PA8642801A1 - Amidas sustituidas de acido tienopirrolcarboxilico, amidas del acido pirrolotiazolcarboxilico y analogos relacionadas como inhibidores de la caseina cinasa i - Google Patents

Amidas sustituidas de acido tienopirrolcarboxilico, amidas del acido pirrolotiazolcarboxilico y analogos relacionadas como inhibidores de la caseina cinasa i

Info

Publication number
PA8642801A1
PA8642801A1 PA20058642801A PA8642801A PA8642801A1 PA 8642801 A1 PA8642801 A1 PA 8642801A1 PA 20058642801 A PA20058642801 A PA 20058642801A PA 8642801 A PA8642801 A PA 8642801A PA 8642801 A1 PA8642801 A1 PA 8642801A1
Authority
PA
Panama
Prior art keywords
amidas
acid
caseina
cinasa
inhibitors
Prior art date
Application number
PA20058642801A
Other languages
English (en)
Inventor
David Marc Fink
Yulin Chiang
Nicola Dawn Collar
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of PA8642801A1 publication Critical patent/PA8642801A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION DESCRIBE Y REIVINDICA COMPUESTOS DE FORMULA (I) Y FORMULA (II), COMO INHIBIDORES DE LA CASEINA CINASA IE HUMANA Y METODOS PARA UTILIZAR DICHOS COMPUESTOS PARA TRATAR ENFERMEDADES Y TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, INCLUYENDO TRASTORNOS DEL ANIMO Y TRASTORNOS DEL SUENO. TAMBIEN SE DESCRIBEN Y SE REIVINDICAN COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN COMPUESTOS DE FORMULA (I) O FORMULA (II) Y UN METODO DE PREPARACION DE COMPUESTOS DE FORMULA (I) O FORMULA (II).
PA20058642801A 2004-08-19 2005-08-19 Amidas sustituidas de acido tienopirrolcarboxilico, amidas del acido pirrolotiazolcarboxilico y analogos relacionadas como inhibidores de la caseina cinasa i PA8642801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60334704P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
PA8642801A1 true PA8642801A1 (es) 2006-05-16

Family

ID=35695546

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058642801A PA8642801A1 (es) 2004-08-19 2005-08-19 Amidas sustituidas de acido tienopirrolcarboxilico, amidas del acido pirrolotiazolcarboxilico y analogos relacionadas como inhibidores de la caseina cinasa i

Country Status (31)

Country Link
US (2) US7393867B2 (es)
EP (1) EP1784409B1 (es)
JP (1) JP4869232B2 (es)
KR (1) KR20070045263A (es)
CN (1) CN100562521C (es)
AR (1) AR051008A1 (es)
AT (1) ATE471326T1 (es)
AU (1) AU2005272584B2 (es)
BR (1) BRPI0514419A (es)
CA (1) CA2577879C (es)
CY (1) CY1110775T1 (es)
DE (1) DE602005021889D1 (es)
DK (1) DK1784409T3 (es)
ES (1) ES2347166T3 (es)
GT (1) GT200500215A (es)
HK (1) HK1105198A1 (es)
HR (1) HRP20100475T1 (es)
IL (1) IL181158A0 (es)
JO (1) JO2629B1 (es)
MY (1) MY139831A (es)
PA (1) PA8642801A1 (es)
PE (1) PE20060630A1 (es)
PL (1) PL1784409T3 (es)
PT (1) PT1784409E (es)
RS (1) RS51413B (es)
RU (1) RU2403257C2 (es)
SI (1) SI1784409T1 (es)
SV (1) SV2006002190A (es)
TW (1) TWI372149B (es)
UY (1) UY29077A1 (es)
WO (1) WO2006021000A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361862C2 (ru) 2003-12-29 2009-07-20 Сепракор Инк. Пиррольные и пиразольные ингибиторы daao
NZ569630A (en) 2006-01-06 2011-09-30 Sepracor Inc Cycloalkylamines as monoamine reuptake inhibitors
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
DK2013835T3 (en) 2006-03-31 2015-12-14 Sunovion Pharmaceuticals Inc Preparation of chiral amides and AMINES
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
EP1955699A1 (en) * 2007-02-08 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Use of flibanserin for the treatment of insomnia
WO2008151156A1 (en) 2007-05-31 2008-12-11 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US9018238B2 (en) 2009-02-12 2015-04-28 Pharmadesign, Inc. Inhibitor of casein kinase 1δ and casein kinase 1ε
EP2435443B1 (en) * 2009-05-28 2013-07-31 Vertex Pharmaceuticals Incorporated Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase
WO2011051858A1 (en) * 2009-10-28 2011-05-05 Pfizer Inc. Imidazole derivatives as casein kinase inhibitors
DE102009058280A1 (de) * 2009-12-14 2011-06-16 Merck Patent Gmbh Thiazolderivate
KR101856266B1 (ko) * 2010-08-09 2018-05-09 가부시키가이샤 에누비 켄코우겡큐쇼 카세인 키나아제 1δ 및 카세인 키나아제 1ε 저해제
CN109748927A (zh) * 2017-11-03 2019-05-14 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ514603A (en) * 1999-06-08 2003-10-31 Aventis Pharma Inc Test compounds that alter the ability of human casein kinase 1 delta and/or epsilon to phosphorylate the human clock proteins
SI1747220T1 (sl) * 2003-12-11 2009-08-31 Aventis Pharma Inc Substituirani 1H-pirolo(3,2-b, 3,2-c in 2,3-c)piridin-2-karboksamidi in sorodni analogi kot inhibitorji kazein kinaze I epsilon

