DE60210265D1 - Verfahren und zwischenprodukte zur herstellung von 4-aminochinolin-cetp-inhibitoren - Google Patents

Verfahren und zwischenprodukte zur herstellung von 4-aminochinolin-cetp-inhibitoren

Info

Publication number
DE60210265D1
DE60210265D1 DE60210265T DE60210265T DE60210265D1 DE 60210265 D1 DE60210265 D1 DE 60210265D1 DE 60210265 T DE60210265 T DE 60210265T DE 60210265 T DE60210265 T DE 60210265T DE 60210265 D1 DE60210265 D1 DE 60210265D1
Authority
DE
Germany
Prior art keywords
aminochinoline
preparation
intermediate products
cetp inhibitors
cetp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60210265T
Other languages
English (en)
Other versions
DE60210265T2 (de
Inventor
David Burns Damon
Robert Wayne Dugger
Robert William Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of DE60210265D1 publication Critical patent/DE60210265D1/de
Application granted granted Critical
Publication of DE60210265T2 publication Critical patent/DE60210265T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE60210265T 2001-04-30 2002-04-08 Verfahren und zwischenprodukte zur herstellung von 4-aminochinolin-cetp-inhibitoren Expired - Fee Related DE60210265T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28752201P 2001-04-30 2001-04-30
US287522P 2001-04-30
PCT/IB2002/001214 WO2002088085A2 (en) 2001-04-30 2002-04-08 Methods and intermediates for preparing 4-aminoquinoline cetp inhibitors

Publications (2)

Publication Number Publication Date
DE60210265D1 true DE60210265D1 (de) 2006-05-18
DE60210265T2 DE60210265T2 (de) 2006-10-12

Family

ID=23103272

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60210265T Expired - Fee Related DE60210265T2 (de) 2001-04-30 2002-04-08 Verfahren und zwischenprodukte zur herstellung von 4-aminochinolin-cetp-inhibitoren
DE60209004T Expired - Fee Related DE60209004T2 (de) 2001-04-30 2002-04-08 Verbindungen,die als zwischenstufen für cholesterylestertransferprotein(cetp)-inhibitoren verwendbar sind

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60209004T Expired - Fee Related DE60209004T2 (de) 2001-04-30 2002-04-08 Verbindungen,die als zwischenstufen für cholesterylestertransferprotein(cetp)-inhibitoren verwendbar sind

Country Status (25)

Country Link
US (3) US6689897B2 (de)
EP (2) EP1425270B1 (de)
JP (2) JP3924250B2 (de)
KR (2) KR100591998B1 (de)
CN (3) CN1297541C (de)
AR (3) AR036331A1 (de)
AT (2) ATE321755T1 (de)
AU (1) AU2002253448B2 (de)
BR (2) BR0209238A (de)
CA (2) CA2445623A1 (de)
CZ (2) CZ20032900A3 (de)
DE (2) DE60210265T2 (de)
DK (2) DK1425270T3 (de)
ES (2) ES2256461T3 (de)
HK (1) HK1062294A1 (de)
HU (2) HUP0304039A3 (de)
IL (2) IL157544A0 (de)
MX (2) MXPA03009936A (de)
PL (2) PL366700A1 (de)
PT (1) PT1425270E (de)
RU (2) RU2265010C2 (de)
TW (1) TWI250974B (de)
WO (2) WO2002088069A2 (de)
YU (2) YU84303A (de)
ZA (2) ZA200306599B (de)

Families Citing this family (34)

