AR086848A1 - Procedimiento de sintesis y forma cristalina del hidrocloruro de 4-{3-[cis-hexahidrociclopenta[c]pirrol-2-(1h)-il]propoxi}benzamida asi como las composiciones farmaceuticas que la contienen - Google Patents
Procedimiento de sintesis y forma cristalina del hidrocloruro de 4-{3-[cis-hexahidrociclopenta[c]pirrol-2-(1h)-il]propoxi}benzamida asi como las composiciones farmaceuticas que la contienenInfo
- Publication number
- AR086848A1 AR086848A1 ARP120102010A ARP120102010A AR086848A1 AR 086848 A1 AR086848 A1 AR 086848A1 AR P120102010 A ARP120102010 A AR P120102010A AR P120102010 A ARP120102010 A AR P120102010A AR 086848 A1 AR086848 A1 AR 086848A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- group
- hexahydrociclopenta
- propoxi
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Medicamentos.Reivindicación 1: Procedimiento de síntesis industrial del compuesto de fórmula (1), caracterizado porque el compuesto de fórmula (2) reacciona con el amoniaco a una temperatura superior a 100ºC para formar el compuesto de fórmula (3) que se reduce para dar lugar a la amina bicíclica de fórmula (4); este último compuesto se somete posteriormente: bien a una reacción de acoplamiento en condición básica en un medio polar con un compuesto de fórmula (5), en la que Y representa un -CH2-Hal en el que Hal es un halógeno, o un grupo -CH2-OSO2-R en el que R es un grupo alquilo C1-6 o un grupo -C6H4-CH3; bien a una aminación reductora en medio ácido con un compuesto de fórmula (6), en la que R’ y R’’ representan independientemente el uno del otro un grupo alquilo C1-6 o bien R’ y R’’ forman juntos un grupo -(CH2)n- en el que n = 2 - 3, o bien uno de los grupos R’ o R’’ representan un átomo de hidrógeno y el otro un grupo alquilo C1-6; bien a una aminación reductora con un compuesto de fórmula (7), para dar lugar a la base libre del compuesto de fórmula (1), la cual se pone en presencia de ácido clorhídrico para formar el compuesto de fórmula (1) que se aísla en la forma de un sólido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1101746A FR2976285B1 (fr) | 2011-06-08 | 2011-06-08 | Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086848A1 true AR086848A1 (es) | 2014-01-29 |
Family
ID=46172744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120102010A AR086848A1 (es) | 2011-06-08 | 2012-06-07 | Procedimiento de sintesis y forma cristalina del hidrocloruro de 4-{3-[cis-hexahidrociclopenta[c]pirrol-2-(1h)-il]propoxi}benzamida asi como las composiciones farmaceuticas que la contienen |
Country Status (43)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3003466B1 (fr) | 2013-03-22 | 2015-08-07 | Servier Lab | Utilisation du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide pour le traitement des douleurs neuropathiques |
| CN103601666B (zh) * | 2013-11-28 | 2015-09-02 | 遵义医学院 | 八氢环戊烷[c]吡咯的制备方法 |
| CN104387313B (zh) * | 2014-10-22 | 2015-12-30 | 滨海博大化工有限公司 | 一种1,2-环戊二甲酰亚胺的制备方法 |
| KR101966221B1 (ko) * | 2017-06-14 | 2019-04-12 | 최상근 | 유해가스 처리 장치 |
| CN115232058A (zh) * | 2022-08-01 | 2022-10-25 | 上海巽田科技股份有限公司 | 一种格列齐特中间体1,2-环戊二甲酰胺的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US756120A (en) * | 1902-07-28 | 1904-03-29 | Krupp Gmbh | Recoil-gun with special devices for protecting the slide-tracks from dust. |
| NL132376C (es) * | 1966-02-10 | |||
| US4895840A (en) * | 1987-06-10 | 1990-01-23 | A. H. Robins Company, Incorporated | N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines |
| CN1314340A (zh) * | 2000-03-21 | 2001-09-26 | 山东省医药工业研究所 | 环戊烷酰亚胺的制备方法 |
| FR2866647B1 (fr) * | 2004-02-20 | 2006-10-27 | Servier Lab | Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN100424077C (zh) * | 2005-06-07 | 2008-10-08 | 台州市四维化工厂 | 一种环戊烷1，2-二酰亚胺的制备方法 |
| FR2937251B1 (fr) * | 2008-10-16 | 2011-03-18 | Servier Lab | Utilisation du 4-{3-°hexahydrocyclopenta°c!pyrrol-2(1h)-yl! propoxy}benzamide pour l'obtention de medicaments destines au traitement des troubles du sommeil |