Also Published As

Publication number Publication date
AU2005272584A1 (en) 2006-02-23
JP2008510712A (ja) 2008-04-10
PL1784409T3 (pl) 2010-10-29
RU2007109812A (ru) 2008-09-27
AU2005272584B2 (en) 2010-11-11
JO2629B1 (en) 2012-06-24
GT200500215A (es) 2006-03-27
TWI372149B (en) 2012-09-11
HRP20100475T1 (hr) 2010-10-31
WO2006021000A3 (en) 2006-06-15
WO2006021000A2 (en) 2006-02-23
BRPI0514419A (pt) 2008-06-10
CN100562521C (zh) 2009-11-25
RS51413B (en) 2011-02-28
US7652046B2 (en) 2010-01-26
US7393867B2 (en) 2008-07-01
EP1784409A2 (en) 2007-05-16
US20080227822A1 (en) 2008-09-18
KR20070045263A (ko) 2007-05-02
UY29077A1 (es) 2006-03-31
SI1784409T1 (sl) 2010-10-29
ES2347166T3 (es) 2010-10-26
RU2403257C2 (ru) 2010-11-10
IL181158A0 (en) 2007-07-04
PE20060630A1 (es) 2006-08-03
CA2577879A1 (en) 2006-02-23
DK1784409T3 (da) 2010-09-27
CA2577879C (en) 2011-07-12
ATE471326T1 (de) 2010-07-15
CN101001861A (zh) 2007-07-18
DE602005021889D1 (en) 2010-07-29
TW200621788A (en) 2006-07-01
AR051008A1 (es) 2006-12-13
US20070299112A1 (en) 2007-12-27
SV2006002190A (es) 2006-05-24
PT1784409E (pt) 2010-09-06
CY1110775T1 (el) 2015-06-10
EP1784409B1 (en) 2010-06-16
MY139831A (en) 2009-10-30
JP4869232B2 (ja) 2012-02-08
HK1105198A1 (en) 2008-02-06

Similar Documents

Publication Publication Date Title
PA8642801A1 (es) Amidas sustituidas de acido tienopirrolcarboxilico, amidas del acido pirrolotiazolcarboxilico y analogos relacionadas como inhibidores de la caseina cinasa i
BR112018008966A2 (pt) compostos inibidores de jak quinase para o tratamento de doença respiratória
EA202091267A1 (ru) 1,2,4-оксадиазольные соединения в качестве ингибиторов сигнальных путей cd47
BR112015028501B8 (pt) Compostos derivados de bipirazol, seus sais, composição compreendendo o composto ou o sal, método de inibição in vitro de uma atividade de jak1, e processo de preparação de sal de ácido fosfórico
CL2020001576A1 (es) Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5.
EA201992601A1 (ru) Конденсированное имидазопиперидиновое соединение, являющееся ингибитором jak
BR112018070956A2 (pt) compostos da fórmula, composições farmacêuticas e métodos para distribuir um ácido nucleico para o fígado de um animal e para preparar um composto da fórmula
UY28482A1 (es) Nuevos compuestos
GT200600193A (es) Imidazoquinolines como inhibidores de lipidos kinase
BR112015022462A2 (pt) inibidores de ido
BRPI0512683A (pt) compostos anti-virais
MX353461B (es) PROCESOS PARA PREPARAR COMPUESTOS ÚTILES COMO INHIBIDORES DE CINASA ATAXIA TELANGIECTASIA MUTADA Y Rad3 RELACIONADOS (ATR).
HRP20070043A2 (en) Antiviral compounds
UY29223A1 (es) Ácidos fenoxiacéticos sustituidos, composiciones farmacéuticas que los contienen y procesos para su preparación
NZ764150A (en) Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
CR20140411A (es) Compuestos de indol e indazol que activan la ampk
BR112015028452A2 (pt) agonistas do receptor somastatina subtipo 4 (sstr4)
EA200701252A1 (ru) Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10
EA200702339A1 (ru) Замещенные амидные производные в качестве ингибиторов протеинкиназы
ECSP088414A (es) Derivados de ácido bifeniloxiacético para el tratamiento de una enfermedad respiratoria
BR112015002118A2 (pt) 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos
BR112014004560A2 (pt) compostos e composições como inibidores de c-kit quinase
HN2003000417A (es) Intermedio de formulacion aceptablemente no higroscopico que comprende un farmaco higroscopico
SV2009003212A (es) Inhibidores de metaloproteasa derivados de heterociclicos ref. prd2727svpct
EA201492283A1 (ru) Замещенные соединения пиразола в качестве антагонистов рецепторов лизофосфатидной кислоты (lpar)