RU2018127242A - Пирролобензодиазепиновые конъюгаты - Google Patents
Пирролобензодиазепиновые конъюгаты Download PDFInfo
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- RU2018127242A RU2018127242A RU2018127242A RU2018127242A RU2018127242A RU 2018127242 A RU2018127242 A RU 2018127242A RU 2018127242 A RU2018127242 A RU 2018127242A RU 2018127242 A RU2018127242 A RU 2018127242A RU 2018127242 A RU2018127242 A RU 2018127242A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Claims (135)
1. Конъюгат формулы I
где L представляет собой звено, представляющее собой лиганд, D представляет собой звено, представляющее собой лекарственное соединение-линкер формулы II
либо:
(a) R10 и R11 образуют двойную азот-углеродную связь между атомами азота и углерода, с которыми они связаны; либо
(b) R10 представляет собой ОН, и R11 представляет собой:
р представляет собой целое число от 1 до 20.
2. Конъюгат по п. 1, отличающийся тем, что DL представляет собой DL-A
3. Конъюгат по п. 1, отличающийся тем, что DL представляет собой DL-B
4. Конъюгат по любому из пп. 1-3, отличающийся тем, что звено, проедставляющее собой лиганд, представляет собой антитело или его активный фрагмент.
5. Конъюгат по п. 4, отличающийся тем, что антитело или фрагмент антитела представляет собой антитело или фрагмент антитела к опухолеассоциированному антигену.
6. Конъюгат по п. 4, отличающийся тем, что антитело или фрагмент антитела представляет собой антитело, которое связывается с одним или более опухолеассоциированными антигенами или рецепторами клеточной поверхности, выбранными из (1)-(88):
(1) BMPR1B;
(2) E16;
(3) STEAP1;
(4) 0772Р;
(5) MPF;
(6) Napi3b;
(7) Sema 5b;
(8) PSCA hlg;
(9) ETBR;
(10) MSG783;
(11) STEAP2;
(12) TrpM4;
(13) CRIPTO;
(14) CD21;
(15) CD79b;
(16) FcRH2;
(17) HER2;
(18) NCA;
(19) MDP;
(20) IL20R-альфа;
(21) Brevican;
(22) EphB2R;
(23) ASLG659;
(24) PSCA;
(25) GEDA;
(26) BAFF-R;
(27) CD22;
(28) CD79a;
(29) CXCR5;
(30) HLA-DOB;
(31) P2X5;
(32) CD72;
(33) LY64;
(34) FcRH1;
(35) IRTA2;
(36) TENB2;
(37) PSMA-FOLH1;
(38) SST;
(38.1) SSTR2;
(38.2) SSTR5;
(38.3) SSTR1;
(38.4) SSTR3;
(38.5) SSTR4;
(39) ITGAV;
(40) ITGB6;
(41) CEACAM5;
(42) MET;
(43) MUC1;
(44) CA9;
(45) EGFRvIII;
(46) CD33;
(47) CD19;
(48) IL2RA;
(49) AXL;
(50) CD30 - TNFRSF8;
(51) BCMA - TNFRSF17;
(52) CT Ags - СТА;
(53) CD174 (Льюис Y) - FUT3;
(54) CLEC14A;
(55) GRP78 - HSPA5;
(56)CD70;
(57) Специфические антигены стволовых клеток;
(58) ASG-5;
(59) ENPP3;
(60) PRR4;
(61) GCC - GUCY2C;
(62) Liv-1 - SLC39A6;
(63) 5T4;
(64) CD56 - NCMA1;
(65) CanAg;
(66) FOLR1;
(67) GPNMB;
(68) TIM-1 - HAVCR1;
(69) RG-1/Мишень опухоли предстательной железы Mindin - Mindin/RG-1;
(70) B7-H4 - VTCN1;
(71) PTK7;
(72) CD37;
(73) CD138 - SDC1;
(74) CD74;
(75) Клаудины - CL;
(76) EGFR;
(77) Her3;
(78) RON - MST1R;
(79) EPHA2;
(80) CD20 - MS4A1;
(81) Тенасцин С - TNC;
(82) FAP;
(83) DKK-1;
(84) CD52;
(85) CS1 - SLAMF7;
(86) Эндоглин - ENG;
(87) Аннексии A1 - ANXA1;
(88) V-CAM (CD106) - VCAM1.
7. Конъюгат по любому из пп. 4-6, отличающийся тем, что антитело или фрагмент антитела представляет собой антитело со сконструированным цистеином.
8. Конъюгат по любому из пп. 1-7, отличающийся тем, что р представляет собой целое число от 1 до 8.
9. Конъюгат по п. 8, отличающийся тем, что р равен 1, 2, 3 или 4.
10. Композиция, содержащая смесь конъюгатов по любому из пп. 1-9, в которой среднее значение р в указанной смеси соединений-конъюгатов составляет от около 1 до около 8.
11. Конъюгат по любому из пп. 1-9 для применения в терапии.
12. Фармацевтическая композиция, содержащая конъюгат по любому из пп. 1-9, содержащая фармацевтически приемлемый разбавитель, носитель или вспомогательное вещество.
13. Конъюгат по любому из пп. 1-9 или фармацевтическая композиция по п. 12 для применения при лечении пролиферативного заболевания у субъекта.
14. Конъюгат для применения по п. 13, отличающийся тем, что заболевание, подлежащее лечению, представляет собой рак.
15. Применение конъюгата по любому из пп. 1-9 или фармацевтической композиции по п. 12 в способе медицинского лечения.
