JP2005534684A5 - - Google Patents
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- JP2005534684A5 JP2005534684A5 JP2004524185A JP2004524185A JP2005534684A5 JP 2005534684 A5 JP2005534684 A5 JP 2005534684A5 JP 2004524185 A JP2004524185 A JP 2004524185A JP 2004524185 A JP2004524185 A JP 2004524185A JP 2005534684 A5 JP2005534684 A5 JP 2005534684A5
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- JP
- Japan
- Prior art keywords
- group
- substituted
- unsubstituted
- alkyl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 CC(*)(*)Cc1c(cccn2)c2ccc1 Chemical compound CC(*)(*)Cc1c(cccn2)c2ccc1 0.000 description 27
- AUQGAQQMGDCJRI-UHFFFAOYSA-O CC(C)C(C([NH2+]C(C)c1ccccc1)=O)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O Chemical compound CC(C)C(C([NH2+]C(C)c1ccccc1)=O)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O AUQGAQQMGDCJRI-UHFFFAOYSA-O 0.000 description 1
- AUQGAQQMGDCJRI-DNVCBOLYSA-N CC(C)[C@H](C(N[C@H](C)c1ccccc1)=O)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O Chemical compound CC(C)[C@H](C(N[C@H](C)c1ccccc1)=O)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O AUQGAQQMGDCJRI-DNVCBOLYSA-N 0.000 description 1
- LTNCYCKOTJDBMA-UHFFFAOYSA-N CC(c1ccc[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O Chemical compound CC(c1ccc[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O LTNCYCKOTJDBMA-UHFFFAOYSA-N 0.000 description 1
- JZUARMCNZIOGMA-UHFFFAOYSA-N CN(C)C(c(cccc1NC(C(C2=O)O)=C2NC2(CC2)c2ccccc2)c1O)=O Chemical compound CN(C)C(c(cccc1NC(C(C2=O)O)=C2NC2(CC2)c2ccccc2)c1O)=O JZUARMCNZIOGMA-UHFFFAOYSA-N 0.000 description 1
- IIFTXCCQGXWRHG-UHFFFAOYSA-N CN(C)C(c1cccc(NC(C(C2=O)=O)=C2NC2CCCCCC2)c1O)=O Chemical compound CN(C)C(c1cccc(NC(C(C2=O)=O)=C2NC2CCCCCC2)c1O)=O IIFTXCCQGXWRHG-UHFFFAOYSA-N 0.000 description 1
- PWBSHAALNNETET-OCCSQVGLSA-N CN(C)C(c1cccc(NC(C(C2=O)=O)=C2N[C@@H]2[C@@H](COC)CCCC2)c1O)=O Chemical compound CN(C)C(c1cccc(NC(C(C2=O)=O)=C2N[C@@H]2[C@@H](COC)CCCC2)c1O)=O PWBSHAALNNETET-OCCSQVGLSA-N 0.000 description 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N c1ccc2ncccc2c1 Chemical compound c1ccc2ncccc2c1 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/208,412 US20040097547A1 (en) | 2001-04-16 | 2002-07-30 | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US10/241,326 US20040106794A1 (en) | 2001-04-16 | 2002-09-11 | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| PCT/US2003/023785 WO2004011418A1 (en) | 2002-07-30 | 2003-07-30 | 3,4-di-substituted cyclobutene-1, 2-diones as cxc-chemokine receptor ligands |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010217953A Division JP2011063591A (ja) | 2002-07-30 | 2010-09-28 | Cxcケモカインレセプタ配位子としての3,4−二置換シクロブテン−1,2−ジオン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005534684A JP2005534684A (ja) | 2005-11-17 |
| JP2005534684A5 true JP2005534684A5 (https=) | 2006-09-14 |
Family
ID=31190690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004524185A Pending JP2005534684A (ja) | 2002-07-30 | 2003-07-30 | Cxcケモカインレセプタ配位子としての3,4−二置換シクロブテン−1,2−ジオン |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20040106794A1 (https=) |
| EP (1) | EP1539678B1 (https=) |
| JP (1) | JP2005534684A (https=) |
| KR (1) | KR20050026060A (https=) |
| AU (1) | AU2003259302B2 (https=) |
| BR (1) | BR0313109A (https=) |
| CA (1) | CA2496676C (https=) |
| IL (1) | IL166427A0 (https=) |
| MX (1) | MXPA05001274A (https=) |
| NO (1) | NO20051036L (https=) |
| NZ (1) | NZ538521A (https=) |
| PL (1) | PL374876A1 (https=) |
| RU (1) | RU2005105692A (https=) |
| TW (1) | TW200716520A (https=) |
| WO (1) | WO2004011418A1 (https=) |
Families Citing this family (63)
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| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| CN101514193B (zh) | 2003-04-18 | 2012-12-19 | 默沙东公司 | 呋喃取代的二氧代环丁烯的合成 |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
