RU2481336C2 - Циклопента(d)пиримидины в качестве ингибиторов протеинкиназ акт - Google Patents

Циклопента(d)пиримидины в качестве ингибиторов протеинкиназ акт Download PDF

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RU2481336C2
RU2481336C2 RU2009103899/04A RU2009103899A RU2481336C2 RU 2481336 C2 RU2481336 C2 RU 2481336C2 RU 2009103899/04 A RU2009103899/04 A RU 2009103899/04A RU 2009103899 A RU2009103899 A RU 2009103899A RU 2481336 C2 RU2481336 C2 RU 2481336C2
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Russia
Prior art keywords
methyl
cyclopenta
dihydro
piperazin
dihydrochloride
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RU2009103899/04A
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Russian (ru)
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RU2009103899A (ru
Inventor
Ян С. МИТЧЕЛ
Джеймс Ф. БЛЭЙК
Руи КСУ
Николас К. КАЛЛАН
Денгминг КСИАО
Кит Ли СПЕНСЕР
Йозеф Р. БЕНКСИК
Дзун ЛИАНГ
Брайан САФИНА
Цзун ЛИ
Кристин ЧАБОТ
Илай М. УОЛЛЕС
Анна Л. БАНКА
Стивен Т. ШЛЕХТЕР
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Эррэй Биофарма Инк.
Дженентек, Инк.
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Application filed by Эррэй Биофарма Инк., Дженентек, Инк. filed Critical Эррэй Биофарма Инк.
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Obesity (AREA)
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RU2009103899/04A 2006-07-06 2007-07-05 Циклопента(d)пиримидины в качестве ингибиторов протеинкиназ акт RU2481336C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81876206P 2006-07-06 2006-07-06
US60/818,762 2006-07-06
PCT/US2007/072876 WO2008006032A1 (en) 2006-07-06 2007-07-05 Cyclopenta [d] pyrimidines as akt protein kinase inhibitors

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RU2009103899A RU2009103899A (ru) 2010-08-20
RU2481336C2 true RU2481336C2 (ru) 2013-05-10

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US (3) US8003651B2 (https=)
EP (1) EP2049500B1 (https=)
JP (3) JP5268904B2 (https=)
KR (2) KR20150041164A (https=)
CN (2) CN101631778B (https=)
AR (1) AR061844A1 (https=)
AT (1) ATE523499T1 (https=)
AU (1) AU2007269052B2 (https=)
BR (1) BRPI0713555A2 (https=)
CA (1) CA2656618C (https=)
CL (1) CL2007001992A1 (https=)
CO (1) CO6160229A2 (https=)
CR (2) CR10601A (https=)
CY (1) CY1112142T1 (https=)
DK (1) DK2049500T3 (https=)
ES (1) ES2372955T3 (https=)
HR (1) HRP20110882T1 (https=)
IL (1) IL196051A (https=)
MA (1) MA30952B1 (https=)
MX (1) MX2008016203A (https=)
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PL (1) PL2049500T3 (https=)
PT (1) PT2049500E (https=)
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RU (1) RU2481336C2 (https=)
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TW (1) TWI428335B (https=)
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WO (1) WO2008006032A1 (https=)

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US20080058327A1 (en) 2008-03-06
BRPI0713555A2 (pt) 2012-03-20
CA2656618A1 (en) 2008-01-10
TWI428335B (zh) 2014-03-01
US20140349996A1 (en) 2014-11-27
UA99597C2 (ru) 2012-09-10
US8846681B2 (en) 2014-09-30
CA2656618C (en) 2014-08-26
CY1112142T1 (el) 2015-11-04
US8003651B2 (en) 2011-08-23
AU2007269052A1 (en) 2008-01-10
EP2049500B1 (en) 2011-09-07
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CL2007001992A1 (es) 2008-07-18
JP2009542721A (ja) 2009-12-03
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AU2007269052B2 (en) 2014-10-23
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ATE523499T1 (de) 2011-09-15
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MA30952B1 (fr) 2009-12-01
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