BRPI0407954A - processo para a produção de derivado de amida de ácido (r)-3-[4-(trifluorometil) fenilamino]-pentanóico - Google Patents

processo para a produção de derivado de amida de ácido (r)-3-[4-(trifluorometil) fenilamino]-pentanóico

Info

Publication number
BRPI0407954A
BRPI0407954A BRPI0407954-0A BRPI0407954A BRPI0407954A BR PI0407954 A BRPI0407954 A BR PI0407954A BR PI0407954 A BRPI0407954 A BR PI0407954A BR PI0407954 A BRPI0407954 A BR PI0407954A
Authority
BR
Brazil
Prior art keywords
trifluoromethyl
phenylamino
production
acid amide
pentanamide
Prior art date
Application number
BRPI0407954-0A
Other languages
English (en)
Inventor
Tatsuyoshi Tanaka
Masanobu Sugawara
Hirofumi Maeda
Akira Nishiyama
Yoshihiko Yasohara
Nobuo Nagashima
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of BRPI0407954A publication Critical patent/BRPI0407954A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Abstract

"PROCESSO PARA A PRODUçãO DE DERIVADO DE AMIDA DE áCIDO (R)-3-¢4-(TRIFLUOROMETIL) FENILAMINO!-PENTANóICO". A invenção apresenta processos pelos quais derivados de (R)-3-¢4-(trifluorometil) fenilamino! pentanamida utilizáveis como intermediários para medicamentos, particularmente inibidor da proteína de transferência de éster colesterílico (CETP), podem ser produzidos de maneira fácil e simples a partir de matérias-primas facilmente obtidas. De acordo com a invenção, (S)-N-¢4-(trifluorometil) fenil!-3-hidroxipentanamida é produzida a partir de matérias-primas facilmente disponíveis e convertida em (R)-3-¢4-(trifluorometil) fenilamino! pentanamida através de (R)-4-etil-1-¢4-(trifluorometil) fenil!-2-azetidinona. Além disso, derivados de (R)-3-¢4-(trifluorometil) fenilamino! pentanamida são produzidos por reação de (R)-4-etil-1-¢4-(trifluorometil) fenil!-2-azetidinona com um éster de ácido carbâmico.
BRPI0407954-0A 2003-03-17 2004-03-17 processo para a produção de derivado de amida de ácido (r)-3-[4-(trifluorometil) fenilamino]-pentanóico BRPI0407954A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003072358 2003-03-17
JP2003098452 2003-04-01
PCT/JP2004/003535 WO2004083166A1 (ja) 2003-03-17 2004-03-17 （ｒ）－３－［４－（トリフルオロメチル）フェニルアミノ］－ペンタン酸アミド誘導体の製造法

Publications (1)

Publication Number Publication Date
BRPI0407954A true BRPI0407954A (pt) 2006-03-07

Family

ID=33032337

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407954-0A BRPI0407954A (pt) 2003-03-17 2004-03-17 processo para a produção de derivado de amida de ácido (r)-3-[4-(trifluorometil) fenilamino]-pentanóico

Country Status (6)

Country Link
EP (1) EP1604975A4 (pt)
JP (1) JPWO2004083166A1 (pt)
BR (1) BRPI0407954A (pt)
CA (1) CA2515789A1 (pt)
MX (1) MXPA05009331A (pt)
WO (1) WO2004083166A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006129628A1 (ja) * 2005-05-31 2009-01-08 株式会社カネカ 光学活性２−置換プロパナール誘導体の製造法
WO2008050858A1 (fr) * 2006-10-27 2008-05-02 The University Of Tokyo Composé amide, son sel et agent d'élimination de biofilm les utilisant
KR102157917B1 (ko) * 2012-12-21 2020-09-21 레크 파마슈티칼스 디.디. 키랄 γ-아릴-β-아미노부티르산 유도체의 제조를 위한 효소 경로
CN109456748B (zh) * 2018-11-15 2021-03-02 重庆地质矿产研究院 一种储层改造压裂用粘土稳定剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225777B1 (en) * 2001-04-30 2007-08-28 Pfizer Prod Inc Compounds useful as intermediates for 4-aminoquinoline derivatwes and process for producing them
WO2004074255A2 (en) * 2003-02-18 2004-09-02 Takasago International Corporation Method for producing an optically active tetrahydroquinoline

