HUE038698T2 - [3-(l-(lH-imidazol-4-il)etil)-2-metilfenil]metanol észter elõvegyületei bõrbetegségek és állapotok kezelésére - Google Patents

[3-(l-(lH-imidazol-4-il)etil)-2-metilfenil]metanol észter elõvegyületei bõrbetegségek és állapotok kezelésére

Info

Publication number
HUE038698T2
HUE038698T2 HUE16161920A HUE16161920A HUE038698T2 HU E038698 T2 HUE038698 T2 HU E038698T2 HU E16161920 A HUE16161920 A HU E16161920A HU E16161920 A HUE16161920 A HU E16161920A HU E038698 T2 HUE038698 T2 HU E038698T2
Authority
HU
Hungary
Prior art keywords
imidazol
methylphenyl
drugs
methanol
ethyl
Prior art date
Application number
HUE16161920A
Other languages
English (en)
Hungarian (hu)
Inventor
Mohammed I Dibas
Ken Chow
John E Donello
Michael E Garst
Daniel W Gil
Liming Wang
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44675870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE038698(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of HUE038698T2 publication Critical patent/HUE038698T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE16161920A 2010-09-16 2011-09-16 [3-(l-(lH-imidazol-4-il)etil)-2-metilfenil]metanol észter elõvegyületei bõrbetegségek és állapotok kezelésére HUE038698T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38337010P 2010-09-16 2010-09-16

Publications (1)

Publication Number Publication Date
HUE038698T2 true HUE038698T2 (hu) 2018-11-28

Family

ID=44675870

Family Applications (5)

Application Number Title Priority Date Filing Date
HUE16161920A HUE038698T2 (hu) 2010-09-16 2011-09-16 [3-(l-(lH-imidazol-4-il)etil)-2-metilfenil]metanol észter elõvegyületei bõrbetegségek és állapotok kezelésére
HUE16161922A HUE039090T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol észter pro-drogjai a szembelnyomás csökkentésére
HUE18157147A HUE048725T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil] metanol észter elõvegyületei retina betegségek kezelésére
HUE16161923A HUE047476T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1-(1H-imidazol-4-il)-etil-2-metilfenil] metanol észter prodrugjai
HUE18160174A HUE049573T2 (hu) 2010-09-16 2011-09-16 3-[(S)-1-(1H-imidazol-4-il)-etil]-2-metilfenil]metanol észter elõvegyületei intraokuláris nyomás csökkentésére

Family Applications After (4)

Application Number Title Priority Date Filing Date
HUE16161922A HUE039090T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol észter pro-drogjai a szembelnyomás csökkentésére
HUE18157147A HUE048725T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil] metanol észter elõvegyületei retina betegségek kezelésére
HUE16161923A HUE047476T2 (hu) 2010-09-16 2011-09-16 [3-(1-(1-(1H-imidazol-4-il)-etil-2-metilfenil] metanol észter prodrugjai
HUE18160174A HUE049573T2 (hu) 2010-09-16 2011-09-16 3-[(S)-1-(1H-imidazol-4-il)-etil]-2-metilfenil]metanol észter elõvegyületei intraokuláris nyomás csökkentésére

Country Status (28)

