JP2019526606A5 - - Google Patents
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- JP2019526606A5 JP2019526606A5 JP2019513756A JP2019513756A JP2019526606A5 JP 2019526606 A5 JP2019526606 A5 JP 2019526606A5 JP 2019513756 A JP2019513756 A JP 2019513756A JP 2019513756 A JP2019513756 A JP 2019513756A JP 2019526606 A5 JP2019526606 A5 JP 2019526606A5
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- pneumonitis
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662393209P | 2016-09-12 | 2016-09-12 | |
| US62/393,209 | 2016-09-12 | ||
| PCT/US2017/050886 WO2018049296A1 (en) | 2016-09-12 | 2017-09-11 | Heteroaryl inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526606A JP2019526606A (ja) | 2019-09-19 |
| JP2019526606A5 true JP2019526606A5 (https=) | 2020-10-22 |
| JP7118951B2 JP7118951B2 (ja) | 2022-08-16 |
Family
ID=59955657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019513756A Active JP7118951B2 (ja) | 2016-09-12 | 2017-09-11 | Ｐａｄ４のヘテロアリール阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11026937B2 (https=) |
| EP (1) | EP3510025B1 (https=) |
| JP (1) | JP7118951B2 (https=) |
| KR (1) | KR102502992B1 (https=) |
| CN (1) | CN110248934B (https=) |
| ES (1) | ES2924522T3 (https=) |
| MA (1) | MA46193A (https=) |
| WO (1) | WO2018049296A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| US12084431B2 (en) * | 2018-05-14 | 2024-09-10 | Takeda Pharmaceutical Company Limited | Pharmaceutical salts of pyrimidine derivatives and method of treating disorders |
| KR102089476B1 (ko) * | 2018-07-11 | 2020-03-16 | 이화여자대학교 산학협력단 | 피부 염증 질환 예방 또는 치료용 조성물 |
| EP3833671B1 (en) | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| CN109467549B (zh) * | 2018-12-07 | 2021-02-09 | 中国药科大学 | 喹啉取代查尔酮类化合物、其制备方法及用途 |
| KR102173983B1 (ko) | 2019-04-18 | 2020-11-04 | 현대모비스 주식회사 | 전자식 유압 브레이크 장치 |
| EP4100405A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| TW202241884A (zh) | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2024112749A1 (en) * | 2022-11-23 | 2024-05-30 | The Children's Medical Center Corporation | Methods of treating heart failure |
| CN115778930B (zh) * | 2022-12-08 | 2024-02-27 | 陕西中医药大学 | 一种具有血管舒张活性的二硫缩醛类化合物在制备具有血管舒张活性药物方面的应用 |
| US11731942B1 (en) | 2023-01-12 | 2023-08-22 | King Faisal University | 3-substituted quinolin-2-one compounds as antibacterial agents |
| AR131956A1 (es) * | 2023-02-28 | 2025-05-21 | Chugai Pharmaceutical Co Ltd | Compuesto heterocíclico que contiene nitrógeno con actividad inhibidora de myt1 |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2876000A (en) | 1999-02-10 | 2000-08-29 | Trustees Of The University Of Pennsylvania, The | Tyrosine kinase inhibitors and methods of using the same |
| WO2002098425A1 (en) * | 2001-06-04 | 2002-12-12 | Cytovia, Inc. | Substituted 4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof |
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| US8778977B2 (en) * | 2006-06-30 | 2014-07-15 | Sunesis Pharmaceuticals, Inc. | Pyridinonyl PDK1 inhibitors |
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| US20120190707A1 (en) | 2008-04-25 | 2012-07-26 | Ronai Ze Ev | Selective inhibitors of akt and methods of using same |
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| US10407407B2 (en) | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| AR107032A1 (es) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
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| JP6926126B2 (ja) | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| CN105820058A (zh) | 2016-03-01 | 2016-08-03 | 南开大学 | 精氨酸脱亚氨酶4的新型抑制剂 |
| KR102398941B1 (ko) | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
-
2017
- 2017-09-11 JP JP2019513756A patent/JP7118951B2/ja active Active
- 2017-09-11 ES ES17772181T patent/ES2924522T3/es active Active
- 2017-09-11 KR KR1020197010110A patent/KR102502992B1/ko active Active
- 2017-09-11 MA MA046193A patent/MA46193A/fr unknown
- 2017-09-11 CN CN201780070039.2A patent/CN110248934B/zh active Active
- 2017-09-11 US US16/331,622 patent/US11026937B2/en active Active
- 2017-09-11 WO PCT/US2017/050886 patent/WO2018049296A1/en not_active Ceased
- 2017-09-11 EP EP17772181.8A patent/EP3510025B1/en active Active
-
2021
- 2021-05-12 US US17/318,078 patent/US20210299115A1/en not_active Abandoned
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