RU2170730C2 - Хинолиновые карбоксамиды и фармацевтическая композиция на их основе - Google Patents
Хинолиновые карбоксамиды и фармацевтическая композиция на их основе Download PDFInfo
- Publication number
- RU2170730C2 RU2170730C2 RU98123074/04A RU98123074A RU2170730C2 RU 2170730 C2 RU2170730 C2 RU 2170730C2 RU 98123074/04 A RU98123074/04 A RU 98123074/04A RU 98123074 A RU98123074 A RU 98123074A RU 2170730 C2 RU2170730 C2 RU 2170730C2
- Authority
- RU
- Russia
- Prior art keywords
- carboxamide
- methoxyquinolin
- dichloropyridin
- compound
- optionally substituted
- Prior art date
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- YNRMQTUOOLBRHW-UHFFFAOYSA-N methyl 8-methoxyquinoline-2-carboxylate Chemical compound C1=CC=C(OC)C2=NC(C(=O)OC)=CC=C21 YNRMQTUOOLBRHW-UHFFFAOYSA-N 0.000 description 1
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- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- VMPITZXILSNTON-UHFFFAOYSA-N o-anisidine Chemical compound COC1=CC=CC=C1N VMPITZXILSNTON-UHFFFAOYSA-N 0.000 description 1
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- 229960001802 phenylephrine Drugs 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
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- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- PAHJPOGEIAZYEN-UHFFFAOYSA-N quinoline-2-carbonyl chloride;hydrochloride Chemical compound Cl.C1=CC=CC2=NC(C(=O)Cl)=CC=C21 PAHJPOGEIAZYEN-UHFFFAOYSA-N 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
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- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
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- 239000001593 sorbitan monooleate Substances 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 239000002278 tabletting lubricant Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- QMMDEILIWGCAJY-UHFFFAOYSA-N tert-butyl n-(5-bromo-8-methoxyquinolin-2-yl)-n-methylcarbamate Chemical compound C1=C(N(C)C(=O)OC(C)(C)C)N=C2C(OC)=CC=C(Br)C2=C1 QMMDEILIWGCAJY-UHFFFAOYSA-N 0.000 description 1
- QNAUHGLBSZTACN-UHFFFAOYSA-N tert-butyl-dimethyl-(2-methylquinolin-8-yl)oxysilane Chemical compound C1=CC=C(O[Si](C)(C)C(C)(C)C)C2=NC(C)=CC=C21 QNAUHGLBSZTACN-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 239000000196 tragacanth Substances 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9610506.9A GB9610506D0 (en) | 1996-05-20 | 1996-05-20 | Novel compounds |
| GB9610506.9 | 1996-05-20 | ||
| GB9623234.3 | 1996-11-07 | ||
| GBGB9623234.3A GB9623234D0 (en) | 1996-11-07 | 1996-11-07 | Novel compounds |
| GB9626883.4 | 1996-12-24 | ||
| GBGB9626883.4A GB9626883D0 (en) | 1996-12-24 | 1996-12-24 | Compounds |
| GB9708072.5 | 1997-04-22 | ||
| GBGB9708072.5A GB9708072D0 (en) | 1997-04-22 | 1997-04-22 | Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98123074A RU98123074A (ru) | 2000-10-10 |
| RU2170730C2 true RU2170730C2 (ru) | 2001-07-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98123074/04A RU2170730C2 (ru) | 1996-05-20 | 1997-05-20 | Хинолиновые карбоксамиды и фармацевтическая композиция на их основе |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5804588A (OSRAM) |
| EP (1) | EP0952832B1 (OSRAM) |
| JP (1) | JP2000510865A (OSRAM) |
| KR (1) | KR20000065219A (OSRAM) |
| CN (1) | CN1148189C (OSRAM) |
| AT (1) | ATE406163T1 (OSRAM) |
| AU (1) | AU722472B2 (OSRAM) |
| BR (1) | BR9709015A (OSRAM) |
| CA (1) | CA2252531A1 (OSRAM) |
| CZ (1) | CZ296163B6 (OSRAM) |
| DE (1) | DE69738949D1 (OSRAM) |
| IL (1) | IL126557A (OSRAM) |
| NO (1) | NO312099B1 (OSRAM) |
| NZ (1) | NZ332341A (OSRAM) |