Country Link
US (9) US8653123B2 (enExample)
EP (13) EP3078376B1 (enExample)
JP (4) JP2013537236A (enExample)
KR (7) KR101952457B1 (enExample)
CN (5) CN105412092B (enExample)
AR (4) AR083018A1 (enExample)
AU (4) AU2011301856C1 (enExample)
BR (4) BR112013006352A2 (enExample)
CA (8) CA2812195A1 (enExample)
CL (4) CL2013000735A1 (enExample)
CY (3) CY1121024T1 (enExample)
DK (9) DK2616069T3 (enExample)
ES (10) ES2613509T3 (enExample)
HU (5) HUE038698T2 (enExample)
IL (4) IL225282A0 (enExample)
MX (4) MX2013003009A (enExample)
MY (4) MY173846A (enExample)
NZ (1) NZ608751A (enExample)
PL (7) PL3050563T3 (enExample)
PT (7) PT3348264T (enExample)
RU (4) RU2612351C2 (enExample)
SG (4) SG188572A1 (enExample)
SI (5) SI3348264T1 (enExample)
TR (1) TR201909249T4 (enExample)
TW (4) TWI591058B (enExample)
UA (1) UA112973C2 (enExample)
WO (4) WO2012037499A1 (enExample)
ZA (4) ZA201302193B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012518007A (ja) 2009-02-13 2012-08-09 アラーガン インコーポレイテッド (3‐(1‐(1h‐イミダゾール‐4‐イル)エチル)‐2‐メチルフェニル)メタノールを含む医薬組成物
KR101841442B1 (ko) 2010-01-11 2018-03-23 오렉시젠 세러퓨틱스 인크. 주우울증 환자들에 있어서 체중 감량 치료를 제공하는 방법
US8653123B2 (en) * 2010-09-16 2014-02-18 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases
WO2013016073A1 (en) * 2011-07-22 2013-01-31 Allergan, Inc. Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye
EP2782569A1 (en) 2011-11-21 2014-10-01 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
USD794650S1 (en) 2014-11-28 2017-08-15 Samsung Electronics Co., Ltd. Display screen or portion thereof with a graphical user interface
CN108310442B (zh) * 2017-01-17 2021-08-27 台北科技大学 眼科用组合物
KR102050506B1 (ko) 2017-06-20 2019-11-29 한국식품연구원 망막 질환 예방, 개선, 완화 또는 치료용 조성물
CN108872431B (zh) * 2018-07-09 2021-03-23 成都倍特药业股份有限公司 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法
CN112552314B (zh) * 2018-08-24 2022-03-04 杭州阿诺生物医药科技有限公司 Sting激动剂小分子抗肿瘤化合物及其应用
AU2022258105A1 (en) * 2021-04-16 2023-10-26 Ads Therapeutics Llc Alpha2 adrenergic agonist codrugs conjugated with muscarinic agonist drugs
KR20250141793A (ko) * 2023-02-08 2025-09-29 보슈 롬 아일랜드 리미티드 시력을 개선시키기 위한 알파-2-아드레날린성 효능제
WO2025179071A1 (en) * 2024-02-20 2025-08-28 Bausch + Lomb Ireland Limited Sustained-release drug delivery compositions for treating ocular diseases

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0642332T3 (da) 1992-05-13 1997-06-16 Sandoz Ltd Ophthalmiske præparater indeholdende cyclosporin
US5459133A (en) * 1992-06-05 1995-10-17 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
JPH09505298A (ja) 1993-11-15 1997-05-27 シェーリング コーポレイション H▲下3▼‐レセプターアンタゴニストとしてのフェニル‐アルキルイミダゾール
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
US20040214829A1 (en) * 2000-07-14 2004-10-28 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
EA010392B1 (ru) * 2003-05-27 2008-08-29 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) Производные имидазолов, способ их получения и их применение в качестве лекарственного средства
US7439241B2 (en) * 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
CN1823518A (zh) * 2003-07-14 2006-08-23 皇家飞利浦电子股份有限公司 投影设备
CA2538445A1 (en) 2003-09-12 2005-04-21 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
MXPA06013649A (es) 2004-05-25 2007-07-09 Sansrosa Pharmaceutical Dev In Compuestos, formulaciones, y metodos para tratar o prevenir desordenes inflamatorios de la piel.
US20050277584A1 (en) 2004-06-09 2005-12-15 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
CN101031549A (zh) * 2004-09-24 2007-09-05 阿勒根公司 作为特异性α2肾上腺素能激动剂的4-(苯甲基和取代苯甲基)-咪唑-2-硫酮
US7931909B2 (en) 2005-05-10 2011-04-26 Allergan, Inc. Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US20070082070A1 (en) * 2005-10-11 2007-04-12 Stookey Evangeline L Treating skin disorders
US7902247B2 (en) 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
AU2010210513A1 (en) 2009-02-06 2011-09-01 Allergan, Inc. Pyridine compounds as subtype selective modulators of alpha2B and/or alpha 2C adrenergic receptors
JP2012518007A (ja) * 2009-02-13 2012-08-09 アラーガン インコーポレイテッド (3‐(1‐(1h‐イミダゾール‐4‐イル)エチル)‐2‐メチルフェニル)メタノールを含む医薬組成物
US8394800B2 (en) * 2009-11-19 2013-03-12 Galderma Laboratories, L.P. Method for treating psoriasis
US8653123B2 (en) * 2010-09-16 2014-02-18 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases

