TW200520790A - The compositions of a vegetarian capsule shell - Google Patents

Abstract

The compositions of a vegetarian capsule shell which comprising a cellulose ether as a base, a gelling agent, a gelling aid and plasticizer is revealed. This invention also described the manufacture process for producting of the vegetarian capsule.

Description

200520790 V. Description of the invention (1) (Technical field to which the invention belongs) The traditional capsule shell is basically composed of gelatin, glycerin and water. For the production of capsules, the stainless steel mold pestle is immersed in the glue solution, and then the mold pestle is taken out of the glue solution. At this time, the adhesive film is attached to the mold pestle, and the film is dried after being dried in air at a certain temperature. At a certain length, peeling the capsule to obtain a capsule production device is a key point. However, the preparation and manufacturing process of the glue solution are more two-fold. The present invention is characterized in that the composition, preparation and manufacturing process of the capsule glue solution are simple, effective. (Prior art) The past Chinese 5 2 9 9 are mainly different from water. The method of making the material for mixing white and white V "After the temperature of the hard capsule of this hair is ° C, the capsules are immersed in capsules with a total of 7,8 6 patents, and there are four pharmaceutical filling vitamin derivatives derived from hydrophile 8 1 2" Chengzhi Hard rubber 10 0 2 The material of the hot casting glue is not. It will be heated V and weaving and weaving. The production method and composition are made of the polymer of the hair capsule. No .: The material of the capsule shell is used to make the capsule. 0 0 'formation of the United States specialty 5 1 cellulose Republic of China specialty 4 7 τ soluble fiber 13 1 Yang So different.. Will be added to the method of use "in the 20-shaped film 1 1 piece 5" colloid colloid, all with hard capsules It is composed of the capsule upper capsule shell. 7 2 Γ The capsule nails are immersed in the same. The capsule bond of 7 and the method of preparing different membranes of the present invention are not included. Its. The improvement of the manufacturing method is worse than heat. 8 13 The shaft bolt is made of polyethylene. Its completion. " The composition and the η re-announcement feature are the hard and the present invention. " The gel, material and manufacturing method are all different from this kind of medicinal hard gelatinous substance 4 "a kind of pre-heated 45 to alcohol admixture material. The report number is: water-soluble used by the present invention

200520790 Fifth, the material of invention description (2) is different. 6,649,1 80 "Hard capsules are formed of membranes containing methoxy and aeropropylpropylcellulose cellulose" series, with fiber radicals containing scorch and reduced groups 2 3-3 7 · 6%, and ㈣ and oxygen glue are formulated. Different from the materials used in the present invention. 6, 4 丄 3, 4 ^ "Process of making hard capsules". It is based on the formulation of oxyhydroxyloxycellulose and gelling agent, and the pestle temperature is between 3 ° C. The composition is different from the materials used in the present invention. 6, 40.0, 〇5 〇 "cellulose capsule pectin and glycerin mixed solution and its related manufacturing process" is hydroxymethylpropyl cellulose and pectin, I oil, glacial acetic acid, strict sugar Fatty acid vinegar, calcium sucrose acetate. The manufacturing method and composition are different from those used in the present invention. 5,756,123 "Capsule shell" is formulated with hydroxypropoxylate cellulose cellulose and gelling agent (deer gum) and gelling aid soil (potassium or calcium salt). The manufacturing method and composition are different from those used in the present invention. 5,756,03 6 "Manufacturing method of medicinal cellulose capsules: using thermosetting material; heating the pestle before sticking it to the glue. The method and composition are different from the materials used in the present invention. 5 , 4 3 1 9 1 7 "Medicinal hard capsules and related manufacturing methods". This patent is based on the formulation of a method and composition different from the materials used in the present invention by using a burn-in-based hydroxide burner-based vitamin and a gelling agent and a gel assisting agent. "Used Hard Capsules and Related Manufacturing Methods". This patent is based on the formulation of alkylhydrogen-based weaving vitamins with gelling agents and gelling aids. The manufacturing method and composition are different from the materials used in the invention. 4, 993, 137 "Methods for Making Hard Gum / Bladder". After the pestle is glued, it quickly produces gel in hot water and adheres to the sample. The manufacturing method and composition are different from the materials used in the present invention. 4, 9 7, 8 8

