RU2012116362A - Кислотоустойчивые капсулы - Google Patents
Кислотоустойчивые капсулы Download PDFInfo
- Publication number
- RU2012116362A RU2012116362A RU2012116362/15A RU2012116362A RU2012116362A RU 2012116362 A RU2012116362 A RU 2012116362A RU 2012116362/15 A RU2012116362/15 A RU 2012116362/15A RU 2012116362 A RU2012116362 A RU 2012116362A RU 2012116362 A RU2012116362 A RU 2012116362A
- Authority
- RU
- Russia
- Prior art keywords
- water
- soluble film
- forming polymers
- aqueous composition
- gellan gum
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims abstract 11
- 239000000203 mixture Substances 0.000 claims abstract 29
- 229920000642 polymer Polymers 0.000 claims abstract 19
- 229920002148 Gellan gum Polymers 0.000 claims abstract 14
- 235000010492 gellan gum Nutrition 0.000 claims abstract 14
- 239000000216 gellan gum Substances 0.000 claims abstract 14
- 239000002253 acid Substances 0.000 claims abstract 9
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract 6
- 239000007787 solid Substances 0.000 claims abstract 6
- 108010010803 Gelatin Proteins 0.000 claims abstract 4
- 239000003125 aqueous solvent Substances 0.000 claims abstract 4
- 239000008273 gelatin Substances 0.000 claims abstract 4
- 229920000159 gelatin Polymers 0.000 claims abstract 4
- 235000019322 gelatine Nutrition 0.000 claims abstract 4
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract 2
- 239000004373 Pullulan Substances 0.000 claims abstract 2
- 229920001218 Pullulan Polymers 0.000 claims abstract 2
- 239000000796 flavoring agent Substances 0.000 claims abstract 2
- 235000019634 flavors Nutrition 0.000 claims abstract 2
- 235000013305 food Nutrition 0.000 claims abstract 2
- 231100000252 nontoxic Toxicity 0.000 claims abstract 2
- 230000003000 nontoxic effect Effects 0.000 claims abstract 2
- 239000000049 pigment Substances 0.000 claims abstract 2
- 239000004014 plasticizer Substances 0.000 claims abstract 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims abstract 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract 2
- 235000019423 pullulan Nutrition 0.000 claims abstract 2
- 239000004094 surface-active agent Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims 4
- 238000007598 dipping method Methods 0.000 claims 3
- 239000007902 hard capsule Substances 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000001341 hydroxy propyl starch Substances 0.000 abstract 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/003—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor characterised by the choice of material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D22/00—Producing hollow articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2001/00—Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material
- B29K2001/08—Cellulose derivatives
- B29K2001/12—Cellulose acetate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2003/00—Use of starch or derivatives as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2005/00—Use of polysaccharides or derivatives as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2089/00—Use of proteins, e.g. casein, gelatine or derivatives thereof, as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/712—Containers; Packaging elements or accessories, Packages
