
PT (7) PT3348264T (enExample)
RU (4) RU2612351C2 (enExample)
SG (4) SG188572A1 (enExample)
SI (5) SI3348264T1 (enExample)
TR (1) TR201909249T4 (enExample)
TW (4) TWI591058B (enExample)
UA (1) UA112973C2 (enExample)
WO (4) WO2012037499A1 (enExample)
ZA (4) ZA201302193B (enExample)

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JP2012518007A (ja) 2009-02-13 2012-08-09 アラーガン インコーポレイテッド (3‐(1‐(1h‐イミダゾール‐4‐イル)エチル)‐2‐メチルフェニル)メタノールを含む医薬組成物
KR101841442B1 (ko) 2010-01-11 2018-03-23 오렉시젠 세러퓨틱스 인크. 주우울증 환자들에 있어서 체중 감량 치료를 제공하는 방법
US8653123B2 (en) * 2010-09-16 2014-02-18 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases
WO2013016073A1 (en) * 2011-07-22 2013-01-31 Allergan, Inc. Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye
EP2782569A1 (en) 2011-11-21 2014-10-01 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
USD794650S1 (en) 2014-11-28 2017-08-15 Samsung Electronics Co., Ltd. Display screen or portion thereof with a graphical user interface
CN108310442B (zh) * 2017-01-17 2021-08-27 台北科技大学 眼科用组合物
KR102050506B1 (ko) 2017-06-20 2019-11-29 한국식품연구원 망막 질환 예방, 개선, 완화 또는 치료용 조성물
CN108872431B (zh) * 2018-07-09 2021-03-23 成都倍特药业股份有限公司 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法
CN112552314B (zh) * 2018-08-24 2022-03-04 杭州阿诺生物医药科技有限公司 Sting激动剂小分子抗肿瘤化合物及其应用
AU2022258105A1 (en) * 2021-04-16 2023-10-26 Ads Therapeutics Llc Alpha2 adrenergic agonist codrugs conjugated with muscarinic agonist drugs
KR20250141793A (ko) * 2023-02-08 2025-09-29 보슈 롬 아일랜드 리미티드 시력을 개선시키기 위한 알파-2-아드레날린성 효능제
WO2025179071A1 (en) * 2024-02-20 2025-08-28 Bausch + Lomb Ireland Limited Sustained-release drug delivery compositions for treating ocular diseases

