AR044706A2 - Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp - Google Patents

Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp

Info

Publication number
AR044706A2
AR044706A2 ARP040102071A ARP040102071A AR044706A2 AR 044706 A2 AR044706 A2 AR 044706A2 AR P040102071 A ARP040102071 A AR P040102071A AR P040102071 A ARP040102071 A AR P040102071A AR 044706 A2 AR044706 A2 AR 044706A2
Authority
AR
Argentina
Prior art keywords
aminoquinolins
procedures
prepare
cetp inhibitors
compound
Prior art date
Application number
ARP040102071A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR044706A2 publication Critical patent/AR044706A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para preparar un compuesto de fórmula (1), que comprende combinar el compuesto de fórmula (2), con un haluro de 3,5-bis(trifluorometil)bencilo en presencia de una base.
ARP040102071A 2001-04-30 2004-06-15 Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp AR044706A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28752201P 2001-04-30 2001-04-30

Publications (1)

Publication Number Publication Date
AR044706A2 true AR044706A2 (es) 2005-09-21

Family

ID=23103272

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP020101575A AR035963A1 (es) 2001-04-30 2002-04-29 Compuestos derivados de trifluormetilbenceno utiles como intermedios de los inhibidores de la proteina de transferencia del ester de colesterilo y procedimientos para su preparacion
ARP020101576A AR036331A1 (es) 2001-04-30 2002-04-29 Compuestos utiles como intermediarios en la elaboracion de inhibidores de cetp y procedimiento para obtener dichos intermediarios e inhibidores
ARP040102071A AR044706A2 (es) 2001-04-30 2004-06-15 Procedimientos para preparar 4-aminoquinolinas, inhibidores de cetp

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP020101575A AR035963A1 (es) 2001-04-30 2002-04-29 Compuestos derivados de trifluormetilbenceno utiles como intermedios de los inhibidores de la proteina de transferencia del ester de colesterilo y procedimientos para su preparacion
ARP020101576A AR036331A1 (es) 2001-04-30 2002-04-29 Compuestos utiles como intermediarios en la elaboracion de inhibidores de cetp y procedimiento para obtener dichos intermediarios e inhibidores

Country Status (24)

Country Link
US (3) US6600045B2 (es)
EP (2) EP1425270B1 (es)
JP (2) JP3924250B2 (es)
KR (2) KR100591998B1 (es)
CN (3) CN1297541C (es)
AR (3) AR035963A1 (es)
AT (2) ATE321755T1 (es)
AU (1) AU2002253448B2 (es)
BR (2) BR0209238A (es)
CA (2) CA2445623A1 (es)
CZ (2) CZ20032900A3 (es)
DE (2) DE60209004T2 (es)
DK (2) DK1383734T3 (es)
ES (2) ES2259080T3 (es)
HU (2) HUP0304039A3 (es)
IL (2) IL157546A0 (es)
MX (2) MXPA03009935A (es)
PL (2) PL366584A1 (es)
PT (1) PT1425270E (es)
RU (2) RU2259355C2 (es)
TW (1) TWI250974B (es)
WO (2) WO2002088069A2 (es)
YU (2) YU84403A (es)
ZA (2) ZA200306599B (es)

Families Citing this family (34)

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US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
JP2006021999A (ja) * 2002-07-12 2006-01-26 Kaneka Corp 光学活性β−アミノニトリル化合物およびその対掌体アミド化合物の製造方法
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
PL376156A1 (en) 2002-10-04 2005-12-27 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
AU2003283769A1 (en) 2002-12-20 2004-07-14 Pfizer Products Inc. Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor
EP1594843B1 (en) * 2003-02-18 2013-05-22 Takasago International Corporation METHOD FOR PRODUCING AN OPTICALLY ACTIVE beta-amino acid derivative
MXPA05009331A (es) * 2003-03-17 2005-11-04 Kaneka Corp Metodo para producir un derivado de amida del acido (r)-3-[4-(trifluorometil)fenilamino]-pentanoico.
US7223859B2 (en) 2003-03-17 2007-05-29 Pfizer Inc. Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
KR20070087197A (ko) 2003-09-26 2007-08-27 니뽄 다바코 산교 가부시키가이샤 잔여 리포프로테인 생산 저해 방법
WO2005037796A1 (en) * 2003-10-08 2005-04-28 Eli Lilly And Company Compounds and methods for treating dyslipidemia
US7390504B2 (en) * 2003-11-07 2008-06-24 Jj Pharma, Inc. HDL-boosting combination therapy complexes
TW200538127A (en) * 2004-04-07 2005-12-01 Millennium Pharm Inc PGD2 receptor antagonists for the treatment of inflammatory diseases
US20080269284A1 (en) * 2004-06-24 2008-10-30 Eli Lilly And Company Compounds and Methods for Treating Dyslipidemia
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
BRPI0608553A2 (pt) 2005-02-24 2010-01-12 Millennium Pharm Inc antagonistas de receptor de pgd2 para o tratamento de doenças inflamatórias
JP2008546765A (ja) * 2005-06-20 2008-12-25 アストラゼネカ アクチボラグ （アルコキシカルボニルアミノ）−アルキルスルホネートの製造方法
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
DE102006031151A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031149A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031262A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031143A1 (de) * 2006-07-04 2008-01-24 Merck Patent Gmbh Fluortenside
DE102006032391A1 (de) * 2006-07-04 2008-01-17 Merck Patent Gmbh Fluortenside
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
JP2011256110A (ja) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd ヘキサヒドロピロロキノリンの製造法
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
PH12013501829A1 (en) 2011-04-12 2015-10-23 Chong Kun Dang Pharmaceutical Corp Cycloalkenyl aryl derivatives for cetp inhibitor
CN103648495A (zh) 2011-07-08 2014-03-19 诺华股份有限公司 在高甘油三酯对象中治疗动脉粥样硬化的方法
AU2014213125B2 (en) 2013-01-31 2016-06-02 Chong Kun Dang Pharmaceutical Corp. Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors
EA201600255A1 (ru) * 2013-11-11 2016-09-30 Лонца Лтд. Способ получения цианосоединений, содержащих элемент 13 группы, с использованием кислоты льюиса
CN107108558B (zh) * 2014-08-12 2019-11-19 狄智玛制药私人有限公司 制备用于制备四氢喹啉衍生物的合成中间体的方法
CN105294559B (zh) * 2015-06-24 2017-11-14 厦门法茉维特动物药业有限公司 一种医药中间体4‑氨基喹啉类化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW205037B (es) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
JP5035813B2 (ja) 1998-07-10 2012-09-26 マサチューセッツ インスティテュート オブ テクノロジー 金属用のリガンドおよびそれらに基づいて改善された金属触媒法
GT199900147A (es) * 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines

