RU2127729C1 - Способ получения 7-триалкилсилил-баккатина iii - Google Patents

Способ получения 7-триалкилсилил-баккатина iii Download PDF

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Publication number
RU2127729C1
RU2127729C1 RU96120192/04A RU96120192A RU2127729C1 RU 2127729 C1 RU2127729 C1 RU 2127729C1 RU 96120192/04 A RU96120192/04 A RU 96120192/04A RU 96120192 A RU96120192 A RU 96120192A RU 2127729 C1 RU2127729 C1 RU 2127729C1
Authority
RU
Russia
Prior art keywords
baccatin iii
trialkylsilyl
deacetyl
iii
general formula
Prior art date
Application number
RU96120192/04A
Other languages
English (en)
Russian (ru)
Other versions
RU96120192A (ru
Inventor
Бастар Жан-Пьер (FR)
Бастар Жан-Пьер
Леконт Жан-Пьер (FR)
Леконт Жан-Пьер
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of RU96120192A publication Critical patent/RU96120192A/ru
Application granted granted Critical
Publication of RU2127729C1 publication Critical patent/RU2127729C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Silicon Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Peptides Or Proteins (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Saccharide Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
  • Silicon Polymers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU96120192/04A 1994-04-05 1995-04-03 Способ получения 7-триалкилсилил-баккатина iii RU2127729C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9403979 1994-04-05
FR9403979A FR2718137B1 (fr) 1994-04-05 1994-04-05 Procédé de préparation de trialcoylsilyl-7 baccatine III.
PCT/FR1995/000419 WO1995026967A1 (fr) 1994-04-05 1995-04-03 Procede de preparation de trialcoylsilyl-7 baccatine iii

Publications (2)

Publication Number Publication Date
RU96120192A RU96120192A (ru) 1998-11-20
RU2127729C1 true RU2127729C1 (ru) 1999-03-20

Family

ID=9461745

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96120192/04A RU2127729C1 (ru) 1994-04-05 1995-04-03 Способ получения 7-триалкилсилил-баккатина iii

Country Status (33)

Country Link
US (1) US5670658A (https=)
EP (1) EP0754185B1 (https=)
JP (1) JP3718225B2 (https=)
KR (1) KR100399246B1 (https=)
CN (1) CN1058497C (https=)
AT (1) ATE160351T1 (https=)
AU (1) AU683560B2 (https=)
BG (1) BG62735B1 (https=)
BR (1) BR9507444A (https=)
CA (1) CA2186916C (https=)
CZ (1) CZ288397B6 (https=)
DE (1) DE69501080T2 (https=)
DK (1) DK0754185T3 (https=)
EE (1) EE03240B1 (https=)
ES (1) ES2109103T3 (https=)
FI (1) FI115970B (https=)
FR (1) FR2718137B1 (https=)
GE (1) GEP19991537B (https=)
GR (1) GR3025448T3 (https=)
HU (1) HU214158B (https=)
LT (1) LT4185B (https=)
LV (1) LV11691B (https=)
MX (1) MX9604466A (https=)
NO (1) NO305839B1 (https=)
NZ (1) NZ284490A (https=)
PL (1) PL316588A1 (https=)
RO (1) RO115631B1 (https=)
RU (1) RU2127729C1 (https=)
SK (1) SK280448B6 (https=)
TW (1) TW284765B (https=)
UA (1) UA44730C2 (https=)
WO (1) WO1995026967A1 (https=)
ZA (1) ZA952733B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2285000C2 (ru) * 2001-10-19 2006-10-10 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната
RU2291866C2 (ru) * 2001-10-19 2007-01-20 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
CA2302699A1 (en) 1997-08-21 1999-02-25 Florida State University Method for the synthesis of taxanes
HUP0302599A3 (en) 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
JP2006513152A (ja) * 2002-10-09 2006-04-20 ファイトジェン ライフ サイエンシズ インコーポレイテッド 新規タキサンならびにその使用および調製に関する方法
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
BRPI0511109A (pt) * 2004-05-14 2007-11-27 Immunogen Inc método fácil para sintetizar compostos de baccatin iii
CZ298333B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy 7-trialkylsilylbaccatinu III
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088391A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Non-ring hydroxy substituted taxanes and methods for synthesizing the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4823167A (en) * 1986-12-16 1989-04-18 Baxter International Inc. Catheter calibration device
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5597931A (en) * 1992-03-30 1997-01-28 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US5449790A (en) * 1994-04-06 1995-09-12 Hauser Chemical Research, Inc. Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.h.Denis et al, "Highry efficient prartical apporoch to natural taxol", 1988, 110, с.5917-19. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2285000C2 (ru) * 2001-10-19 2006-10-10 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната
RU2291866C2 (ru) * 2001-10-19 2007-01-20 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната

Also Published As

Publication number Publication date
WO1995026967A1 (fr) 1995-10-12
HU214158B (hu) 1998-01-28
NO305839B1 (no) 1999-08-02
CZ288397B6 (en) 2001-06-13
LT96137A (en) 1997-02-25
LT4185B (en) 1997-07-25
CN1058497C (zh) 2000-11-15
KR100399246B1 (ko) 2004-02-11
HUT76035A (en) 1997-06-30
TW284765B (https=) 1996-09-01
FI964001L (fi) 1996-10-04
BR9507444A (pt) 1997-09-16
SK126596A3 (en) 1997-04-09
PL316588A1 (en) 1997-01-20
LV11691A (lv) 1997-02-20
EP0754185A1 (fr) 1997-01-22
EE03240B1 (et) 1999-12-15
GEP19991537B (en) 1999-03-05
DE69501080D1 (de) 1998-01-02
NO964103D0 (no) 1996-09-27
LV11691B (en) 1997-06-20
HU9602735D0 (en) 1996-11-28
US5670658A (en) 1997-09-23
BG100886A (en) 1998-01-30
ES2109103T3 (es) 1998-01-01
DE69501080T2 (de) 1998-04-02
DK0754185T3 (da) 1998-01-26
JPH09512522A (ja) 1997-12-16
FR2718137A1 (fr) 1995-10-06
FI115970B (fi) 2005-08-31
UA44730C2 (uk) 2002-03-15
SK280448B6 (sk) 2000-02-14
CZ290096A3 (en) 1997-01-15
FR2718137B1 (fr) 1996-04-26
AU2309695A (en) 1995-10-23
ATE160351T1 (de) 1997-12-15
CN1145073A (zh) 1997-03-12
GR3025448T3 (en) 1998-02-27
JP3718225B2 (ja) 2005-11-24
CA2186916A1 (fr) 1995-10-12
NO964103L (no) 1996-09-27
ZA952733B (en) 1996-01-09
CA2186916C (fr) 2004-05-25
NZ284490A (en) 1998-08-26
BG62735B1 (bg) 2000-06-30
AU683560B2 (en) 1997-11-13
RO115631B1 (ro) 2000-04-28
EP0754185B1 (fr) 1997-11-19
MX9604466A (es) 1997-07-31
FI964001A0 (fi) 1996-10-04

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