GEP19991537B - Process for Preparing 7-Trialkylsilyl Baccatin III - Google Patents
Process for Preparing 7-Trialkylsilyl Baccatin IIIInfo
- Publication number
- GEP19991537B GEP19991537B GEAP19953433A GEAP1995003433A GEP19991537B GE P19991537 B GEP19991537 B GE P19991537B GE AP19953433 A GEAP19953433 A GE AP19953433A GE AP1995003433 A GEAP1995003433 A GE AP1995003433A GE P19991537 B GEP19991537 B GE P19991537B
- Authority
- GE
- Georgia
- Prior art keywords
- preparing
- baccatin iii
- trialkylsilyl
- trialkylsilyl baccatin
- product
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- OVMSOCFBDVBLFW-VHLOTGQHSA-N (-)-Baccatin III Natural products O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 title 1
- 229930014667 baccatin III Natural products 0.000 title 1
- YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
- -1 acetate anhydride Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Silicon Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Peptides Or Proteins (AREA)
- Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
- Saccharide Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
- Cephalosporin Compounds (AREA)
- Steroid Compounds (AREA)
- Silicon Polymers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9403979A FR2718137B1 (fr) | 1994-04-05 | 1994-04-05 | Procédé de préparation de trialcoylsilyl-7 baccatine III. |
| PCT/FR1995/000419 WO1995026967A1 (fr) | 1994-04-05 | 1995-04-03 | Procede de preparation de trialcoylsilyl-7 baccatine iii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP19991537B true GEP19991537B (en) | 1999-03-05 |
Family
ID=9461745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP19953433A GEP19991537B (en) | 1994-04-05 | 1995-04-03 | Process for Preparing 7-Trialkylsilyl Baccatin III |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5670658A (https=) |
| EP (1) | EP0754185B1 (https=) |
| JP (1) | JP3718225B2 (https=) |
| KR (1) | KR100399246B1 (https=) |
| CN (1) | CN1058497C (https=) |
| AT (1) | ATE160351T1 (https=) |
| AU (1) | AU683560B2 (https=) |
| BG (1) | BG62735B1 (https=) |
| BR (1) | BR9507444A (https=) |
| CA (1) | CA2186916C (https=) |
| CZ (1) | CZ288397B6 (https=) |
| DE (1) | DE69501080T2 (https=) |
| DK (1) | DK0754185T3 (https=) |
| EE (1) | EE03240B1 (https=) |
| ES (1) | ES2109103T3 (https=) |
| FI (1) | FI115970B (https=) |
| FR (1) | FR2718137B1 (https=) |
| GE (1) | GEP19991537B (https=) |
| GR (1) | GR3025448T3 (https=) |
| HU (1) | HU214158B (https=) |
| LT (1) | LT4185B (https=) |
| LV (1) | LV11691B (https=) |
| MX (1) | MX9604466A (https=) |
| NO (1) | NO305839B1 (https=) |
| NZ (1) | NZ284490A (https=) |
| PL (1) | PL316588A1 (https=) |
| RO (1) | RO115631B1 (https=) |
| RU (1) | RU2127729C1 (https=) |
| SK (1) | SK280448B6 (https=) |
| TW (1) | TW284765B (https=) |
| UA (1) | UA44730C2 (https=) |
| WO (1) | WO1995026967A1 (https=) |
| ZA (1) | ZA952733B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5973160A (en) * | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| CA2302699A1 (en) | 1997-08-21 | 1999-02-25 | Florida State University | Method for the synthesis of taxanes |
| HUP0302599A3 (en) | 2000-09-22 | 2005-05-30 | Bristol Myers Squibb Co | Method for reducing toxicity of combined chemotherapic compositions |
| ITMI20012185A1 (it) * | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato |
| ITMI20012186A1 (it) * | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato |
| JP2006513152A (ja) * | 2002-10-09 | 2006-04-20 | ファイトジェン ライフ サイエンシズ インコーポレイテッド | 新規タキサンならびにその使用および調製に関する方法 |
| US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
| BRPI0511109A (pt) * | 2004-05-14 | 2007-11-27 | Immunogen Inc | método fácil para sintetizar compostos de baccatin iii |
| CZ298333B6 (cs) * | 2005-09-26 | 2007-08-29 | Zentiva, A. S | Zpusob prípravy 7-trialkylsilylbaccatinu III |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| WO2012088391A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Non-ring hydroxy substituted taxanes and methods for synthesizing the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4823167A (en) * | 1986-12-16 | 1989-04-18 | Baxter International Inc. | Catheter calibration device |
| FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
| US5597931A (en) * | 1992-03-30 | 1997-01-28 | Sloan-Kettering Institute For Cancer Research | Total synthesis of taxol and analogues thereof |
| US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
| US5449790A (en) * | 1994-04-06 | 1995-09-12 | Hauser Chemical Research, Inc. | Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C |
-
1994