16. Способ медицинского лечения, включающий введение пациенту фармацевтической композиции по п. 12.
17. Способ по п. 16, отличающийся тем, что способ медицинского лечения предназначен для лечения рака.
18. Способ по п. 17, отличающийся тем, что в комбинации с указанным конъюгатом пациенту вводят химиотерапевтический агент.
19. Применение конъюгата по любому из пп. 1-9 в способе производства лекарственного средства для лечения пролиферативного заболевания.
20. Способ лечения млекопитающего, страдающего от пролиферативного заболевания, включающий введение эффективного количества конъюгата по любому из пп. 1-9 или фармацевтической композиции по п. 12.
21. Соединение формулы III
где
либо
(a) R10 и R11 образуют двойную азот-углеродную связь между атомами азота и углерода, с которыми они связаны; либо
(b) R10 представляет собой ОН, и R11 представляет собой
22. Соединение по п. 21, представляющее собой А
23. Соединение по п. 21, представляющее собой В
24. Способ синтеза конъюгата по любому из пп. 1-9, включающий стадию конъюгирования соединения по любому из пп. 21-23 с клеточно-связывающим агентом.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1602356.6A GB201602356D0 (en) | 2016-02-10 | 2016-02-10 | Pyrrolobenzodiazepine Conjugates |
GB1602356.6 | 2016-02-10 | ||
PCT/EP2017/052988 WO2017137553A1 (en) | 2016-02-10 | 2017-02-10 | Pyrrolobenzodiazepine conjugates |
Publications (3)
Publication Number | Publication Date |
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RU2018127242A true RU2018127242A (ru) | 2020-03-10 |
RU2018127242A3 RU2018127242A3 (ru) | 2020-04-15 |
RU2744200C2 RU2744200C2 (ru) | 2021-03-03 |
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RU2018127242A RU2744200C2 (ru) | 2016-02-10 | 2017-02-10 | Пирролобензодиазепиновые конъюгаты |
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US (2) | US11517626B2 (ru) |
EP (1) | EP3413923B1 (ru) |
JP (1) | JP6970104B2 (ru) |
KR (1) | KR20180108597A (ru) |
CN (1) | CN108463253B (ru) |
AU (1) | AU2017216846B2 (ru) |
BR (1) | BR112018016418B1 (ru) |
CA (1) | CA3010552C (ru) |
CL (1) | CL2018002111A1 (ru) |
CO (1) | CO2018008340A2 (ru) |
ES (1) | ES2791316T3 (ru) |
GB (1) | GB201602356D0 (ru) |
IL (1) | IL260595B (ru) |
MX (1) | MX2018009546A (ru) |
MY (1) | MY197127A (ru) |
RU (1) | RU2744200C2 (ru) |
SG (1) | SG11201806485RA (ru) |
WO (1) | WO2017137553A1 (ru) |
ZA (1) | ZA201805526B (ru) |
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CN111065638B (zh) * | 2017-08-18 | 2021-04-09 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂䓬缀合物 |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
JP7177848B2 (ja) * | 2018-03-28 | 2022-11-24 | 田辺三菱製薬株式会社 | cMETモノクローナル結合剤の薬物複合体とその使用 |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
EP4013494A1 (en) | 2019-08-12 | 2022-06-22 | Regeneron Pharmaceuticals, Inc. | Macrophage stimulating 1 receptor (mst1r) variants and uses thereof |
US20240123081A1 (en) | 2019-10-25 | 2024-04-18 | Medimmune, Llc | Branched moiety for use in conjugates |
CA3192236A1 (en) | 2020-09-10 | 2022-03-17 | Tony Lahoutte | Antibody fragment against fap |
GB202015226D0 (en) | 2020-09-25 | 2020-11-11 | Adc Therapeutics S A | Pyrrol obenzodiazepine-antibody conugates and uses thereof |
US20230201366A1 (en) | 2021-11-19 | 2023-06-29 | Adc Therapeutics Sa | Anti-psma conjugates |
WO2023088963A1 (en) | 2021-11-19 | 2023-05-25 | Adc Therapeutics Sa | Anti-il-13ralpha2 conjugates |
WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
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JP2019504851A (ja) | 2019-02-21 |
ZA201805526B (en) | 2019-05-29 |
JP6970104B2 (ja) | 2021-11-24 |
CA3010552A1 (en) | 2017-08-17 |
US20210187117A1 (en) | 2021-06-24 |
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BR112018016418B1 (pt) | 2023-10-24 |
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AU2017216846B2 (en) | 2023-06-01 |
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CA3010552C (en) | 2023-12-12 |
EP3413923B1 (en) | 2020-04-08 |
RU2018127242A3 (ru) | 2020-04-15 |
WO2017137553A1 (en) | 2017-08-17 |
AU2017216846A1 (en) | 2018-08-02 |
GB201602356D0 (en) | 2016-03-23 |
RU2744200C2 (ru) | 2021-03-03 |
CN108463253A (zh) | 2018-08-28 |
BR112018016418A2 (pt) | 2018-12-26 |
EP3413923A1 (en) | 2018-12-19 |
CL2018002111A1 (es) | 2018-10-05 |
MY197127A (en) | 2023-05-26 |
CN108463253B (zh) | 2022-03-04 |
US11517626B2 (en) | 2022-12-06 |
CO2018008340A2 (es) | 2018-08-21 |
SG11201806485RA (en) | 2018-08-30 |
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