BR112013006352A2 - profármacos compostos profármacos de éster de [3-(1 -{1h-imidazol-4-il)etil)-2-metilfenil] metanol para tratar doenças e condições da pele, composição farmacêutica e artigo de fabricação - Google Patents

profármacos compostos profármacos de éster de [3-(1 -{1h-imidazol-4-il)etil)-2-metilfenil] metanol para tratar doenças e condições da pele, composição farmacêutica e artigo de fabricação

Info

Publication number
BR112013006352A2
BR112013006352A2 BR112013006352A BR112013006352A BR112013006352A2 BR 112013006352 A2 BR112013006352 A2 BR 112013006352A2 BR 112013006352 A BR112013006352 A BR 112013006352A BR 112013006352 A BR112013006352 A BR 112013006352A BR 112013006352 A2 BR112013006352 A2 BR 112013006352A2
Authority
BR
Brazil
Prior art keywords
conditions
methylphenyl
ethyl
imidazol
article
Prior art date
Application number
BR112013006352A
Other languages
English (en)
Inventor
Daniel W Gil
John E Donello
Ken Chow
Liming Wang
Michael E Garst
Mohammed I Dibas
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44675870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013006352(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112013006352A2 publication Critical patent/BR112013006352A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

profármacos de éster de [3-(1 -{1h-imidazol-4-il)etil)-2-metilfenil] metanol para tratar doenças e condições da pele. a presente invenção refere-se um método para tratar doenças e condições da pele em um indivíduo em necessidade de tal tratamento, que compreende administrar uma quantidade terapeuticamente eficaz de uma composição compreendendo profármacos de éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil]metanol, ou enantiômeros dos mesmos, composições farmacêuticas contendo-os e seus usos como produtos farmacêuticos.
BR112013006352A 2010-09-16 2011-09-16 profármacos compostos profármacos de éster de [3-(1 -{1h-imidazol-4-il)etil)-2-metilfenil] metanol para tratar doenças e condições da pele, composição farmacêutica e artigo de fabricação BR112013006352A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38337010P 2010-09-16 2010-09-16
PCT/US2011/051979 WO2012037484A1 (en) 2010-09-16 2011-09-16 Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating skin diseases and conditions

Publications (1)

Publication Number Publication Date
BR112013006352A2 true BR112013006352A2 (pt) 2016-06-28

Family

ID=44675870

Family Applications (4)

Application Number Title Priority Date Filing Date
BR112013006320-3A BR112013006320B1 (pt) 2010-09-16 2011-09-16 Composto, composição farmacêutica e seu uso
BR112013006362A BR112013006362A2 (pt) 2010-09-16 2011-09-16 uso de compostos profármacos de éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil] metanol para reduzir a pressão intraocular, composição farmacêutica e artigo de fabricação
BR112013006352A BR112013006352A2 (pt) 2010-09-16 2011-09-16 profármacos compostos profármacos de éster de [3-(1 -{1h-imidazol-4-il)etil)-2-metilfenil] metanol para tratar doenças e condições da pele, composição farmacêutica e artigo de fabricação
BR112013006355A BR112013006355A2 (pt) 2010-09-16 2011-09-16 profármacos de éster de [3-(1-(1h-imidazol-4-il)etil-2-metilfenil] metanol para tratar doenças retinais

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BR112013006320-3A BR112013006320B1 (pt) 2010-09-16 2011-09-16 Composto, composição farmacêutica e seu uso
BR112013006362A BR112013006362A2 (pt) 2010-09-16 2011-09-16 uso de compostos profármacos de éster de [3-(1-(1h-imidazol-4-il)etil)-2-metilfenil] metanol para reduzir a pressão intraocular, composição farmacêutica e artigo de fabricação

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112013006355A BR112013006355A2 (pt) 2010-09-16 2011-09-16 profármacos de éster de [3-(1-(1h-imidazol-4-il)etil-2-metilfenil] metanol para tratar doenças retinais

Country Status (29)

Country Link
US (9) US8653123B2 (pt)
EP (13) EP2616066B1 (pt)
JP (4) JP6045495B2 (pt)
KR (7) KR101840501B1 (pt)
CN (5) CN103221045A (pt)
AR (4) AR083019A1 (pt)
AU (4) AU2011301847B2 (pt)
BR (4) BR112013006320B1 (pt)
CA (8) CA3116249A1 (pt)
CL (4) CL2013000736A1 (pt)
CY (3) CY1121024T1 (pt)
DK (9) DK3050563T3 (pt)
ES (10) ES2607084T3 (pt)
HK (5) HK1185540A1 (pt)
HU (5) HUE047476T2 (pt)
IL (4) IL225282A0 (pt)
MX (4) MX2013003004A (pt)
MY (4) MY161607A (pt)
NZ (1) NZ608751A (pt)
PL (7) PL3338777T3 (pt)
PT (7) PT3050564T (pt)
RU (4) RU2013116405A (pt)
SG (4) SG188573A1 (pt)
SI (5) SI3348264T1 (pt)
TR (1) TR201909249T4 (pt)
TW (4) TWI591058B (pt)
UA (1) UA112973C2 (pt)
WO (4) WO2012037484A1 (pt)
ZA (4) ZA201302194B (pt)