| PL (1) | PL329922A1 (OSRAM) |
| RU (1) | RU2170730C2 (OSRAM) |
| SK (1) | SK283162B6 (OSRAM) |
| TR (1) | TR199802385T2 (OSRAM) |
| WO (1) | WO1997044036A1 (OSRAM) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2332405C2 (ru) * | 2003-02-28 | 2008-08-27 | Новартис Аг | Способ получения соли 5-[(r)-2-(5, 6-диэтилиндан-2-иламино)-1-гидроксиэтил]-8-гидрокси-(1н)-хинолин-2-она, полезной в качестве адренорецепторного агониста |
| RU2339621C2 (ru) * | 2003-04-02 | 2008-11-27 | Новартис Аг | Способ получения 5-(альфа-галогенацетил)-8-(замещенный окси)-(1н)-хинолин-2-онов |
| RU2348618C2 (ru) * | 2002-07-16 | 2009-03-10 | Прана Биотехнолоджи Лимитэд | Производные 8-гидроксихинолина |
| RU2383534C2 (ru) * | 2004-06-22 | 2010-03-10 | Новартис Аг | Энантиоселективный способ получения производных хинолина |
| RU2391338C2 (ru) * | 2004-10-19 | 2010-06-10 | Ф.Хоффманн-Ля Рош Аг | Производные хинолина |
| RU2411043C2 (ru) * | 2004-04-01 | 2011-02-10 | Юниверсите Де Льеж | Фармацевтические композиции пиримидин-2,4,6-трионов |
| RU2495029C2 (ru) * | 2007-02-09 | 2013-10-10 | Альмираль, С.А. | ГЕМИНАПАДИЗИЛАТ 5-(2-{[6-(2,2-ДИФТОР-2-ФЕНИЛЭТОКСИ)ГЕКСИЛ]АМИНО}-1-ГИДРОКСИЭТИЛ)-8-ГИДРОКСИХИНОЛИН-2(1H)-ОНА КАК АГОНИСТ β2 АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА |
| RU2624906C2 (ru) * | 2015-12-22 | 2017-07-10 | федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Производные 2-хинальдинкарбоновой кислоты и их противогриппозная активность |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69633196D1 (de) * | 1995-10-16 | 2004-09-23 | Fujisawa Pharmaceutical Co | Heterocyclische verbindungen als h+-atpasen |
| GB9712761D0 (en) * | 1997-06-17 | 1997-08-20 | Chiroscience Ltd | Quinolines and their therapeutic use |
| GB9824160D0 (en) * | 1998-11-04 | 1998-12-30 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| US6262070B1 (en) | 1998-11-04 | 2001-07-17 | Darwin Discovery Ltd. | Heterocyclic compounds and their therapeutic use |
| HRP20020158B1 (en) * | 1999-08-21 | 2007-08-31 | Altana Pharma Ag | Action of synergistic combination |
| AU1053501A (en) * | 1999-11-02 | 2001-05-14 | Ajinomoto Co., Inc. | Polyazanaphthalene compound and medicinal use thereof |
| JP4603646B2 (ja) * | 1999-11-15 | 2010-12-22 | 富士フイルムファインケミカルズ株式会社 | 新規なジピリジル誘導体 |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| GB0003256D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| US6521618B2 (en) | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
| DE10035928A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
| AU2001277731A1 (en) * | 2000-08-09 | 2002-02-18 | Welfide Corporation | Fused bicyclic amide compounds and medicinal use thereof |
| US6953774B2 (en) | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
| JP2002300373A (ja) * | 2001-03-30 | 2002-10-11 | Minolta Co Ltd | 画像処理方法、画像処理装置、記録媒体及びプログラム |
| CA2447618A1 (en) * | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | A composition for regenerative treatment of cartilage disease |
| WO2002094321A1 (en) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | Compositions for promoting healing of bone fracture |
| EP1409481B1 (en) | 2001-07-16 | 2006-10-04 | Astrazeneca AB | Quinoline derivatives and their use as tyrosine kinase inhibitors |
| EP1417204B1 (en) * | 2001-08-15 | 2006-01-18 | E. I. du Pont de Nemours and Company | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
| JP4532115B2 (ja) | 2001-12-14 | 2010-08-25 | メルク セローノ ソシエテ アノニム | 非ポリペプチドｃＡＭＰレベル調節剤を使用する排卵誘発方法 |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
| ES2195785B1 (es) * | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
