RU2214233C2 - Препараты ранолазина с пролонгированным действием - Google Patents

Препараты ранолазина с пролонгированным действием Download PDF

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Publication number
RU2214233C2
RU2214233C2 RU2001109431/14A RU2001109431A RU2214233C2 RU 2214233 C2 RU2214233 C2 RU 2214233C2 RU 2001109431/14 A RU2001109431/14 A RU 2001109431/14A RU 2001109431 A RU2001109431 A RU 2001109431A RU 2214233 C2 RU2214233 C2 RU 2214233C2
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Russia
Prior art keywords
ranolazine
dosage form
pharmaceutical dosage
form according
methacrylic acid
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RU2001109431/14A
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English (en)
Russian (ru)
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RU2001109431A (ru
Inventor
Эндрю А. ВОЛЬФФ
Фиона БЭЙКЕР
Джон ЛЭНГРИДЖ
Original Assignee
Си Ви Терапьютикс, Инк.
Синтекс (Ю.Эс.Эй), Ллс.
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Application filed by Си Ви Терапьютикс, Инк., Синтекс (Ю.Эс.Эй), Ллс. filed Critical Си Ви Терапьютикс, Инк.
Publication of RU2001109431A publication Critical patent/RU2001109431A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
RU2001109431/14A 1998-09-10 1999-09-09 Препараты ранолазина с пролонгированным действием RU2214233C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9980498P 1998-09-10 1998-09-10
US60/099,804 1998-09-10
US09/321,522 US6303607B1 (en) 1998-09-10 1999-05-27 Method for administering a sustained release ranolanolazine formulation
US09/321,522 1999-05-27

Publications (2)

Publication Number Publication Date
RU2001109431A RU2001109431A (ru) 2003-05-20
RU2214233C2 true RU2214233C2 (ru) 2003-10-20

Family

ID=26796494

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2001109431/14A RU2214233C2 (ru) 1998-09-10 1999-09-09 Препараты ранолазина с пролонгированным действием
RU2001109432/14A RU2207856C2 (ru) 1998-09-10 1999-09-09 Способ лечения сердечно-сосудистых заболеваний

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2001109432/14A RU2207856C2 (ru) 1998-09-10 1999-09-09 Способ лечения сердечно-сосудистых заболеваний

Country Status (33)

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US (14) US6303607B1 (enExample)
EP (3) EP1096937B9 (enExample)
JP (2) JP3745621B2 (enExample)
KR (1) KR100475759B1 (enExample)
CN (2) CN1211086C (enExample)
AR (3) AR022085A1 (enExample)
AT (2) ATE285774T1 (enExample)
AU (4) AU760435B2 (enExample)
BR (2) BR9913553A (enExample)
CA (2) CA2342390C (enExample)
CY (1) CY2008020I2 (enExample)
CZ (2) CZ301341B6 (enExample)
DE (3) DE122008000065I1 (enExample)
DK (2) DK1109558T3 (enExample)
ES (2) ES2177346T3 (enExample)
FR (1) FR09C0001I2 (enExample)
GE (1) GEP20053420B (enExample)
HK (1) HK1044284B (enExample)
HU (2) HU224215B1 (enExample)
IL (6) IL141892A0 (enExample)
LU (1) LU91504I2 (enExample)
MX (2) MXPA01002598A (enExample)
NL (1) NL300371I2 (enExample)
NO (4) NO320986B1 (enExample)
NZ (2) NZ510384A (enExample)
PL (3) PL196668B1 (enExample)
PT (2) PT1096937E (enExample)
RU (2) RU2214233C2 (enExample)
SI (2) SI1096937T1 (enExample)
TR (2) TR200101261T2 (enExample)
TW (1) TWI241911B (enExample)
UA (2) UA75027C2 (enExample)
WO (2) WO2000013687A2 (enExample)