- 1994-04-05 FR FR9403979A patent/FR2718137B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-22 TW TW084102793A patent/TW284765B/zh not_active IP Right Cessation
- 1995-04-03 JP JP52546695A patent/JP3718225B2/ja not_active Expired - Lifetime
- 1995-04-03 AT AT95916696T patent/ATE160351T1/de active
- 1995-04-03 RU RU96120192/04A patent/RU2127729C1/ru active
- 1995-04-03 US US08/722,103 patent/US5670658A/en not_active Expired - Lifetime
- 1995-04-03 EE EE9600143A patent/EE03240B1/xx unknown
- 1995-04-03 WO PCT/FR1995/000419 patent/WO1995026967A1/fr not_active Ceased
- 1995-04-03 BR BR9507444A patent/BR9507444A/pt not_active IP Right Cessation
- 1995-04-03 KR KR1019960705642A patent/KR100399246B1/ko not_active Expired - Fee Related
- 1995-04-03 PL PL95316588A patent/PL316588A1/xx unknown
- 1995-04-03 NZ NZ284490A patent/NZ284490A/en not_active IP Right Cessation
- 1995-04-03 RO RO96-01921A patent/RO115631B1/ro unknown
- 1995-04-03 HU HU9602735A patent/HU214158B/hu unknown
- 1995-04-03 DE DE69501080T patent/DE69501080T2/de not_active Expired - Lifetime
- 1995-04-03 UA UA96093735A patent/UA44730C2/uk unknown
- 1995-04-03 AU AU23096/95A patent/AU683560B2/en not_active Expired
- 1995-04-03 SK SK1265-96A patent/SK280448B6/sk not_active IP Right Cessation
- 1995-04-03 MX MX9604466A patent/MX9604466A/es unknown
- 1995-04-03 ES ES95916696T patent/ES2109103T3/es not_active Expired - Lifetime
- 1995-04-03 GE GEAP19953433A patent/GEP19991537B/en unknown
- 1995-04-03 CZ CZ19962900A patent/CZ288397B6/cs not_active IP Right Cessation
- 1995-04-03 EP EP95916696A patent/EP0754185B1/fr not_active Expired - Lifetime
- 1995-04-03 CA CA002186916A patent/CA2186916C/fr not_active Expired - Lifetime
- 1995-04-03 ZA ZA952733A patent/ZA952733B/xx unknown
- 1995-04-03 DK DK95916696.8T patent/DK0754185T3/da active
- 1995-04-03 CN CN95192429A patent/CN1058497C/zh not_active Expired - Lifetime
-
1996
- 1996-09-24 LT LT96-137A patent/LT4185B/lt not_active IP Right Cessation
- 1996-09-27 NO NO964103A patent/NO305839B1/no not_active IP Right Cessation
- 1996-10-04 BG BG100886A patent/BG62735B1/bg unknown
- 1996-10-04 FI FI964001A patent/FI115970B/fi not_active IP Right Cessation
- 1996-10-07 LV LVP-96-392A patent/LV11691B/lv unknown
-
1997
- 1997-11-20 GR GR970401504T patent/GR3025448T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GEP19991537B (en) | Process for Preparing 7-Trialkylsilyl Baccatin III | |
| DE69112463D1 (de) | Vorrichtung zur Herstellung von Monokristallen nach dem Czochralski-Verfahren. | |
| SU915807A3 (en) | Process for producing derivatives of cyclodextrin | |
| IT7927487A0 (it) | Procedimento per la produzione di acidi treo-3-ammino-2-idrossibutanoilammi noacetici nonche' di loro nuovi intermedi. | |
| DE69809962D1 (de) | Verfahren zur herstellung von hydroxysubstituierten gamma-butyrolactonen | |
| GB2035380B (en) | Process for the chemical deposition of gold by autocatalytic reduction | |
| GEP19991748B (en) | Paclitaxel Synthesis from Precursor Compounds and Methods of Producing the Same | |
| MY117381A (en) | Use of 1-hydroxy-2-pyridone for the treatment of seborrheic dermatitis | |
| IL57005A (en) | Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor | |
| MY107160A (en) | N-aryl-3-aryl-4-substituted-4,5-dihydro-1h-pyrazole-1- carboxamides and processes for their production. | |
| YU13499A (sh) | Primena 1-hidroksi-2-piridona za lečenje seboroitičnog dermatitisa | |
| JPS5585552A (en) | New lactyltetrapeptide | |
| CS470587A2 (en) | Method of 4-hydroxypyrrolidine-2-on-1-ylacetamide production | |
| RU95108602A (ru) | Способ получения динитротолуола | |
| GEP19991535B (en) | Process for the Preparation of 7-Hydroxy Taxanes | |
| GB2036590B (en) | Process and apparatus for the production of ga a1 as:si epitaxial coatings | |
| FI902590A0 (fi) | Foerfarande foer framstaellning av 2-oxoindol-1-karboxamider. | |
| DE3563436D1 (en) | Methyl substituted bicyclo ad2.2.1 bdheptane nitriles, process for production of these nitriles and their use as scents | |
| FR2426664A1 (fr) | Hydrocarbures polyhalogenes utiles notamment comme composes intermediaires pour insecticides et leur procede de production | |
| JPS5759883A (en) | Production of chromone-3-carboxylic acid | |
| JPS53133688A (en) | Preparation of d-n-carbamyl phenylglycine and its substitution derivative | |
| JPS51128952A (en) | Process for preparing bicyclo (3,1,0) hexane-2-one derivatives | |
| JPS5419985A (en) | Production of hydroxycarbostyril derivative | |
| JPS55133393A (en) | Validoxylamine a derivative | |
| JPS5775988A (en) | Novel cephem compound and its preparation |