- B29L2031/7174—Capsules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24539209P | 2009-09-24 | 2009-09-24 | |
| US61/245,392 | 2009-09-24 | ||
| PCT/IB2010/054131 WO2011036601A1 (en) | 2009-09-24 | 2010-09-14 | Acid resistant capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012116362A true RU2012116362A (ru) | 2013-10-27 |
Family
ID=43027570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012116362/15A RU2012116362A (ru) | 2009-09-24 | 2010-09-14 | Кислотоустойчивые капсулы |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8852631B2 (https=) |
| EP (1) | EP2480218B1 (https=) |
| JP (1) | JP5777625B2 (https=) |
| KR (1) | KR101762460B1 (https=) |
| CN (1) | CN102665697B (https=) |
| AU (1) | AU2010299527A1 (https=) |
| BR (1) | BR112012006651B1 (https=) |
| CA (1) | CA2775227C (https=) |
| CO (1) | CO6531471A2 (https=) |
| DK (1) | DK2480218T3 (https=) |
| ES (1) | ES2804779T3 (https=) |
| MX (1) | MX2012003540A (https=) |
| PL (1) | PL2480218T3 (https=) |
| RU (1) | RU2012116362A (https=) |
| TW (1) | TW201127370A (https=) |
| WO (1) | WO2011036601A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9700517B2 (en) | 2009-09-24 | 2017-07-11 | Capsugel Belgium Nv | Acid resistant capsules |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013150331A1 (en) | 2011-11-09 | 2013-10-10 | Capsugel Belgium Nv | Acid resistant banding solution for acid resistant two piece hard capsules |
| CA2870134C (en) | 2012-05-02 | 2020-04-28 | Capsugel France SAS | Aqueous dispersions of hydroxypropyl methylcellulose acetate succinate (hpmcas) |
| CA2873837C (en) * | 2012-05-21 | 2021-01-19 | Capsugel Belgium Nv | Acid resistant banding solution for two piece hard capsules |
| WO2013174884A1 (en) | 2012-05-23 | 2013-11-28 | Capsugel France SAS | Capsules having an incorporated taste modifying component |
| JP2014172850A (ja) * | 2013-03-07 | 2014-09-22 | Capsugel Belgium Nv | ハードカプセル製剤 |
| JP6133702B2 (ja) * | 2013-06-18 | 2017-05-24 | 紀州技研工業株式会社 | インクジェットインキ、その製造方法及びその使用方法 |
| US20160256399A1 (en) | 2013-11-04 | 2016-09-08 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| JP6060102B2 (ja) * | 2014-03-13 | 2017-01-11 | 紀州技研工業株式会社 | インクジェットインク及びその作製方法並びにインクジェットインクを用いた印字方法 |
| CN103893772B (zh) | 2014-04-21 | 2015-08-26 | 湖南尔康制药股份有限公司 | 一种羟丙基淀粉空心胶囊及其制备工艺 |
| CN103937038B (zh) * | 2014-04-28 | 2016-08-17 | 中国科学院化学研究所 | 用于制备空心胶囊的组合物及其淀粉基质空心胶囊 |
| EP3181125B1 (en) * | 2014-07-31 | 2025-02-19 | Capsugel Belgium NV | Capsule formulation |
| JP6297441B2 (ja) * | 2014-07-31 | 2018-03-20 | 森永乳業株式会社 | ビフィドバクテリウム属細菌含有カプセルおよびその製造方法 |
| EP3028694B1 (en) | 2014-12-02 | 2017-07-12 | Capsugel Belgium NV | Dosage form articles for delayed release |
| EP3236993B1 (en) | 2014-12-23 | 2023-09-13 | Theriva Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| AU2016206765B2 (en) * | 2015-01-13 | 2018-10-18 | New Chapter, Inc. | Vegetarian capsules containing supercritical herbal extracts |
| EP3566699A1 (en) | 2015-11-10 | 2019-11-13 | Capsugel Belgium NV | Acid resistant banding or sealing solution for acid resistant two piece hard capsules |
| US20170157058A1 (en) * | 2015-12-08 | 2017-06-08 | Dah Feng Capsule Industry Co., Ltd. | Acid resistant capsule shell composition, acid resistant capsule shell and its preparing process |
| EP3246000A1 (en) | 2016-05-18 | 2017-11-22 | Capsugel Belgium NV | Separable capsule for sprinkling applications |