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US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
JP2006021999A (ja) * 2002-07-12 2006-01-26 Kaneka Corp 光学活性β−アミノニトリル化合物およびその対掌体アミド化合物の製造方法
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
AU2003277285B2 (en) * 2002-10-04 2007-12-13 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
AU2003283769A1 (en) 2002-12-20 2004-07-14 Pfizer Products Inc. Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor
JP4644658B2 (ja) * 2003-02-18 2011-03-02 高砂香料工業株式会社 光学活性テトラヒドロキノリン類の製造方法
US7223859B2 (en) 2003-03-17 2007-05-29 Pfizer Inc. Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
BRPI0407954A (pt) * 2003-03-17 2006-03-07 Kaneka Corp processo para a produção de derivado de amida de ácido (r)-3-[4-(trifluorometil) fenilamino]-pentanóico
EP1670446A2 (de) 2003-09-26 2006-06-21 Japan Tobacco Inc. Verfahren zur hemmung der restlichen lipoprotein-produktion
MXPA06003927A (es) * 2003-10-08 2008-02-07 Lilly Co Eli Compuestos y metodos para tratar dislipidemia.
CA2543596A1 (en) * 2003-11-07 2005-05-26 Jj Pharma, Inc. Hdl-boosting combination therapy complexes
MXPA06011540A (es) * 2004-04-07 2007-01-26 Millennium Pharm Inc Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias.
WO2006012093A1 (en) * 2004-06-24 2006-02-02 Eli Lilly And Company Compounds and methods for treating dyslipidemia
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
KR20070114762A (ko) 2005-02-24 2007-12-04 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료를 위한 ｐｇｄ2 수용체 길항제
JP2008546765A (ja) * 2005-06-20 2008-12-25 アストラゼネカ アクチボラグ （アルコキシカルボニルアミノ）−アルキルスルホネートの製造方法
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
DE102006031143A1 (de) * 2006-07-04 2008-01-24 Merck Patent Gmbh Fluortenside
DE102006031151A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031149A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031262A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006032391A1 (de) * 2006-07-04 2008-01-17 Merck Patent Gmbh Fluortenside
EP2134169A2 (de) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Kombination von metformid-r-(+)-lipoat und antihyperlipidämika für die behandlung von diabetes-hyperglykämie und diabetesbedingte komplikationen
JP2011256110A (ja) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd ヘキサヒドロピロロキノリンの製造法
AR077208A1 (es) * 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
MX342104B (es) 2011-04-12 2016-09-13 Chong Kun Dang Pharmaceutical Corp Derivados de cicloalquenil arilo para inhibidor de cetp.
RU2609200C2 (ru) 2011-07-08 2017-01-30 Новартис Аг Способ лечения атеросклероза у субъектов с высоким уровнем триглицеридов
CN105143193B (zh) 2013-01-31 2017-12-15 株式会社钟根堂 作为cetp抑制剂的联芳基或杂环联芳基取代的环己烯衍生化合物
US9458180B2 (en) * 2013-11-11 2016-10-04 Lonza Ltd. Method for preparation of cyano compounds of the 13th group with a lewis acid
CA2958040C (en) * 2014-08-12 2022-09-13 Dezima Pharma B.V. Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives
CN105294559B (zh) * 2015-06-24 2017-11-14 厦门法茉维特动物药业有限公司 一种医药中间体4‑氨基喹啉类化合物的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1097158T3 (da) 1998-07-10 2006-05-29 Massachusetts Inst Technology Ligander til metaller og metalkatalyserede metoder
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines

Also Published As

Publication number Publication date
HUP0304039A3 (en) 2005-10-28
US20030216576A1 (en) 2003-11-20
CN1297541C (zh) 2007-01-31
IL157544A0 (en) 2004-03-28
WO2002088069A9 (en) 2003-12-04
TWI250974B (en) 2006-03-11
ES2256461T3 (es) 2006-07-16
YU84403A (sh) 2006-08-17
CN1505609A (zh) 2004-06-16
ZA200306599B (en) 2004-10-22
CN1529696A (zh) 2004-09-15
EP1383734A2 (de) 2004-01-28
ATE316957T1 (de) 2006-02-15
HUP0304039A2 (hu) 2004-03-29
DK1425270T3 (da) 2006-07-03
JP2004531541A (ja) 2004-10-14
US6600045B2 (en) 2003-07-29
CZ20032898A3 (cs) 2004-07-14
PL366700A1 (en) 2005-02-07
YU84303A (sh) 2006-05-25
WO2002088069A3 (en) 2003-02-20
KR20040030603A (ko) 2004-04-09
RU2259355C2 (ru) 2005-08-27
CN100357265C (zh) 2007-12-26
RU2003131870A (ru) 2005-01-27
RU2265010C2 (ru) 2005-11-27
US6706881B2 (en) 2004-03-16
ES2259080T3 (es) 2006-09-16
DE60210265T2 (de) 2006-10-12
CZ20032900A3 (cs) 2004-06-16
WO2002088069A2 (en) 2002-11-07
US20020177716A1 (en) 2002-11-28
EP1425270B1 (de) 2006-03-29
CA2445623A1 (en) 2002-11-07
JP3924251B2 (ja) 2007-06-06
CN1680292A (zh) 2005-10-12
EP1383734B1 (de) 2006-02-01
MXPA03009936A (es) 2004-01-29
US20030073843A1 (en) 2003-04-17
KR100639745B1 (ko) 2006-10-30
AR044706A2 (es) 2005-09-21
PT1425270E (pt) 2006-07-31
PL366584A1 (en) 2005-02-07
US6689897B2 (en) 2004-02-10
DE60209004T2 (de) 2006-09-28
WO2002088085A3 (en) 2004-03-25
JP3924250B2 (ja) 2007-06-06
CA2445693A1 (en) 2002-11-07
ATE321755T1 (de) 2006-04-15
JP2004527556A (ja) 2004-09-09
HUP0304041A3 (en) 2005-08-29
IL157546A0 (en) 2004-03-28
RU2003131871A (ru) 2005-04-10
HUP0304041A2 (hu) 2004-04-28
KR20040015200A (ko) 2004-02-18
HU225777B1 (en) 2007-08-28
AU2002253448B2 (en) 2007-07-05
AR036331A1 (es) 2004-09-01
BR0209238A (pt) 2004-06-15
EP1425270A2 (de) 2004-06-09
KR100591998B1 (ko) 2006-06-22
MXPA03009935A (es) 2004-01-29
DE60209004D1 (de) 2006-04-13
CN1267411C (zh) 2006-08-02
ZA200306600B (en) 2004-08-25
HK1062294A1 (en) 2004-10-29
BR0209291A (pt) 2004-07-13
DK1383734T3 (da) 2006-05-15
AR035963A1 (es) 2004-07-28
WO2002088085A2 (en) 2002-11-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee