RU2005105692A - 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора - Google Patents
3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора Download PDFInfo
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- RU2005105692A RU2005105692A RU2005105692/04A RU2005105692A RU2005105692A RU 2005105692 A RU2005105692 A RU 2005105692A RU 2005105692/04 A RU2005105692/04 A RU 2005105692/04A RU 2005105692 A RU2005105692 A RU 2005105692A RU 2005105692 A RU2005105692 A RU 2005105692A
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- 0 Cc1c(C)c(*)c(*)c(C)c1* Chemical compound Cc1c(C)c(*)c(*)c(C)c1* 0.000 description 6
- IXSLKMLRCXISOG-UHFFFAOYSA-N CC(C)CC(c(cccc1NC(C(C2=O)=O)=C2NC2(CC2)c2ccccc2)c1O)=O Chemical compound CC(C)CC(c(cccc1NC(C(C2=O)=O)=C2NC2(CC2)c2ccccc2)c1O)=O IXSLKMLRCXISOG-UHFFFAOYSA-N 0.000 description 1
- YEBWSRUQHMZPSX-MHPPCMCBSA-N CC([C@@H](C(N)=O)N1)[O]=C(C2=O)C1=C2Nc1cccc(C(N(C)C)=O)c1O Chemical compound CC([C@@H](C(N)=O)N1)[O]=C(C2=O)C1=C2Nc1cccc(C(N(C)C)=O)c1O YEBWSRUQHMZPSX-MHPPCMCBSA-N 0.000 description 1
- GPAIJWDRZKOGLW-UHFFFAOYSA-N CC(c1cccc(NC(C(C2=O)=O)=C2NCc2ccccc2)c1O)=O Chemical compound CC(c1cccc(NC(C(C2=O)=O)=C2NCc2ccccc2)c1O)=O GPAIJWDRZKOGLW-UHFFFAOYSA-N 0.000 description 1
- WHPJQEMKJZVBHS-UHFFFAOYSA-N CCC(CC)(C=C)NC(C(C1=O)=O)=C1Nc(cccc1C(N(C)C)=O)c1O Chemical compound CCC(CC)(C=C)NC(C(C1=O)=O)=C1Nc(cccc1C(N(C)C)=O)c1O WHPJQEMKJZVBHS-UHFFFAOYSA-N 0.000 description 1
- XOYRBACCQDGSQP-UHFFFAOYSA-N CCC(c1cccc(OC)c1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O Chemical compound CCC(c1cccc(OC)c1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O XOYRBACCQDGSQP-UHFFFAOYSA-N 0.000 description 1
- KXZMHPJCGOYMMR-UHFFFAOYSA-N CCC(c1cccc(OCC)c1)NC(C(C1=O)=O)=C1Nc1cccc(C(CC(C)C)=O)c1O Chemical compound CCC(c1cccc(OCC)c1)NC(C(C1=O)=O)=C1Nc1cccc(C(CC(C)C)=O)c1O KXZMHPJCGOYMMR-UHFFFAOYSA-N 0.000 description 1
- MIDBIFUTMVSOGU-UHFFFAOYSA-N CCC(c1ccccc1F)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O Chemical compound CCC(c1ccccc1F)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O MIDBIFUTMVSOGU-UHFFFAOYSA-N 0.000 description 1
- NIWIDPUKWAYMCO-UHFFFAOYSA-N CCCC(c1cc(C)c[o]1)NC(C(C1=O)=O)=C1Nc1n[s]c(S(N(C)C)(=O)=O)c1O Chemical compound CCCC(c1cc(C)c[o]1)NC(C(C1=O)=O)=C1Nc1n[s]c(S(N(C)C)(=O)=O)c1O NIWIDPUKWAYMCO-UHFFFAOYSA-N 0.000 description 1
- IAVHABRNPDEGBX-UHFFFAOYSA-N CCCC(c1ccccc1)NC(C(C1=O)=O)=C1Nc(cccc1C(N(CC2)CCN2c2ncccn2)=O)c1O Chemical compound CCCC(c1ccccc1)NC(C(C1=O)=O)=C1Nc(cccc1C(N(CC2)CCN2c2ncccn2)=O)c1O IAVHABRNPDEGBX-UHFFFAOYSA-N 0.000 description 1
- STEVBRMCBZWWSJ-UHFFFAOYSA-N CCCC(c1ccccc1)NC(C(C1=O)=O)=C1Nc1cc(C#N)cc(C(N(C)C)=O)c1O Chemical compound CCCC(c1ccccc1)NC(C(C1=O)=O)=C1Nc1cc(C#N)cc(C(N(C)C)=O)c1O STEVBRMCBZWWSJ-UHFFFAOYSA-N 0.000 description 1
- ZUHBISJJKJFVJR-NSHDSACASA-N CC[C@H](C)NC(C(C1=O)=O)=C1Nc(cc(cc1C(CC(C)C)=O)C#N)c1O Chemical compound CC[C@H](C)NC(C(C1=O)=O)=C1Nc(cc(cc1C(CC(C)C)=O)C#N)c1O ZUHBISJJKJFVJR-NSHDSACASA-N 0.000 description 1
- AMYHNXLXSQOHQV-HXUWFJFHSA-N CC[C@H](c1ccccc1)NC(C(C1=O)=O)=C1Nc(cccc1C(N(CC2)CCN2C(c2ccc[o]2)=O)=O)c1O Chemical compound CC[C@H](c1ccccc1)NC(C(C1=O)=O)=C1Nc(cccc1C(N(CC2)CCN2C(c2ccc[o]2)=O)=O)c1O AMYHNXLXSQOHQV-HXUWFJFHSA-N 0.000 description 1
- GFUQQUSTTXUMIW-UHFFFAOYSA-N CN(C)C(c(cccc1NC(C(C2=O)=O)=C2NCc2ccc[s]2)c1O)=O Chemical compound CN(C)C(c(cccc1NC(C(C2=O)=O)=C2NCc2ccc[s]2)c1O)=O GFUQQUSTTXUMIW-UHFFFAOYSA-N 0.000 description 1
- HZHOTAJKJGIIRP-UHFFFAOYSA-N OC(C1)CN1C(c(cccc1NC(C(C2=O)=O)=C2NCc2ccccc2)c1O)=O Chemical compound OC(C1)CN1C(c(cccc1NC(C(C2=O)=O)=C2NCc2ccccc2)c1O)=O HZHOTAJKJGIIRP-UHFFFAOYSA-N 0.000 description 1
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- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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| US10/208.412 | 2002-07-30 | ||
| US10/241.326 | 2002-09-11 | ||
| US10/241,326 US20040106794A1 (en) | 2001-04-16 | 2002-09-11 | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
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| CA2580762A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
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| JP2009500328A (ja) * | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドとしての5,6−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン |
