PE20100399A1 - Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas - Google Patents

Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas

Info

Publication number
PE20100399A1
PE20100399A1 PE2010000225A PE2010000225A PE20100399A1 PE 20100399 A1 PE20100399 A1 PE 20100399A1 PE 2010000225 A PE2010000225 A PE 2010000225A PE 2010000225 A PE2010000225 A PE 2010000225A PE 20100399 A1 PE20100399 A1 PE 20100399A1
Authority
PE
Peru
Prior art keywords
quinolin
ona
hydroxy
oxy
acetyl
Prior art date
Application number
PE2010000225A
Other languages
English (en)
Inventor
Olivier Lohse
Gerhard Penn
Hanspeter Schilling
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33131902&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100399(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20100399A1 publication Critical patent/PE20100399A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR OXI-(1H)-QUINOLIN-2-ONAS 5-(a -HALOACETIL)-8-SUSTITUIDAS QUE COMPRENDE: A) HACER REACCIONAR 8-HIDROXI-(1H)-QUINOLIN-2-ONA CON UN AGENTE DE ACILACION TAL COMO ANHIDRIDO ACETICO, Y UN ACIDO DE LEWIS TAL COMO TRIFLUORURO DE BORO PARA FORMAR 5-ACETIL-8-HIDROXI-(1H)-QUINOLIN-2-ONA; B) HACER REACCIONAR LA 5-ACETIL-8-HIDROXI-(1H)-QUINOLIN-2-ONA CON UN COMPUESTO DE FORMULA RL TAL COMO CLORURO DE BENCILO EN PRESENCIA DE UNA BASE TAL COMO HIDROXIDO DE SODIO PARA FORMAR OXI-(1H)-QUINOLIN-2-ONA 5-ACETIL-8-SUSTITUIDA, EN DONDE R ES UN GRUPO PROTECTOR Y L ES UN GRUPO SALIENTE; C) HACER REACCIONAR LA OXI-(1H)-QUINOLIN-2-ONA 5-ACETIL-8-SUSTITUIDA CON UN AGENTE DE HALOGENACION TAL COMO ACIDO BROMHIDRICO PARA FORMAR OXI-(1H)-QUINOLIN-2-ONA 5-(a-HALOACETIL)-8-SUSTITUIDA. DICHOS COMPUESTOS SON INTERMEDIARIOS PARA PREPARAR SALES DE 5[(R)-2-(5,6-DIETIL-INDAN-2-ILAMINO)-1-HIDROXI-ETIL]-8-HIDROXI-(1H)-QUINOLIN-2-ONA LOS CUALES SON AGONISTAS ADRENOCEPTORES B-SELECTIVOS CON ACTIVIDAD BRONQUIODILATADORA
PE2010000225A 2003-04-02 2004-03-31 Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas PE20100399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45972403P 2003-04-02 2003-04-02

Publications (1)

Publication Number Publication Date
PE20100399A1 true PE20100399A1 (es) 2010-06-01

Family

ID=33131902

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2010000225A PE20100399A1 (es) 2003-04-02 2004-03-31 Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas
PE2004000341A PE20050211A1 (es) 2003-04-02 2004-03-31 Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2004000341A PE20050211A1 (es) 2003-04-02 2004-03-31 Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas

Country Status (35)