Also Published As

Publication number Publication date
JPWO2004083166A1 (ja) 2006-06-22
WO2004083166A1 (ja) 2004-09-30
CA2515789A1 (en) 2004-09-30
EP1604975A4 (en) 2006-11-02
MXPA05009331A (es) 2005-11-04
EP1604975A1 (en) 2005-12-14

Similar Documents

Publication Publication Date Title
BRPI0415855A (pt) processo para preparação de ésteres de ácido 2-dihalogenacil-3-amino-acrìlico e ésteres de ácido 3-dihalogeno-metil-pirazol-4-carboxìlico
MX2009007141A (es) Acidos 1-(3-piridinil)pirazol-4-il-aceticos sustituidos, procedimiento para su preparacion y su utilizacion como agentes herbicidas y reguladores del crecimiento de las plantas.
BR0307721A (pt) Processo para preparação de derivados de indolinona
AR047746A1 (es) Un procedimiento para la sintesis del (1s)-4,5-dimetoxi-1-(metilaminometil)-benzo-ciclobutano y sus sales de adicion, un metodo para la resolucion de su intermediario de sintesis racemico y su aplicacion a la sintesis de la ivabradina y sus sales de adicion con un acido farmaceuticamente aceptable
BRPI0607792A2 (pt) processo para a preparação de moduladores de opióides
CY1111070T1 (el) Παραγωγα 2-αμινο-κουιναζολινης χρησιμα ως αναστολεις της β-σεκρετασης (bace)
HRP20040690B1 (en) Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals
ATE424384T1 (de) Imidazolderivate, verfahren zu deren herstellung und deren anwendungen
BR0307574A (pt) Derivados de nicotinamida úteis como inibidores de pde4
CY1109569T1 (el) Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης
BR112015011974A8 (pt) derivados de azaquinazolina carboxamida, seus usos e processo para sua produção, medicamento e composição farmacêutica
ATE496026T1 (de) 1,3-disubstituierte 4-methyl-1 h-pyrrol-2- carbonsäureamide und ihre verwendung zur herstellung von arzneimitteln
BRPI0508430A (pt) processo para a preparação de inibidores da triptase
TW200719889A (en) Amino acid derivatives
BRPI0407954A (pt) processo para a produção de derivado de amida de ácido (r)-3-[4-(trifluorometil) fenilamino]-pentanóico
BR0312593A (pt) Aciluréias substituìdas por uréia e uretano, processo para a sua produção e sua aplicação
HK1107984A1 (en) Pyrrolopyridine-2-carboxylic acid amide derivativeuseful as inhibitor of glycogen phosphorylase
ATE496907T1 (de) Verfahren zur herstellung von cilostazol
BR112017025135A2 (pt) processos para isolar um composto e para preparar um composto
BRPI0909752B8 (pt) processos para a produção de sulfonilpirróis como inibidores de hdac e de uma composição farmacêutica compreendendo os mesmos
DE60128797D1 (de) EINTOPFSYNTHESE VON 3-CYCLOPROPYLAMINO-2- 2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYLö-2-PROPENSÄURE ALKYLESTER ALS NÜTZLICHES ZWISCHENPRODUKT FÜR ANTIBAKTERIELLE QUINOLON-ARZNEISTOFFE
BR0115262A (pt) Derivados de amina opticamente ativos e processo de preparação destes
BR0316392A (pt) Processo para preparar ácido indan-1,3-dicarboxìlico
RS49971B (sr) Novi derivati benzoilgvanidina sa svojstvima koja imaju prednost, postupak za njihovo pripremanje i njihova primena u pripremanju lekova
ITMI20041271A1 (it) Processo di preparazione di gabapentina

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.