| US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
| CN1946690A (zh) * | 2004-02-27 | 2007-04-11 | 先灵公司 | 用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的含环丁烯二酮基团化合物 |
| WO2005113534A2 (en) * | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| CA2580762A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| CA2580857A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| JP2009500328A (ja) * | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドとしての5,6−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン |
| CN101448778A (zh) * | 2006-05-26 | 2009-06-03 | 艾博特公司 | Polo样激酶的抑制剂 |
| EP2026770A1 (en) * | 2006-06-12 | 2009-02-25 | Schering Corporation | Pharmaceutical formulations and compositions of a selective antagonist of either cxcr2 or both cxcr1 and cxcr2 and methods of using the same for treating inflammatory disorders |
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| UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
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| WO2010063802A1 (en) * | 2008-12-05 | 2010-06-10 | Novartis Ag | 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists |
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| AU2010290131C1 (en) | 2009-08-24 | 2015-12-03 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
| CA2838833A1 (en) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Pro-coagulant compounds and methods of use thereof |
| HUE035751T2 (hu) | 2011-09-02 | 2018-08-28 | Novartis Ag | Gyulladásgátló szubsztituált ciklobuténdion vegyület kolinsó |
| FR2981936B1 (fr) | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
| BR112014020694A2 (pt) | 2012-02-15 | 2018-05-08 | Amunix Operating Inc. | proteína de fusão do fator viii compreendendo polipeptídeo do fator viii fusionado a polipeptí-deo recombinante estendido (xten) e seu método de fabricação, ácido nucleico, vetores, célula hospedeira, bem como composição farmacêutica e seu uso no tratamento de coagulopatia, episódio de hemorragia e hemofilia a |
| KR20140138293A (ko) | 2012-03-16 | 2014-12-03 | 액시킨 파마수티컬스 인코포레이티드 | 3,5-다이아미노피라졸 키나아제 억제제 |
| EP2858659B1 (en) | 2012-06-08 | 2019-12-25 | Bioverativ Therapeutics Inc. | Procoagulant compounds |
| JP2015525222A (ja) | 2012-06-08 | 2015-09-03 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | キメラ性凝固因子 |
| CA2888806A1 (en) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Methods of using a fixed dose of a clotting factor |
| SI3889173T1 (sl) | 2013-02-15 | 2023-11-30 | Bioverativ Therapeutics Inc. | Optimiran gen dejavnika VIII |
| US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
| EP4108254A1 (en) | 2013-08-14 | 2022-12-28 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| WO2015048330A2 (en) | 2013-09-25 | 2015-04-02 | Biogen Idec Ma Inc. | On-column viral inactivation methods |
| US20180022780A1 (en) | 2014-09-26 | 2018-01-25 | Bayer Pharma Aktiengesellschaft | Stabilization adrenomedullin derivatives and use thereof |
| ES2753391T3 (es) | 2014-10-14 | 2020-04-08 | Halozyme Inc | Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas |
| US9546163B2 (en) | 2014-12-23 | 2017-01-17 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
| WO2016199906A1 (ja) * | 2015-06-12 | 2016-12-15 | 国立大学法人筑波大学 | スルホンアミド誘導体またはその薬学的に許容される酸付加塩 |
| BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| TWI724056B (zh) * | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Cxcr2抑制劑 |
| WO2017136358A1 (en) | 2016-02-01 | 2017-08-10 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| IL319473A (en) | 2016-12-02 | 2025-05-01 | Bioverativ Therapeutics Inc | Methods for treating hemophilic arthritis using chimeric blood clotting factors |
| GB201708856D0 (en) * | 2017-06-02 | 2017-07-19 | Ucb Biopharma Sprl | Seletalisib crystalline forms |
