JP2009542721A5 - - Google Patents
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- Publication number
- JP2009542721A5 JP2009542721A5 JP2009518634A JP2009518634A JP2009542721A5 JP 2009542721 A5 JP2009542721 A5 JP 2009542721A5 JP 2009518634 A JP2009518634 A JP 2009518634A JP 2009518634 A JP2009518634 A JP 2009518634A JP 2009542721 A5 JP2009542721 A5 JP 2009542721A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- cyclopenta
- dihydro
- piperazin
- dihydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(CCN)(C(*)=O)c(cc1)ccc1Cl Chemical compound CC(CCN)(C(*)=O)c(cc1)ccc1Cl 0.000 description 6
- CHIKWHCJOJMBFW-UHFFFAOYSA-N CC(C(CCN)c(cc1)ccc1Br)=O Chemical compound CC(C(CCN)c(cc1)ccc1Br)=O CHIKWHCJOJMBFW-UHFFFAOYSA-N 0.000 description 1
- FVNZUMZSHCJXOG-UHFFFAOYSA-N CC(C(Cc(cc1)ccc1Cl)C1(CC1)N)=O Chemical compound CC(C(Cc(cc1)ccc1Cl)C1(CC1)N)=O FVNZUMZSHCJXOG-UHFFFAOYSA-N 0.000 description 1
- CQSISKSBGLSTRW-UHFFFAOYSA-N CC(C(Cc(cc1F)ccc1Cl)CN)=O Chemical compound CC(C(Cc(cc1F)ccc1Cl)CN)=O CQSISKSBGLSTRW-UHFFFAOYSA-N 0.000 description 1
- STHHIRBHSKKCFW-UHFFFAOYSA-N CC(C)(CC(C(C)=O)c(cc1)cc(F)c1Cl)N Chemical compound CC(C)(CC(C(C)=O)c(cc1)cc(F)c1Cl)N STHHIRBHSKKCFW-UHFFFAOYSA-N 0.000 description 1
- SUZFULZBSCLXSF-MRVPVSSYSA-N CC(C)(C[C@@H](C(N)=O)c(cc1)cc(F)c1Cl)N Chemical compound CC(C)(C[C@@H](C(N)=O)c(cc1)cc(F)c1Cl)N SUZFULZBSCLXSF-MRVPVSSYSA-N 0.000 description 1
- FGTBJDQJHUFZSB-UHFFFAOYSA-N CC(C1(CCNCC1)c(cc1)cc(F)c1Cl)=O Chemical compound CC(C1(CCNCC1)c(cc1)cc(F)c1Cl)=O FGTBJDQJHUFZSB-UHFFFAOYSA-N 0.000 description 1
- MFWXQOFWCJRMFG-RXMQYKEDSA-N N[C@H](Cc([s]1)ccc1Br)C(N)=O Chemical compound N[C@H](Cc([s]1)ccc1Br)C(N)=O MFWXQOFWCJRMFG-RXMQYKEDSA-N 0.000 description 1
- RUYQMPPZHNOIDP-ZCFIWIBFSA-N N[C@H](Cc1ccc[s]1)[I]=O Chemical compound N[C@H](Cc1ccc[s]1)[I]=O RUYQMPPZHNOIDP-ZCFIWIBFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81876206P | 2006-07-06 | 2006-07-06 | |
| US60/818,762 | 2006-07-06 | ||
| PCT/US2007/072876 WO2008006032A1 (en) | 2006-07-06 | 2007-07-05 | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013097595A Division JP5586735B2 (ja) | 2006-07-06 | 2013-05-07 | Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542721A JP2009542721A (ja) | 2009-12-03 |
| JP2009542721A5 true JP2009542721A5 (https=) | 2010-08-19 |
| JP5268904B2 JP5268904B2 (ja) | 2013-08-21 |
Family
ID=38686844
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009518634A Expired - Fee Related JP5268904B2 (ja) | 2006-07-06 | 2007-07-05 | Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン |
| JP2013097595A Expired - Fee Related JP5586735B2 (ja) | 2006-07-06 | 2013-05-07 | Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン |
| JP2013118690A Withdrawn JP2013231040A (ja) | 2006-07-06 | 2013-06-05 | Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013097595A Expired - Fee Related JP5586735B2 (ja) | 2006-07-06 | 2013-05-07 | Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン |
| JP2013118690A Withdrawn JP2013231040A (ja) | 2006-07-06 | 2013-06-05 | Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US8003651B2 (https=) |
| EP (1) | EP2049500B1 (https=) |
| JP (3) | JP5268904B2 (https=) |