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| ES2386489T3 (es) | 2007-06-06 | 2012-08-21 | Novartis Ag | Compuestos ciclobutanediona sustituidos anti-inflamatorios |
| WO2009005801A1 (en) * | 2007-07-03 | 2009-01-08 | Schering Corporation | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
| WO2009012375A2 (en) * | 2007-07-19 | 2009-01-22 | Wyeth | Squarate kinase inhibitors |
| UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
| WO2010042998A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators |
| NZ592748A (en) * | 2008-10-17 | 2013-01-25 | Akaal Pharma Pty Ltd | 2-Amino-(oxadiazol-3-yl)-benzofuran derivatives and their use as S1P receptor modulators |
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| AU2010290131C1 (en) | 2009-08-24 | 2015-12-03 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| CA2838833A1 (en) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Pro-coagulant compounds and methods of use thereof |
| HUE035751T2 (hu) | 2011-09-02 | 2018-08-28 | Novartis Ag | Gyulladásgátló szubsztituált ciklobuténdion vegyület kolinsó |
| FR2981936B1 (fr) | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| BR112014020694A2 (pt) | 2012-02-15 | 2018-05-08 | Amunix Operating Inc. | proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a |
| KR20140138293A (ko) | 2012-03-16 | 2014-12-03 | 액시킨 파마수티컬스 인코포레이티드 | 3,5-다이아미노피라졸 키나아제 억제제 |
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| CA2888806A1 (en) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Methods of using a fixed dose of a clotting factor |
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| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
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2002
- 2002-09-11 US US10/241,326 patent/US20040106794A1/en not_active Abandoned
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2003
- 2003-07-30 PL PL03374876A patent/PL374876A1/xx not_active Application Discontinuation
- 2003-07-30 JP JP2004524185A patent/JP2005534684A/ja active Pending
- 2003-07-30 CA CA2496676A patent/CA2496676C/en not_active Expired - Fee Related
- 2003-07-30 AU AU2003259302A patent/AU2003259302B2/en not_active Ceased
- 2003-07-30 EP EP03772075A patent/EP1539678B1/en not_active Expired - Lifetime
- 2003-07-30 RU RU2005105692/04A patent/RU2005105692A/ru not_active Application Discontinuation
- 2003-07-30 TW TW095140972A patent/TW200716520A/zh unknown
- 2003-07-30 BR BR0313109-2A patent/BR0313109A/pt not_active IP Right Cessation
- 2003-07-30 MX MXPA05001274A patent/MXPA05001274A/es active IP Right Grant
- 2003-07-30 KR KR1020057001672A patent/KR20050026060A/ko not_active Ceased
- 2003-07-30 WO PCT/US2003/023785 patent/WO2004011418A1/en not_active Ceased
- 2003-07-30 NZ NZ538521A patent/NZ538521A/en unknown
- 2003-07-30 IL IL16642703A patent/IL166427A0/xx unknown
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2005
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2006
- 2006-08-08 US US11/500,739 patent/US7964646B2/en not_active Expired - Fee Related
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2009
- 2009-01-13 US US12/352,781 patent/US7947720B2/en not_active Expired - Fee Related
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2011
- 2011-05-06 US US13/102,554 patent/US20110213029A1/en not_active Abandoned
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| MXPA05001274A (es) | 2005-09-08 |
| US20070021494A1 (en) | 2007-01-25 |
| BR0313109A (pt) | 2005-06-21 |
| US7964646B2 (en) | 2011-06-21 |
| TW200716520A (en) | 2007-05-01 |
| CA2496676A1 (en) | 2004-02-05 |
| NZ538521A (en) | 2008-02-29 |
| PL374876A1 (en) | 2005-11-14 |
| EP1539678A1 (en) | 2005-06-15 |
| WO2004011418A1 (en) | 2004-02-05 |
| EP1539678B1 (en) | 2012-09-05 |
| KR20050026060A (ko) | 2005-03-14 |
| US7947720B2 (en) | 2011-05-24 |
| US20110213029A1 (en) | 2011-09-01 |
| US20040106794A1 (en) | 2004-06-03 |
| US20090306079A1 (en) | 2009-12-10 |
| NO20051036L (no) | 2005-04-20 |
| AU2003259302A1 (en) | 2004-02-16 |
| IL166427A0 (en) | 2006-01-15 |
| AU2003259302B2 (en) | 2008-06-26 |
| CA2496676C (en) | 2011-06-14 |
| JP2005534684A (ja) | 2005-11-17 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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