JP2019505568A5 - - Google Patents
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- JP2019505568A5 JP2019505568A5 JP2018549402A JP2018549402A JP2019505568A5 JP 2019505568 A5 JP2019505568 A5 JP 2019505568A5 JP 2018549402 A JP2018549402 A JP 2018549402A JP 2018549402 A JP2018549402 A JP 2018549402A JP 2019505568 A5 JP2019505568 A5 JP 2019505568A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- syndrome
- compound according
- aliphatic group
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C=CCc1ccccc1)I Chemical compound C*(C=CCc1ccccc1)I 0.000 description 4
- YSAXEHWHSLANOM-UHFFFAOYSA-N CC1=Cc2ccccc2C1 Chemical compound CC1=Cc2ccccc2C1 YSAXEHWHSLANOM-UHFFFAOYSA-N 0.000 description 1
- OVRKATYHWPCGPZ-UHFFFAOYSA-N CC1CCOCC1 Chemical compound CC1CCOCC1 OVRKATYHWPCGPZ-UHFFFAOYSA-N 0.000 description 1
- BEEIHTCHVRPYOV-VOTSOKGWSA-N NS/C=C/c1ccccc1 Chemical compound NS/C=C/c1ccccc1 BEEIHTCHVRPYOV-VOTSOKGWSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264925P | 2015-12-09 | 2015-12-09 | |
| US62/264,925 | 2015-12-09 | ||
| PCT/US2016/065857 WO2017100594A1 (en) | 2015-12-09 | 2016-12-09 | Bicyclic inhibitors of pad4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505568A JP2019505568A (ja) | 2019-02-28 |
| JP2019505568A5 true JP2019505568A5 (https=) | 2020-01-16 |
| JP6932136B2 JP6932136B2 (ja) | 2021-09-08 |
Family
ID=59013640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018549402A Active JP6932136B2 (ja) | 2015-12-09 | 2016-12-09 | Ｐａｄ４の二環式阻害剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9963448B2 (https=) |
| EP (2) | EP3885342B1 (https=) |
| JP (1) | JP6932136B2 (https=) |
| KR (1) | KR102729670B1 (https=) |
| CN (1) | CN109069869B (https=) |
| AR (1) | AR107032A1 (https=) |
| AU (1) | AU2016366398A1 (https=) |
| BR (1) | BR112018011709A2 (https=) |
| CA (1) | CA3007639A1 (https=) |
| EA (1) | EA201891251A1 (https=) |
| ES (2) | ES3007582T3 (https=) |
| IL (1) | IL259794A (https=) |
| MX (1) | MX2018006632A (https=) |
| SG (1) | SG11201804668UA (https=) |
| TW (1) | TW201726674A (https=) |
| UY (1) | UY37018A (https=) |
| WO (1) | WO2017100594A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10407407B2 (en) * | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
| JP6926126B2 (ja) * | 2016-02-23 | 2021-08-25 | パドロック・セラピューティクス・インコーポレイテッドＰａｄｌｏｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐａｄ４のヘテロアリール阻害剤 |
| KR102398941B1 (ko) | 2016-07-27 | 2022-05-17 | 패들락 테라퓨틱스, 인코포레이티드 | Pad4의 공유결합성 억제제 |
| JP7118951B2 (ja) | 2016-09-12 | 2022-08-16 | パドロック・セラピューティクス・インコーポレイテッド | Ｐａｄ４のヘテロアリール阻害剤 |
| EP3760628A4 (en) * | 2018-02-26 | 2021-10-13 | Nanjing Transthera Biosciences Co., Ltd. | PEPTIDYLARGININE DEIMINASE INHIBITOR AND ITS USES |
| CN112789087B (zh) * | 2018-08-08 | 2024-08-13 | 百时美施贵宝公司 | Pad酶的苯并咪唑抑制剂 |
| EP3833671B1 (en) * | 2018-08-08 | 2022-08-24 | Bristol-Myers Squibb Company | Substituted thienopyrroles as pad4 inhibitors |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| WO2020033488A1 (en) * | 2018-08-08 | 2020-02-13 | Bristol-Myers Squibb Company | Substituted benzimidazoles as pad4 inhibitors |
| JP7530380B2 (ja) | 2019-03-28 | 2024-08-07 | ルピン・リミテッド | Ｓｔｉｎｇアゴニストとしての大環状化合物 |
| TW202115083A (zh) * | 2019-09-27 | 2021-04-16 | 大陸商南京藥捷安康生物科技有限公司 | 肽醯精胺酸脫亞胺酶抑制劑及其用途 |
| EP4100405A1 (en) * | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| EP4143189A1 (en) * | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| WO2022040267A1 (en) | 2020-08-19 | 2022-02-24 | Bristol-Myers Squibb Company | 1h-pyrrolo[3,2-c]pyridine and 1h-pyrrolo[2,3-c]pyridine derivatives as tlr9 inhibitors for the treatment of fibrosis |