| KR (2) | KR20150041164A (https=) |
| CN (2) | CN101631778B (https=) |
| AR (1) | AR061844A1 (https=) |
| AT (1) | ATE523499T1 (https=) |
| AU (1) | AU2007269052B2 (https=) |
| BR (1) | BRPI0713555A2 (https=) |
| CA (1) | CA2656618C (https=) |
| CL (1) | CL2007001992A1 (https=) |
| CO (1) | CO6160229A2 (https=) |
| CR (2) | CR10601A (https=) |
| CY (1) | CY1112142T1 (https=) |
| DK (1) | DK2049500T3 (https=) |
| ES (1) | ES2372955T3 (https=) |
| HR (1) | HRP20110882T1 (https=) |
| IL (1) | IL196051A (https=) |
| MA (1) | MA30952B1 (https=) |
| MX (1) | MX2008016203A (https=) |
| MY (1) | MY147628A (https=) |
| NO (1) | NO20090580L (https=) |
| NZ (1) | NZ573979A (https=) |
| PL (1) | PL2049500T3 (https=) |
| PT (1) | PT2049500E (https=) |
| RS (1) | RS52210B (https=) |
| RU (1) | RU2481336C2 (https=) |
| SI (1) | SI2049500T1 (https=) |
| TW (1) | TWI428335B (https=) |
| UA (1) | UA99597C2 (https=) |
| WO (1) | WO2008006032A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE532789T1 (de) * | 2006-07-06 | 2011-11-15 | Array Biopharma Inc | Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren |
| US8329701B2 (en) | 2006-07-06 | 2012-12-11 | Array Biopharma Inc. | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
| UA95641C2 (xx) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| EP2049500B1 (en) | 2006-07-06 | 2011-09-07 | Array Biopharma, Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| AU2014201211B2 (en) * | 2006-07-06 | 2016-04-14 | Array Biopharma Inc. | Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| CN101918373B (zh) | 2007-07-05 | 2013-06-05 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
| CN103396409B (zh) | 2007-07-05 | 2015-03-11 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| US8841304B2 (en) | 2008-01-08 | 2014-09-23 | Array Biopharma, Inc. | Pyrrolopyridines as kinase inhibitors |
| CA2711782C (en) | 2008-01-09 | 2017-01-03 | Array Biopharma Inc. | 5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors |
| US8853216B2 (en) * | 2008-01-09 | 2014-10-07 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
| CN102015708B (zh) * | 2008-01-09 | 2014-03-26 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
| CN101965347B (zh) | 2008-01-09 | 2013-01-02 | 阵列生物制药公司 | 作为激酶抑制剂的吡唑并吡啶 |
| NZ586346A (en) * | 2008-01-09 | 2012-02-24 | Array Biopharma Inc | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2010091306A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| US20100233733A1 (en) * | 2009-02-10 | 2010-09-16 | Nodality, Inc., A Delaware Corporation | Multiple mechanisms for modulation of the pi3 kinase pathway |
| MX2012011887A (es) * | 2010-04-16 | 2012-11-30 | Genentech Inc | Foxo 3a como biomarcador predictivo para la eficacia del inhibidor de la via de quinasa pi3k/akt. |
| TR201815685T4 (tr) | 2011-04-01 | 2018-11-21 | Genentech Inc | Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları. |
| KR102021157B1 (ko) | 2011-04-01 | 2019-09-11 | 제넨테크, 인크. | Ａｋｔ 억제제 화합물 및 아비라테론의 조합물, 및 사용 방법 |
| ME03455B (me) | 2012-09-10 | 2020-01-20 | Principia Biopharma Inc | Jedinjenja pirazolopirimidina kao inhibitori kinaze |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| CN105764501A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群治疗效益的组合物 |
