RU95109153A - Гидрогелевый препарат с длительным высвобождением лекарства - Google Patents
Гидрогелевый препарат с длительным высвобождением лекарстваInfo
- Publication number
- RU95109153A RU95109153A RU95109153/14A RU95109153A RU95109153A RU 95109153 A RU95109153 A RU 95109153A RU 95109153/14 A RU95109153/14 A RU 95109153/14A RU 95109153 A RU95109153 A RU 95109153A RU 95109153 A RU95109153 A RU 95109153A
- Authority
- RU
- Russia
- Prior art keywords
- drug
- hydrogel
- preparation
- additive
- sustained release
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title claims 10
- 239000000499 gel Substances 0.000 title 1
- 239000003814 drug Substances 0.000 claims 20
- 229940079593 drugs Drugs 0.000 claims 19
- 238000002360 preparation method Methods 0.000 claims 12
- 230000000996 additive Effects 0.000 claims 9
- 239000000654 additive Substances 0.000 claims 9
- 229920000642 polymer Polymers 0.000 claims 8
- 230000002459 sustained Effects 0.000 claims 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- 210000001035 Gastrointestinal Tract Anatomy 0.000 claims 3
- 230000035515 penetration Effects 0.000 claims 3
- AIKVCUNQWYTVTO-UHFFFAOYSA-N 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydron;chloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 AIKVCUNQWYTVTO-UHFFFAOYSA-N 0.000 claims 1
- 229960002289 Nicardipine hydrochloride Drugs 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 210000002784 Stomach Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
Claims (8)
1. Гидрогелевый препарат с длительным высвобождением лекарства, содержащий (1) по меньшей мере одно лекарственное средство, (2) добавку, которая обеспечивает проникновение воды в ядро препарата и (3) гидрогельобразующий полимер, отличающийся тем, что вышеуказанный препарат обладает способностью подвергаться практически полной желатинизации, пока он находится в верхней части пищеварительного тракта, включая желудок и тонкий кишечник, и обладает способностью высвобождать лекарство в нижней части пищеварительного тракта, в том числе в толстой кишке.
2. Гидрогелевый препарат с длительным высвобождением лекарства по п. 1, отличающийся тем, что вышеуказанная добавка, обеспечивающая проникновение воды в ядро препарата, представляет собой по меньшей мере одну добавку, имеющую такую растворимость, при которой для растворения одного грамма вышеуказанной добавки требуется объем воды не более 5 мл.
3. Гидрогелевый препарат с длительным высвобождением лекарства по п. 2, отличающийся тем, что вышеуказанная добавка, обеспечивающая проникновение воды в ядро препарата, представляет собой по меньшей мере одну добавку, имеющую такую растворимость, при которой для растворения одного грамма вышеуказанной добавки требуется объем воды не более 4 мл.
4. Гидрогелевый препарат с длительным высвобождением лекарства по п. 1, отличающийся тем, что вышеуказанный гидрогельобразующий полимер представляет собой либо полимер, имеющий средний молекулярный вес не менее 2000000, либо полимер, имеющий вязкость не менее 1000 сПз, которую измеряют при 1%-ной концентрации в воде при 25oС, либо смесь двух или более таких полимеров.
5. Гидрогелевый препарат с длительным высвобождением лекарства по пп. 1 или 4, отличающийся тем, что вышеуказанный гидрогельобразующий полимер включает по меньшей мере один полиэтиленоксид.
6. Гидрогелевый препарат с длительным высвобождением лекарства по любому из п. 1 - 5, который содержит (1) по меньшей мере одно лекарственное средство в количестве не более 85 мас.% из расчета на весь препарат, (2) добавку, которая обеспечивает проникновение воды в ядро препарата в количестве от 5 до 80 мас.% из расчета на весь препарат и (3) гидрогельобразующий полимер в количестве от 10 до 95 мас.% из расчета на препарат.