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US8853251B2 (en) 2014-10-07
SI3338777T1 (sl) 2020-08-31
SI3050564T1 (sl) 2020-02-28
AU2011301847B2 (en) 2016-02-11
PL2616068T3 (pl) 2016-11-30
HUE038698T2 (hu) 2018-11-28
WO2012037499A1 (en) 2012-03-22
KR101840501B1 (ko) 2018-05-04
PT3050564T (pt) 2019-12-11
US20130289088A1 (en) 2013-10-31
SG188570A1 (en) 2013-04-30
MX2013003002A (es) 2013-06-28
HK1185538A1 (zh) 2014-02-21
TW201305116A (zh) 2013-02-01
SI3050563T1 (sl) 2018-10-30
ES2684055T3 (es) 2018-10-01
KR20140005154A (ko) 2014-01-14
UA112973C2 (uk) 2016-11-25
AR083020A1 (es) 2013-01-23
US8492422B2 (en) 2013-07-23
CA2812197C (en) 2024-01-02
CL2013000736A1 (es) 2013-07-12
CN103200942A (zh) 2013-07-10
DK2616069T3 (en) 2016-12-19
US20150148394A1 (en) 2015-05-28
US8501796B2 (en) 2013-08-06
ES2737230T3 (es) 2020-01-10
US20120136036A1 (en) 2012-05-31
US20120142746A1 (en) 2012-06-07
DK3050563T3 (en) 2018-08-13
EP3636263A1 (en) 2020-04-15
CN103209694A (zh) 2013-07-17
RU2612351C2 (ru) 2017-03-07
EP3053576A1 (en) 2016-08-10
HUE048725T2 (hu) 2020-09-28
EP2616066B1 (en) 2016-07-13
EP3050563A1 (en) 2016-08-03
JP2013540749A (ja) 2013-11-07
IL225278A0 (en) 2013-06-27
AU2011301932B2 (en) 2016-02-25
DK2616068T3 (en) 2016-08-29
EP3338777B1 (en) 2020-02-05
ES2781681T3 (es) 2020-09-04
SI3348264T1 (sl) 2020-07-31
EP3348264A1 (en) 2018-07-18
EP3338777A1 (en) 2018-06-27
MX2013003004A (es) 2013-06-28
KR20140003407A (ko) 2014-01-09
CA2811559A1 (en) 2012-03-22
CN103221045A (zh) 2013-07-24
KR101952457B1 (ko) 2019-02-26
CL2013000735A1 (es) 2013-11-29
KR20190022895A (ko) 2019-03-06
PL3050563T3 (pl) 2018-12-31
AU2011301856C1 (en) 2016-09-08
IL225281A0 (en) 2013-06-27
JP2013537237A (ja) 2013-09-30
EP3078376B1 (en) 2019-03-27
PT3053576T (pt) 2018-10-08
KR20130105658A (ko) 2013-09-25
RU2013116763A (ru) 2014-10-27
AR083019A1 (es) 2013-01-23
EP2616067A1 (en) 2013-07-24
PT3338777T (pt) 2020-05-06
HK1185541A1 (zh) 2014-02-21
DK3348264T3 (da) 2020-03-23
TR201909249T4 (tr) 2019-07-22
CL2013000734A1 (es) 2013-11-08
BR112013006352A2 (pt) 2016-06-28
PT3348264T (pt) 2020-04-02
RU2013116405A (ru) 2014-10-27
MX2013003009A (es) 2013-06-28
PL3348264T3 (pl) 2020-08-24
KR102104760B1 (ko) 2020-04-27
ES2613509T3 (es) 2017-05-24
IL225278A (en) 2015-11-30
KR20130114140A (ko) 2013-10-16
WO2012037453A1 (en) 2012-03-22
DK3078376T3 (da) 2019-06-24
ZA201302288B (en) 2013-11-27
KR101840500B1 (ko) 2018-03-20
TWI591058B (zh) 2017-07-11
PT2616069T (pt) 2016-12-06
EP3050564B1 (en) 2019-09-04
EP3078376A1 (en) 2016-10-12
EP2616067B1 (en) 2016-05-18
PT3050563T (pt) 2018-10-01
CA2812191C (en) 2021-04-13
JP2013537236A (ja) 2013-09-30
ES2788051T3 (es) 2020-10-20
ZA201302291B (en) 2013-11-27
PL3050564T3 (pl) 2020-06-01
EP3050564A1 (en) 2016-08-03
CA3116249A1 (en) 2012-03-22
EP2616069A1 (en) 2013-07-24
ES2760920T3 (es) 2020-05-18
MX2013003008A (es) 2013-06-28
AU2011301847A1 (en) 2013-05-02
AU2011301856A1 (en) 2013-05-02
PL2616069T3 (pl) 2017-04-28
SI3053576T1 (sl) 2018-11-30
JP6045495B2 (ja) 2016-12-14
CA2812191A1 (en) 2012-03-22
EP3053576B1 (en) 2018-05-16
AU2011301901A1 (en) 2013-05-02
CN105412092B (zh) 2020-11-17
NZ608751A (en) 2015-04-24
TW201240661A (en) 2012-10-16
ES2607084T3 (es) 2017-03-29
ES2687420T3 (es) 2018-10-25
HUE049573T2 (hu) 2020-10-28
CA3077732A1 (en) 2012-03-22
CA3079450A1 (en) 2012-03-22
US20130296394A1 (en) 2013-11-07
AU2011301932C1 (en) 2016-09-01
PT2616068T (pt) 2016-09-13
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IL225282A0 (en) 2013-06-27
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US20140057958A1 (en) 2014-02-27
CN103200941A (zh) 2013-07-10
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US20160354346A1 (en) 2016-12-08
ZA201302193B (en) 2013-11-27
RU2013116403A (ru) 2014-10-27
CN105412092A (zh) 2016-03-23
TW201240662A (en) 2012-10-16
HUE039090T2 (hu) 2018-12-28
CY1121024T1 (el) 2019-12-11
TW201305117A (zh) 2013-02-01
DK3050564T3 (da) 2019-11-25
BR112013006320A2 (pt) 2016-06-21
EP3636263B1 (en) 2021-11-03
JP2013541527A (ja) 2013-11-14
CA3122745A1 (en) 2012-03-22
EP3050563B1 (en) 2018-05-09
US8653123B2 (en) 2014-02-18
KR102139905B1 (ko) 2020-07-31
CL2013000733A1 (es) 2013-08-23
EP2616068A1 (en) 2013-07-24
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AR083018A1 (es) 2013-01-23
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WO2012037484A1 (en) 2012-03-22
HUE047476T2 (hu) 2020-04-28
BR112013006320B1 (pt) 2022-08-30
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IL225280A0 (en) 2013-06-27
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US20120149746A1 (en) 2012-06-14
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BR112013006355A2 (pt) 2016-06-28
US20120122945A1 (en) 2012-05-17
ES2904479T3 (es) 2022-04-05
PL3053576T3 (pl) 2018-11-30
JP6073229B2 (ja) 2017-02-01
US8492557B2 (en) 2013-07-23
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AU2011301932A1 (en) 2013-05-02
CA2812195A1 (en) 2012-03-22
CN103200941B (zh) 2015-12-16
HK1185539A1 (zh) 2014-02-21
EP2616068B1 (en) 2016-07-13
HK1185540A1 (en) 2014-02-21

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