| EP3272340A1 (en) | 2016-07-22 | 2018-01-24 | Capsugel Belgium NV | Acid resistant capsules |
| ES3025836T3 (en) | 2016-08-24 | 2025-06-09 | Prilenia Neurotherapeutics Ltd | Use of pridopidine for treating functional decline |
| JP2018199631A (ja) * | 2017-05-26 | 2018-12-20 | 株式会社ファンケル | ビフィズス菌含有カプセル製剤 |
| JP7198205B2 (ja) | 2017-07-11 | 2022-12-28 | クオリカプス株式会社 | 腸溶性硬質カプセル |
| CO2017007322A1 (es) * | 2017-07-24 | 2019-01-31 | Novamed S A | Cápsulas duras resistentes al ácido con bajo contenido de coadyuvantes de gelificacion |
| WO2019032573A1 (en) | 2017-08-07 | 2019-02-14 | Finch Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR MAINTAINING AND RESTORING A HEALTHY INTESTINAL BARRIER |
| US11083738B2 (en) | 2017-09-28 | 2021-08-10 | Natals, Inc. | Dietary nutrient compositions |
| CA3087569A1 (en) | 2018-01-09 | 2019-07-18 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| BR112020017090A8 (pt) | 2018-02-23 | 2022-07-05 | Crestovo Holdings Llc | Imunoterapias relacionadas com microbioma |
| WO2019183208A1 (en) | 2018-03-20 | 2019-09-26 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase formulations |
| EP4275761A3 (en) | 2018-03-20 | 2024-02-28 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| US20210016471A1 (en) * | 2018-03-21 | 2021-01-21 | Ryan Selby | Vaporizer capsules and methods of manufacture |
| EP3549578A1 (en) * | 2018-04-06 | 2019-10-09 | Bio Minerals N.V. | Silicic acid formulation and use thereof |
| BR112020026058A2 (pt) | 2018-06-22 | 2021-04-13 | Qualicaps Co., Ltd. | Cápsula entérica dura |
| EP3632449A1 (en) | 2018-10-05 | 2020-04-08 | Bio Minerals N.V. | Silicic acids for use in the treatment of periodontitis |
| EP3650011A1 (en) | 2018-11-09 | 2020-05-13 | Bio Minerals NV | Water soluble silicon-containing granulate |
| KR102182326B1 (ko) * | 2019-02-19 | 2020-11-24 | 주식회사 서흥 | 내산성 셀룰로오스 캡슐의 제조방법 |
| EP3937909B1 (en) * | 2019-03-14 | 2026-03-04 | Evonik Operations GmbH | Capsule shell comprising a core-shell polymer and a cellulose |
| CA3146738A1 (en) | 2019-07-18 | 2021-01-21 | Synthetic Biologics, Inc. | Intestinal alkaline phosphatase-based treatments of metabolic disorders |
| US12290538B2 (en) | 2019-07-19 | 2025-05-06 | Finch Therapeutics Holdings Llc | Methods and products for treatment of gastrointestinal disorders |
| CN114650833A (zh) | 2019-09-13 | 2022-06-21 | 芬奇治疗控股有限责任公司 | 用于治疗孤独症谱群障碍的组合物和方法 |
| CA3153332A1 (en) * | 2019-10-16 | 2021-04-22 | Aouatef Bellamine | Method and composition for increasing muscle protein synthesis |
| CA3153328A1 (en) * | 2019-10-16 | 2021-04-22 | Aouatef Bellamine | Method and composition for increasing muscle protein synthesis |
| AU2020366529A1 (en) | 2019-10-18 | 2022-05-19 | Finch Therapeutics Holdings Llc | Compositions and methods for delivering a bacterial metabolite to a subject |
| WO2021097288A1 (en) | 2019-11-15 | 2021-05-20 | Finch Therapeutics Holdings Llc | Compositions and methods for treating neurodegenerative diseases |
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| TW202140049A (zh) | 2020-01-10 | 2021-11-01 | 美商芬奇治療控股有限責任公司 | 用於治療ｂ型肝炎（ｈｂｖ）及ｄ型肝炎（ｈｄｖ）之組合物及方法 |
| WO2021142347A1 (en) | 2020-01-10 | 2021-07-15 | Finch Therapeutics Holdings Llc | Compositions and methods for non-alcoholic steatohepatitis (nash) |