| CN116075510A (zh) | 2020-08-19 | 2023-05-05 | 百时美施贵宝公司 | 1H-苯并[d]咪唑衍生物作为TLR9抑制剂用于治疗纤维化 |
| CN112618546B (zh) * | 2020-12-22 | 2022-03-01 | 陈昊 | Pad4抑制剂在制备放射治疗增敏药物方面的应用 |
| TW202241884A (zh) | 2020-12-22 | 2022-11-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140428A2 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| WO2024109945A1 (en) * | 2022-11-24 | 2024-05-30 | Helios Huaming Biopharma Co., Ltd. | Selenium containing heterocycle compounds and use thereof |
| WO2025024265A1 (en) | 2023-07-21 | 2025-01-30 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad4 modulators |
| WO2025181830A2 (en) * | 2024-03-01 | 2025-09-04 | Jubilant Epipad LLC | Polyheterocyclic compounds as peptidyl arginine deiminase 4 (pad4) inhibitors |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20012060A1 (it) * | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
| US6897208B2 (en) | 2001-10-26 | 2005-05-24 | Aventis Pharmaceuticals Inc. | Benzimidazoles |
| EP1581217A4 (en) | 2002-11-01 | 2007-07-11 | Merck & Co Inc | CARBONYLAMINO-BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ANDROGENIC RECEPTORS |
| CA2709883A1 (en) | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Benzimidazoles and analogs as rho kinase inhibitors |
| CN103189063B (zh) * | 2010-11-01 | 2016-10-19 | 宾夕法尼亚州研究基金会 | 治疗组合物和方法 |
| JP5721484B2 (ja) | 2011-03-17 | 2015-05-20 | 富士フイルム株式会社 | 重合性液晶組成物、それを用いた高分子材料および光学異方性フィルム、並びに重合性液晶化合物 |
| WO2013052263A2 (en) | 2011-09-16 | 2013-04-11 | Microbiotix, Inc. | Antifungal compounds |
| WO2013157021A1 (en) | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| US9550737B2 (en) | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
| WO2014001973A1 (en) * | 2012-06-29 | 2014-01-03 | Pfizer Inc. | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS |
| RS55684B1 (sr) * | 2012-07-26 | 2017-07-31 | Glaxo Group Ltd | 2-(azaindol-2-il)benzimidazoli kao pad4 inhibitori |
| US10407407B2 (en) * | 2015-05-21 | 2019-09-10 | Glaxosmithkline Intellectual Property Development Limited | Benzoimidazole derivatives as PAD4 inhibitors |
-
2016
- 2016-12-07 AR ARP160103778A patent/AR107032A1/es unknown
- 2016-12-08 TW TW105140709A patent/TW201726674A/zh unknown
- 2016-12-09 CA CA3007639A patent/CA3007639A1/en not_active Abandoned
- 2016-12-09 EP EP21171167.6A patent/EP3885342B1/en active Active
- 2016-12-09 MX MX2018006632A patent/MX2018006632A/es unknown
- 2016-12-09 EP EP16873928.2A patent/EP3386590B1/en active Active
- 2016-12-09 ES ES21171167T patent/ES3007582T3/es active Active
- 2016-12-09 KR KR1020187019382A patent/KR102729670B1/ko active Active
- 2016-12-09 CN CN201680081403.0A patent/CN109069869B/zh active Active
- 2016-12-09 AU AU2016366398A patent/AU2016366398A1/en not_active Abandoned
- 2016-12-09 JP JP2018549402A patent/JP6932136B2/ja active Active
- 2016-12-09 WO PCT/US2016/065857 patent/WO2017100594A1/en not_active Ceased
- 2016-12-09 US US15/374,159 patent/US9963448B2/en active Active
- 2016-12-09 UY UY0001037018A patent/UY37018A/es unknown
- 2016-12-09 BR BR112018011709A patent/BR112018011709A2/pt not_active Application Discontinuation
- 2016-12-09 ES ES16873928T patent/ES2877543T3/es active Active
- 2016-12-09 EA EA201891251A patent/EA201891251A1/ru unknown
- 2016-12-09 SG SG11201804668UA patent/SG11201804668UA/en unknown
-
2018
- 2018-06-04 IL IL259794A patent/IL259794A/en unknown
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