| CA2920317A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| ES2765511T3 (es) | 2013-11-15 | 2020-06-09 | Hoffmann La Roche | Procesos para la preparación de compuestos de pirimidinilciclopentano |
| PT3107544T (pt) | 2014-02-21 | 2021-01-05 | Principia Biopharma Inc | Sais e forma sólida de um inibidor de btk |
| SG11201701402QA (en) * | 2014-08-27 | 2017-03-30 | Peptimed Inc | Anti-tumor compositions and methods |
| US10485797B2 (en) | 2014-12-18 | 2019-11-26 | Principia Biopharma Inc. | Treatment of pemphigus |
| TW201718572A (zh) | 2015-06-24 | 2017-06-01 | 普林斯匹亞生物製藥公司 | 酪胺酸激酶抑制劑 |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| MA45547A (fr) | 2016-06-29 | 2019-05-08 | Principia Biopharma Inc | Formulations à libération modifiée à base de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl)pipérazine-1-yl]pent-2-ènenitrile |
| EP3532464A4 (en) | 2016-10-28 | 2020-07-08 | Icahn School of Medicine at Mount Sinai | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EZH2 MEDIATION CANCER |
| US11766455B2 (en) | 2017-12-14 | 2023-09-26 | Ezy Biotech Llc | Subject-specific tumor inhibiting cells and the use thereof |
| US12274703B2 (en) | 2017-12-21 | 2025-04-15 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
| US12310967B2 (en) | 2017-12-21 | 2025-05-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
| CA3092677A1 (en) * | 2018-03-06 | 2019-09-12 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (akt) degradation / disruption compounds and methods of use |
| TWI830733B (zh) * | 2018-05-11 | 2024-02-01 | 中國大陸商迪哲（江蘇）醫藥有限公司 | 環戊烷化合物 |
| IT201800005561A1 (it) * | 2018-05-21 | 2019-11-21 | Metodo per la pulizia dei denti mediante una composizione in polvere a base di idrossiapatite. | |
| CA3104298A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use |
| WO2020132378A2 (en) | 2018-12-22 | 2020-06-25 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising depression |
| PL3919491T3 (pl) | 2019-01-29 | 2025-10-20 | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. | Inhibitor akt |
| CN118908962A (zh) | 2019-05-06 | 2024-11-08 | 西奈山伊坎医学院 | 作为hpk1的降解剂的异双功能化合物 |
| TWI877239B (zh) | 2019-10-14 | 2025-03-21 | 美商普林斯匹亞生物製藥公司 | 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法 |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| JP2023511105A (ja) | 2020-01-22 | 2023-03-16 | プリンシピア バイオファーマ インコーポレイテッド | ２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）－１ｈ－ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペンタ－２－エンニトリルの結晶形態 |
| CN115485276B (zh) * | 2020-05-15 | 2024-05-31 | 南京正大天晴制药有限公司 | 氘代akt激酶抑制剂 |
| US12103924B2 (en) | 2020-06-01 | 2024-10-01 | Icahn School Of Medicine At Mount Sinai | Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use |
| CN119302960A (zh) * | 2020-07-22 | 2025-01-14 | 南京正大天晴制药有限公司 | Akt抑制剂的单位剂量组合物 |
| CN115836069B (zh) | 2020-07-22 | 2024-02-06 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐、其制备方法及用途 |
| CN117677614A (zh) * | 2021-12-17 | 2024-03-08 | 中国医药研究开发中心有限公司 | 具有akt激酶抑制活性的杂环化合物及其制备方法和医药用途 |
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