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EP3050563B1 (en) 2018-05-09
AU2011301856A1 (en) 2013-05-02
CN103221045A (zh) 2013-07-24
BR112013006320A2 (pt) 2016-06-21
IL225281A0 (en) 2013-06-27
JP2013537237A (ja) 2013-09-30
US8492422B2 (en) 2013-07-23
US8653123B2 (en) 2014-02-18
DK3348264T3 (da) 2020-03-23
AR083020A1 (es) 2013-01-23
EP3659600A1 (en) 2020-06-03
SI3050563T1 (sl) 2018-10-30
TW201305117A (zh) 2013-02-01
DK2616069T3 (en) 2016-12-19
US20120149746A1 (en) 2012-06-14
WO2012037453A1 (en) 2012-03-22
US20120136036A1 (en) 2012-05-31
MX2013003009A (es) 2013-06-28
KR20130105658A (ko) 2013-09-25
RU2013116763A (ru) 2014-10-27
EP3698789A1 (en) 2020-08-26
CA3122745A1 (en) 2012-03-22
CN103200941A (zh) 2013-07-10
ES2593612T3 (es) 2016-12-12
SG188573A1 (en) 2013-04-30
EP3348264A1 (en) 2018-07-18
KR102104760B1 (ko) 2020-04-27
MY191369A (en) 2022-06-20
DK3050563T3 (en) 2018-08-13
CN103200941B (zh) 2015-12-16
EP3348264B1 (en) 2020-01-01
EP2616069A1 (en) 2013-07-24
BR112013006320B1 (pt) 2022-08-30
CN103200942A (zh) 2013-07-10
PT3053576T (pt) 2018-10-08
ES2760920T3 (es) 2020-05-18
US8492557B2 (en) 2013-07-23
HK1257416A1 (zh) 2019-10-18
ES2607084T3 (es) 2017-03-29
CA2811559A1 (en) 2012-03-22
MY168763A (en) 2018-12-04
CA2812191C (en) 2021-04-13
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TW201240661A (en) 2012-10-16
DK3053576T3 (en) 2018-08-20
CA2812191A1 (en) 2012-03-22
KR20190022895A (ko) 2019-03-06
MY161607A (en) 2017-04-28
DK3338777T3 (da) 2020-04-20
RU2013116403A (ru) 2014-10-27
WO2012037499A1 (en) 2012-03-22
SG188570A1 (en) 2013-04-30
TR201909249T4 (tr) 2019-07-22
CN103209694A (zh) 2013-07-17
EP3636263B1 (en) 2021-11-03
PT3050564T (pt) 2019-12-11
CL2013000735A1 (es) 2013-11-29
MX2013003004A (es) 2013-06-28
PL2616068T3 (pl) 2016-11-30
KR101840501B1 (ko) 2018-05-04
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IL225282A0 (en) 2013-06-27
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CA3116249A1 (en) 2012-03-22
EP2616066B1 (en) 2016-07-13
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TWI591058B (zh) 2017-07-11
PT2616068T (pt) 2016-09-13
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US20150148394A1 (en) 2015-05-28
EP2616068A1 (en) 2013-07-24
JP2013540749A (ja) 2013-11-07
CY1122809T1 (el) 2021-05-05
WO2012037484A1 (en) 2012-03-22
EP2616067B1 (en) 2016-05-18
KR101840500B1 (ko) 2018-03-20
EP2616069B1 (en) 2016-11-16
KR20200044147A (ko) 2020-04-28
ES2613509T3 (es) 2017-05-24
IL225278A (en) 2015-11-30
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NZ608751A (en) 2015-04-24
ZA201302193B (en) 2013-11-27
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JP2013541527A (ja) 2013-11-14
ES2781681T3 (es) 2020-09-04
DK3050564T3 (da) 2019-11-25
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TW201240662A (en) 2012-10-16
SI3348264T1 (sl) 2020-07-31
US8501796B2 (en) 2013-08-06
KR20140005154A (ko) 2014-01-14
ZA201302291B (en) 2013-11-27
JP6073229B2 (ja) 2017-02-01
CL2013000736A1 (es) 2013-07-12
MX2013003008A (es) 2013-06-28
AU2011301901A1 (en) 2013-05-02
ZA201302194B (en) 2013-11-27
US20120122945A1 (en) 2012-05-17
PL3050564T3 (pl) 2020-06-01
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CL2013000734A1 (es) 2013-11-08
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EP3078376B1 (en) 2019-03-27
AU2011301856C1 (en) 2016-09-08
EP3053576B1 (en) 2018-05-16
AU2011301901B2 (en) 2016-02-11
CY1122958T1 (el) 2021-10-29
HUE047476T2 (hu) 2020-04-28
AU2011301847A1 (en) 2013-05-02
EP2616067A1 (en) 2013-07-24

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