BR112017025135A2 - processos para isolar um composto e para preparar um composto - Google Patents
processos para isolar um composto e para preparar um compostoInfo
- Publication number
- BR112017025135A2 BR112017025135A2 BR112017025135A BR112017025135A BR112017025135A2 BR 112017025135 A2 BR112017025135 A2 BR 112017025135A2 BR 112017025135 A BR112017025135 A BR 112017025135A BR 112017025135 A BR112017025135 A BR 112017025135A BR 112017025135 A2 BR112017025135 A2 BR 112017025135A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- formula
- isolating
- preparing
- processes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/02—Formation or introduction of functional groups containing nitrogen of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/08—Formation or introduction of functional groups containing nitrogen of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
- C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/613—Unsaturated compounds containing a keto groups being part of a ring polycyclic
- C07C49/617—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system
- C07C49/623—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
- C07C49/627—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings the condensed ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
a presente invenção refere-se a um processo para isolar um composto de fórmula (2a) ou um sal ou solvato do mesmo, compreendendo a) fazer reagir uma mistura de diastereoisómeros de fórmulas (2a, 2b) com um composto aldeído heterocíclico básico e uma amina opticamente ativa na presença de um base; e b) separar o composto de fórmula (2a) do produto do passo a) por extração com ácido. o composto de fórmula (2a) pode ser produzido com um excesso enantiomérico de 98%. os compostos de fórmula (2a) são intermediários úteis num processo para preparar um derivado bicíclico de ¿-amino tetrazol de fórmula (i) que encontra utilidade no tratamento de dor neuropática e distúrbios do sistema nervoso central.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562167232P | 2015-05-27 | 2015-05-27 | |
US62/167,232 | 2015-05-27 | ||
PCT/EP2016/052176 WO2016146299A1 (en) | 2015-05-27 | 2016-02-02 | Separation of enantiomers of 3-ethylbicyclo[3.2.0]hept-3-en-6-one |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017025135A2 true BR112017025135A2 (pt) | 2018-08-07 |
BR112017025135B1 BR112017025135B1 (pt) | 2023-01-17 |
Family
ID=55404679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017025135-3A BR112017025135B1 (pt) | 2015-05-27 | 2016-02-02 | Processo para isolar um composto de fórmula 2a |
Country Status (11)
Country | Link |
---|---|
US (1) | US10150723B2 (pt) |
EP (1) | EP3303308B1 (pt) |
JP (1) | JP6775009B2 (pt) |
KR (1) | KR102598202B1 (pt) |
CN (1) | CN107667097B (pt) |
AU (1) | AU2016232606A1 (pt) |
BR (1) | BR112017025135B1 (pt) |
CA (1) | CA2986954C (pt) |
RU (1) | RU2734475C2 (pt) |
WO (1) | WO2016146299A1 (pt) |
ZA (1) | ZA201708769B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114264751B (zh) * | 2021-12-28 | 2024-02-27 | 江苏威凯尔医药科技有限公司 | 一种高效液相色谱法分离米洛巴林中间体及其对映异构体的方法 |
CN115745764B (zh) * | 2022-12-08 | 2024-03-12 | 重庆华森制药股份有限公司 | 一种米洛巴林中间体的制备方法 |
WO2024134671A1 (en) * | 2022-12-21 | 2024-06-27 | Bhisaj Pharmaceuticals Pvt Ltd | Preparation of 3-ethylbicyclo[3.2.0]hept-3-en-6-one |
CN116903468B (zh) * | 2023-07-14 | 2024-01-26 | 山东新时代药业有限公司 | 一种米洛巴林中间体的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU147182A1 (ru) * | 1961-07-18 | 1961-11-30 | Е.С. Жданович | Способ расщеплени синтетического рацемического альфа-окси-бета1-бета-диметил-гамма-бутиролактона |
EP0074856A3 (en) * | 1981-09-16 | 1984-02-01 | Glaxo Group Limited | Resolution of racemic bicycloheptenones |
WO2010084798A1 (ja) * | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | 3環性化合物 |
ES2635354T3 (es) * | 2009-03-26 | 2017-10-03 | Daiichi Sankyo Company, Limited | Procedimiento de producción de un derivado de ácido gamma-amino bicíclico |
BR112013031360B1 (pt) * | 2011-06-08 | 2022-01-25 | Daiichi Sankyo Company, Limited | Método para produzir um composto |
WO2012169475A1 (ja) | 2011-06-08 | 2012-12-13 | 第一三共株式会社 | クライゼン転位反応による二環性化合物の製造方法 |
BR112014014432B1 (pt) | 2011-12-15 | 2022-03-29 | Daiichi Sankyo Company, Limited | Método para produzir um composto |
ES2624314T3 (es) | 2012-04-10 | 2017-07-13 | Daiichi Sankyo Company, Limited | Procedimiento de resolución óptica para compuestos bicíclicos usando enzima |
JP2013245215A (ja) * | 2012-05-29 | 2013-12-09 | Daiichi Sankyo Co Ltd | 不斉環化反応による光学活性二環性化合物の製造方法 |
EP3083572B1 (en) * | 2013-12-18 | 2019-02-13 | Novassay SA | Gamma-aminobutyric acid (gaba) analogues for the treatment of pain and other disorders |
-
2016
- 2016-02-02 US US15/576,720 patent/US10150723B2/en not_active Expired - Fee Related
