MX2012003540A - Capsulas resistentes a acido. - Google Patents
Capsulas resistentes a acido.Info
- Publication number
- MX2012003540A MX2012003540A MX2012003540A MX2012003540A MX2012003540A MX 2012003540 A MX2012003540 A MX 2012003540A MX 2012003540 A MX2012003540 A MX 2012003540A MX 2012003540 A MX2012003540 A MX 2012003540A MX 2012003540 A MX2012003540 A MX 2012003540A
- Authority
- MX
- Mexico
- Prior art keywords
- water
- soluble film
- aqueous composition
- hard
- forming polymers
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 76
- 239000002253 acid Substances 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 claims abstract description 62
- 229920000642 polymer Polymers 0.000 claims abstract description 53
- 229920002148 Gellan gum Polymers 0.000 claims abstract description 40
- 239000000216 gellan gum Substances 0.000 claims abstract description 37
- 235000010492 gellan gum Nutrition 0.000 claims abstract description 37
- 238000004519 manufacturing process Methods 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 24
- 241001465754 Metazoa Species 0.000 claims abstract description 14
- 239000007902 hard capsule Substances 0.000 claims description 36
- 239000000126 substance Substances 0.000 claims description 21
- 230000002496 gastric effect Effects 0.000 claims description 19
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 19
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 19
- 238000007654 immersion Methods 0.000 claims description 17
- 229920000159 gelatin Polymers 0.000 claims description 12
- 235000019322 gelatine Nutrition 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 10
- 238000000465 moulding Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 239000003125 aqueous solvent Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 4
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 4
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- -1 pullulana Polymers 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 235000013355 food flavoring agent Nutrition 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 16
- 235000015872 dietary supplement Nutrition 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 10
- 238000004090 dissolution Methods 0.000 description 9
- 241000282412 Homo Species 0.000 description 7
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 4
- 208000029618 autoimmune pulmonary alveolar proteinosis Diseases 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 239000007903 gelatin capsule Substances 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 238000007922 dissolution test Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 2
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 description 2
- 239000004922 lacquer Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000019426 modified starch Nutrition 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920002444 Exopolysaccharide Polymers 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 description 1
- 239000004063 acid-resistant material Substances 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- JFVXEJADITYJHK-UHFFFAOYSA-L disodium 2-(3-hydroxy-5-sulfonato-1H-indol-2-yl)-3-oxoindole-5-sulfonate Chemical compound [Na+].[Na+].Oc1c([nH]c2ccc(cc12)S([O-])(=O)=O)C1=Nc2ccc(cc2C1=O)S([O-])(=O)=O JFVXEJADITYJHK-UHFFFAOYSA-L 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/003—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor characterised by the choice of material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D22/00—Producing hollow articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2001/00—Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material
- B29K2001/08—Cellulose derivatives
