JP2019526606A5 - - Google Patents
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- JP2019526606A5 JP2019526606A5 JP2019513756A JP2019513756A JP2019526606A5 JP 2019526606 A5 JP2019526606 A5 JP 2019526606A5 JP 2019513756 A JP2019513756 A JP 2019513756A JP 2019513756 A JP2019513756 A JP 2019513756A JP 2019526606 A5 JP2019526606 A5 JP 2019526606A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662393209P | 2016-09-12 | 2016-09-12 | |
| US62/393,209 | 2016-09-12 | ||
| PCT/US2017/050886 WO2018049296A1 (en) | 2016-09-12 | 2017-09-11 | Heteroaryl inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526606A JP2019526606A (ja) | 2019-09-19 |
| JP2019526606A5 true JP2019526606A5 (https=) | 2020-10-22 |
| JP7118951B2 JP7118951B2 (ja) | 2022-08-16 |
Family
ID=59955657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019513756A Active JP7118951B2 (ja) | 2016-09-12 | 2017-09-11 | Ｐａｄ４のヘテロアリール阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11026937B2 (https=) |
| EP (1) | EP3510025B1 (https=) |
| JP (1) | JP7118951B2 (https=) |
| KR (1) | KR102502992B1 (https=) |
| CN (1) | CN110248934B (https=) |
| ES (1) | ES2924522T3 (https=) |
| MA (1) | MA46193A (https=) |
| WO (1) | WO2018049296A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3015482A1 (en) | 2016-02-23 | 2017-08-31 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| WO2018022897A1 (en) | 2016-07-27 | 2018-02-01 | Padlock Therapeutics, Inc. | Covalent inhibitors of pad4 |
| JP2021523208A (ja) * | 2018-05-14 | 2021-09-02 | アリアド ファーマシューティカルズ， インコーポレイテッド | ピリミジン誘導体の医薬塩及び障害の処置方法 |
| KR102089476B1 (ko) * | 2018-07-11 | 2020-03-16 | 이화여자대학교 산학협력단 | 피부 염증 질환 예방 또는 치료용 조성물 |
| MX2021001565A (es) | 2018-08-08 | 2021-04-19 | Bristol Myers Squibb Co | Inhibidores tipo indol y azaindol de enzimas peptidil arginina deiminasas (pad). |
| JP7447080B2 (ja) | 2018-08-08 | 2024-03-11 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐａｄ４阻害剤としての置換チエノピロール |
| CN109467549B (zh) * | 2018-12-07 | 2021-02-09 | 中国药科大学 | 喹啉取代查尔酮类化合物、其制备方法及用途 |
| KR102173983B1 (ko) | 2019-04-18 | 2020-11-04 | 현대모비스 주식회사 | 전자식 유압 브레이크 장치 |
| WO2021158840A1 (en) | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| WO2021222353A1 (en) | 2020-04-30 | 2021-11-04 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| WO2022140390A1 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| TW202233174A (zh) | 2020-12-22 | 2022-09-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2024112749A1 (en) * | 2022-11-23 | 2024-05-30 | The Children's Medical Center Corporation | Methods of treating heart failure |
| CN115778930B (zh) * | 2022-12-08 | 2024-02-27 | 陕西中医药大学 | 一种具有血管舒张活性的二硫缩醛类化合物在制备具有血管舒张活性药物方面的应用 |
| US11731942B1 (en) | 2023-01-12 | 2023-08-22 | King Faisal University | 3-substituted quinolin-2-one compounds as antibacterial agents |
| KR20250153810A (ko) * | 2023-02-28 | 2025-10-27 | 추가이 세이야쿠 가부시키가이샤 | Myt1 억제 활성을 갖는 질소 함유 헤테로사이클릭 화합물 |
| KR20260041867A (ko) | 2023-07-21 | 2026-03-27 | 브리스톨-마이어스 스큅 컴퍼니 | Pad4 조정제의 시트룰린화 및 활성을 평가하는 방법 |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2876000A (en) * | 1999-02-10 | 2000-08-29 | Trustees Of The University Of Pennsylvania, The | Tyrosine kinase inhibitors and methods of using the same |
| US20050165053A1 (en) * | 2001-06-04 | 2005-07-28 | Cytovia, Inc. | Substituted4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof |
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| CN105315333A (zh) * | 2014-06-10 | 2016-02-10 | 首都医科大学 | 异喹啉-3-甲酰-RV-OBzl,其制备,纳米结构,活性和应用 |
| US10577349B2 (en) * | 2015-03-02 | 2020-03-03 | Sanford Burnham Prebys Medical Discovery Institute | Quinolinones as inhibitors of translation initiation complex |
| KR20180005250A (ko) | 2015-05-21 | 2018-01-15 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Pad4 억제제로서의 벤조이미다졸 유도체 |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| AR107030A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
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| CN105820058A (zh) * | 2016-03-01 | 2016-08-03 | 南开大学 | 精氨酸脱亚氨酶4的新型抑制剂 |
| WO2018022897A1 (en) | 2016-07-27 | 2018-02-01 | Padlock Therapeutics, Inc. | Covalent inhibitors of pad4 |
-
2017
- 2017-09-11 US US16/331,622 patent/US11026937B2/en active Active
- 2017-09-11 KR KR1020197010110A patent/KR102502992B1/ko active Active
- 2017-09-11 WO PCT/US2017/050886 patent/WO2018049296A1/en not_active Ceased
- 2017-09-11 CN CN201780070039.2A patent/CN110248934B/zh active Active
- 2017-09-11 MA MA046193A patent/MA46193A/fr unknown
- 2017-09-11 ES ES17772181T patent/ES2924522T3/es active Active
- 2017-09-11 EP EP17772181.8A patent/EP3510025B1/en active Active
- 2017-09-11 JP JP2019513756A patent/JP7118951B2/ja active Active
-
2021
- 2021-05-12 US US17/318,078 patent/US20210299115A1/en not_active Abandoned
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