RU2017134863A - Многостадийный способ разделения - Google Patents

Многостадийный способ разделения Download PDF

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RU2017134863A
RU2017134863A RU2017134863A RU2017134863A RU2017134863A RU 2017134863 A RU2017134863 A RU 2017134863A RU 2017134863 A RU2017134863 A RU 2017134863A RU 2017134863 A RU2017134863 A RU 2017134863A RU 2017134863 A RU2017134863 A RU 2017134863A
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organic solvent
pufa
volume
parts
product
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RU2017134863A
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Адам КЕЛЛИХЕР
Ангус МОРРИСОН
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Басф Фарма (Калланиш) Лимитед
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterized by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B3/00—Refining fats or fatty oils
    • C11B3/10—Refining fats or fatty oils by adsorption
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B7/00—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils
    • C11B7/0008—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils by differences of solubilities, e.g. by extraction, by separation from a solution by means of anti-solvents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B7/00—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils
    • C11B7/0008—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils by differences of solubilities, e.g. by extraction, by separation from a solution by means of anti-solvents
    • C11B7/0033—Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils by differences of solubilities, e.g. by extraction, by separation from a solution by means of anti-solvents in solvents containing other heteroatoms in their molecule
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
    • A23D9/04—Working-up

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Fats And Perfumes (AREA)
  • Amplifiers (AREA)
  • Separation By Low-Temperature Treatments (AREA)

Claims (19)

1. Способ хроматографического разделения для получения продукта полиненасыщенных жирных кислот (PUFA) из подаваемой смеси, который включает:
(a) очистку подаваемой смеси на первом этапе хроматографического разделения с использованием в качестве элюента смеси воды и первого органического растворителя с получением промежуточного продукта; и
(b) очистку промежуточного продукта на втором этапе хроматографического разделения с использованием в качестве элюента смеси воды и второго органического растворителя с получением PUFA-продукта,
где второй органический растворитель отличается от первого органического растворителя и,
где первый этап хроматографического разделения включает введение подаваемой смеси в аппарат для хроматографии с псевдодвижущимся или реально движущимся слоем, а второй этап хроматографического разделения включает введение промежуточного продукта в аппарат для хроматографии с неподвижным слоем.
2. Способ по п. 1, где первый и второй органические растворители выбраны среди спиртов, простых эфиров, сложных эфиров, кетонов и нитрилов
3. Способ по п. 2, где кетон представляет собой ацетон, метилэтилкетон и метилизобутилкетон (MIBK), предпочтительно ацетон.
4. Способ по п. 1, где один из первого и второго органических растворителей представляет собой метанол.
5. Способ по п. 1, где второй органический растворитель представляет собой метанол.
6. Способ по п. 1, где соотношение первого органического растворителя и воды составляет от 99,9:0,1 до 75:25 частей по объему, предпочтительно от 99,5:0,5 до 80:20 частей по объему.
7. Способ по п. 1, где соотношение второго органического растворителя и воды составляет от 99,9:0,1 до 75:25 частей по объему, предпочтительно от 90:10 до 85:15 частей по объему.
8. Способ по п. 1, где второй органический растворитель представляет собой метанол, и соотношение метанола и воды составляет от 95:5 до 85:15 частей по объему, предпочтительно от 93:7 до 90:10 частей по объему.
9. Способ по п. 1, где PUFA-продукт представляет собой по меньшей мере одну из 3-ω-PUFA или по меньшей мере одну из производных 3-ω-PUFA.
10. Способ по п. 1, где PUFA-продукт представляет собой эйкозапентаеновую кислоту (EPA), докозагексаеновую кислоту (DHA), триглицерид ЕРА, триглицерид DHA, этиловый эфир EPA или этиловый эфир DHA.
11. Способ по п. 1, где PUFA-продукт представляет собой EPA или этиловый эфир EPA.
12. Способ по п. 1, где PUFA-продукт получают на втором этапе разделения с чистотой более 95% по массе, предпочтительно более 97% по массе, более предпочтительно более 98% по массе, еще более предпочтительно более 98,4% по массе.
13. Способ по п. 1, где первый органический растворитель представляет собой ацетон, а второй органический растворитель представляет собой метанол.
14. PUFA-продукт, полученный способом по любому из пп. 1-13.
15. Композиция, содержащая PUFA-продукт, полученный способом по любому из пп. 1-13.
RU2017134863A 2013-01-09 2014-01-09 Многостадийный способ разделения RU2017134863A (ru)

Applications Claiming Priority (4)

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US201361750389P 2013-01-09 2013-01-09
GB1300354.6 2013-01-09
GBGB1300354.6A GB201300354D0 (en) 2013-01-09 2013-01-09 Multi-step separation process
US61/750,389 2013-01-09

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US (4) US9694302B2 (ru)
EP (3) EP3170543B1 (ru)
JP (4) JP6228612B2 (ru)
KR (4) KR20190000386A (ru)
CN (2) CN104968404B (ru)
AU (2) AU2014204673B2 (ru)
BR (1) BR112015016529A2 (ru)
CA (3) CA3013488A1 (ru)
DK (2) DK2943261T3 (ru)
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GB (1) GB201300354D0 (ru)
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RU (2) RU2638206C2 (ru)
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