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CN1227004C (zh) 2000-02-18 2005-11-16 Cv治疗公司 治疗充血性心力衰竭的部分脂肪酸氧化抑制剂
AU2001277938A1 (en) * 2000-07-21 2002-02-05 Cv Therapeutics, Inc. Method for treating angina
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AU2008207703A1 (en) 2008-09-25
DE122008000065I1 (de) 2009-04-09
EP1109558A2 (en) 2001-06-27
TR200101261T2 (tr) 2002-05-21
FR09C0001I1 (enExample) 2009-02-27
UA75027C2 (uk) 2006-03-15
IL175371A0 (en) 2006-09-05
DK1109558T3 (da) 2002-08-26
AR052921A1 (es) 2007-04-11
IL180864A0 (en) 2007-07-04
US20060147521A1 (en) 2006-07-06
WO2000013687A2 (en) 2000-03-16
LU91504I2 (fr) 2009-02-03
MXPA01002598A (es) 2002-04-08
GEP20053420B (en) 2005-01-25
HK1044284A1 (en) 2002-10-18
US20030166659A1 (en) 2003-09-04
AU6036499A (en) 2000-03-27
JP3745621B2 (ja) 2006-02-15
NO319434B1 (no) 2005-08-15
PT1096937E (pt) 2005-04-29
NO20011192L (no) 2001-04-30
SI1109558T1 (en) 2002-10-31
NZ510384A (en) 2002-10-25
US6864258B2 (en) 2005-03-08
US20060217397A1 (en) 2006-09-28
PT1109558E (pt) 2002-10-31
BR9913553A (pt) 2001-10-23
TR200101262T2 (tr) 2001-12-21
NZ510386A (en) 2003-08-29
CA2343376A1 (en) 2000-03-16
CZ2001880A3 (cs) 2001-08-15
US20020090396A1 (en) 2002-07-11
US6503911B2 (en) 2003-01-07
IL141892A0 (en) 2002-03-10
ATE285774T1 (de) 2005-01-15
PL348249A1 (en) 2002-05-20
US20050153982A1 (en) 2005-07-14
WO2000013687A3 (en) 2000-06-29
HUP0103844A2 (hu) 2002-04-29
NO20011191L (no) 2001-04-30
AU6142599A (en) 2000-03-27
KR20010089874A (ko) 2001-10-12
CA2342390A1 (en) 2000-03-16
US6562826B1 (en) 2003-05-13
DE69901570T2 (de) 2003-01-09
EP1096937A2 (en) 2001-05-09
US6852724B2 (en) 2005-02-08
ATE217794T1 (de) 2002-06-15
IL141893A (en) 2008-08-07
PL196263B1 (pl) 2007-12-31
AR022085A1 (es) 2002-09-04
RU2207856C2 (ru) 2003-07-10
NO320986B1 (no) 2006-02-20
CA2342390C (en) 2006-08-29
NO2009005I1 (no) 2009-03-16
DE69901570D1 (de) 2002-06-27
CA2343376C (en) 2007-01-09
US6620814B2 (en) 2003-09-16
US6303607B1 (en) 2001-10-16
UA67793C2 (uk) 2004-07-15
AR053440A2 (es) 2007-05-09
US6525057B2 (en) 2003-02-25
JP2006096757A (ja) 2006-04-13
NO20011191D0 (no) 2001-03-08
US20030100566A1 (en) 2003-05-29
US6617328B2 (en) 2003-09-09
EP1096937B1 (en) 2004-12-29
NL300371I2 (nl) 2009-10-01
US20030099705A1 (en) 2003-05-29
DE69922964T2 (de) 2005-12-08
DK1096937T3 (da) 2005-05-09
ES2234302T3 (es) 2005-06-16
ES2177346T3 (es) 2002-12-01
SI1096937T1 (en) 2005-04-30
US20020004506A1 (en) 2002-01-10
AU744071B2 (en) 2002-02-14
PL202207B1 (pl) 2009-06-30
PL347073A1 (en) 2002-03-11
WO2000013686A2 (en) 2000-03-16
TWI241911B (en) 2005-10-21
CN1193757C (zh) 2005-03-23
HU224215B1 (hu) 2005-06-28
IL141893A0 (en) 2002-03-10
CZ301375B6 (cs) 2010-02-03
US6369062B1 (en) 2002-04-09
NO20054324L (no) 2001-04-30
EP1109558B1 (en) 2002-05-22
HK1040060A1 (en) 2002-05-24
CN1321088A (zh) 2001-11-07
US20050059667A1 (en) 2005-03-17
FR09C0001I2 (enExample) 2009-12-18
DE69922964D1 (de) 2005-02-03
CZ2001879A3 (cs) 2001-08-15
CY2008020I1 (el) 2010-07-28
HUP0103844A3 (en) 2002-11-28
BR9913626A (pt) 2001-12-04
MXPA01002599A (es) 2005-02-17
PL196668B1 (pl) 2008-01-31
CN1354665A (zh) 2002-06-19
KR100475759B1 (ko) 2005-03-10
JP2002524416A (ja) 2002-08-06
HK1044284B (zh) 2005-07-15
CZ301341B6 (cs) 2010-01-20
NO20011192D0 (no) 2001-03-08
NO2009005I2 (enExample) 2010-06-28
CY2008020I2 (el) 2010-07-28
EP1096937B9 (en) 2007-02-28
AU760435B2 (en) 2003-05-15
WO2000013686A3 (en) 2000-07-06
AU2008207707A1 (en) 2008-09-25
US20040097514A1 (en) 2004-05-20
CN1211086C (zh) 2005-07-20
HUP0104088A2 (hu) 2002-05-29
HUP0104088A3 (en) 2002-12-28
LU91504I9 (enExample) 2019-01-02
IL141892A (en) 2006-08-20
EP1527779A1 (en) 2005-05-04
US20040029890A1 (en) 2004-02-12
NL300371I1 (nl) 2009-02-02

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