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US8853251B2 (en) 2014-10-07
SI3338777T1 (sl) 2020-08-31
SI3050564T1 (sl) 2020-02-28
AU2011301847B2 (en) 2016-02-11
PL2616068T3 (pl) 2016-11-30
WO2012037499A1 (en) 2012-03-22
KR101840501B1 (ko) 2018-05-04
PT3050564T (pt) 2019-12-11
US20130289088A1 (en) 2013-10-31
SG188570A1 (en) 2013-04-30
MX2013003002A (es) 2013-06-28
HK1185538A1 (zh) 2014-02-21
TW201305116A (zh) 2013-02-01
SI3050563T1 (sl) 2018-10-30
ES2684055T3 (es) 2018-10-01
KR20140005154A (ko) 2014-01-14
UA112973C2 (uk) 2016-11-25
AR083020A1 (es) 2013-01-23
US8492422B2 (en) 2013-07-23
CA2812197C (en) 2024-01-02
CL2013000736A1 (es) 2013-07-12
CN103200942A (zh) 2013-07-10
DK2616069T3 (en) 2016-12-19
US20150148394A1 (en) 2015-05-28
US8501796B2 (en) 2013-08-06
ES2737230T3 (es) 2020-01-10
US20120136036A1 (en) 2012-05-31
US20120142746A1 (en) 2012-06-07
DK3050563T3 (en) 2018-08-13
EP3636263A1 (en) 2020-04-15
CN103209694A (zh) 2013-07-17
RU2612351C2 (ru) 2017-03-07
EP3053576A1 (en) 2016-08-10
HUE048725T2 (hu) 2020-09-28
EP2616066B1 (en) 2016-07-13
EP3050563A1 (en) 2016-08-03
JP2013540749A (ja) 2013-11-07
IL225278A0 (en) 2013-06-27
AU2011301932B2 (en) 2016-02-25
DK2616068T3 (en) 2016-08-29
EP3338777B1 (en) 2020-02-05
ES2781681T3 (es) 2020-09-04
SI3348264T1 (sl) 2020-07-31
EP3348264A1 (en) 2018-07-18
EP3338777A1 (en) 2018-06-27
MX2013003004A (es) 2013-06-28
KR20140003407A (ko) 2014-01-09
CA2811559A1 (en) 2012-03-22
CN103221045A (zh) 2013-07-24
KR101952457B1 (ko) 2019-02-26
CL2013000735A1 (es) 2013-11-29
KR20190022895A (ko) 2019-03-06
PL3050563T3 (pl) 2018-12-31
AU2011301856C1 (en) 2016-09-08
IL225281A0 (en) 2013-06-27
JP2013537237A (ja) 2013-09-30
EP3078376B1 (en) 2019-03-27
PT3053576T (pt) 2018-10-08
KR20130105658A (ko) 2013-09-25
RU2013116763A (ru) 2014-10-27
AR083019A1 (es) 2013-01-23
EP2616067A1 (en) 2013-07-24
PT3338777T (pt) 2020-05-06
HK1185541A1 (zh) 2014-02-21
DK3348264T3 (da) 2020-03-23
TR201909249T4 (tr) 2019-07-22
CL2013000734A1 (es) 2013-11-08
BR112013006352A2 (pt) 2016-06-28
PT3348264T (pt) 2020-04-02
RU2013116405A (ru) 2014-10-27
MX2013003009A (es) 2013-06-28
PL3348264T3 (pl) 2020-08-24
KR102104760B1 (ko) 2020-04-27
ES2613509T3 (es) 2017-05-24
IL225278A (en) 2015-11-30
KR20130114140A (ko) 2013-10-16
WO2012037453A1 (en) 2012-03-22
DK3078376T3 (da) 2019-06-24
ZA201302288B (en) 2013-11-27
KR101840500B1 (ko) 2018-03-20
TWI591058B (zh) 2017-07-11
PT2616069T (pt) 2016-12-06
EP3050564B1 (en) 2019-09-04
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EP2616067B1 (en) 2016-05-18
PT3050563T (pt) 2018-10-01
CA2812191C (en) 2021-04-13
JP2013537236A (ja) 2013-09-30
ES2788051T3 (es) 2020-10-20
