KR860000288A - 비스-트리아졸 유도체의 제조방법 - Google Patents

비스-트리아졸 유도체의 제조방법 Download PDF

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Publication number
KR860000288A
KR860000288A KR1019850003935A KR850003935A KR860000288A KR 860000288 A KR860000288 A KR 860000288A KR 1019850003935 A KR1019850003935 A KR 1019850003935A KR 850003935 A KR850003935 A KR 850003935A KR 860000288 A KR860000288 A KR 860000288A
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South Korea
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formula
compound
triazole
base
compounds
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KR1019850003935A
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English (en)
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KR870001829B1 (ko
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제이. 바스 알. (외 2)
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윌리암 존 윌슨
화이자 코포레이션
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Publication of KR860000288A publication Critical patent/KR860000288A/ko
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Publication of KR870001829B1 publication Critical patent/KR870001829B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

비스-트리아졸 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(Ⅱ)의 옥시란을 1,2,4-트리아졸 또는 그의 염기염과 반응시켜 X가 OH인 일반식(Ⅰ)의 화합물을 수득한 다음, 임의로는 (a) X가 OH인 일반식(Ⅰ)의 화합물을 할로겐화하여 X가 F,Cl 또는 Br인 일반식(Ⅰ)의 화합물을 제조하는 단계; (b) X가 OH인 일반식(Ⅰ)의 화합물을 O-에스테르 또는 O-에스테르로 전환시키는 단계; 및 (c) 일반식(Ⅰ)의 화합물을 적절한 산과 반응시켜 약제학적 또는 농업적으로 허용되는 염으로 전환시키는 단계중의 하나 또는 그 이상을 수행함을 특징으로 하여, 일반식(Ⅰ)의 화합물또는 그의 O-에스테르 또는 0-에테르, 또는 이들 화합물의 약제학적 또는 농업적으로 허용되는 염을 제조하는 방법.
    상기 식에서 R은 F,Cl,Br,I,CF3, C1-C4알킬 및 C1-C4알콕시 중에서 각각 독립적으로 선택된 1내지 3개의 치환체로 임의 치환된 페닐그룹이거나, 5-클로로피리드-2-일 그룹이고; X는 OH, F, Cl또는 Br이다.
  2. 제1항에 있어서, 옥시란(Ⅱ)를 염기 존재하에서 1,2,4-트리아졸과 반응시키는 방법.
  3. 제2항에 있어서, 염기가 탄산칼륨인 방법.
  4. 제1항에 있어서, 1,2,4-트리아졸의 염기염이 알칼리 금속염인 방법.
  5. 제1내지 4항중 어느 하나에 있어서, 디에틸-아미노설퍼 트리플루오라이드, 티오닐 클로라이드 또는 티오닐 브로마이드를 사용하여 할로겐화를 수행하는 방법.
  6. 제5항에 있어서, 이미다졸 존재하에서 티오닐 클로라이드를 사용하여 할로겐화를 수행하는 방법.
  7. 제1내지 6항중 어느 하나에 있어서 R이 F,Cl,Br,I 및 CF3중에서 각각 독립적으로 선택된 1내지 3개의 치환체로 치환된 페닐그룹인 방법.
  8. 제7항에 있어서, R이 2,4-디플루오로페닐, 4-클로로페닐 또는 4-플루오로페닐인 방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850003935A 1984-06-07 1985-06-05 비스-트리아졸 유도체의 제조방법 KR870001829B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8414519 1984-06-07
GB848414519A GB8414519D0 (en) 1984-06-07 1984-06-07 Triazole antifungal agents

Publications (2)

Publication Number Publication Date
KR860000288A true KR860000288A (ko) 1986-01-27
KR870001829B1 KR870001829B1 (ko) 1987-10-15

Family

ID=10562061

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003935A KR870001829B1 (ko) 1984-06-07 1985-06-05 비스-트리아졸 유도체의 제조방법

Country Status (25)