- B29K2001/12—Cellulose acetate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2003/00—Use of starch or derivatives as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2005/00—Use of polysaccharides or derivatives as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2089/00—Use of proteins, e.g. casein, gelatine or derivatives thereof, as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/712—Containers; Packaging elements or accessories, Packages
- B29L2031/7174—Capsules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24539209P | 2009-09-24 | 2009-09-24 | |
| PCT/IB2010/054131 WO2011036601A1 (en) | 2009-09-24 | 2010-09-14 | Acid resistant capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012003540A true MX2012003540A (es) | 2012-09-07 |
Family
ID=43027570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012003540A MX2012003540A (es) | 2009-09-24 | 2010-09-14 | Capsulas resistentes a acido. |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8852631B2 (https=) |
| EP (1) | EP2480218B1 (https=) |
| JP (1) | JP5777625B2 (https=) |
| KR (1) | KR101762460B1 (https=) |
| CN (1) | CN102665697B (https=) |
| AU (1) | AU2010299527A1 (https=) |
| BR (1) | BR112012006651B1 (https=) |
| CA (1) | CA2775227C (https=) |
| CO (1) | CO6531471A2 (https=) |
| DK (1) | DK2480218T3 (https=) |
| ES (1) | ES2804779T3 (https=) |
| MX (1) | MX2012003540A (https=) |
| PL (1) | PL2480218T3 (https=) |
| RU (1) | RU2012116362A (https=) |
| TW (1) | TW201127370A (https=) |
| WO (1) | WO2011036601A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9700517B2 (en) | 2009-09-24 | 2017-07-11 | Capsugel Belgium Nv | Acid resistant capsules |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6219836B2 (ja) | 2011-11-09 | 2017-10-25 | キャプシュゲル・ベルジウム・エヌ・ヴィ | 耐酸性ツーピースハードカプセル用の耐酸性バンディング溶液 |
| EP3446713A3 (en) | 2012-05-02 | 2019-05-15 | Capsugel Belgium NV | Aqueous dispersions of controlled release polymers and shells and capsules thereof |
| ES2879892T3 (es) | 2012-05-21 | 2021-11-23 | Capsugel Belgium Nv | Uso de una solución banda resistente a los ácidos para sellar cápsulas duras de dos piezas |
| WO2013174884A1 (en) | 2012-05-23 | 2013-11-28 | Capsugel France SAS | Capsules having an incorporated taste modifying component |
| JP2014172850A (ja) * | 2013-03-07 | 2014-09-22 | Capsugel Belgium Nv | ハードカプセル製剤 |
| JP6133702B2 (ja) * | 2013-06-18 | 2017-05-24 | 紀州技研工業株式会社 | インクジェットインキ、その製造方法及びその使用方法 |
| US20160256399A1 (en) | 2013-11-04 | 2016-09-08 | Capsugel Belgium Nv | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| JP6060102B2 (ja) * | 2014-03-13 | 2017-01-11 | 紀州技研工業株式会社 | インクジェットインク及びその作製方法並びにインクジェットインクを用いた印字方法 |
| CN103893772B (zh) | 2014-04-21 | 2015-08-26 | 湖南尔康制药股份有限公司 | 一种羟丙基淀粉空心胶囊及其制备工艺 |
| CN103937038B (zh) * | 2014-04-28 | 2016-08-17 | 中国科学院化学研究所 | 用于制备空心胶囊的组合物及其淀粉基质空心胶囊 |
| JP6297441B2 (ja) * | 2014-07-31 | 2018-03-20 | 森永乳業株式会社 | ビフィドバクテリウム属細菌含有カプセルおよびその製造方法 |
| WO2016017006A1 (ja) * | 2014-07-31 | 2016-02-04 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | カプセル製剤 |
| EP3028694B1 (en) | 2014-12-02 | 2017-07-12 | Capsugel Belgium NV | Dosage form articles for delayed release |
| EP3236993B1 (en) | 2014-12-23 | 2023-09-13 | Theriva Biologics, Inc. | Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics |
| EP3244906B1 (en) * | 2015-01-13 | 2020-02-19 | New Chapter, Inc. | Vegetarian capsules containing supercritical herbal extracts |
| EP3566699A1 (en) | 2015-11-10 | 2019-11-13 | Capsugel Belgium NV | Acid resistant banding or sealing solution for acid resistant two piece hard capsules |
| US20170157058A1 (en) * | 2015-12-08 | 2017-06-08 | Dah Feng Capsule Industry Co., Ltd. | Acid resistant capsule shell composition, acid resistant capsule shell and its preparing process |