ZA201302291B (en) 2013-11-27
PL3050564T3 (pl) 2020-06-01
EP3050564A1 (en) 2016-08-03
CA3116249A1 (en) 2012-03-22
EP2616069A1 (en) 2013-07-24
ES2760920T3 (es) 2020-05-18
MX2013003008A (es) 2013-06-28
AU2011301847A1 (en) 2013-05-02
AU2011301856A1 (en) 2013-05-02
PL2616069T3 (pl) 2017-04-28
SI3053576T1 (sl) 2018-11-30
JP6045495B2 (ja) 2016-12-14
CA2812191A1 (en) 2012-03-22
EP3053576B1 (en) 2018-05-16
AU2011301901A1 (en) 2013-05-02
CN105412092B (zh) 2020-11-17
NZ608751A (en) 2015-04-24
TW201240661A (en) 2012-10-16
ES2607084T3 (es) 2017-03-29
ES2687420T3 (es) 2018-10-25
HUE049573T2 (hu) 2020-10-28
CA3077732A1 (en) 2012-03-22
CA3079450A1 (en) 2012-03-22
US20130296394A1 (en) 2013-11-07
AU2011301932C1 (en) 2016-09-01
PT2616068T (pt) 2016-09-13
AU2011301901B2 (en) 2016-02-11
IL225282A0 (en) 2013-06-27
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US20140057958A1 (en) 2014-02-27
CN103200941A (zh) 2013-07-10
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EP2616066A1 (en) 2013-07-24
US20160354346A1 (en) 2016-12-08
ZA201302193B (en) 2013-11-27
RU2013116403A (ru) 2014-10-27
CN105412092A (zh) 2016-03-23
TW201240662A (en) 2012-10-16
HUE039090T2 (hu) 2018-12-28
CY1121024T1 (el) 2019-12-11
TW201305117A (zh) 2013-02-01
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BR112013006320A2 (pt) 2016-06-21
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US8653123B2 (en) 2014-02-18
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CL2013000733A1 (es) 2013-08-23
EP2616068A1 (en) 2013-07-24
KR20200091507A (ko) 2020-07-30
AR083017A1 (es) 2013-01-23
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WO2012037490A1 (en) 2012-03-22
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SG188571A1 (en) 2013-04-30
KR102354097B1 (ko) 2022-01-20
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WO2012037484A1 (en) 2012-03-22
HUE047476T2 (hu) 2020-04-28
BR112013006320B1 (pt) 2022-08-30
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RU2013116541A (ru) 2014-10-27
SG188572A1 (en) 2013-04-30
DK3338777T3 (da) 2020-04-20
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US20120149746A1 (en) 2012-06-14
EP3698789A1 (en) 2020-08-26
DK3636263T3 (da) 2022-01-10
BR112013006355A2 (pt) 2016-06-28
US20120122945A1 (en) 2012-05-17
ES2904479T3 (es) 2022-04-05
PL3053576T3 (pl) 2018-11-30
JP6073229B2 (ja) 2017-02-01
US8492557B2 (en) 2013-07-23
DK3053576T3 (en) 2018-08-20
AU2011301932A1 (en) 2013-05-02
CA2812195A1 (en) 2012-03-22
CN103200941B (zh) 2015-12-16
HK1185539A1 (zh) 2014-02-21
EP2616068B1 (en) 2016-07-13
HK1185540A1 (en) 2014-02-21

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