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Page 6 200520790 V. Description of the invention (3) 5 "Medicinal hard capsules" Vitamins and alkylhydroxane samples must be used in different materials. 4 Medicinal cellulose made from cellulose ether is dried. Production method and group (content) Capsules are the source of animal bones, skin, and materials for the quality of pharmaceutical capsule shells and the development of new traditional capsule shells, and most of them are hardened, softened by absorption of water, and should not be filled with substances that are hygroscopic and contain aldehyde groups. In recent years, the zoonotic epidemic has spread, and the launch of the Vc a field for traditional gelatin companies has been a success, increasing year by year. V c a (Η P M C) has a natural concept for the process and drying technology, which is not clear. Based on the use of calcined cellulose, oxycellulose, polyethylene preheated at 00 ° C, manufacturing method, 0.01, 2 1 "change capsules." Department of Economics and C. The pestle must be preheated, and the capsules are the most commonly used capsules for the materials and health foods used in the present invention. The pharmaceutical research is basically gelatin, glycerin, and white animal connective tissue. They are obtained from pigs and cattle. Deals weathered and happened with capsules. Muslims do n’t eat pork, and the disease is increasing. “The capsule market is also impacting the ps vegetarian capsules. In Europe, billions of ps vegetarian capsules are sold every year. They are based on hydroxy materials and obtained by C apsug, which is about to heat the pestle mold. Back gelatin capsules are available. , Alkyl hydroxide alkyl cellulose composition formula, and composition and methyl methyl cellulose and methyl group of the present invention for gelation into heat

Need to be different at 45-80 ° C. One of the formulations to improve the focus of research. Water composition. Gelatin is made by hydrolysis. Gelatin capsules are susceptible to water-based curing reactions, so the contents of the reaction (such as vegetarians and mad cows and feet and feet). For this reason, Pfizer Pharmaceuticals and Health Products in the United States has a double-digit rate. Methylcellulose e 1 unique dipping moulded dipping gum. Vegetarian capsules with

200520790 V. Description of the invention (4) Advantages of vegetarian capsules: 1 · Low water content. The moisture content of vegetarian capsules is 5-8%, which is very suitable for filling medicines or health foods with strong hygroscopicity and sensitivity to water. The elasticity and toughness of gelatin capsules are mainly determined by the water content of the f capsule shell, while gelatin capsules usually contain 10 to 17 Torr of water. Generally, traditional Chinese medicine extracts have strong hygroscopicity and can easily absorb the moisture in gelatin and capsules, leading to quality problems such as the contents of the capsules becoming agglomerated, the capsule shells becoming hard, brittle, disintegration time, or dissolution dissimilarity; and vegetarian food Because the capsule uses propyl fluorenyl cellulose as the capsule material, the water content in the capsule shell is lower than that of gelatin. The observation and dissolution rate are not sensitive to changes in moisture and environmental humidity in the capsule shell. The product quality is easier to control. 2 · Wide applicability. Moxibustion tends to lead to reduced dissolution or dissolution, and vegetarian capsules have no risk of cross-linking reactions. The risk of cross-linking reaction with propylmethyl oryzanol = acid, followed by 3 · Low requirements for storage conditions. Almost no kneeling in low-humidity environment (30% RH brittleness rate = good stability at temperature 80t, capsule changes < capsules easily lose water under high temperature and low humidity conditions) temperature of meniscus, Humidity and packaging material requirements are high, and = has a more obvious impact on the quality of the storage environment capsules. Stolen gelatin gelatin 4 · Has good coating properties. Especially suitable for slow-release coated capsules

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Cellulose easily adheres to vegetarian capsules with most high scores, and the coating material and sub-material have good affinity and good uniformity. 'Prompts its hermeticity such as vinegar ammonia age. 5. The oxygen permeability of vegetarian capsules is significantly worse than that of gelatin capsules; and the pH of the dissolution medium affects certain drugs (degrees of separation. For pharmaceutical and health food companies, the value and Differentiate products. Using VC a ^ ^ with vegetarian capsules can increase the brand price and become a marketing tool for merchants. Taiwan: Two stamps are printed on the product packaging, and have reached more than 3 Q countries around the world. Products have been around since 2000, and Sunrider has passed on eight companions and millions of consumers. As a vegetarian capsule, it highlights the natural n all of its products in the United States that have been transformed into differentiated marketing have achieved great success ^. And the implementation of vegetarian capsules for competitors to enter the domestic brand value of counterfeit products in China? The product market can not only increase the production and production steps of our country. ^, 疋 can accelerate the domestic preparation of international preparations such as traditional Chinese medicine and other second-quality manufacturers It ’s in the special trend. I believe that Vc a fast Western special culture and the natural health food market, will vegan vegetarian capsules to show our medicines and health greatly promote the capsules in our country: 2: the change of people ’s consumption concept Leather and vegetarian capsules have developed rapidly and healthily in the United States. They are mentioned in the invention used in this invention and in domestic patents, but the US patent 6, 5 1 7 and the manufacturing process are different. Strict Note, blue gum, citrate, deer H = formula contains hydroxypropyl methylcellulose, a plasticizer, an appropriate amount of plasticizer > f gum, potassium gasification, citric acid. Increase the quality of capsules. Therefore, the present invention