Country Link
US (1) US7605267B2 (es)
EP (1) EP1613599B8 (es)
JP (1) JP4726778B2 (es)
KR (1) KR101073740B1 (es)
CN (1) CN1774423A (es)
AR (2) AR043825A1 (es)
AT (1) ATE491690T1 (es)
AU (1) AU2004226212B2 (es)
BR (1) BRPI0409154B1 (es)
CA (1) CA2520990C (es)
CL (1) CL2004000706A1 (es)
CO (1) CO5700779A2 (es)
CY (1) CY1111515T1 (es)
DE (1) DE602004030553D1 (es)
DK (1) DK1613599T3 (es)
EC (1) ECSP056059A (es)
ES (1) ES2358193T3 (es)
HK (1) HK1086833A1 (es)
HR (1) HRP20110184T1 (es)
IL (1) IL171053A (es)
IS (1) IS2800B (es)
MA (1) MA27761A1 (es)
MX (1) MXPA05010616A (es)
MY (1) MY141871A (es)
NO (1) NO331980B1 (es)
NZ (1) NZ542623A (es)
PE (2) PE20100399A1 (es)
PL (1) PL1613599T3 (es)
PT (1) PT1613599E (es)
RU (1) RU2339621C2 (es)
SI (1) SI1613599T1 (es)
TN (1) TNSN05245A1 (es)
TW (1) TWI324151B (es)
WO (1) WO2004087668A1 (es)
ZA (1) ZA200507603B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GB0413960D0 (en) * 2004-06-22 2004-07-28 Novartis Ag Organic compounds
BRPI0713951B8 (pt) 2006-06-30 2021-05-25 Novartis Ag derivados de quinazolina, e composição farmacêutica
WO2013132514A2 (en) * 2012-03-09 2013-09-12 Rao Davuluri Ramamohan A novel process for the preparation of (r)-5-[2-[(5, 6-diethyl-2, 3-dihydro-1h-inden-2-yl) amino]-1-hydroxyethyl]-8-hydroxy quinolin-2(1h)-one
CN102633717B (zh) * 2012-03-30 2013-11-20 西南大学 N-乙酰-喹啉-2(1h)酮类化合物及其制备方法和应用
WO2014008640A1 (zh) * 2012-07-11 2014-01-16 上海威智医药科技有限公司 茚达特罗中间体及茚达特罗的合成方法
CZ306252B6 (cs) 2013-03-15 2016-10-26 Zentiva, K.S. Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)
EP3092217B1 (en) 2014-01-09 2020-06-03 Davuluri, Ramamohan Rao A novel process for preparation of indacaterol or its pharmaceutically acceptable salts
CN105693603B (zh) * 2014-11-24 2019-11-29 上海医药工业研究院 改良的马来酸茚达特罗制备工艺
CN107531636B (zh) * 2015-04-09 2022-11-25 正大天晴药业集团股份有限公司 茚达特罗或其盐的制备方法
CN107868045A (zh) * 2016-09-28 2018-04-03 四川海思科制药有限公司 一种茚达特罗中间体的制备方法
CN108264483A (zh) * 2016-12-31 2018-07-10 天津金耀集团有限公司 一种马来酸茚达特罗的制备方法
CN109721534B (zh) * 2018-09-25 2022-05-20 四川海思科制药有限公司 一种马来酸茚达特罗中间体及其制备方法和用途
CN114751857A (zh) * 2022-04-29 2022-07-15 梯尔希（南京）药物研发有限公司 一种茚达特罗杂质的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539228B2 (es) * 1974-01-31 1978-04-04
CA1164459A (en) * 1980-11-11 1984-03-27 Yung-Hsiung Yang Process for preparing (imidazo¬1,2-a|pyridine- 2-yl)-carbostyril or -3,4-dihydrocarbostyryl derivatives
JPS5896022A (ja) * 1981-11-30 1983-06-07 Otsuka Pharmaceut Co Ltd 強心剤
ES8403457A1 (es) * 1983-01-28 1984-03-16 Espanola Farma Therapeut Procedimiento para la obtencion de un compuesto derivado de la 2-quinolinona.
ES8605239A1 (es) * 1985-12-04 1986-03-16 Astur Pharma Un procedimiento para la preparacion de quinolonas sustitui-das
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
GB0029562D0 (en) * 2000-12-04 2001-01-17 Novartis Ag Organic compounds
US6653323B2 (en) * 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
TWI324150B (en) * 2003-02-28 2010-05-01 Novartis Ag Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt

Also Published As

Publication number Publication date
EP1613599A1 (en) 2006-01-11
CA2520990A1 (en) 2004-10-14
ATE491690T1 (de) 2011-01-15
CN1774423A (zh) 2006-05-17
IL171053A (en) 2010-12-30
HRP20110184T1 (hr) 2011-04-30
NO20055099D0 (no) 2005-11-01
EP1613599B1 (en) 2010-12-15
CO5700779A2 (es) 2006-11-30
US20060189653A1 (en) 2006-08-24
IS2800B (is) 2012-09-15
AR043825A1 (es) 2005-08-17
RU2339621C2 (ru) 2008-11-27
CA2520990C (en) 2011-08-09
DK1613599T3 (da) 2011-03-28
KR20050119678A (ko) 2005-12-21
JP2006522055A (ja) 2006-09-28
US7605267B2 (en) 2009-10-20
KR101073740B1 (ko) 2011-10-13
NO331980B1 (no) 2012-05-21
TWI324151B (en) 2010-05-01
ZA200507603B (en) 2006-11-29
NO20055099L (no) 2006-01-02
PL1613599T3 (pl) 2011-05-31
TNSN05245A1 (en) 2007-06-11
JP4726778B2 (ja) 2011-07-20
HK1086833A1 (en) 2006-09-29
MY141871A (en) 2010-07-16
DE602004030553D1 (de) 2011-01-27
CY1111515T1 (el) 2015-08-05
TW200504025A (en) 2005-02-01
NZ542623A (en) 2008-07-31
BRPI0409154B1 (pt) 2014-03-25
BRPI0409154A (pt) 2006-03-28
AR103508A2 (es) 2017-05-17
MA27761A1 (fr) 2006-02-01
AU2004226212A1 (en) 2004-10-14
SI1613599T1 (sl) 2011-04-29
EP1613599B8 (en) 2011-06-22
MXPA05010616A (es) 2005-11-23
PE20050211A1 (es) 2005-04-27
PT1613599E (pt) 2011-03-17
CL2004000706A1 (es) 2005-01-14
IS8095A (is) 2005-10-27
WO2004087668A1 (en) 2004-10-14
ES2358193T3 (es) 2011-05-06
ECSP056059A (es) 2006-01-27
AU2004226212B2 (en) 2008-02-21

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