RU2127729C1 - Способ получения 7-триалкилсилил-баккатина iii - Google Patents

Способ получения 7-триалкилсилил-баккатина iii Download PDF

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Publication number
RU2127729C1
RU2127729C1 RU96120192/04A RU96120192A RU2127729C1 RU 2127729 C1 RU2127729 C1 RU 2127729C1 RU 96120192/04 A RU96120192/04 A RU 96120192/04A RU 96120192 A RU96120192 A RU 96120192A RU 2127729 C1 RU2127729 C1 RU 2127729C1
Authority
RU
Russia
Prior art keywords
baccatin iii
trialkylsilyl
deacetyl
iii
general formula
Prior art date
Application number
RU96120192/04A
Other languages
English (en)
Russian (ru)
Other versions
RU96120192A (ru
Inventor
Бастар Жан-Пьер (FR)
Бастар Жан-Пьер
Леконт Жан-Пьер (FR)
Леконт Жан-Пьер
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of RU96120192A publication Critical patent/RU96120192A/ru
Application granted granted Critical
Publication of RU2127729C1 publication Critical patent/RU2127729C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Silicon Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Cephalosporin Compounds (AREA)
  • Silicon Polymers (AREA)
  • Steroid Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
RU96120192/04A 1994-04-05 1995-04-03 Способ получения 7-триалкилсилил-баккатина iii RU2127729C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9403979A FR2718137B1 (fr) 1994-04-05 1994-04-05 Procédé de préparation de trialcoylsilyl-7 baccatine III.
FR9403979 1994-04-05
PCT/FR1995/000419 WO1995026967A1 (fr) 1994-04-05 1995-04-03 Procede de preparation de trialcoylsilyl-7 baccatine iii

Publications (2)

Publication Number Publication Date
RU96120192A RU96120192A (ru) 1998-11-20
RU2127729C1 true RU2127729C1 (ru) 1999-03-20

Family

ID=9461745

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96120192/04A RU2127729C1 (ru) 1994-04-05 1995-04-03 Способ получения 7-триалкилсилил-баккатина iii

Country Status (33)

Country Link
US (1) US5670658A (enExample)
EP (1) EP0754185B1 (enExample)
JP (1) JP3718225B2 (enExample)
KR (1) KR100399246B1 (enExample)
CN (1) CN1058497C (enExample)
AT (1) ATE160351T1 (enExample)
AU (1) AU683560B2 (enExample)
BG (1) BG62735B1 (enExample)
BR (1) BR9507444A (enExample)
CA (1) CA2186916C (enExample)
CZ (1) CZ288397B6 (enExample)
DE (1) DE69501080T2 (enExample)
DK (1) DK0754185T3 (enExample)
EE (1) EE03240B1 (enExample)
ES (1) ES2109103T3 (enExample)
FI (1) FI115970B (enExample)
FR (1) FR2718137B1 (enExample)
GE (1) GEP19991537B (enExample)
GR (1) GR3025448T3 (enExample)
HU (1) HU214158B (enExample)
LT (1) LT4185B (enExample)
LV (1) LV11691B (enExample)
MX (1) MX9604466A (enExample)
NO (1) NO305839B1 (enExample)
NZ (1) NZ284490A (enExample)
PL (1) PL316588A1 (enExample)
RO (1) RO115631B1 (enExample)
RU (1) RU2127729C1 (enExample)
SK (1) SK280448B6 (enExample)
TW (1) TW284765B (enExample)
UA (1) UA44730C2 (enExample)
WO (1) WO1995026967A1 (enExample)
ZA (1) ZA952733B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2285000C2 (ru) * 2001-10-19 2006-10-10 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната
RU2291866C2 (ru) * 2001-10-19 2007-01-20 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
EP1019347B1 (en) * 1997-08-21 2003-03-19 Florida State University Method for the synthesis of taxanes
JP2004525860A (ja) 2000-09-22 2004-08-26 ブリストル−マイヤーズ スクイブ カンパニー 併用化学療法剤の毒性を低下させる方法
AU2003273671A1 (en) * 2002-10-09 2004-05-04 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2005113528A1 (en) * 2004-05-14 2005-12-01 Immunogen, Inc. A facile method for synthesizing baccatin iii compounds
CZ298333B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy 7-trialkylsilylbaccatinu III
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US9199954B2 (en) 2010-12-22 2015-12-01 Nektar Therapeutics Non-ring hydroxy substituted taxanes and methods for synthesizing the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4823167A (en) * 1986-12-16 1989-04-18 Baxter International Inc. Catheter calibration device
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5597931A (en) * 1992-03-30 1997-01-28 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US5449790A (en) * 1994-04-06 1995-09-12 Hauser Chemical Research, Inc. Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.h.Denis et al, "Highry efficient prartical apporoch to natural taxol", 1988, 110, с.5917-19. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2285000C2 (ru) * 2001-10-19 2006-10-10 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната
RU2291866C2 (ru) * 2001-10-19 2007-01-20 Индена С.П.А. Способ получения 14бета-гидроксибаккатин iii-1,14-карбоната

Also Published As

Publication number Publication date
ES2109103T3 (es) 1998-01-01
SK280448B6 (sk) 2000-02-14
LT96137A (en) 1997-02-25
CN1058497C (zh) 2000-11-15
LV11691A (lv) 1997-02-20
FR2718137B1 (fr) 1996-04-26
BR9507444A (pt) 1997-09-16
TW284765B (enExample) 1996-09-01
FI964001A0 (fi) 1996-10-04
BG62735B1 (bg) 2000-06-30
CA2186916C (fr) 2004-05-25
MX9604466A (es) 1997-07-31
ATE160351T1 (de) 1997-12-15
FI115970B (fi) 2005-08-31
UA44730C2 (uk) 2002-03-15
EP0754185A1 (fr) 1997-01-22
AU2309695A (en) 1995-10-23
GEP19991537B (en) 1999-03-05
LT4185B (en) 1997-07-25
EP0754185B1 (fr) 1997-11-19
FR2718137A1 (fr) 1995-10-06
HUT76035A (en) 1997-06-30
CZ288397B6 (en) 2001-06-13
HU9602735D0 (en) 1996-11-28
NO964103D0 (no) 1996-09-27
HU214158B (hu) 1998-01-28
AU683560B2 (en) 1997-11-13
DK0754185T3 (da) 1998-01-26
KR100399246B1 (ko) 2004-02-11
US5670658A (en) 1997-09-23
SK126596A3 (en) 1997-04-09
DE69501080T2 (de) 1998-04-02
RO115631B1 (ro) 2000-04-28
EE03240B1 (et) 1999-12-15
WO1995026967A1 (fr) 1995-10-12
JP3718225B2 (ja) 2005-11-24
ZA952733B (en) 1996-01-09
CZ290096A3 (en) 1997-01-15
NO305839B1 (no) 1999-08-02
NZ284490A (en) 1998-08-26
CN1145073A (zh) 1997-03-12
CA2186916A1 (fr) 1995-10-12
LV11691B (en) 1997-06-20
JPH09512522A (ja) 1997-12-16
BG100886A (en) 1998-01-30
DE69501080D1 (de) 1998-01-02
NO964103L (no) 1996-09-27
PL316588A1 (en) 1997-01-20
FI964001L (fi) 1996-10-04
GR3025448T3 (en) 1998-02-27

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