| JP2020530848A (ja) | 2017-08-14 | 2020-10-29 | アラーガン、インコーポレイテッドAllergan,Incorporated | 3,4−二置換3−シクロブテン−1,2−ジオンおよびその使用 |
| IL275839B2 (en) | 2018-01-08 | 2024-02-01 | Chemocentryx Inc | Methods for the treatment of generalized abscess psoriasis using a CCR6 or CXCR2 antagonist |
| BR112020022164A2 (pt) | 2018-05-18 | 2021-02-02 | Bioverativ Therapeutics Inc. | métodos de tratamento de hemofilia a |
| CN110577472B (zh) * | 2018-06-11 | 2023-06-02 | 重庆博腾制药科技股份有限公司 | 一种(1r,3s)-3-氨基-1-环戊醇盐酸盐的制备方法 |
| CA3104686A1 (en) | 2018-07-03 | 2020-01-09 | Bristol-Myers Squibb Company | Fgf-21 formulations |
| GEP20237476B (en) | 2018-09-21 | 2023-03-27 | Pfizer | N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors |
| EP4015501A1 (en) * | 2020-12-16 | 2022-06-22 | Consejo Superior de Investigaciones Científicas (CSIC) | N-benzyl-alpha-aminoamides as anaphase-promoting complex/cyclosome (apc/c) inhibitors |
| EP4703354A1 (en) * | 2023-04-28 | 2026-03-04 | Wuhan Createrna Science and Technology Co.,Ltd. | Compound as ccr6 antagonist, and pharmaceutical composition and use thereof |
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| RU2003126913A (ru) | 2001-02-02 | 2005-03-10 | Шеринг Корпорейшн (US) | 3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс |
| US20030204085A1 (en) | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
| PL208928B1 (pl) * | 2001-04-16 | 2011-06-30 | Pharmacopeia | 3, 4-di-podstawione cyklobuten-1, 2-diony jako ligandy receptora CXC chemokiny |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040097547A1 (en) * | 2001-04-16 | 2004-05-20 | Taveras Arthur G. | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| JP2005505595A (ja) | 2001-10-12 | 2005-02-24 | シェーリング コーポレイション | Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物 |
| US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| US20040053953A1 (en) * | 2002-03-18 | 2004-03-18 | Schering Corporation | Treatment of chemokine mediated diseases |
| MY139601A (en) | 2002-10-09 | 2009-10-30 | Schering Corp | Thiadiazoledioxides and thiadiazoleoxides as cxc-and cc-chemokine receptor ligands |
| CN101514193B (zh) * | 2003-04-18 | 2012-12-19 | 默沙东公司 | 呋喃取代的二氧代环丁烯的合成 |
| AU2005210504B2 (en) | 2004-01-30 | 2009-01-08 | Merck Sharp & Dohme Corp. | Crystalline polymorphs of a CXC-chemokine receptor ligand |
| US20080190441A1 (en) * | 2007-02-13 | 2008-08-14 | Michael Victor Vecchiola | Ergonomic hair brush |
-
2002
- 2002-09-11 US US10/241,326 patent/US20040106794A1/en not_active Abandoned
-
2003
- 2003-07-30 PL PL03374876A patent/PL374876A1/xx not_active Application Discontinuation
- 2003-07-30 JP JP2004524185A patent/JP2005534684A/ja active Pending
- 2003-07-30 CA CA2496676A patent/CA2496676C/en not_active Expired - Fee Related
- 2003-07-30 AU AU2003259302A patent/AU2003259302B2/en not_active Ceased
- 2003-07-30 EP EP03772075A patent/EP1539678B1/en not_active Expired - Lifetime
- 2003-07-30 RU RU2005105692/04A patent/RU2005105692A/ru not_active Application Discontinuation
- 2003-07-30 TW TW095140972A patent/TW200716520A/zh unknown
- 2003-07-30 BR BR0313109-2A patent/BR0313109A/pt not_active IP Right Cessation
- 2003-07-30 MX MXPA05001274A patent/MXPA05001274A/es active IP Right Grant
- 2003-07-30 KR KR1020057001672A patent/KR20050026060A/ko not_active Ceased
- 2003-07-30 WO PCT/US2003/023785 patent/WO2004011418A1/en not_active Ceased
- 2003-07-30 NZ NZ538521A patent/NZ538521A/en unknown
- 2003-07-30 IL IL16642703A patent/IL166427A0/xx unknown
-
2005
- 2005-02-25 NO NO20051036A patent/NO20051036L/no not_active Application Discontinuation
-
2006
- 2006-08-08 US US11/500,739 patent/US7964646B2/en not_active Expired - Fee Related
-
2009
- 2009-01-13 US US12/352,781 patent/US7947720B2/en not_active Expired - Fee Related
-
2011
- 2011-05-06 US US13/102,554 patent/US20110213029A1/en not_active Abandoned
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