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- 1997-05-20 CN CNB97194735XA patent/CN1148189C/zh not_active Expired - Fee Related
- 1997-05-20 TR TR1998/02385T patent/TR199802385T2/xx unknown
- 1997-05-20 DE DE69738949T patent/DE69738949D1/de not_active Expired - Fee Related
- 1997-05-20 JP JP09541788A patent/JP2000510865A/ja active Pending
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- 1997-05-20 CZ CZ0365198A patent/CZ296163B6/cs not_active IP Right Cessation
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- 1997-05-20 BR BR9709015A patent/BR9709015A/pt not_active IP Right Cessation
- 1997-05-20 AT AT97923191T patent/ATE406163T1/de not_active IP Right Cessation
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- 1997-05-20 SK SK1605-98A patent/SK283162B6/sk unknown
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- 1997-05-20 RU RU98123074/04A patent/RU2170730C2/ru not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2348618C2 (ru) * | 2002-07-16 | 2009-03-10 | Прана Биотехнолоджи Лимитэд | Производные 8-гидроксихинолина |
| US7619091B2 (en) | 2002-07-16 | 2009-11-17 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
| US8975278B2 (en) | 2002-07-16 | 2015-03-10 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
| US9169211B2 (en) | 2002-07-16 | 2015-10-27 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
| US9302993B2 (en) | 2002-07-16 | 2016-04-05 | Prana Biotechnology Limited | 8-hydroxy quinoline derivatives |
| RU2332405C2 (ru) * | 2003-02-28 | 2008-08-27 | Новартис Аг | Способ получения соли 5-[(r)-2-(5, 6-диэтилиндан-2-иламино)-1-гидроксиэтил]-8-гидрокси-(1н)-хинолин-2-она, полезной в качестве адренорецепторного агониста |
| RU2339621C2 (ru) * | 2003-04-02 | 2008-11-27 | Новартис Аг | Способ получения 5-(альфа-галогенацетил)-8-(замещенный окси)-(1н)-хинолин-2-онов |
| RU2411043C2 (ru) * | 2004-04-01 | 2011-02-10 | Юниверсите Де Льеж | Фармацевтические композиции пиримидин-2,4,6-трионов |
| RU2383534C2 (ru) * | 2004-06-22 | 2010-03-10 | Новартис Аг | Энантиоселективный способ получения производных хинолина |
| RU2391338C2 (ru) * | 2004-10-19 | 2010-06-10 | Ф.Хоффманн-Ля Рош Аг | Производные хинолина |
| RU2495029C2 (ru) * | 2007-02-09 | 2013-10-10 | Альмираль, С.А. | ГЕМИНАПАДИЗИЛАТ 5-(2-{[6-(2,2-ДИФТОР-2-ФЕНИЛЭТОКСИ)ГЕКСИЛ]АМИНО}-1-ГИДРОКСИЭТИЛ)-8-ГИДРОКСИХИНОЛИН-2(1H)-ОНА КАК АГОНИСТ β2 АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА |
| RU2624906C2 (ru) * | 2015-12-22 | 2017-07-10 | федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Производные 2-хинальдинкарбоновой кислоты и их противогриппозная активность |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997044036A1 (en) | 1997-11-27 |
| NO985376D0 (no) | 1998-11-19 |
| CN1219131A (zh) | 1999-06-09 |
| CA2252531A1 (en) | 1997-11-27 |
| NO312099B1 (no) | 2002-03-18 |
| PL329922A1 (en) | 1999-04-26 |
| CZ296163B6 (cs) | 2006-01-11 |
| BR9709015A (pt) | 1999-08-03 |
| IL126557A0 (en) | 1999-08-17 |
| KR20000065219A (ko) | 2000-11-06 |
| NO985376L (no) | 1998-11-19 |
| AU722472B2 (en) | 2000-08-03 |
| EP0952832B1 (en) | 2008-08-27 |
| JP2000510865A (ja) | 2000-08-22 |
| EP0952832A1 (en) | 1999-11-03 |
| IL126557A (en) | 2002-09-12 |
| NZ332341A (en) | 2000-05-26 |
| US5804588A (en) | 1998-09-08 |
| CN1148189C (zh) | 2004-05-05 |
| TR199802385T2 (xx) | 1999-04-21 |
| DE69738949D1 (de) | 2008-10-09 |
| AU2905897A (en) | 1997-12-09 |
| SK283162B6 (sk) | 2003-03-04 |
| SK160598A3 (en) | 1999-12-10 |
| ATE406163T1 (de) | 2008-09-15 |
| CZ365198A3 (cs) | 1999-03-17 |
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