| KR20110091784A (ko) * | 2008-11-26 | 2011-08-12 | 아보트 러보러터리즈 | 칼슘 채널 차단제로서의 치환된 옥타하이드로사이클로펜타［ｃ］피롤4아민 |
| FR2953515B1 (fr) * | 2009-12-09 | 2011-12-23 | Servier Lab | Nouveaux derives du type hexahydrocyclopenta[b]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2974729B1 (fr) * | 2011-05-02 | 2013-04-19 | Servier Lab | Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent |
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2011
- 2011-06-08 FR FR1101746A patent/FR2976285B1/fr not_active Expired - Fee Related
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2012
- 2012-05-22 PE PE2012000695A patent/PE20130046A1/es not_active Application Discontinuation
- 2012-05-22 IL IL219925A patent/IL219925A0/en unknown
- 2012-05-23 CR CR20120274A patent/CR20120274A/es unknown
- 2012-05-24 SG SG2012038055A patent/SG186546A1/en unknown
- 2012-05-24 TN TNP2012000254A patent/TN2012000254A1/fr unknown
- 2012-05-24 AU AU2012203062A patent/AU2012203062B2/en not_active Expired - Fee Related
- 2012-05-28 AP AP2012006280A patent/AP2012006280A0/xx unknown
- 2012-05-30 CA CA2779045A patent/CA2779045C/fr not_active Expired - Fee Related
- 2012-05-31 CU CU2012000087A patent/CU20120087A7/es unknown
- 2012-05-31 UY UY0001034110A patent/UY34110A/es unknown
- 2012-06-01 EC ECSP12011941 patent/ECSP12011941A/es unknown
- 2012-06-04 MA MA34937A patent/MA33883B1/fr unknown
- 2012-06-05 BR BRBR102012013573-6A patent/BR102012013573A2/pt not_active IP Right Cessation
- 2012-06-05 GE GEAP201212735A patent/GEP20156395B/en unknown
- 2012-06-05 KR KR1020120060635A patent/KR20120136296A/ko active IP Right Grant
- 2012-06-06 US US13/489,691 patent/US8664408B2/en not_active Expired - Fee Related
- 2012-06-06 CO CO12095647A patent/CO6580197A1/es unknown
- 2012-06-06 SV SV2012004237A patent/SV2012004237A/es unknown
- 2012-06-07 RS RS20150642A patent/RS54279B1/en unknown
- 2012-06-07 ES ES12171118.8T patent/ES2554933T3/es active Active
- 2012-06-07 HU HUE12171118A patent/HUE028050T2/en unknown
- 2012-06-07 MX MX2012006525A patent/MX2012006525A/es not_active Application Discontinuation
- 2012-06-07 AR ARP120102010A patent/AR086848A1/es unknown
- 2012-06-07 ZA ZA2012/04183A patent/ZA201204183B/en unknown
- 2012-06-07 PL PL12171118T patent/PL2532651T3/pl unknown
- 2012-06-07 GT GT201200182A patent/GT201200182A/es unknown
- 2012-06-07 EP EP12171118.8A patent/EP2532651B1/fr active Active
- 2012-06-07 SI SI201230309T patent/SI2532651T1/sl unknown
- 2012-06-07 CL CL2012001500A patent/CL2012001500A1/es unknown
- 2012-06-07 JP JP2012129440A patent/JP5680022B2/ja not_active Expired - Fee Related
- 2012-06-07 DK DK12171118.8T patent/DK2532651T3/en active
- 2012-06-07 MD MDA20120049A patent/MD4345C1/ro not_active IP Right Cessation
- 2012-06-07 ME MEP-2015-148A patent/ME02346B/me unknown
- 2012-06-07 TW TW101120546A patent/TWI499584B/zh not_active IP Right Cessation
- 2012-06-07 WO PCT/FR2012/051272 patent/WO2012168657A1/fr active Application Filing
- 2012-06-07 RU RU2013158817/04A patent/RU2013158817A/ru not_active Application Discontinuation
- 2012-06-07 PT PT121711188T patent/PT2532651E/pt unknown
- 2012-06-08 EA EA201200726A patent/EA022741B1/ru not_active IP Right Cessation
- 2012-06-08 NI NI201200102A patent/NI201200102A/es unknown
- 2012-06-08 CN CN201210189156XA patent/CN102816102A/zh active Pending
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2013
- 2013-12-11 US US14/103,006 patent/US8952179B2/en not_active Expired - Fee Related
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2014
- 2014-02-06 US US14/174,272 patent/US20140155453A1/en not_active Abandoned
- 2014-05-27 KR KR1020140063712A patent/KR20140079346A/ko not_active Application Discontinuation
- 2014-10-31 JP JP2014223181A patent/JP2015044840A/ja active Pending
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2015
- 2015-10-02 CY CY20151100875T patent/CY1116739T1/el unknown
- 2015-10-09 HR HRP20151073TT patent/HRP20151073T1/hr unknown
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