200520790 Fifth, the description of the invention (6) is significantly different. US patent 6,4; middle to 50 degrees, this fever 'US patent 6,413, patent 6,410,0050 Glycerin, glacial acetic acid, sucrose fat Ming used different gels, materials used Significantly less and effective. different. Propyl cellulose is a capsule shell that can help cellulose ether to stick to the shell of the pestle. The plasticizer is enhanced. The advantages shown are: lower moisture content than traditional gelatin capsules and US Patent 6,517,865.1 The temperature of 3,46 3 mold pestle can be operated at 3 t open mold pestle at room temperature, and no need to add 4 6 3 is obviously different from the present invention. The US material is composed of hydroxypropyl cellulose and pectin, acid ester, and sucrose ester calcium. With the present invention, other coagulating gels can be used, and the patent 6,410,050 and the cellulose ether used in the present invention are based on a hydroxyl group, and a hydrophilic gum and a coagulation aid are added, and then 'solidly coagulate on a pestle. , Increase the strength of the capsule vegetarian capsule. Compared with the previous patents 1. The vegetarian capsule produced by the present invention 2 The capsule shell produced by the present invention has a uniform mouth and a smooth surface. 3. The present invention uses fewer capsules and produces capsules with a simple process and good results. 4 · The mold pestle of the present invention can be operated at room temperature, and does not need to be heated in advance. 5 · The present invention uses a plasticizer, so the robustness of the vegetarian capsules produced 6 · The present invention does not use a coagulant and does not need to add salt. • The process of the present invention is the same as the current traditional gelatin capsules. It is based on existing capsule production and capsule filling models; complete models and specifications. No need to replace with new

200520790 V. Description of invention (7) Machine parts. (Embodiment) Example 1 The first trial production of 10,000 hydroxypropyl methylcellulose capsules, the theoretical weight: 100 mg, weight difference: 95 ~ 105 mg, thickness: 0.1 mm 〇 Formula: 1020 g of propionyl cellulose gellan gum 210 g of glycerol 4. 10 g of water, add an appropriate amount of water to 6 0 〇cc P 2 of water-soluble water ο step 5 to the temperature to dissolve the leptin, after P dissolves and maintains ο the base of water fiber gas 8 to 1 oxygen liquid Heat-solubilization plus step-based water solution in alkane, peptin-soluble propane 3, lanoleuric acid, oxygenation, glycine hydrogenation step, will pass ^ Nly \) / XI / \ ly tune τ 丄 2 3 4 Mechanical deformation test: Capsule 1 Capsule 2 Capsule 3 The vegetarian capsule produced by the traditional transparent gelatin capsule of the present invention in Example 1

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Page 12 200520790 Capsule percentage 100% soluble%% 8 8 0 CO 12 V. Description of the invention (9) Dissolution test: Capsules 1 > 2 and 3 each filled with aspirin and lactose > Percentage of dissolution after 30 minutes at 37 ° C according to the 25th edition of American Medicine: Capsule Dissolution Percentage Capsule 18.7% Capsule 2 9: L% Capsule 3 8 ί 5% Capsule Dissolution Test After Crosslinking Capsules 1 2 3 each filled with aspirin and 80 PP m formaldehyde-containing sugars> Stored in room temperature and closed bottles for 3 months and 30 minutes Dissolution percentage Hygroscopicity test capsules 1, 2, 3 Each pouch was filled with lactose and placed in a closed bottle, and the change was observed after three months. Initial water content and final water content

Page 13 200520790 V. Description of the invention (10) Capsules Capsules after filling Capsules Capsules after filling 1 6.4% 0% 1.4% 1.1% Capsules 2 1 4% 0% 4.7% 2.0% Capsules 3 1 3% 0% 5.6% 3.1% Example Dihydroxypropylmethylcellulose Carrageenan Glycerine Potassium Gum Gum Glycerin Appropriate amount of water is added to 6,000 0 cc 15 0 0 6 0 3 0 10 ggggg Example Trihydroxymethylcellulose Carrageenan Phosphate Diphosphonate Add potassium acacia glycerin with water to 6 0 0 Occ 2 0 0 6 0 2 4 12 6 ggggg 1 3 2 0 g Example 4 Formulation: Hypromellose

