NO985376L - Kinolinkarboksamider som TNF-inhibitorer og som PDA-IV inhibitorer - Google Patents

Kinolinkarboksamider som TNF-inhibitorer og som PDA-IV inhibitorer

Info

Publication number
NO985376L
NO985376L NO985376A NO985376A NO985376L NO 985376 L NO985376 L NO 985376L NO 985376 A NO985376 A NO 985376A NO 985376 A NO985376 A NO 985376A NO 985376 L NO985376 L NO 985376L
Authority
NO
Norway
Prior art keywords
inhibitors
pda
subject invention
compounds
tnf
Prior art date
Application number
NO985376A
Other languages
English (en)
Other versions
NO985376D0 (no
NO312099B1 (no
Inventor
Hazel Joan Dyke
John Gary Montana
Christopher Lowe
Hannah Jayne Kendall
Verity Margaret Sabin
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9610506.9A external-priority patent/GB9610506D0/en
Priority claimed from GBGB9623234.3A external-priority patent/GB9623234D0/en
Priority claimed from GBGB9626883.4A external-priority patent/GB9626883D0/en
Priority claimed from GBGB9708072.5A external-priority patent/GB9708072D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of NO985376D0 publication Critical patent/NO985376D0/no
Publication of NO985376L publication Critical patent/NO985376L/no
Publication of NO312099B1 publication Critical patent/NO312099B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
NO19985376A 1996-05-20 1998-11-19 Kinolinkarboksamider som er TNF-inhibitorer og PDA-IV inhibitorer, anvendelse av dem og farmasöytiske preparaterinneholdende dem NO312099B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9610506.9A GB9610506D0 (en) 1996-05-20 1996-05-20 Novel compounds
GBGB9623234.3A GB9623234D0 (en) 1996-11-07 1996-11-07 Novel compounds
GBGB9626883.4A GB9626883D0 (en) 1996-12-24 1996-12-24 Compounds
GBGB9708072.5A GB9708072D0 (en) 1997-04-22 1997-04-22 Compounds
PCT/GB1997/001359 WO1997044036A1 (en) 1996-05-20 1997-05-20 Quinoline carboxamides as tnf inhibitors and as pde-iv inhibitors

Publications (3)

Publication Number Publication Date
NO985376D0 NO985376D0 (no) 1998-11-19
NO985376L true NO985376L (no) 1998-11-19
NO312099B1 NO312099B1 (no) 2002-03-18

Family

ID=27451451

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19985376A NO312099B1 (no) 1996-05-20 1998-11-19 Kinolinkarboksamider som er TNF-inhibitorer og PDA-IV inhibitorer, anvendelse av dem og farmasöytiske preparaterinneholdende dem

Country Status (19)

Country Link
US (1) US5804588A (no)
EP (1) EP0952832B1 (no)
JP (1) JP2000510865A (no)
KR (1) KR20000065219A (no)
CN (1) CN1148189C (no)
AT (1) ATE406163T1 (no)
AU (1) AU722472B2 (no)
BR (1) BR9709015A (no)
CA (1) CA2252531A1 (no)
CZ (1) CZ296163B6 (no)
DE (1) DE69738949D1 (no)
IL (1) IL126557A (no)
NO (1) NO312099B1 (no)
NZ (1) NZ332341A (no)
PL (1) PL329922A1 (no)
RU (1) RU2170730C2 (no)
SK (1) SK283162B6 (no)
TR (1) TR199802385T2 (no)
WO (1) WO1997044036A1 (no)

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US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
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CN103254291B (zh) * 2013-05-30 2014-06-25 常州亚当生物技术有限公司 肿瘤坏死因子-α多肽抑制剂及其应用
CN103285373A (zh) * 2013-05-30 2013-09-11 苏州普罗达生物科技有限公司 肿瘤坏死因子-α多肽抑制剂制备及其应用
KR102103256B1 (ko) * 2013-10-14 2020-04-23 에자이 알앤드디 매니지먼트 가부시키가이샤 선택적으로 치환된 퀴놀린 화합물
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
RU2624906C2 (ru) * 2015-12-22 2017-07-10 федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Производные 2-хинальдинкарбоновой кислоты и их противогриппозная активность
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Also Published As

Publication number Publication date
BR9709015A (pt) 1999-08-03
CA2252531A1 (en) 1997-11-27
CZ296163B6 (cs) 2006-01-11
CN1148189C (zh) 2004-05-05
NZ332341A (en) 2000-05-26
SK160598A3 (en) 1999-12-10
KR20000065219A (ko) 2000-11-06
EP0952832A1 (en) 1999-11-03
EP0952832B1 (en) 2008-08-27
DE69738949D1 (de) 2008-10-09
US5804588A (en) 1998-09-08
IL126557A0 (en) 1999-08-17
NO985376D0 (no) 1998-11-19
IL126557A (en) 2002-09-12
PL329922A1 (en) 1999-04-26
NO312099B1 (no) 2002-03-18
RU2170730C2 (ru) 2001-07-20
CZ365198A3 (cs) 1999-03-17
JP2000510865A (ja) 2000-08-22
SK283162B6 (sk) 2003-03-04
CN1219131A (zh) 1999-06-09
WO1997044036A1 (en) 1997-11-27
AU722472B2 (en) 2000-08-03
ATE406163T1 (de) 2008-09-15
TR199802385T2 (xx) 1999-04-21
AU2905897A (en) 1997-12-09

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