7. Гидрогелевый препарат с длительным высвобождением лекарства по любому из пп. 1-6, который содержит (1) по меньшей мере одно лекарственное средство в количестве не более 80 мас.% из расчета на весь препарат, (2) добавку, которая обеспечивает проникновение воды в ядро препарата в количестве от 5 до 60 мас.% из расчета на весь препарат и (3) гидрогельобразующий полимер в количестве от N 15 до 90 мас.% из расчета на весь препарат.
8. Гидрогелевый препарат с длительным высвобождением лекарства по любому из пп. 1-7, отличающийся тем, что вышеуказанное лекарство представляет собой хлоргидрат никардипина.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27497992 | 1992-09-18 | ||
JPHEI-4-274979 | 1992-09-18 | ||
JPHEI-5-165263 | 1993-06-08 | ||
JP16526393 | 1993-06-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU95109153A true RU95109153A (ru) | 1997-12-10 |
RU2121830C1 RU2121830C1 (ru) | 1998-11-20 |
Family
ID=26490061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95109153/14A RU2121830C1 (ru) | 1992-09-18 | 1993-09-10 | Гидрогелевый препарат с длительным высвобождением лекарства |
Country Status (23)
Country | Link |
---|---|
US (3) | US6436441B1 (ru) |
EP (1) | EP0661045B1 (ru) |
JP (1) | JP3140465B2 (ru) |
KR (1) | KR100355130B1 (ru) |
CN (1) | CN1048397C (ru) |
AT (1) | ATE219933T1 (ru) |
AU (1) | AU682827B2 (ru) |
BG (1) | BG61861B1 (ru) |
CA (1) | CA2144077C (ru) |
CZ (1) | CZ291495B6 (ru) |
DE (1) | DE69332081T2 (ru) |
DK (1) | DK0661045T3 (ru) |
ES (1) | ES2179829T3 (ru) |
FI (1) | FI115697B (ru) |
HU (1) | HU226456B1 (ru) |
NO (1) | NO312811B1 (ru) |
NZ (1) | NZ255579A (ru) |
PL (1) | PL175026B1 (ru) |
PT (1) | PT661045E (ru) |
RO (1) | RO112991B1 (ru) |
RU (1) | RU2121830C1 (ru) |
SK (1) | SK281042B6 (ru) |
WO (1) | WO1994006414A1 (ru) |
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- 1993-09-10 HU HU9500808A patent/HU226456B1/hu unknown
- 1993-09-10 RU RU95109153/14A patent/RU2121830C1/ru active
- 1993-09-10 AU AU49838/93A patent/AU682827B2/en not_active Expired
- 1993-09-10 SK SK338-95A patent/SK281042B6/sk not_active IP Right Cessation
- 1993-09-10 ES ES93919648T patent/ES2179829T3/es not_active Expired - Lifetime
- 1993-09-10 KR KR1019950701051A patent/KR100355130B1/ko not_active IP Right Cessation
- 1993-09-10 PL PL93308137A patent/PL175026B1/pl unknown
- 1993-09-10 US US08/403,752 patent/US6436441B1/en not_active Expired - Fee Related
- 1993-09-10 DK DK93919648T patent/DK0661045T3/da active
- 1993-09-10 DE DE69332081T patent/DE69332081T2/de not_active Expired - Lifetime
- 1993-09-10 RO RO95-00542A patent/RO112991B1/ro unknown
- 1993-09-10 PT PT93919648T patent/PT661045E/pt unknown
- 1993-09-10 JP JP06507964A patent/JP3140465B2/ja not_active Expired - Lifetime
- 1993-09-10 CA CA002144077A patent/CA2144077C/en not_active Expired - Lifetime
- 1993-09-10 NZ NZ255579A patent/NZ255579A/en not_active IP Right Cessation
- 1993-09-10 WO PCT/JP1993/001297 patent/WO1994006414A1/ja active IP Right Grant
- 1993-09-10 EP EP93919648A patent/EP0661045B1/en not_active Expired - Lifetime
- 1993-09-10 AT AT93919648T patent/ATE219933T1/de active
- 1993-09-18 CN CN93117868A patent/CN1048397C/zh not_active Expired - Lifetime
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1995
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2000
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2002
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