- 2016-02-02 AU AU2016232606A patent/AU2016232606A1/en not_active Abandoned
- 2016-02-02 JP JP2018513721A patent/JP6775009B2/ja active Active
- 2016-02-02 CA CA2986954A patent/CA2986954C/en active Active
- 2016-02-02 RU RU2017143338A patent/RU2734475C2/ru active
- 2016-02-02 KR KR1020177037104A patent/KR102598202B1/ko active IP Right Grant
- 2016-02-02 CN CN201680030795.8A patent/CN107667097B/zh active Active
- 2016-02-02 WO PCT/EP2016/052176 patent/WO2016146299A1/en active Application Filing
- 2016-02-02 EP EP16705440.2A patent/EP3303308B1/en active Active
- 2016-02-02 BR BR112017025135-3A patent/BR112017025135B1/pt active IP Right Grant
-
2017
- 2017-12-21 ZA ZA2017/08769A patent/ZA201708769B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3303308B1 (en) | 2019-10-09 |
KR20180036919A (ko) | 2018-04-10 |
RU2017143338A (ru) | 2019-06-27 |
US10150723B2 (en) | 2018-12-11 |
WO2016146299A1 (en) | 2016-09-22 |
JP2018517768A (ja) | 2018-07-05 |
KR102598202B1 (ko) | 2023-11-03 |
ZA201708769B (en) | 2019-04-24 |
JP6775009B2 (ja) | 2020-10-28 |
US20180134643A1 (en) | 2018-05-17 |
CA2986954A1 (en) | 2016-09-22 |
BR112017025135B1 (pt) | 2023-01-17 |
RU2734475C2 (ru) | 2020-10-16 |
RU2017143338A3 (pt) | 2019-07-17 |
CA2986954C (en) | 2023-06-27 |
CN107667097B (zh) | 2021-02-12 |
EP3303308A1 (en) | 2018-04-11 |
CN107667097A (zh) | 2018-02-06 |
AU2016232606A1 (en) | 2017-12-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018075433A2 (pt) | derivados de piperidinila, processo para sua preparação e composições farmacêuticas contendo-os | |
BR112017025135A2 (pt) | processos para isolar um composto e para preparar um composto | |
UY32025A (es) | Derivados sustituídos de la 6-cloro-2-hidroxi-3-(3,4-dioxo-ciclobut-1-enil-amino)-n-metoxi-n-metil-bencen-sulfonamida, solvatos, hidratos o sales farmacéuticamente aceptables de los mismos, proceso de preparación, composiciones y aplicaciones. | |
BR112017027831A2 (pt) | derivados de hidroxiácido, um processo para sua preparação e composições farmacêuticas contendo-os | |
BR112012006031A2 (pt) | processo para preparação de compostos azabicíclicos. | |
BR112016028273A8 (pt) | derivados radiorrotulados de composto de 2-amino6-fluoro-n-[5-fluoro-piridin-3-il]-pirazol[1,5-a]pirimidin3-carboxamida úteis como inibidor de atr cinase, processo para preparação do referido composto, bem como diferentes formas sólidas do mesmo, uso destas, e composição farmacêutica | |
BR112015028452A2 (pt) | agonistas do receptor somastatina subtipo 4 (sstr4) | |
BR112014018756A8 (pt) | Processo para preparo de etil éster de ácido n-(4-ciclo-hexil-3-trifluorometil-benziloxi)-acetimídico | |
PA8642801A1 (es) | Amidas sustituidas de acido tienopirrolcarboxilico, amidas del acido pirrolotiazolcarboxilico y analogos relacionadas como inhibidores de la caseina cinasa i | |
BR112014003079A2 (pt) | derivado de 1,2,3,4-tetra-hidroquinolina útil para o tratamento de diabetes | |
BR112018073490A2 (pt) | 6.7.beta-epóxidos esteroides como intermediários químicos | |
MX2018014164A (es) | Intermedios para la sintesis de derivados de acido biliar, en particular, de acido obeticolico. | |
AR084864A1 (es) | Proceso de preparacion de girasa e inhibidores de topoisomerasa iv y compuestos intermediarios de dicho proceso | |
BR112016013618A8 (pt) | derivados de maleimida como moduladores de série de reação de wnt, seus usos, composição farmacêutica e processo para a preparação dos mesmos | |
WO2016038628A3 (en) | A process for preparing olodaterol and intermediates thereof | |
ATE551312T1 (de) | Verfahren zur racematspaltung von zopiclon und zwischenprodukten | |
AR086848A1 (es) | Procedimiento de sintesis y forma cristalina del hidrocloruro de 4-{3-[cis-hexahidrociclopenta[c]pirrol-2-(1h)-il]propoxi}benzamida asi como las composiciones farmaceuticas que la contienen | |
AR061890A1 (es) | Sal xinafoato del etil ester de la 1-[[5-(1s)-aminoetil)-2-[8-metoxi-2(trifluorometil)-5-quinolil]-4-oxazolil]carbonil]-(4r)-[(ciclopropil-carbonil)amino]-l-prolina. | |
BR112018013346A2 (pt) | processo de preparação de 1,1,3-trioxo-1,2-benzotiazol-6-carboxamida | |
BR112015021151A2 (pt) | processo para a preparação de (2s,5r)-ácido sulfúrico mono-{[(4-aminopiperidin-4-il)carbonil]-7-oxo-1,6-diazabiciclo[3.2.1]-oct-6-il} éster | |
BR112018016656A2 (pt) | processo para preparar compostos do éster de aminotiol e seus sais | |
MX2022002568A (es) | Proceso para preparar (r)-4-aminoindano y amidas correspondientes. | |
BRPI0416663A (pt) | processos para a preparação de ftalimidas n-substituìdas | |
BR112018071742A2 (pt) | processo para a preparação de compostos herbicidas de piridinilimidazolona | |
CO2020006788A2 (es) | Método de producción de un compuesto intermedio para sintetizar un medicamento |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/02/2016, OBSERVADAS AS CONDICOES LEGAIS |