Page 14 200520790 V. Description of the invention (11) Carrageenan, vaporized potassium glycerol, add water to 600,000 cc, 60 g, 1 2 g, 6 g Example 5 Formulation: Hypromellose cellulose gum fruit Add glycerol salt to 6000cc 9 0 0 g 3 0 g 6 g 6 g

Lingshi 1 column ττ Formula: Hypromellose Cellulose Gelatin Liquid Carrageenan Gasified Potassium Glycerin Add water to 6000CC 6 0 0 g 6 0 g 6 0 g 1 2 g 6 g On a fully automatic capsule making machine The capsule manufacturing process is as follows

Page 15 1 200520790 V. Description of the invention (12) —After the above glue solution is prepared, put the glue solution in a glue dipping tank to maintain a certain temperature-clean the surface of the mold pestle with room temperature wind-place the mold on the oiler Grease the pestle—immerse the mold into the cellulose glue—pull out and rotate the cellulose-coated mold pestle—dry the cellulose on the mold pestle at 3 5 t on a drying oven—put the head and body mold The pestle corresponds to the correct corresponding position. The machine removes the capsule head body from the mold pestle-trimming the capsule head body position to an appropriate length-combining the capsule head body to the pre-locked position of the capsule

Page 16 200520790 Schematic Illustration Page 17

Claims (1)

Sixth, the scope of the application for patent ten. A combination of vegetarian capsule shells (a) hydroxypropyl methylcellulose 'contains ... (b) a gelling agent, # 中 胶剂 系 Selected from agaran gum, tragacanth gum And Guanhua bean gum = carrageenan, arabica knee, knot (c) coagulant aid, locust bean gum, where the coagulant aid is selected from monovalent ^ citrate), divalent cation (qi) ion: (gasification Potassium, thoron, or ^ x D <calcification of calcium, magnesium gasification) and fruit acid vd) plasticizer, wherein the plasticizer is selected from the group consisting of sorbitol, glycerin, polyethylene glycol ®) The rest is water ^ The composition of a vegetarian capsule shell according to item 1 of the scope of patent application, wherein fa) 10 to 40 weight percent of hydroxypropylmethyl cellulose has a viscosity of 4.5 to 6 centipoise; ； b). 0% to 20% by weight of gellan gum; c) 0 to 10% by weight of the fruit salt; d) 0. 0 0 to 10% by weight; the amount of glycerol; (e) The rest is a composition of a vegetarian capsule shell for water according to item 2 of the scope of the patent application, which contains: C 10 to 30 weight of rabbit hydroxypropyl methylcellulose; j 〇 · 0 5 to 10 weight percent of gellan gum solution; L) 0 to 5 weight percent of fruit salt; 200520790 VI. Patent application range (d) 0.00 5 to 5 weight percent glycerin; (e) The rest is water 4. The composition of a vegetarian capsule shell according to item 3 of the patent application range, which includes: (a) 15 to 25 weight percent of hydroxypropyl methylcellulose; (b) 0.1 to 2 weight percent of gellan gum solution; (c) 0 to 1 weight percent of fruit salt; (d) 0. 0 5 to 1 weight Percentage of glycerin; (e) The rest is water. 5. A method of manufacturing a composition of a vegetarian capsule shell, wherein, after the capsule composition according to item 1 of the patent application is formulated, the gelatin is prepared. Keep the liquid in the dipping tank to maintain a certain temperature (the glue temperature is 2 5 ~ 4 0 ° C) — clean the surface of the mold pestle with a room temperature wind on the oiler and oil the mold pestle — immerse the mold pestle in the cellulose glue —Pull out and rotate the cellulose-coated mold pestle—Dry the cellulose on the mold pestle on a drying oven at 35 ° C—Match the head and body mold pestle to the correct corresponding positions—the machine will Remove the capsule body from the mold pestle-trim the capsule body to the proper length-remove the capsule body Pre-engagement position to a capsule 6. The lock range patent vegetarian, Paragraph 1 of the composition of the capsule shell, which can be administered orally as a dosage, applied to foods such as confectionery coating, Page 19 200520790 Page 20