Country Link
US (1) US4618616A (ko)
EP (1) EP0164246B1 (ko)
JP (1) JPS611672A (ko)
KR (1) KR870001829B1 (ko)
CN (1) CN85104471B (ko)
AT (1) ATE36328T1 (ko)
AU (1) AU554476B2 (ko)
CA (1) CA1287059C (ko)
DD (1) DD235641A5 (ko)
DE (1) DE3564266D1 (ko)
DK (1) DK170301B1 (ko)
ES (1) ES8604170A1 (ko)
FI (1) FI86176C (ko)
GB (1) GB8414519D0 (ko)
GR (1) GR851382B (ko)
HU (1) HU195647B (ko)
IE (1) IE57804B1 (ko)
IL (1) IL75410A (ko)
NO (1) NO852287L (ko)
NZ (1) NZ212317A (ko)
PH (1) PH22870A (ko)
PL (1) PL144920B1 (ko)
PT (1) PT80598B (ko)
YU (1) YU94985A (ko)
ZA (1) ZA854250B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3440117A1 (de) * 1984-11-02 1986-05-15 Bayer Ag, 5090 Leverkusen Substituierte azolylcyclopropyl-azolylmethyl-carbinol-derivate
DE3440114A1 (de) * 1984-11-02 1986-05-07 Bayer Ag, 5090 Leverkusen Antimykotische mittel
EP0180850A3 (de) * 1984-11-02 1987-05-27 Bayer Ag Antimykotische Azolylmethyl-cyclopropyl-carbinol Derivate
GB8429932D0 (en) * 1984-11-27 1985-01-03 Pfizer Ltd Triazole antifungal agents
DE3608792A1 (de) * 1986-03-15 1987-09-24 Hoechst Ag 1,1-disubstituierte cyclopropanderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3608727A1 (de) * 1986-03-15 1987-09-17 Hoechst Ag 1,1-disubstituierte cyclopropanderivate, verfahren zu ihrer herstellung sowie ihre verwendung als antimykotika oder als zwischenprodukte
DE3837463A1 (de) * 1988-11-04 1990-05-10 Bayer Ag Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3921162A1 (de) * 1989-06-28 1991-01-10 Bayer Ag Verwendung von substituierten bis-azolyl-derivaten zur bekaempfung von pilzen im pflanzenschutz
US5247094A (en) * 1990-01-24 1993-09-21 Bayer Aktiengesellschaft 1-(3- or 5-halo-1,2,4-triazol-1-yl)ethyl phenyl ketone intermediates
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
US5488035A (en) * 1991-12-06 1996-01-30 Pioneer Hi-Bred International, Inc. Peptide with inhibitory activity towards plant pathogenic fungi
JPH06340636A (ja) * 1993-05-31 1994-12-13 Ss Pharmaceut Co Ltd トリアゾール誘導体又はその塩、及びこれを含有する抗真菌剤
JP6404235B2 (ja) * 2013-02-04 2018-10-10 シンジェンタ パーティシペーションズ アーゲー 新規な殺微生物剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051565A1 (de) * 1980-11-03 1982-05-12 Ciba-Geigy Ag 1-N,N-Dimethylcarbamoyl-3(5)-cyclopropyl-1,2,4-triazole, Verfahren zu ihrer Herstellung und ihre Verwendung in der Schädlingsbekämpfung
DE3337937A1 (de) * 1982-10-28 1984-05-03 Sandoz-Patent-GmbH, 7850 Lörrach Neue azolderivate
GB8302500D0 (en) * 1983-01-29 1983-03-02 Pfizer Ltd Antifungal agents
DE3305834A1 (de) * 1983-02-19 1984-08-23 Bayer Ag, 5090 Leverkusen Mikrobizides mittel zum schutz technischer mineralien
EP0180850A3 (de) * 1984-11-02 1987-05-27 Bayer Ag Antimykotische Azolylmethyl-cyclopropyl-carbinol Derivate
DE3440114A1 (de) * 1984-11-02 1986-05-07 Bayer Ag, 5090 Leverkusen Antimykotische mittel
GB8429932D0 (en) * 1984-11-27 1985-01-03 Pfizer Ltd Triazole antifungal agents

Also Published As

Publication number Publication date
FI852223L (fi) 1985-12-08
PT80598B (en) 1987-04-23
ATE36328T1 (de) 1988-08-15
DK253685A (da) 1985-12-08
DD235641A5 (de) 1986-05-14
DK253685D0 (da) 1985-06-06
CA1287059C (en) 1991-07-30
NZ212317A (en) 1988-04-29
PL253666A1 (en) 1986-06-17
EP0164246B1 (en) 1988-08-10
IE851416L (en) 1985-12-07
HU195647B (en) 1988-06-28
PT80598A (en) 1985-07-01
US4618616A (en) 1986-10-21
DE3564266D1 (en) 1988-09-15
AU4334885A (en) 1985-12-12
IE57804B1 (en) 1993-04-07
EP0164246A2 (en) 1985-12-11
DK170301B1 (da) 1995-07-31
IL75410A (en) 1989-02-28
ZA854250B (en) 1987-01-28
FI852223A0 (fi) 1985-06-03
PL144920B1 (en) 1988-07-30
FI86176C (fi) 1992-07-27
FI86176B (fi) 1992-04-15
ES8604170A1 (es) 1986-01-16
JPS611672A (ja) 1986-01-07
CN85104471B (zh) 1987-10-21
HUT38326A (en) 1986-05-28
EP0164246A3 (en) 1987-01-28
ES543998A0 (es) 1986-01-16
YU94985A (en) 1987-10-31
JPH0521108B2 (ko) 1993-03-23
CN85104471A (zh) 1986-12-10
GB8414519D0 (en) 1984-07-11
NO852287L (no) 1985-12-09
GR851382B (ko) 1985-11-25
PH22870A (en) 1989-01-19
KR870001829B1 (ko) 1987-10-15
AU554476B2 (en) 1986-08-21

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