Also Published As

Publication number Publication date
CZ20032898A3 (cs) 2004-07-14
KR100591998B1 (ko) 2006-06-22
JP2004531541A (ja) 2004-10-14
CN1267411C (zh) 2006-08-02
MXPA03009936A (es) 2004-01-29
WO2002088085A2 (en) 2002-11-07
HUP0304039A3 (en) 2005-10-28
DK1425270T3 (da) 2006-07-03
PL366700A1 (en) 2005-02-07
WO2002088069A3 (en) 2003-02-20
ATE321755T1 (de) 2006-04-15
CN1505609A (zh) 2004-06-16
DK1383734T3 (da) 2006-05-15
CA2445693A1 (en) 2002-11-07
KR20040030603A (ko) 2004-04-09
RU2259355C2 (ru) 2005-08-27
AR036331A1 (es) 2004-09-01
BR0209238A (pt) 2004-06-15
EP1383734B1 (en) 2006-02-01
US20030073843A1 (en) 2003-04-17
DE60209004T2 (de) 2006-09-28
WO2002088069A9 (en) 2003-12-04
TWI250974B (en) 2006-03-11
AR035963A1 (es) 2004-07-28
JP3924250B2 (ja) 2007-06-06
US20030216576A1 (en) 2003-11-20
HUP0304041A2 (hu) 2004-04-28
AU2002253448B2 (en) 2007-07-05
RU2003131871A (ru) 2005-04-10
US6689897B2 (en) 2004-02-10
CN1529696A (zh) 2004-09-15
KR20040015200A (ko) 2004-02-18
RU2265010C2 (ru) 2005-11-27
EP1425270B1 (en) 2006-03-29
RU2003131870A (ru) 2005-01-27
MXPA03009935A (es) 2004-01-29
US6600045B2 (en) 2003-07-29
CN1297541C (zh) 2007-01-31
EP1425270A2 (en) 2004-06-09
DE60210265D1 (de) 2006-05-18
HK1062294A1 (en) 2004-10-29
IL157544A0 (en) 2004-03-28
WO2002088085A3 (en) 2004-03-25
JP2004527556A (ja) 2004-09-09
YU84403A (sh) 2006-08-17
CZ20032900A3 (cs) 2004-06-16
YU84303A (sh) 2006-05-25
WO2002088069A2 (en) 2002-11-07
ES2256461T3 (es) 2006-07-16
CN100357265C (zh) 2007-12-26
US6706881B2 (en) 2004-03-16
HU225777B1 (en) 2007-08-28
HUP0304041A3 (en) 2005-08-29
EP1383734A2 (en) 2004-01-28
HUP0304039A2 (hu) 2004-03-29
ZA200306599B (en) 2004-10-22
PT1425270E (pt) 2006-07-31
KR100639745B1 (ko) 2006-10-30
BR0209291A (pt) 2004-07-13
CA2445623A1 (en) 2002-11-07
IL157546A0 (en) 2004-03-28
DE60210265T2 (de) 2006-10-12
JP3924251B2 (ja) 2007-06-06
ATE316957T1 (de) 2006-02-15
ES2259080T3 (es) 2006-09-16
PL366584A1 (en) 2005-02-07
ZA200306600B (en) 2004-08-25
CN1680292A (zh) 2005-10-12
DE60209004D1 (de) 2006-04-13
US20020177716A1 (en) 2002-11-28

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