| EP3246000A1 (en) | 2016-05-18 | 2017-11-22 | Capsugel Belgium NV | Separable capsule for sprinkling applications |
| EP3272340A1 (en) | 2016-07-22 | 2018-01-24 | Capsugel Belgium NV | Acid resistant capsules |
| EP4516356A3 (en) | 2016-08-24 | 2025-05-14 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating functional decline |
| JP2018199631A (ja) * | 2017-05-26 | 2018-12-20 | 株式会社ファンケル | ビフィズス菌含有カプセル製剤 |
| BR112020000011A2 (pt) | 2017-07-11 | 2020-07-21 | Qualicaps Co., Ltd. | cápsula dura entérica |
| CO2017007322A1 (es) * | 2017-07-24 | 2019-01-31 | Novamed S A | Cápsulas duras resistentes al ácido con bajo contenido de coadyuvantes de gelificacion |
| JP2020530494A (ja) | 2017-08-07 | 2020-10-22 | フィンチ セラピューティクス、インコーポレイテッド． | 健康な腸バリアを維持及び回復するための組成物及び方法 |
| US11083738B2 (en) | 2017-09-28 | 2021-08-10 | Natals, Inc. | Dietary nutrient compositions |
| US11338020B2 (en) | 2018-01-09 | 2022-05-24 | Synthetic Biologics, Inc. | Alkaline phosphatase agents for treatment of neurodevelopmental disorders |
| KR20200125637A (ko) | 2018-02-23 | 2020-11-04 | 크레스토보 홀딩스 엘엘씨 | 마이크로바이옴 관련 면역요법 |
| ES3032290T3 (en) | 2018-03-20 | 2025-07-16 | Theriva Biologics Inc | Intestinal alkaline phosphatase formulations |
| US11654184B2 (en) | 2018-03-20 | 2023-05-23 | Theriva Biologics, Inc. | Alkaline phosphatase agents for treatment of radiation disorders |
| EP3768773B1 (en) * | 2018-03-21 | 2025-06-18 | Altria Client Services LLC | Vaporizer capsules and methods of manufacture |
| EP3549578A1 (en) * | 2018-04-06 | 2019-10-09 | Bio Minerals N.V. | Silicic acid formulation and use thereof |
| KR20210022716A (ko) | 2018-06-22 | 2021-03-03 | 쿠오리카프스 가부시키가이샤 | 장용성 경질 캡슐 |
| EP3632449A1 (en) | 2018-10-05 | 2020-04-08 | Bio Minerals N.V. | Silicic acids for use in the treatment of periodontitis |
| EP3650011A1 (en) | 2018-11-09 | 2020-05-13 | Bio Minerals NV | Water soluble silicon-containing granulate |
| KR102182326B1 (ko) * | 2019-02-19 | 2020-11-24 | 주식회사 서흥 | 내산성 셀룰로오스 캡슐의 제조방법 |
| EP3937909B1 (en) * | 2019-03-14 | 2026-03-04 | Evonik Operations GmbH | Capsule shell comprising a core-shell polymer and a cellulose |
| EP3999637B1 (en) | 2019-07-18 | 2025-04-02 | Theriva Biologics, Inc. | Intestinal alkaline phosphatase-based treatments of metabolic disorders |
| PH12021553137A1 (en) | 2019-07-19 | 2022-07-25 | Finch Therapeutics Holdings Llc | Methods and products for treatment of gastrointestinal disorders |
| AU2020346061A1 (en) | 2019-09-13 | 2022-03-31 | Finch Therapeutics Holdings Llc | Compositions and methods for treating Autism Spectrum Disorder |
| WO2021076920A1 (en) * | 2019-10-16 | 2021-04-22 | Capsugel Belgium Nv | Method and composition for increasing muscle protein synthesis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9700517B2 (en) | 2009-09-24 | 2017-07-11 | Capsugel Belgium Nv | Acid resistant capsules |
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| CA2775227C (en) | 2017-12-19 |
| US20170231918A1 (en) | 2017-08-17 |
| BR112012006651B1 (pt) | 2021-11-03 |
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| KR20120079836A (ko) | 2012-07-13 |
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| AU2010299527A1 (en) | 2012-04-19 |
| CA2775227A1 (en) | 2011-03-31 |
| US10231934B2 (en) | 2019-03-19 |
| US9700517B2 (en) | 2017-07-11 |
| PL2480218T3 (pl) | 2020-11-16 |
| CN102665697A (zh) | 2012-09-12 |
| ES2804779T3 (es) | 2021-02-09 |
| US20120288562A1 (en) | 2012-11-15 |
| WO2011036601A1 (en) | 2011-03-31 |
| CN102665697B (zh) | 2014-07-09 |
| US20190175514A1 (en) | 2019-06-13 |
| JP2013505928A (ja) | 2013-02-21 |
| KR101762460B1 (ko) | 2017-07-27 |
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