| WO2021202806A1 (en) | 2020-03-31 | 2021-10-07 | Finch Therapeutics Holdings Llc | Compositions comprising non-viable fecal microbiota and methods of use thereof |
| EP4157231A1 (en) * | 2020-05-31 | 2023-04-05 | EirGen Pharma Ltd. | Hard capsule dosage form and uses thereof |
| WO2022055993A1 (en) * | 2020-09-08 | 2022-03-17 | The Johns Hopkins University | Method of treatment of irritable bowel syndrome |
| JP2023553309A (ja) * | 2020-11-25 | 2023-12-21 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 二重層遅延放出硬質カプセル |
| JP7719609B2 (ja) * | 2021-02-12 | 2025-08-06 | クオリカプス株式会社 | 腸溶性硬質カプセル |
| US20240263251A1 (en) | 2021-02-19 | 2024-08-08 | Finch Therapeutics Holdings Llc | Compositions and methods for providing secondary bile acids to a subject |
| JP7833456B2 (ja) * | 2021-05-18 | 2026-03-19 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 非ゼラチン硬カプセル及びその製造方法 |
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-
2010
- 2010-09-14 DK DK10759732.0T patent/DK2480218T3/da active
- 2010-09-14 AU AU2010299527A patent/AU2010299527A1/en not_active Abandoned
- 2010-09-14 WO PCT/IB2010/054131 patent/WO2011036601A1/en not_active Ceased
- 2010-09-14 MX MX2012003540A patent/MX2012003540A/es active IP Right Grant
- 2010-09-14 CN CN201080042764.7A patent/CN102665697B/zh active Active
- 2010-09-14 BR BR112012006651-0A patent/BR112012006651B1/pt active IP Right Grant
- 2010-09-14 EP EP10759732.0A patent/EP2480218B1/en active Active
- 2010-09-14 KR KR1020127010224A patent/KR101762460B1/ko active Active
- 2010-09-14 JP JP2012530383A patent/JP5777625B2/ja active Active
- 2010-09-14 RU RU2012116362/15A patent/RU2012116362A/ru not_active Application Discontinuation
- 2010-09-14 US US13/497,974 patent/US8852631B2/en active Active
- 2010-09-14 ES ES10759732T patent/ES2804779T3/es active Active
- 2010-09-14 PL PL10759732T patent/PL2480218T3/pl unknown
- 2010-09-14 CA CA2775227A patent/CA2775227C/en active Active
- 2010-09-21 TW TW099132015A patent/TW201127370A/zh unknown
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2012
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9700517B2 (en) | 2009-09-24 | 2017-07-11 | Capsugel Belgium Nv | Acid resistant capsules |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2480218A1 (en) | 2012-08-01 |
| US20120288562A1 (en) | 2012-11-15 |
| CN102665697B (zh) | 2014-07-09 |
| JP5777625B2 (ja) | 2015-09-09 |
| JP2013505928A (ja) | 2013-02-21 |
| BR112012006651B1 (pt) | 2021-11-03 |
| TW201127370A (en) | 2011-08-16 |
| CO6531471A2 (es) | 2012-09-28 |
| US20150050334A1 (en) | 2015-02-19 |
| ES2804779T3 (es) | 2021-02-09 |
| CN102665697A (zh) | 2012-09-12 |
| CA2775227C (en) | 2017-12-19 |
| US10231934B2 (en) | 2019-03-19 |
| EP2480218B1 (en) | 2020-05-27 |
| WO2011036601A1 (en) | 2011-03-31 |
| PL2480218T3 (pl) | 2020-11-16 |
| KR20120079836A (ko) | 2012-07-13 |
| KR101762460B1 (ko) | 2017-07-27 |
| US10874619B2 (en) | 2020-12-29 |
| CA2775227A1 (en) | 2011-03-31 |
| AU2010299527A1 (en) | 2012-04-19 |
| BR112012006651A2 (pt) | 2020-08-11 |
| US8852631B2 (en) | 2014-10-07 |
| US20190175514A1 (en) | 2019-06-13 |
| US20170231918A1 (en) | 2017-08-17 |
| US9700517B2 (en) | 2017-07-11 |
| MX2012003540A (es) | 2012-09-07 |
| DK2480218T3 (da) | 2020-08-24 |
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